NO323826B1 - 2-amino-nikotinamidderivater og deres anvendelse for fremstilling av farmasoytiske preparater, fremgangsmate for fremstilling av derivatene samt farmasoytiske preparater omfattende disse - Google Patents

2-amino-nikotinamidderivater og deres anvendelse for fremstilling av farmasoytiske preparater, fremgangsmate for fremstilling av derivatene samt farmasoytiske preparater omfattende disse Download PDF

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Publication number
NO323826B1
NO323826B1 NO20023218A NO20023218A NO323826B1 NO 323826 B1 NO323826 B1 NO 323826B1 NO 20023218 A NO20023218 A NO 20023218A NO 20023218 A NO20023218 A NO 20023218A NO 323826 B1 NO323826 B1 NO 323826B1
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NO
Norway
Prior art keywords
methyl
pyridinecarboxamide
pyridyl
compound
phenyl
Prior art date
Application number
NO20023218A
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English (en)
Norwegian (no)
Other versions
NO20023218L (no
NO20023218D0 (no
Inventor
Guido Bold
Paul William Manley
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Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20023218D0 publication Critical patent/NO20023218D0/no
Publication of NO20023218L publication Critical patent/NO20023218L/no
Publication of NO323826B1 publication Critical patent/NO323826B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20023218A 2000-01-27 2002-07-02 2-amino-nikotinamidderivater og deres anvendelse for fremstilling av farmasoytiske preparater, fremgangsmate for fremstilling av derivatene samt farmasoytiske preparater omfattende disse NO323826B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0001930.7A GB0001930D0 (en) 2000-01-27 2000-01-27 Organic compounds
PCT/EP2001/000835 WO2001055114A1 (fr) 2000-01-27 2001-01-25 Derives de 2-amino-nicotinamide et leur utilisation comme inhibiteurs de tyrosine kinase du recepteur vegf

Publications (3)

Publication Number Publication Date
NO20023218D0 NO20023218D0 (no) 2002-07-02
NO20023218L NO20023218L (no) 2002-09-16
NO323826B1 true NO323826B1 (no) 2007-07-09

Family

ID=9884488

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023218A NO323826B1 (no) 2000-01-27 2002-07-02 2-amino-nikotinamidderivater og deres anvendelse for fremstilling av farmasoytiske preparater, fremgangsmate for fremstilling av derivatene samt farmasoytiske preparater omfattende disse

Country Status (24)

Country Link
US (1) US6624174B2 (fr)
EP (2) EP1259487B8 (fr)
JP (1) JP3894793B2 (fr)
KR (1) KR100554988B1 (fr)
CN (1) CN1216867C (fr)
AT (1) ATE452880T1 (fr)
AU (1) AU771626B2 (fr)
BR (1) BR0107805A (fr)
CA (1) CA2396590C (fr)
CZ (1) CZ20022582A3 (fr)
DE (1) DE60140860D1 (fr)
ES (2) ES2490191T3 (fr)
GB (1) GB0001930D0 (fr)
HU (1) HUP0204083A3 (fr)
IL (2) IL150481A0 (fr)
MX (1) MXPA02007319A (fr)
NO (1) NO323826B1 (fr)
NZ (1) NZ520005A (fr)
PL (1) PL356307A1 (fr)
PT (2) PT1259487E (fr)
RU (1) RU2296124C2 (fr)
SK (1) SK287426B6 (fr)
WO (1) WO2001055114A1 (fr)
ZA (1) ZA200205988B (fr)

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US20030032656A1 (en) 2003-02-13
JP2003520853A (ja) 2003-07-08
DE60140860D1 (de) 2010-02-04
US6624174B2 (en) 2003-09-23
EP2168948B1 (fr) 2014-05-07
HK1050895A1 (en) 2003-07-11
SK287426B6 (sk) 2010-09-07
KR100554988B1 (ko) 2006-02-24
NZ520005A (en) 2004-02-27
BR0107805A (pt) 2002-10-22
AU2849901A (en) 2001-08-07
NO20023218L (no) 2002-09-16
CA2396590A1 (fr) 2001-08-02
ATE452880T1 (de) 2010-01-15
WO2001055114A1 (fr) 2001-08-02
IL150481A (en) 2009-09-22
MXPA02007319A (es) 2002-11-29
EP1259487B8 (fr) 2014-04-23
ES2490191T3 (es) 2014-09-03
CZ20022582A3 (cs) 2002-10-16
JP3894793B2 (ja) 2007-03-22
AU771626B2 (en) 2004-04-01
RU2296124C2 (ru) 2007-03-27
SK10852002A3 (sk) 2003-05-02
CN1216867C (zh) 2005-08-31
HUP0204083A2 (hu) 2003-03-28
PT1259487E (pt) 2010-03-26
NO20023218D0 (no) 2002-07-02
IL150481A0 (en) 2002-12-01
CA2396590C (fr) 2011-03-01
KR20020071973A (ko) 2002-09-13
ES2338407T3 (es) 2010-05-07
HUP0204083A3 (en) 2005-03-29
PL356307A1 (en) 2004-06-28
CN1396912A (zh) 2003-02-12
EP1259487A1 (fr) 2002-11-27
GB0001930D0 (en) 2000-03-22
EP1259487B1 (fr) 2009-12-23
PT2168948E (pt) 2014-08-26
EP2168948A1 (fr) 2010-03-31
ZA200205988B (en) 2003-07-28

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