NO324818B1 - Anvendelse av amylin eller en amylinagonist - Google Patents
Anvendelse av amylin eller en amylinagonist Download PDFInfo
- Publication number
- NO324818B1 NO324818B1 NO19995996A NO995996A NO324818B1 NO 324818 B1 NO324818 B1 NO 324818B1 NO 19995996 A NO19995996 A NO 19995996A NO 995996 A NO995996 A NO 995996A NO 324818 B1 NO324818 B1 NO 324818B1
- Authority
- NO
- Norway
- Prior art keywords
- amylin
- ser
- asn
- leu
- ala
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/870,762 US7910548B2 (en) | 1997-06-06 | 1997-06-06 | Methods for treating obesity |
| PCT/US1998/011753 WO1998055144A1 (en) | 1997-06-06 | 1998-06-05 | Methods for treating obesity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995996D0 NO995996D0 (no) | 1999-12-06 |
| NO995996L NO995996L (no) | 2000-02-07 |
| NO324818B1 true NO324818B1 (no) | 2007-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995996A NO324818B1 (no) | 1997-06-06 | 1999-12-06 | Anvendelse av amylin eller en amylinagonist |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7910548B2 (cs) |
| AU (1) | AU7823098A (cs) |
| BR (1) | BR9809951A (cs) |
| CZ (1) | CZ294983B6 (cs) |
| HU (1) | HUP0004271A3 (cs) |
| NO (1) | NO324818B1 (cs) |
| NZ (1) | NZ501451A (cs) |
| PL (1) | PL193236B1 (cs) |
| RU (2) | RU2207871C2 (cs) |
| WO (1) | WO1998055144A1 (cs) |
Families Citing this family (27)
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| DE122007000044I2 (de) * | 1997-01-07 | 2011-05-05 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US6410511B2 (en) | 1997-01-08 | 2002-06-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US20040022807A1 (en) * | 1998-06-05 | 2004-02-05 | Duft Bradford J | Methods for treating obesity |
| EP1044015B1 (en) * | 1998-01-09 | 2008-10-08 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides with insulin |
| ATE412421T1 (de) * | 2002-01-08 | 2008-11-15 | Amylin Pharmaceuticals Inc | Verwendung von amylin, amylinanaloga und amylin derivaten zur behandlung von dyslipidämie und hypertriglyceridämie |
| EP1663289A2 (en) * | 2003-08-29 | 2006-06-07 | Amylin Pharmaceuticals, Inc. | Methods for treating or ameliorating ghrelin-associated diseases and disorders |
| US8076288B2 (en) * | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| NZ579621A (en) * | 2004-02-11 | 2011-03-31 | Amylin Pharmaceuticals Inc | Hybrid polypeptides with selectable properties |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| US8394765B2 (en) * | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| CN101094689B (zh) † | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
| WO2007022123A2 (en) * | 2005-08-11 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| KR20070115947A (ko) | 2005-02-11 | 2007-12-06 | 아밀린 파마슈티칼스, 인크. | 선택가능한 특성들을 가지는 gip 유사체 및 하이브리드폴리펩타이드 |
| EP2330125A3 (en) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| KR20100036326A (ko) * | 2007-06-29 | 2010-04-07 | 론자 아게 | 프람린타이드의 생산 방법 |
| RU2403038C2 (ru) * | 2008-09-18 | 2010-11-10 | Общество с ограниченной ответственностью "Идеи для здоровья. Группа компаний" | Способ лечения и/или профилактики избыточной массы тела, и/или ожирения, и/или метаболических нарушений |
| WO2010107874A2 (en) | 2009-03-17 | 2010-09-23 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition using amylin agonists |
| EP2416797A4 (en) | 2009-04-10 | 2013-04-24 | Amylin Pharmaceuticals Llc | AMYLINAGONIST COMPOUNDS FOR OXYGEN ANIMAL MICE |
| RU2552221C2 (ru) * | 2010-07-15 | 2015-06-10 | Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" | Способ лечения ожирения и сопутствующих метаболических расстройств и лекарственное средство для лечения ожирения и сопутствующих метаболических расстройств |
| ES2640285T3 (es) | 2012-04-19 | 2017-11-02 | Novo Nordisk A/S | Análogos de amilina humana |
| RU2523558C2 (ru) * | 2012-08-22 | 2014-07-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Россиской Федерации | Способ лечения и повышения качества жизни больных с синдромом диспепсии в сочетании с ожирением |
| BR112017019378A2 (pt) | 2015-03-18 | 2019-02-19 | Zealand Pharma A/S | análogos de amilina |
| US10071140B2 (en) | 2016-09-09 | 2018-09-11 | Zealand Pharma A/S | Amylin analogues |
| KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
| JP7761567B2 (ja) | 2020-02-18 | 2025-10-28 | ノヴォ ノルディスク アー/エス | 医薬製剤 |
| EP4138780A4 (en) * | 2020-04-20 | 2024-05-15 | I2O Therapeutics, Inc. | Use of human amylin analog polypeptides for providing superior glycemic control to type 1 diabetics |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443619A (en) * | 1978-12-26 | 1984-04-17 | Hoffmann-La Roche Inc. | Chlorocitric acids |
| US5367052A (en) | 1987-04-27 | 1994-11-22 | Amylin Pharmaceuticals, Inc. | Amylin peptides |
| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| US5364841A (en) | 1988-01-11 | 1994-11-15 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
| US5280014A (en) * | 1988-01-11 | 1994-01-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
| US5266561A (en) | 1988-01-11 | 1993-11-30 | Amylin Pharmaceuticals, Inc. | Treatment of type 2 diabetes mellitus |
| IT1219667B (it) * | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
| US5175145A (en) | 1988-08-26 | 1992-12-29 | Amylin Pharmaceuticals, Inc. | Treatment of diabetes mellitus with amylin agonists |
| ES2080802T3 (es) * | 1989-07-10 | 1996-02-16 | Amylin Pharmaceuticals Inc | Uso de un antagonista de amilina en la preparacion de un medicamento para el tratamiento de la obesidad e hipertension intrinseca y desordenes asociados. |
| AU7316591A (en) * | 1990-02-28 | 1991-09-18 | Upjohn Company, The | Use of 3-guanidinopropionic acid in the treatment and prevention of metabolic disorders |
| WO1991016917A1 (en) * | 1990-05-02 | 1991-11-14 | The Upjohn Company | Method of treating gastric ulcers and obesity |
| SE466130B (sv) * | 1990-11-22 | 1992-01-07 | Kabi Pharmacia Ab | Gelbildande flytande dietfiberkomposition |
| US5187154A (en) * | 1990-12-13 | 1993-02-16 | Board Of Regents, The University Of Texas System | Diagnosis and treatment of humans with diabetes or at risk to develop diabetes |
| US5321008A (en) * | 1991-01-10 | 1994-06-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions |
| US5234906A (en) | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
| US5264372A (en) | 1991-03-15 | 1993-11-23 | Amylin Pharmaceuticals, Inc. | Receptor-based screening methods for amylin agonists and antagonists |
| WO1992015317A1 (en) | 1991-03-08 | 1992-09-17 | Amylin Pharmaceuticals, Inc. | Synthetic preparation of amylin and amylin analogues |
| HU222249B1 (hu) * | 1991-03-08 | 2003-05-28 | Amylin Pharmaceuticals Inc. | Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| SG49239A1 (en) | 1991-05-24 | 1998-05-18 | Amylin Pharmaceuticals Inc | Amylin and possibly insulin containing composition for the treatment of aneroxia and related states |
| EP0601001B1 (en) * | 1991-08-26 | 1997-04-16 | PHARMACIA & UPJOHN COMPANY | Liquid food product containing 3-guanidinopropionic acid |
| CA2100745C (en) | 1991-11-19 | 2007-07-31 | Laura S. L. Gaeta | Amylin agonist peptides and uses therefor |
| DK0623021T3 (da) * | 1992-01-21 | 1999-02-08 | Abbott Lab | 4"-deoxyerythromycinderivater |
| US5376638A (en) | 1992-09-01 | 1994-12-27 | Amylin Pharmaceuticals, Inc. | Methods for treating renin-related disorders with amylin antagonists |
| JPH07509008A (ja) * | 1993-05-12 | 1995-10-05 | ユニバーシティ・オブ・シンシナティ | アミリン・アンタゴニストおよびアゴニスト |
| CZ69596A3 (en) * | 1993-09-07 | 1997-06-11 | Amylin Pharmaceuticals Inc | Application of amylin, amylin agonist, amylin analog agonist or amylin antagonist for preparing a pharmaceutical preparation used for the control of gastrointestinal motility |
| US5527788A (en) * | 1994-01-18 | 1996-06-18 | Louisiana State Univ. Medical Center Foundation | Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent |
| US5739129A (en) * | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
| RU2152939C1 (ru) * | 1994-04-14 | 2000-07-20 | Глаксо Веллкам Инк. | 5-гетероцикло-1,5-бензодиазепины и их фармацевтически приемлемые соли |
| US5498424A (en) * | 1994-11-30 | 1996-03-12 | Klein; Ira | Method of treating obesity |
| TW448046B (en) * | 1995-01-20 | 2001-08-01 | Novo Nordisk As | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity |
| US5766851A (en) * | 1995-05-19 | 1998-06-16 | The Johns Hopkins University School Of Medicine | Susceptibility gene for obesity and type II diabetes mellitus |
| US6187991B1 (en) * | 1995-05-23 | 2001-02-13 | Pfizer Inc | Transgenic animal models for type II diabetes mellitus |
| US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
| US6143718A (en) * | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| US5646040A (en) * | 1995-06-30 | 1997-07-08 | Millennium Pharmaceutical, Inc. | Mammalian tub gene |
| RU2060012C1 (ru) * | 1995-08-07 | 1996-05-20 | Ирина Львовна Медкова | Способ профилактики и лечения заболеваний, связанных с нарушением липидного обмена |
| US5972621A (en) * | 1995-11-27 | 1999-10-26 | Millennium Pharmaceuticals, Inc. | Methods of identifying compounds that modulate body weight using the OB receptor |
| US6110707A (en) * | 1996-01-19 | 2000-08-29 | Board Of Regents, The University Of Texas System | Recombinant expression of proteins from secretory cell lines |
| US5690691A (en) * | 1996-05-08 | 1997-11-25 | The Center For Innovative Technology | Gastro-intestinal pacemaker having phased multi-point stimulation |
| US5932779A (en) * | 1996-06-10 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Screening methods for compounds useful in the regulation of body weight |
| US5965607A (en) * | 1996-12-30 | 1999-10-12 | American Home Products Corporation | Substituted Benzo[1,4]dioxines as antiobesity agents |
| DE122007000044I2 (de) * | 1997-01-07 | 2011-05-05 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| US5830434A (en) * | 1997-02-26 | 1998-11-03 | Medical University Of South Carolina Foundation For Research Development | Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide |
| US5955443A (en) * | 1998-03-19 | 1999-09-21 | Isis Pharmaceuticals Inc. | Antisense modulation of PECAM-1 |
| US6100047A (en) * | 1999-04-07 | 2000-08-08 | Zen Bio, Inc. | Modulation of the sulfonylurea receptor and calcium in adipocytes for treatment of obesity/diabetes |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
-
1997
- 1997-06-06 US US08/870,762 patent/US7910548B2/en not_active Expired - Fee Related
-
1998
- 1998-06-05 BR BR9809951-5A patent/BR9809951A/pt not_active Application Discontinuation
- 1998-06-05 PL PL338082A patent/PL193236B1/pl unknown
- 1998-06-05 CZ CZ19994360A patent/CZ294983B6/cs not_active IP Right Cessation
- 1998-06-05 AU AU78230/98A patent/AU7823098A/en not_active Abandoned
- 1998-06-05 WO PCT/US1998/011753 patent/WO1998055144A1/en not_active Ceased
- 1998-06-05 RU RU2000100346/14A patent/RU2207871C2/ru not_active IP Right Cessation
- 1998-06-05 NZ NZ501451A patent/NZ501451A/en not_active IP Right Cessation
- 1998-06-05 HU HU0004271A patent/HUP0004271A3/hu unknown
-
1999
- 1999-12-06 NO NO19995996A patent/NO324818B1/no not_active IP Right Cessation
-
2002
- 2002-11-11 RU RU2002130192/14A patent/RU2314121C9/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004271A2 (hu) | 2001-05-28 |
| CZ294983B6 (cs) | 2005-04-13 |
| NO995996L (no) | 2000-02-07 |
| WO1998055144A1 (en) | 1998-12-10 |
| RU2207871C2 (ru) | 2003-07-10 |
| HUP0004271A3 (en) | 2001-08-28 |
| US20030026812A1 (en) | 2003-02-06 |
| NZ501451A (en) | 2001-10-26 |
| RU2314121C2 (ru) | 2008-01-10 |
| RU2314121C9 (ru) | 2008-08-10 |
| NO995996D0 (no) | 1999-12-06 |
| BR9809951A (pt) | 2000-08-01 |
| AU7823098A (en) | 1998-12-21 |
| US7910548B2 (en) | 2011-03-22 |
| PL193236B1 (pl) | 2007-01-31 |
| PL338082A1 (en) | 2000-09-25 |
| CZ9904360A3 (cs) | 2000-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: ASTRAZENECA PHARMACEUTICALS LP, US |
|
| MM1K | Lapsed by not paying the annual fees |