NO324352B1 - Aminotiazolderivater, fremgangsmate for deres fremstilling, deres anvendelse samt farmasoytisk preparat - Google Patents

Aminotiazolderivater, fremgangsmate for deres fremstilling, deres anvendelse samt farmasoytisk preparat Download PDF

Info

Publication number: NO324352B1
Authority: NO; Norway
Prior art keywords: methylphenyl; methoxy; prop; chloro; group
Prior art date: 1999-07-15

Application number

NO20020155A

Other languages

English (en)

Norwegian (no)

Other versions

NO20020155D0 (no

NO20020155L (no

Inventor

Danielle Gully

Pierre Roger

Antoine Pradines

Evelyne Fontaine

Michel Geslin

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-15

Filing date

2002-01-11

Publication date

2007-09-24

2002-01-11 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2002-01-11 Publication of NO20020155D0 publication Critical patent/NO20020155D0/no

2002-03-15 Publication of NO20020155L publication Critical patent/NO20020155L/no

2007-09-24 Publication of NO324352B1 publication Critical patent/NO324352B1/no

Links

238000000034 method Methods 0.000 title claims description 38
238000002360 preparation method Methods 0.000 title claims description 23
230000008569 process Effects 0.000 title claims description 5
RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 title description 12
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 126
IKXNIQJDNKPPCH-UHFFFAOYSA-N hydron;prop-2-yn-1-amine;chloride Chemical compound [Cl-].[NH3+]CC#C IKXNIQJDNKPPCH-UHFFFAOYSA-N 0.000 claims description 47
-1 2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl Chemical group 0.000 claims description 32
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
208000035475 disorder Diseases 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 15
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
125000005843 halogen group Chemical group 0.000 claims description 10
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IXWGQFWPELLZJB-BQAIUKQQSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1r)-2-methoxy-1-[4-(methoxymethyl)phenyl]ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](COC)C=1C=CC(COC)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl IXWGQFWPELLZJB-BQAIUKQQSA-N 0.000 claims description 4
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APSCIIYYEZZAFL-FTBISJDPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1r)-1-(3-fluoro-4-methylphenyl)-2-methoxyethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](COC)C=1C=C(F)C(C)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl APSCIIYYEZZAFL-FTBISJDPSA-N 0.000 claims 2
LWWDYICCOYDRAV-JIDHJSLPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-(3-fluoro-4-methylphenyl)pentyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCCC)C=1C=C(F)C(C)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl LWWDYICCOYDRAV-JIDHJSLPSA-N 0.000 claims 2
JRFDJIVNQOIVMA-BQAIUKQQSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-(4-chlorophenyl)-2-cyclopropylethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C1=C(C)C(OC)=CC(Cl)=C1C1=C(C)SC(N(CC#C)[C@@H](CC2CC2)C=2C=CC(Cl)=CC=2)=N1 JRFDJIVNQOIVMA-BQAIUKQQSA-N 0.000 claims 2
CSNMMZFZVWGSBL-FTBISJDPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-(4-fluorophenyl)butyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCC)C=1C=CC(F)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl CSNMMZFZVWGSBL-FTBISJDPSA-N 0.000 claims 2
XNLZVDGMPUXCEL-BQAIUKQQSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-(4-fluorophenyl)pentyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCCC)C=1C=CC(F)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl XNLZVDGMPUXCEL-BQAIUKQQSA-N 0.000 claims 2
GXLIBRLAEKOOLG-JIDHJSLPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-[3-fluoro-4-(methoxymethyl)phenyl]butyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCC)C=1C=C(F)C(COC)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl GXLIBRLAEKOOLG-JIDHJSLPSA-N 0.000 claims 2
GTWWNSQCSNGXQO-UQIIZPHYSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-[4-(methoxymethyl)phenyl]pentyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCCC)C=1C=CC(COC)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl GTWWNSQCSNGXQO-UQIIZPHYSA-N 0.000 claims 2
NHYMDRBLBZKOIA-JIDHJSLPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-2-cyclobutyl-1-(4-fluorophenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C1=C(C)C(OC)=CC(Cl)=C1C1=C(C)SC(N(CC#C)[C@@H](CC2CCC2)C=2C=CC(F)=CC=2)=N1 NHYMDRBLBZKOIA-JIDHJSLPSA-N 0.000 claims 2
BMXALUHUEGRRCH-JIDHJSLPSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C1=C(C)C(OC)=CC(Cl)=C1C1=C(C)SC(N(CC#C)[C@@H](CC2CC2)C=2C=C(F)C(C)=CC=2)=N1 BMXALUHUEGRRCH-JIDHJSLPSA-N 0.000 claims 2
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- C07D277/38—Nitrogen atoms
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NO20020155A 1999-07-15 2002-01-11 Aminotiazolderivater, fremgangsmate for deres fremstilling, deres anvendelse samt farmasoytisk preparat NO324352B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9909144A FR2796380B3 (fr)	1999-07-15	1999-07-15	Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2000/001995 WO2001005776A1 (fr)	1999-07-15	2000-07-11	Derives d'aminothiazole et leur utilisation comme ligands des recepteurs crf

Publications (3)

Publication Number	Publication Date
NO20020155D0 NO20020155D0 (no)	2002-01-11
NO20020155L NO20020155L (no)	2002-03-15
NO324352B1 true NO324352B1 (no)	2007-09-24

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NO20020155A NO324352B1 (no)	1999-07-15	2002-01-11	Aminotiazolderivater, fremgangsmate for deres fremstilling, deres anvendelse samt farmasoytisk preparat

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US (2)	US6586456B1 (sr)
EP (1)	EP1200419B1 (sr)
JP (1)	JP4949582B2 (sr)
KR (1)	KR100707320B1 (sr)
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EE (1)	EE05004B1 (sr)
ES (1)	ES2220504T3 (sr)
FR (1)	FR2796380B3 (sr)
HK (1)	HK1045692B (sr)
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IS (1)	IS2314B (sr)
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NO (1)	NO324352B1 (sr)
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SI (1)	SI1200419T1 (sr)
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TR (1)	TR200200125T2 (sr)
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Publication number	Publication date
EE200200022A (et)	2003-04-15
BR0012478A (pt)	2002-04-02
EA200101234A1 (ru)	2002-08-29
EE05004B1 (et)	2008-04-15
KR100707320B1 (ko)	2007-04-13
TR200200125T2 (tr)	2002-09-23
AR024747A1 (es)	2002-10-23
MEP26608A (en)	2010-06-10
US20070281919A1 (en)	2007-12-06
UA73125C2 (uk)	2005-06-15
DK1200419T3 (da)	2004-07-19
KR20020015373A (ko)	2002-02-27
IS6219A (is)	2002-01-03
NZ516397A (en)	2004-01-30
SK287069B6 (sk)	2009-11-05
HK1045692B (zh)	2004-11-26
IL147282A (en)	2008-04-13
JP2003505380A (ja)	2003-02-12
FR2796380B3 (fr)	2001-08-17
DE60009911T2 (de)	2005-03-10
HK1045692A1 (en)	2002-12-06
ES2220504T3 (es)	2004-12-16
CN1370154A (zh)	2002-09-18
ATE264315T1 (de)	2004-04-15
CZ300937B6 (cs)	2009-09-16
PL206515B1 (pl)	2010-08-31
ZA200200221B (en)	2003-04-30
US6586456B1 (en)	2003-07-01
SI1200419T1 (en)	2004-08-31
PL352901A1 (en)	2003-09-22
WO2001005776A1 (fr)	2001-01-25
CO5200792A1 (es)	2002-09-27
HUP0202387A2 (hu)	2002-11-28
EA005159B1 (ru)	2004-12-30
PT1200419E (pt)	2004-07-30
JP4949582B2 (ja)	2012-06-13
SK382002A3 (en)	2002-07-02
NO20020155D0 (no)	2002-01-11
MXPA02000545A (es)	2002-07-30
DE60009911D1 (de)	2004-05-19
TWI278453B (en)	2007-04-11
YU1302A (sh)	2005-03-15
FR2796380A1 (fr)	2001-01-19
BR0012478B1 (pt)	2013-10-15
CZ2002137A3 (cs)	2002-04-17
CA2378792C (en)	2009-11-10
NO20020155L (no)	2002-03-15
RS50443B (sr)	2010-03-02
AU6452100A (en)	2001-02-05
CA2378792A1 (en)	2001-01-25
US8420679B2 (en)	2013-04-16
AU772683B2 (en)	2004-05-06
EP1200419B1 (fr)	2004-04-14
IS2314B (is)	2007-11-15
HUP0202387A3 (en)	2004-12-28
HU229069B1 (en)	2013-07-29
IL147282A0 (en)	2002-08-14
EP1200419A1 (fr)	2002-05-02
CN1167692C (zh)	2004-09-22

Legal Events

Date	Code	Title	Description
2017-02-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US8420679B2 (en)	2013-04-16	Aminothiazole derivatives and their use as CRF receptor ligands
US5880135A (en)	1999-03-09	Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them
US6344470B1 (en)	2002-02-05	Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same
SI9300337A (en)	1994-03-31	Alkylamino thiazole branched, a process for the production thereof and pharmaceutical composition containing same
NO338263B1 (no)	2016-08-08	Imidazolforbindelser, farmasøytiske sammensetninger inneholdende slike, og anvendelse derav for behandling av en sykdom eller tilstand assosiert med modulering av Notch signaliseringsreaksjonsveien
CZ323094A3 (en)	1995-07-12	Branched amino derivatives of thiazole, process of their preparation and pharmaceutical compositions containing thereof
US6806282B2 (en)	2004-10-19	Branched substituted amino derivatives of 3-amino-1-phenyl-1h-[1,2,4]triazol, methods for producing them and pharmaceutical compositions containing them
US20020019427A1 (en)	2002-02-14	Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof
WO1994006791A1 (fr)	1994-03-31	Nouveau derive de thiazole condense, son procede de production et composition pharmaceutique le contenant
AU2001266123B2 (en)	2007-01-25	4,5-dihydro-thiazo-2-ylamine derivatives and their use as no-synthase inhibitors
MXPA99003241A (en)	2000-07-01	Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same
MXPA97010378A (en)	1998-11-09	Derivatives of 4-finilaminotiazol, its process of preparation and the pharmaceutical compositions that contains them
JPWO1995006035A1 (ja)	1996-01-23	ベンズアゼピン誘導体及びその医薬組成物並びに中間体
MXPA06011118A (en)	2007-04-20	Isoxazole- and isothiazole-amine compounds for the treatment of neurodegenerative disorders