NO324177B1 - Svovelsyremono-[3-({1-[2-(4-fluor-fenyl)-etyl]-piperidin-4-YL}-hydroxy-metyl)-2-metoksy-fenyl]ester, fremgangsmate for fremstilling derav samt mellomprodukt, fremgangsmate for a isolere forbindelsen, anvendelse av forbindelsen samt farmasoytisk sammensetning - Google Patents

Svovelsyremono-[3-({1-[2-(4-fluor-fenyl)-etyl]-piperidin-4-YL}-hydroxy-metyl)-2-metoksy-fenyl]ester, fremgangsmate for fremstilling derav samt mellomprodukt, fremgangsmate for a isolere forbindelsen, anvendelse av forbindelsen samt farmasoytisk sammensetning Download PDF

Info

Publication number: NO324177B1
Authority: NO; Norway
Prior art keywords: compound; phenyl; ethyl; methoxy; give
Prior art date: 1999-07-16

Application number

NO20020213A

Other languages

English (en)

Norwegian (no)

Other versions

NO20020213D0 (no

NO20020213L (no

Inventor

Chi-Hsin R King

Ronald Charles Bernotas

Paul Brown

Gary Emmons

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2002-01-15

Publication date

2007-09-03

2002-01-15 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-01-15 Publication of NO20020213D0 publication Critical patent/NO20020213D0/no

2002-02-22 Publication of NO20020213L publication Critical patent/NO20020213L/no

2007-09-03 Publication of NO324177B1 publication Critical patent/NO324177B1/no

Links

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239000008194 pharmaceutical composition Substances 0.000 title claims description 4
CFCNFOWLAPIQEJ-UHFFFAOYSA-N [3-[[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]-hydroxymethyl]-2-methoxyphenyl] hydrogen sulfate Chemical compound COC1=C(OS(O)(=O)=O)C=CC=C1C(O)C1CCN(CCC=2C=CC(F)=CC=2)CC1 CFCNFOWLAPIQEJ-UHFFFAOYSA-N 0.000 title 1
239000002904 solvent Substances 0.000 claims description 36
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QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 22
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YPNGFLWBGDIDMK-UHFFFAOYSA-N [2-methoxy-3-tri(propan-2-yl)silyloxyphenyl]-piperidin-4-ylmethanone Chemical compound COC1=C(O[Si](C(C)C)(C(C)C)C(C)C)C=CC=C1C(=O)C1CCNCC1 YPNGFLWBGDIDMK-UHFFFAOYSA-N 0.000 claims description 3
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125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO20020213A 1999-07-16 2002-01-15 Svovelsyremono-[3-({1-[2-(4-fluor-fenyl)-etyl]-piperidin-4-YL}-hydroxy-metyl)-2-metoksy-fenyl]ester, fremgangsmate for fremstilling derav samt mellomprodukt, fremgangsmate for a isolere forbindelsen, anvendelse av forbindelsen samt farmasoytisk sammensetning NO324177B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35470499A	1999-07-16	1999-07-16
PCT/US2000/019065 WO2001005764A2 (en)	1999-07-16	2000-07-13	Sulfuric acid mono-[3-({1- [2-(4-fluoro-phenyl)-ethyl]- piperidin-4-yl}- hydroxy- methyl)-2- methoxy-phenyl]ester

Publications (3)

Publication Number	Publication Date
NO20020213D0 NO20020213D0 (no)	2002-01-15
NO20020213L NO20020213L (no)	2002-02-22
NO324177B1 true NO324177B1 (no)	2007-09-03

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Application Number	Title	Priority Date	Filing Date
NO20020213A NO324177B1 (no)	1999-07-16	2002-01-15	Svovelsyremono-[3-({1-[2-(4-fluor-fenyl)-etyl]-piperidin-4-YL}-hydroxy-metyl)-2-metoksy-fenyl]ester, fremgangsmate for fremstilling derav samt mellomprodukt, fremgangsmate for a isolere forbindelsen, anvendelse av forbindelsen samt farmasoytisk sammensetning

Country Status (21)

Country	Link
EP (1)	EP1202967B1 (de)
JP (1)	JP2003505374A (de)
KR (1)	KR100737718B1 (de)
AR (1)	AR024762A1 (de)
AT (1)	ATE348807T1 (de)
AU (1)	AU769484B2 (de)
BR (1)	BR0012477A (de)
CA (1)	CA2374635C (de)
CY (1)	CY1107658T1 (de)
DE (1)	DE60032489T2 (de)
DK (1)	DK1202967T3 (de)
ES (1)	ES2276688T3 (de)
HU (1)	HUP0202297A3 (de)
IL (2)	IL147310A0 (de)
MX (1)	MXPA02000444A (de)
NO (1)	NO324177B1 (de)
NZ (1)	NZ516286A (de)
PL (1)	PL353749A1 (de)
PT (1)	PT1202967E (de)
WO (1)	WO2001005764A2 (de)
ZA (1)	ZA200200101B (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5169096A (en) *	1985-07-02	1992-12-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl-piperidine-methanol derivatives
KR100211713B1 (ko) *	1990-06-01	1999-08-02	슈테펜 엘. 네스비트	(+)-알파-(2,3-디메톡시페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists

2000
- 2000-07-13 DK DK00947304T patent/DK1202967T3/da active
- 2000-07-13 PL PL00353749A patent/PL353749A1/xx not_active Application Discontinuation
- 2000-07-13 IL IL14731000A patent/IL147310A0/xx active IP Right Grant
- 2000-07-13 WO PCT/US2000/019065 patent/WO2001005764A2/en not_active Ceased
- 2000-07-13 KR KR1020027000670A patent/KR100737718B1/ko not_active Expired - Fee Related
- 2000-07-13 DE DE60032489T patent/DE60032489T2/de not_active Expired - Fee Related
- 2000-07-13 ES ES00947304T patent/ES2276688T3/es not_active Expired - Lifetime
- 2000-07-13 EP EP00947304A patent/EP1202967B1/de not_active Expired - Lifetime
- 2000-07-13 CA CA002374635A patent/CA2374635C/en not_active Expired - Fee Related
- 2000-07-13 AU AU60939/00A patent/AU769484B2/en not_active Ceased
- 2000-07-13 AT AT00947304T patent/ATE348807T1/de not_active IP Right Cessation
- 2000-07-13 HU HU0202297A patent/HUP0202297A3/hu unknown
- 2000-07-13 MX MXPA02000444A patent/MXPA02000444A/es active IP Right Grant
- 2000-07-13 NZ NZ516286A patent/NZ516286A/xx unknown
- 2000-07-13 JP JP2001511425A patent/JP2003505374A/ja active Pending
- 2000-07-13 PT PT00947304T patent/PT1202967E/pt unknown
- 2000-07-13 BR BR0012477-0A patent/BR0012477A/pt not_active Application Discontinuation
- 2000-07-17 AR ARP000103646A patent/AR024762A1/es not_active Application Discontinuation
2001
- 2001-12-25 IL IL147310A patent/IL147310A/en not_active IP Right Cessation
2002
- 2002-01-04 ZA ZA200200101A patent/ZA200200101B/xx unknown
- 2002-01-15 NO NO20020213A patent/NO324177B1/no not_active IP Right Cessation
2007
- 2007-02-13 CY CY20071100192T patent/CY1107658T1/el unknown

Also Published As

Publication number	Publication date
CY1107658T1 (el)	2013-04-18
EP1202967B1 (de)	2006-12-20
EP1202967A2 (de)	2002-05-08
HUP0202297A2 (en)	2002-10-28
PT1202967E (pt)	2007-02-28
MXPA02000444A (es)	2002-07-02
ZA200200101B (en)	2003-06-25
WO2001005764A2 (en)	2001-01-25
AU6093900A (en)	2001-02-05
NO20020213D0 (no)	2002-01-15
NZ516286A (en)	2004-03-26
DK1202967T3 (da)	2007-04-10
CA2374635C (en)	2007-04-17
KR100737718B1 (ko)	2007-07-11
WO2001005764A3 (en)	2001-10-04
DE60032489D1 (de)	2007-02-01
CA2374635A1 (en)	2001-01-25
IL147310A (en)	2007-10-31
HUP0202297A3 (en)	2010-01-28
AR024762A1 (es)	2002-10-23
NO20020213L (no)	2002-02-22
AU769484B2 (en)	2004-01-29
PL353749A1 (en)	2003-12-01
JP2003505374A (ja)	2003-02-12
BR0012477A (pt)	2002-04-02
ATE348807T1 (de)	2007-01-15
IL147310A0 (en)	2002-08-14
KR20020042619A (ko)	2002-06-05
ES2276688T3 (es)	2007-07-01
DE60032489T2 (de)	2007-10-11

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Date	Code	Title	Description
2010-03-01	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US7951821B2 (en)	2011-05-31	N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy
EP0374801B1 (de)	1997-03-19	N-substituierte azaheterocyclische Carbonsäuren
CZ62293A3 (en)	1994-02-16	Pyridine and pyridine-n-oxide derivatives of diaryl-methyl-piperidines or piperazines and preparations therefrom as well as method of their application
CZ300295B6 (cs)	2009-04-15	Cyklické aminoderiváty
CA2833493A1 (en)	2012-11-01	Amide compound and pharmaceutical application therefor
CA2957898C (en)	2023-02-21	Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
IL174942A (en)	2011-03-31	Derivatives of n-[phenyl(piperidine-2-yl)methyl]arylamides, pharmaceutical compositions comprising them and their use in the preparation of medicaments
FR2785902A1 (fr)	2000-05-19	4-aroylpiperidines antagonistes du recepteur du ccr-3, compositions pharmaceutiques les contenant, procede pour les utiliser et les preparer
NO861897L (no)	1986-11-17	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO300592B1 (no)	1997-06-23	Imidazopyridin PAF/H1 antagonister
US4727072A (en)	1988-02-23	3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
EA022043B1 (ru)	2015-10-30	Сульфоновые соединения в качестве лигандов 5-htрецептора
JPH05213751A (ja)	1993-08-24	一連のアレコロンおよびイソアレコロンのニコチン様活性
KR101815123B1 (ko)	2018-01-04	5ht2b 수용체 길항제
US6465490B1 (en)	2002-10-15	Sulfuric acid mono-[3({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester
WO2007114916A2 (en)	2007-10-11	Arylbenzylpiperidine compounds
EA017154B1 (ru)	2012-10-30	Аминоарилсульфонамидные соединения и их применение в качестве 5-нтлигандов
NO324177B1 (no)	2007-09-03	Svovelsyremono-[3-({1-[2-(4-fluor-fenyl)-etyl]-piperidin-4-YL}-hydroxy-metyl)-2-metoksy-fenyl]ester, fremgangsmate for fremstilling derav samt mellomprodukt, fremgangsmate for a isolere forbindelsen, anvendelse av forbindelsen samt farmasoytisk sammensetning
NO319534B1 (no)	2005-08-29	Mellomprodukt og fremgangsmater for fremstilling av antihistaminiske piperidinderivater og anvendelse derav for fremstilling av et medikament.
US4758563A (en)	1988-07-19	3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
JP4717306B2 (ja)	2011-07-06	Ｄ４拮抗剤として有用なチエノイソキサゾールフェノキシ非置換エチルおよびプロピル誘導体
EP1856052B1 (de)	2009-09-02	Nk1-antagonisten
EP1151993A1 (de)	2001-11-07	Cyclische aminderivate und ihre anwendungen
EP2784065B1 (de)	2016-10-05	Glycinwiederaufnahmehemmer und verwendung davon
MXPA00013006A (en)	2002-07-25	Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof