UA73270C2 - Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted - Google Patents

Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted Download PDF

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Publication number: UA73270C2
Authority: UA; Ukraine
Prior art keywords: cells; gene; host; cell; rejection
Prior art date: 1996-11-29

Application number

UA99063590A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-29

Filing date

1996-11-29

Publication date

2005-07-15

1996-11-29 Application filed filed Critical

2005-07-15 Publication of UA73270C2 publication Critical patent/UA73270C2/uk

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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
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Biochemistry (AREA)
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Wood Science & Technology (AREA)
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General Engineering & Computer Science (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Toxicology (AREA)
Transplantation (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UA99063590A 1996-11-29 1996-11-29 Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted UA73270C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP1996/005280 WO1998023748A1 (fr)	1996-11-29	1996-11-29	Procede de prevention de rejet de greffon dans une transplantation et de production d'une cellule hote universelle de therapie genique a partir du gene d'activation des lymphocytes (lag-3)

Publications (1)

Publication Number	Publication Date
UA73270C2 true UA73270C2 (en)	2005-07-15

Family

ID=8166413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA99063590A UA73270C2 (en)	1996-11-29	1996-11-29	Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted

Country Status (19)

Country	Link
US (1)	US6500422B2 (fr)
EP (1)	EP0941329B1 (fr)
JP (1)	JP3920928B2 (fr)
KR (1)	KR100481230B1 (fr)
AR (1)	AR018489A1 (fr)
AT (1)	ATE271607T1 (fr)
AU (1)	AU733825B2 (fr)
BR (1)	BR9612821A (fr)
CA (1)	CA2272130C (fr)
DE (1)	DE69632967T2 (fr)
DK (1)	DK0941329T3 (fr)
EA (1)	EA003772B1 (fr)
ES (1)	ES2225901T3 (fr)
IL (1)	IL130168A (fr)
NO (1)	NO324378B1 (fr)
PT (1)	PT941329E (fr)
UA (1)	UA73270C2 (fr)
WO (1)	WO1998023748A1 (fr)
ZA (1)	ZA9710737B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT941329E (pt) *	1996-11-29	2004-11-30	Applied Research Systems	Metodo para prevenir a rejeicao de enxertos em transplantacao e para produzir uma celula-hospedeiro para terapia genetica universal utilizando activacao de linfocitos (lag-3)
PL1897548T5 (pl)	2003-02-28	2025-03-17	The Johns Hopkins University	Regulacja komórek T
KR20050082389A (ko) *	2004-02-18	2005-08-23	메덱스젠 주식회사	직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
EP2044949A1 (fr)	2007-10-05	2009-04-08	Immutep	Utilisation de lag-3 recombinant ou ses dérivatifs pour déclencher la réponse immune des monocytes
AR072999A1 (es)	2008-08-11	2010-10-06	Medarex Inc	Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
UY34887A (es)	2012-07-02	2013-12-31	Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware	Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
JP6595458B2 (ja)	2013-09-20	2019-10-23	ブリストル−マイヤーズスクイブカンパニー	腫瘍を処置するための抗ｌａｇ−３抗体と抗ｐｄ−１抗体との組合せ
GB201322626D0 (en)	2013-12-19	2014-02-05	Immutep S A	Combined preparations for the treatment of cancer
JO3663B1 (ar)	2014-08-19	2020-08-27	Merck Sharp & Dohme	الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en)	2015-01-09	2015-02-25	Immutep S A	Combined preparations for the treatment of cancer
WO2017055404A1 (fr)	2015-10-02	2017-04-06	F. Hoffmann-La Roche Ag	Anticorps bispécifiques spécifiques de pd1 et tim3
US11045547B2 (en)	2015-12-16	2021-06-29	Merck Sharp & Dohme Corp.	Anti-LAG3 antibodies and antigen-binding fragments
MY201482A (en)	2017-04-03	2024-02-26	Hoffmann La Roche	Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
EP4516809A3 (fr)	2017-04-05	2025-09-03	F. Hoffmann-La Roche AG	Anticorps bispécifiques se liant spécifiquement à pd1 et lag3
CN110678200B (zh)	2017-05-30	2024-05-17	百时美施贵宝公司	包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物
ES2965352T3 (es)	2017-05-30	2024-04-12	Bristol Myers Squibb Co	Tratamiento de tumores positivos a gen 3 de activación de linfocitos (LAG-3)
WO2020084034A1 (fr)	2018-10-26	2020-04-30	F. Hoffmann-La Roche Ag	Procédé de criblage d'anticorps multispécifiques utilisant un échange de cassette à médiation par recombinase
KR20230093282A (ko)	2020-10-23	2023-06-27	브리스톨-마이어스 스큅 컴퍼니	폐암에 대한 lag-3 길항제 요법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2656800B1 (fr) *	1990-01-08	1992-05-15	Roussy Inst Gustave	Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5876708A (en) *	1992-02-19	1999-03-02	The General Hospital Corporation	Allogeneic and xenogeneic transplantation
CA2189657C (fr)	1994-05-06	2002-03-12	Florence Faure	Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype
PT941329E (pt) *	1996-11-29	2004-11-30	Applied Research Systems	Metodo para prevenir a rejeicao de enxertos em transplantacao e para produzir uma celula-hospedeiro para terapia genetica universal utilizando activacao de linfocitos (lag-3)

1996
- 1996-11-29 PT PT96940658T patent/PT941329E/pt unknown
- 1996-11-29 DE DE69632967T patent/DE69632967T2/de not_active Expired - Fee Related
- 1996-11-29 EA EA199900507A patent/EA003772B1/ru not_active IP Right Cessation
- 1996-11-29 EP EP96940658A patent/EP0941329B1/fr not_active Expired - Lifetime
- 1996-11-29 JP JP52611398A patent/JP3920928B2/ja not_active Expired - Fee Related
- 1996-11-29 IL IL130168A patent/IL130168A/en not_active IP Right Cessation
- 1996-11-29 ES ES96940658T patent/ES2225901T3/es not_active Expired - Lifetime
- 1996-11-29 WO PCT/EP1996/005280 patent/WO1998023748A1/fr not_active Ceased
- 1996-11-29 DK DK96940658T patent/DK0941329T3/da active
- 1996-11-29 KR KR10-1999-7004274A patent/KR100481230B1/ko not_active Expired - Fee Related
- 1996-11-29 UA UA99063590A patent/UA73270C2/uk unknown
- 1996-11-29 CA CA002272130A patent/CA2272130C/fr not_active Expired - Fee Related
- 1996-11-29 AU AU10667/97A patent/AU733825B2/en not_active Ceased
- 1996-11-29 AT AT96940658T patent/ATE271607T1/de not_active IP Right Cessation
- 1996-11-29 US US09/319,147 patent/US6500422B2/en not_active Expired - Fee Related
- 1996-11-29 BR BR9612821-6A patent/BR9612821A/pt not_active Application Discontinuation
1997
- 1997-11-28 ZA ZA9710737A patent/ZA9710737B/xx unknown
- 1997-11-28 AR ARP970105619A patent/AR018489A1/es not_active Application Discontinuation
1999
- 1999-05-27 NO NO19992569A patent/NO324378B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2225901T3 (es)	2005-03-16
DK0941329T3 (da)	2004-11-29
NO992569D0 (no)	1999-05-27
JP3920928B2 (ja)	2007-05-30
ZA9710737B (en)	1998-07-30
JP2001505770A (ja)	2001-05-08
IL130168A0 (en)	2000-06-01
DE69632967D1 (de)	2004-08-26
ATE271607T1 (de)	2004-08-15
US6500422B2 (en)	2002-12-31
US20020081282A1 (en)	2002-06-27
EP0941329A1 (fr)	1999-09-15
EA199900507A1 (ru)	2000-02-28
KR20000053291A (ko)	2000-08-25
NO992569L (no)	1999-05-27
PT941329E (pt)	2004-11-30
AU1066797A (en)	1998-06-22
IL130168A (en)	2006-09-05
CA2272130C (fr)	2007-10-23
CA2272130A1 (fr)	1998-06-04
AR018489A1 (es)	2001-11-28
NO324378B1 (no)	2007-10-01
EA003772B1 (ru)	2003-08-28
AU733825B2 (en)	2001-05-24
DE69632967T2 (de)	2005-08-11
BR9612821A (pt)	2000-04-11
KR100481230B1 (ko)	2005-04-07
EP0941329B1 (fr)	2004-07-21
WO1998023748A1 (fr)	1998-06-04
HK1023599A1 (en)	2000-09-15

Publication	Publication Date	Title
UA73270C2 (en)	2005-07-15	Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted
ES2205792T3 (es)	2004-05-01	Celulas madre mesenquimatosas como inmunosupresores.
US8071085B2 (en)	2011-12-06	Primary cultured adipocytes for gene therapy
Yasuda et al.	1998	Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.
JP6018081B2 (ja)	2016-11-02	自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞
US20140242037A1 (en)	2014-08-28	Apc-mediated tolerance induction for therapy of multiple sclerosis
Andreoletti et al.	2001	Engraftment of autologous retrovirally transduced hepatocytes after intraportal transplantation into nonhuman primates: implication for ex vivo gene therapy
Tamura et al.	1997	Targeted killing of migrating glioma cells by injection of HTK-modified glioma cells
JP4879867B2 (ja)	2012-02-22	遺伝子治療用初代培養脂肪細胞
MXPA99004550A (en)	2000-02-02	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)
Rahim et al.	2014	Gene therapy modalities in lung transplantation
Whartenby et al.	1995	Gene therapy: clinical potential and relationships to drug treatment
CA2158933A1 (fr)	1995-03-09	Methodes de suppression du rejet de greffes
ROY et al.	1996	Gene therapy: Current status and future
Tremblay	2000	Immune Reaction Following Cell and Gene Therapy
Hotel et al.	2005	The Australasian Gene Therapy Society
Ma et al.	2006	984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS I Mice after Retroviral Vector-Mediated Gene Therapy, but Transient Immunomodulation with CTLA4-Ig Combined with Anti-CD4 or Anti-CD40 Ligand Does
HK1023599B (en)	2005-08-05	Cells for preventing graft rejection in transplantation and their uses
KR20050024341A (ko)	2005-03-10	유전자 치료용 초대 배양 지방세포