NO324430B1 - Vandige insulinpreparater som inneholder et halogenid, parenterale farmasoytiske preparater som omfatter slike insulinpreparater og fremgangsmate for forbedring av den kjemiske stabiliteten til slike insulinpreparater. - Google Patents

Vandige insulinpreparater som inneholder et halogenid, parenterale farmasoytiske preparater som omfatter slike insulinpreparater og fremgangsmate for forbedring av den kjemiske stabiliteten til slike insulinpreparater. Download PDF

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Publication number
NO324430B1
NO324430B1 NO19985981A NO985981A NO324430B1 NO 324430 B1 NO324430 B1 NO 324430B1 NO 19985981 A NO19985981 A NO 19985981A NO 985981 A NO985981 A NO 985981A NO 324430 B1 NO324430 B1 NO 324430B1
Authority
NO
Norway
Prior art keywords
insulin
human insulin
preparation according
human
des
Prior art date
Application number
NO19985981A
Other languages
English (en)
Norwegian (no)
Other versions
NO985981L (no
NO985981D0 (no
Inventor
Liselotte Langkjaer
Svend Havelund
Elsebeth Norup
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8096378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO324430(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO985981L publication Critical patent/NO985981L/no
Publication of NO985981D0 publication Critical patent/NO985981D0/no
Publication of NO324430B1 publication Critical patent/NO324430B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19985981A 1996-06-20 1998-12-18 Vandige insulinpreparater som inneholder et halogenid, parenterale farmasoytiske preparater som omfatter slike insulinpreparater og fremgangsmate for forbedring av den kjemiske stabiliteten til slike insulinpreparater. NO324430B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK68596 1996-06-20
PCT/DK1997/000268 WO1997048414A1 (fr) 1996-06-20 1997-06-19 Preparations d'insuline contenant du nacl

Publications (3)

Publication Number Publication Date
NO985981L NO985981L (no) 1998-12-18
NO985981D0 NO985981D0 (no) 1998-12-18
NO324430B1 true NO324430B1 (no) 2007-10-15

Family

ID=8096378

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19985981A NO324430B1 (no) 1996-06-20 1998-12-18 Vandige insulinpreparater som inneholder et halogenid, parenterale farmasoytiske preparater som omfatter slike insulinpreparater og fremgangsmate for forbedring av den kjemiske stabiliteten til slike insulinpreparater.

Country Status (21)

Country Link
EP (1) EP0921812B2 (fr)
JP (2) JP4404380B2 (fr)
KR (1) KR100451778B1 (fr)
CN (1) CN1120019C (fr)
AT (1) ATE208208T1 (fr)
AU (1) AU720484B2 (fr)
BR (1) BR9709845B1 (fr)
CA (1) CA2258097C (fr)
CZ (1) CZ297937B6 (fr)
DE (1) DE69708121T3 (fr)
DK (1) DK0921812T4 (fr)
ES (1) ES2167751T5 (fr)
HU (1) HU228094B1 (fr)
IL (2) IL127366A0 (fr)
NO (1) NO324430B1 (fr)
PL (1) PL189964B1 (fr)
PT (1) PT921812E (fr)
RU (1) RU2182015C2 (fr)
UA (1) UA49890C2 (fr)
WO (1) WO1997048414A1 (fr)
ZA (1) ZA975470B (fr)

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Publication number Priority date Publication date Assignee Title
DE69924232D1 (de) 1998-01-09 2005-04-21 Novo Nordisk As Stabilisierte insulin-zubereitungen
EP1131089B1 (fr) * 1998-11-18 2004-02-18 Novo Nordisk A/S Preparations stables d'insuline aqueuse sans phenol ni cresol
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
PT1146896E (pt) * 1999-01-26 2002-10-31 Lilly Co Eli Formulacoes monodispersas de analogo acilado e hexamerico insulina
EP1165063A1 (fr) * 1999-04-05 2002-01-02 Verteletsky, Pavel Vasilievich Utilisation d'acide succinique ou de ses sels dans le traitement du diabete et la cicatrisation de blessures
EP1523993A1 (fr) * 1999-12-16 2005-04-20 Eli Lilly & Company Compositions contenant un polypeptide et ayant une plus grande stabilité
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
DE60018105T2 (de) * 1999-12-16 2005-12-29 Eli Lilly And Co., Indianapolis Polypeptidzusammensetzungen mit verbesserter stabilität
AU2005291233B2 (en) 2004-10-05 2011-02-03 Novo Nordisk A/S A pharmaceutical formulation comprising crystalline insulin and dissolved insulin
RU2288000C1 (ru) * 2005-04-27 2006-11-27 Институт нефтехимического синтеза им. А.В. Топчиева РАН (ИНХС РАН) Раствор инсулина для перорального введения
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
DK2498802T3 (en) 2009-11-13 2015-04-13 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
KR101337322B1 (ko) 2009-11-13 2013-12-06 사노피-아벤티스 도이칠란트 게엠베하 Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es) 2010-08-30 2017-03-24 Sanofi-Aventis Deutschland Gmbh Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl) 2011-08-29 2015-12-31 Sanofi Aventis Deutschland Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
BR112015013223A2 (pt) * 2012-12-26 2017-07-11 Wockhardt Ltd composição farmacêutica
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
JP2020143105A (ja) * 2014-01-09 2020-09-10 サノフイＳａｎｏｆｉ インスリンアスパルトの安定化された医薬製剤
EP3091965A1 (fr) 2014-01-09 2016-11-16 Sanofi Formulations pharmaceutiques stabilisées sans glycérol d'analogues de l'insuline et/ou de dérivés de l'insuline
SG11201604706TA (en) * 2014-01-09 2016-07-28 Sanofi Sa Stabilized pharmaceutical formulations of insulin aspart
JP2020114861A (ja) * 2014-01-09 2020-07-30 サノフイＳａｎｏｆｉ インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
CN112957455A (zh) 2014-01-09 2021-06-15 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
AU2015359376B2 (en) 2014-12-12 2021-09-09 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
SG11202111312UA (en) 2019-06-14 2021-12-30 Zealand Pharma As Pharmaceutical parenteral composition of dual glp1/2 agonist
AU2021379990A1 (en) * 2020-11-16 2023-06-29 W. L. Gore & Associates, Inc. Formulations, methods, and pre-filled multi-dose injection devices without cloud point

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
SU1528496A1 (ru) * 1972-10-17 1989-12-15 Днепропетровский Научно-Исследовательский Институт Гастроэнтерологии Дегидратирующее средство
US4783441A (en) † 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4439181A (en) * 1981-01-26 1984-03-27 Regents Of The University Of Minnesota Polyol-hormone mixture for use in chronic parenteral hormone administration
AU550068B2 (en) † 1981-03-10 1986-02-27 Novo Nordisk A/S Zinc insulin stabilized with calcium or magnesium salts
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
DE122006000015I1 (de) * 1993-06-21 2006-06-29 Novo Nordisk As Asp-B28-Insulinkristalle
SI0792290T1 (en) * 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations

Also Published As

Publication number Publication date
CZ297937B6 (cs) 2007-05-02
CZ395698A3 (cs) 1999-05-12
UA49890C2 (uk) 2002-10-15
NO985981L (no) 1998-12-18
BR9709845B1 (pt) 2008-11-18
CN1120019C (zh) 2003-09-03
EP0921812B1 (fr) 2001-11-07
KR100451778B1 (ko) 2004-11-16
JP4404380B2 (ja) 2010-01-27
DK0921812T4 (da) 2012-04-02
ES2167751T3 (es) 2002-05-16
JP2009235075A (ja) 2009-10-15
WO1997048414A1 (fr) 1997-12-24
HUP9904031A2 (hu) 2000-04-28
NO985981D0 (no) 1998-12-18
HUP9904031A3 (en) 2000-10-30
IL127366A (en) 2007-07-04
KR20000022031A (ko) 2000-04-25
HU228094B1 (en) 2012-10-29
PL189964B1 (pl) 2005-10-31
PT921812E (pt) 2002-04-29
ES2167751T5 (es) 2012-03-30
BR9709845A (pt) 1999-08-10
AU720484B2 (en) 2000-06-01
EP0921812A1 (fr) 1999-06-16
CA2258097C (fr) 2011-02-08
IL127366A0 (en) 1999-10-28
AU3253697A (en) 1998-01-07
EP0921812B2 (fr) 2011-12-21
CN1222083A (zh) 1999-07-07
PL330763A1 (en) 1999-05-24
ATE208208T1 (de) 2001-11-15
ZA975470B (en) 1997-12-22
DK0921812T3 (da) 2002-02-11
RU2182015C2 (ru) 2002-05-10
DE69708121D1 (de) 2001-12-13
DE69708121T2 (de) 2002-08-01
JP2000513344A (ja) 2000-10-10
CA2258097A1 (fr) 1997-12-24
DE69708121T3 (de) 2012-05-16

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