NO324378B1 - Anvendelse av en genetisk konstruert celle for fremstilling av et medikament for a indusere beskyttelse mot podingsforkastelse - Google Patents

Anvendelse av en genetisk konstruert celle for fremstilling av et medikament for a indusere beskyttelse mot podingsforkastelse Download PDF

Info

Publication number: NO324378B1
Authority: NO; Norway
Prior art keywords: cells; cell; lag; use according; gene
Prior art date: 1996-11-29

Application number

NO19992569A

Other languages

English (en)

Norwegian (no)

Other versions

NO992569L (no

NO992569D0 (no

Inventor

Mauro Biffoni

Ruben Papoian

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-29

Filing date

1999-05-27

Publication date

2007-10-01

1999-05-27 Application filed by Applied Research Systems filed Critical Applied Research Systems

1999-05-27 Publication of NO992569L publication Critical patent/NO992569L/no

1999-05-27 Publication of NO992569D0 publication Critical patent/NO992569D0/no

2007-10-01 Publication of NO324378B1 publication Critical patent/NO324378B1/no

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230000003442 weekly effect Effects 0.000 description 1
238000001262 western blot Methods 0.000 description 1
238000002689 xenotransplantation Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Transplantation (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO19992569A 1996-11-29 1999-05-27 Anvendelse av en genetisk konstruert celle for fremstilling av et medikament for a indusere beskyttelse mot podingsforkastelse NO324378B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP1996/005280 WO1998023748A1 (fr)	1996-11-29	1996-11-29	Procede de prevention de rejet de greffon dans une transplantation et de production d'une cellule hote universelle de therapie genique a partir du gene d'activation des lymphocytes (lag-3)

Publications (3)

Publication Number	Publication Date
NO992569L NO992569L (no)	1999-05-27
NO992569D0 NO992569D0 (no)	1999-05-27
NO324378B1 true NO324378B1 (no)	2007-10-01

Family

ID=8166413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19992569A NO324378B1 (no)	1996-11-29	1999-05-27	Anvendelse av en genetisk konstruert celle for fremstilling av et medikament for a indusere beskyttelse mot podingsforkastelse

Country Status (19)

Country	Link
US (1)	US6500422B2 (fr)
EP (1)	EP0941329B1 (fr)
JP (1)	JP3920928B2 (fr)
KR (1)	KR100481230B1 (fr)
AR (1)	AR018489A1 (fr)
AT (1)	ATE271607T1 (fr)
AU (1)	AU733825B2 (fr)
BR (1)	BR9612821A (fr)
CA (1)	CA2272130C (fr)
DE (1)	DE69632967T2 (fr)
DK (1)	DK0941329T3 (fr)
EA (1)	EA003772B1 (fr)
ES (1)	ES2225901T3 (fr)
IL (1)	IL130168A (fr)
NO (1)	NO324378B1 (fr)
PT (1)	PT941329E (fr)
UA (1)	UA73270C2 (fr)
WO (1)	WO1998023748A1 (fr)
ZA (1)	ZA9710737B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69632967T2 (de) *	1996-11-29	2005-08-11	Applied Research Systems Ars Holding N.V.	Verfahren zur Verhinderung der Transplantabstoßung bei einer Transplantation und zur Herstellung einer universalen Gentherapie-Wirtszelle unter Anwendung von Lymphocyten-Aktivierungsgen (LAG-3)
US20060240024A1 (en) *	2003-02-28	2006-10-26	The Johns Hopkins University	T cell regulation
KR20050082389A (ko) *	2004-02-18	2005-08-23	메덱스젠 주식회사	직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
EP2044949A1 (fr) *	2007-10-05	2009-04-08	Immutep	Utilisation de lag-3 recombinant ou ses dérivatifs pour déclencher la réponse immune des monocytes
AR072999A1 (es)	2008-08-11	2010-10-06	Medarex Inc	Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AR091649A1 (es)	2012-07-02	2015-02-18	Bristol Myers Squibb Co	Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
RS64268B1 (sr)	2013-09-20	2023-07-31	Bristol Myers Squibb Co	Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
GB201322626D0 (en)	2013-12-19	2014-02-05	Immutep S A	Combined preparations for the treatment of cancer
JO3663B1 (ar)	2014-08-19	2020-08-27	Merck Sharp & Dohme	الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en)	2015-01-09	2015-02-25	Immutep S A	Combined preparations for the treatment of cancer
MA43028B1 (fr)	2015-10-02	2021-09-30	Hoffmann La Roche	Anticorps bispécifiques pour pd1 et tim3
BR112018012352A2 (pt)	2015-12-16	2018-12-11	Merck Sharp & Dohme Corp.	anticorpos anti-lag3 e fragmentos de ligação ao antígeno
KR102461885B1 (ko)	2017-04-03	2022-11-03	에프. 호프만-라 로슈 아게	항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
CA3052532A1 (fr)	2017-04-05	2018-10-11	F. Hoffmann-La Roche Ag	Anticorps bispecifiques se liant particulierement a pd1 et lag3
JP7301002B2 (ja)	2017-05-30	2023-06-30	ブリストル－マイヤーズスクイブカンパニー	抗ｌａｇ－３抗体または抗ｌａｇ－３抗体および抗ｐｄ－１もしくは抗ｐｄ－ｌ１抗体を含む組成物
WO2018222718A1 (fr)	2017-05-30	2018-12-06	Bristol-Myers Squibb Company	Traitement de tumeurs positives pour lag-3
KR102559149B1 (ko)	2018-10-26	2023-07-24	에프. 호프만-라 로슈 아게	재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법
CA3196496A1 (fr)	2020-10-23	2022-04-28	Laurence David TOMS	Therapie par antagoniste de lag-3 pour le cancer du poumon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2656800B1 (fr) *	1990-01-08	1992-05-15	Roussy Inst Gustave	Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5876708A (en) *	1992-02-19	1999-03-02	The General Hospital Corporation	Allogeneic and xenogeneic transplantation
JP3700859B2 (ja)	1994-05-06	2005-09-28	アンスティテュギュスタブルシ	Ｌａｇ−３タンパク質の可溶性ポリペプチドフラクション；製造方法、治療用製剤、抗イディオタイプ抗体
DE69632967T2 (de) *	1996-11-29	2005-08-11	Applied Research Systems Ars Holding N.V.	Verfahren zur Verhinderung der Transplantabstoßung bei einer Transplantation und zur Herstellung einer universalen Gentherapie-Wirtszelle unter Anwendung von Lymphocyten-Aktivierungsgen (LAG-3)

1996
- 1996-11-29 DE DE69632967T patent/DE69632967T2/de not_active Expired - Fee Related
- 1996-11-29 EP EP96940658A patent/EP0941329B1/fr not_active Expired - Lifetime
- 1996-11-29 AT AT96940658T patent/ATE271607T1/de not_active IP Right Cessation
- 1996-11-29 KR KR10-1999-7004274A patent/KR100481230B1/ko not_active Expired - Fee Related
- 1996-11-29 IL IL130168A patent/IL130168A/en not_active IP Right Cessation
- 1996-11-29 PT PT96940658T patent/PT941329E/pt unknown
- 1996-11-29 AU AU10667/97A patent/AU733825B2/en not_active Ceased
- 1996-11-29 US US09/319,147 patent/US6500422B2/en not_active Expired - Fee Related
- 1996-11-29 WO PCT/EP1996/005280 patent/WO1998023748A1/fr not_active Ceased
- 1996-11-29 UA UA99063590A patent/UA73270C2/uk unknown
- 1996-11-29 DK DK96940658T patent/DK0941329T3/da active
- 1996-11-29 BR BR9612821-6A patent/BR9612821A/pt not_active Application Discontinuation
- 1996-11-29 CA CA002272130A patent/CA2272130C/fr not_active Expired - Fee Related
- 1996-11-29 EA EA199900507A patent/EA003772B1/ru not_active IP Right Cessation
- 1996-11-29 JP JP52611398A patent/JP3920928B2/ja not_active Expired - Fee Related
- 1996-11-29 ES ES96940658T patent/ES2225901T3/es not_active Expired - Lifetime
1997
- 1997-11-28 ZA ZA9710737A patent/ZA9710737B/xx unknown
- 1997-11-28 AR ARP970105619A patent/AR018489A1/es not_active Application Discontinuation
1999
- 1999-05-27 NO NO19992569A patent/NO324378B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO992569L (no)	1999-05-27
AR018489A1 (es)	2001-11-28
CA2272130C (fr)	2007-10-23
AU733825B2 (en)	2001-05-24
US6500422B2 (en)	2002-12-31
ATE271607T1 (de)	2004-08-15
EP0941329B1 (fr)	2004-07-21
ZA9710737B (en)	1998-07-30
DE69632967D1 (de)	2004-08-26
WO1998023748A1 (fr)	1998-06-04
ES2225901T3 (es)	2005-03-16
CA2272130A1 (fr)	1998-06-04
DK0941329T3 (da)	2004-11-29
HK1023599A1 (en)	2000-09-15
EP0941329A1 (fr)	1999-09-15
KR100481230B1 (ko)	2005-04-07
US20020081282A1 (en)	2002-06-27
PT941329E (pt)	2004-11-30
BR9612821A (pt)	2000-04-11
EA003772B1 (ru)	2003-08-28
AU1066797A (en)	1998-06-22
EA199900507A1 (ru)	2000-02-28
DE69632967T2 (de)	2005-08-11
IL130168A (en)	2006-09-05
IL130168A0 (en)	2000-06-01
NO992569D0 (no)	1999-05-27
JP3920928B2 (ja)	2007-05-30
UA73270C2 (en)	2005-07-15
JP2001505770A (ja)	2001-05-08
KR20000053291A (ko)	2000-08-25

Legal Events

Date	Code	Title	Description
2008-01-14	CREP	Change of representative	Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS
2008-02-04	CREP	Change of representative	Representative=s name: PROTECTOR INTELLECTUAL PROPERTY CONSULTANTS AS, PO
2010-06-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US7638498B2 (en)	2009-12-29	Substances for preventing and treating autoimmune diseases
EP0941329B1 (fr)	2004-07-21	Procede de prevention de rejet de greffon dans une transplantation et de production d'une cellule hote universelle de therapie genique a partir du gene d'activation des lymphocytes (lag-3)
WO2002026827A1 (fr)	2002-04-04	Polypeptides extracellulaires de recpteurs eph b et ligands ephrine b, et molecules d'acide nucleiques correspondantes
US6491925B2 (en)	2002-12-10	Compositions and methods for cancer prophylaxis and/or treatment
Yamamoto et al.	2001	The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy
US8227437B2 (en)	2012-07-24	Restoration of hearing loss
US7064111B1 (en)	2006-06-20	Use of soluble costimulatory factor for tumor immuno-gene therapy
CN1196786C (zh)	2005-04-13	抗移植排斥细胞及其用途
MXPA99004550A (en)	2000-02-02	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)
Evans et al.	1995	Section Review: Biologicals & Immunologicals: Gene therapy as a treatment for rheumatoid arthritis
HK1023599B (en)	2005-08-05	Cells for preventing graft rejection in transplantation and their uses
AU2005244519B2 (en)	2007-03-08	Substances for preventing and treating autoimmune diseases
Short	1999	Establishment of insulin synthesis and secretion by transfer of a modified human proinsulin gene into mice and cultured cells