NO325333B1 - Kalsilytiske forbindelser og anvendelsen av slike for fremstilling av et preparat for behandling av ulike lidelser - Google Patents

Kalsilytiske forbindelser og anvendelsen av slike for fremstilling av et preparat for behandling av ulike lidelser Download PDF

Info

Publication number: NO325333B1
Authority: NO; Norway
Prior art keywords: cyano; ethylamine; dimethyl; hydroxy; propyl
Prior art date: 2000-07-21

Application number

NO20030303A

Other languages

English (en)

Norwegian (no)

Other versions

NO20030303D0 (no

NO20030303L (no

Inventor

Pradip Kumar Bhatnagar

James Francis Callahan

Amparo M Lago

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2003-01-20

Publication date

2008-03-31

2003-01-20 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2003-01-20 Publication of NO20030303D0 publication Critical patent/NO20030303D0/no

2003-03-20 Publication of NO20030303L publication Critical patent/NO20030303L/no

2008-03-31 Publication of NO325333B1 publication Critical patent/NO325333B1/no

Links

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Classifications

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
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Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20030303A 2000-07-21 2003-01-20 Kalsilytiske forbindelser og anvendelsen av slike for fremstilling av et preparat for behandling av ulike lidelser NO325333B1 (no)

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Application Number	Priority Date	Filing Date	Title
US21984200P	2000-07-21	2000-07-21
US22063600P	2000-07-25	2000-07-25
PCT/US2001/022267 WO2002007673A2 (en)	2000-07-21	2001-07-16	Calcilytic compounds

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NO20030303D0 NO20030303D0 (no)	2003-01-20
NO20030303L NO20030303L (no)	2003-03-20
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Country Status (19)

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EP (1)	EP1368318B1 (cs)
JP (1)	JP2004509077A (cs)
KR (1)	KR20030017642A (cs)
CN (1)	CN1582275A (cs)
AR (1)	AR033987A1 (cs)
AT (1)	ATE380177T1 (cs)
AU (2)	AU7692301A (cs)
BR (1)	BR0112600A (cs)
CA (1)	CA2416537A1 (cs)
CZ (1)	CZ2003142A3 (cs)
DE (1)	DE60131781T2 (cs)
ES (1)	ES2296774T3 (cs)
HU (1)	HUP0300758A2 (cs)
IL (1)	IL154058A0 (cs)
MX (1)	MXPA03000556A (cs)
MY (1)	MY133881A (cs)
NO (1)	NO325333B1 (cs)
PL (1)	PL365703A1 (cs)
WO (1)	WO2002007673A2 (cs)

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ATE411275T1 (de)	2000-08-11	2008-10-15	Japan Tobacco Inc	Calciumrezeptor-antagonisten
TWI316511B (en)	2002-11-26	2009-11-01	Smithkline Beecham Corp	Calcilytic compounds
BRPI0407097A (pt)	2003-04-23	2006-01-24	Japan Tobacco Inc	Antagonista do casr
EP1630157A4 (en)	2003-05-28	2007-05-23	Japan Tobacco Inc	ANTAGONIST OF CASR
JP2008515902A (ja) *	2004-10-06	2008-05-15	エヌピーエスファーマシューティカルズインコーポレイテッド	カルシウム拮抗化合物としての相補ピリミジノン化合物
US20100004459A1 (en) *	2006-12-12	2010-01-07	Nippon Zoki Pharmaceutical Co., Ltd.	2-phenylnicotinic acid derivative
CN102056897B (zh)	2008-06-05	2014-05-07	旭化成制药株式会社	磺酰胺化合物及其用途
WO2015089842A1 (en) *	2013-12-20	2015-06-25	Merck Sharp & Dohme Corp.	Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis
UY36548A (es)	2015-02-05	2016-06-01	Bayer Cropscience Ag	Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2024160842A1 (en)	2023-01-30	2024-08-08	Medizinische Universität Wien	Use of calcilytics for preventing or treating hypoparathyroidism associated with anterior neck surgery

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US5258379A (en) *	1990-05-04	1993-11-02	Eli Lilly And Company	Method of inhibiting gastric acid secretion with n-arylpiperazines
US5158956A (en) *	1990-05-04	1992-10-27	Eli Lilly And Company	Method of inhibiting gastric acid secretion with benzodioxanes
DE69733649T2 (de) *	1996-04-09	2006-05-18	NPS Pharmaceuticals, Inc., Salt Lake City	Calcylitische verbindungen
AR014975A1 (es) *	1998-04-08	2001-04-11	Nps Pharma Inc	Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento

2001
- 2001-07-16 ES ES01954696T patent/ES2296774T3/es not_active Expired - Lifetime
- 2001-07-16 MX MXPA03000556A patent/MXPA03000556A/es active IP Right Grant
- 2001-07-16 DE DE60131781T patent/DE60131781T2/de not_active Expired - Fee Related
- 2001-07-16 AU AU7692301A patent/AU7692301A/xx active Pending
- 2001-07-16 AT AT01954696T patent/ATE380177T1/de not_active IP Right Cessation
- 2001-07-16 AU AU2001276923A patent/AU2001276923B2/en not_active Expired - Fee Related
- 2001-07-16 BR BR0112600-8A patent/BR0112600A/pt not_active Application Discontinuation
- 2001-07-16 CA CA002416537A patent/CA2416537A1/en not_active Abandoned
- 2001-07-16 JP JP2002513411A patent/JP2004509077A/ja not_active Withdrawn
- 2001-07-16 WO PCT/US2001/022267 patent/WO2002007673A2/en not_active Ceased
- 2001-07-16 HU HU0300758A patent/HUP0300758A2/hu unknown
- 2001-07-16 KR KR10-2003-7000846A patent/KR20030017642A/ko not_active Ceased
- 2001-07-16 EP EP01954696A patent/EP1368318B1/en not_active Expired - Lifetime
- 2001-07-16 PL PL01365703A patent/PL365703A1/xx not_active Application Discontinuation
- 2001-07-16 CN CNA018131166A patent/CN1582275A/zh active Pending
- 2001-07-16 IL IL15405801A patent/IL154058A0/xx unknown
- 2001-07-16 CZ CZ2003142A patent/CZ2003142A3/cs unknown
- 2001-07-19 MY MYPI20013427 patent/MY133881A/en unknown
- 2001-07-20 AR ARP010103456A patent/AR033987A1/es not_active Application Discontinuation
2003
- 2003-01-20 NO NO20030303A patent/NO325333B1/no unknown

Also Published As

Publication number	Publication date
WO2002007673A3 (en)	2003-10-16
NO20030303D0 (no)	2003-01-20
PL365703A1 (en)	2005-01-10
IL154058A0 (en)	2003-07-31
AU2001276923B2 (en)	2005-02-03
ATE380177T1 (de)	2007-12-15
CA2416537A1 (en)	2002-01-31
ES2296774T3 (es)	2008-05-01
AU7692301A (en)	2002-02-05
NO20030303L (no)	2003-03-20
DE60131781D1 (de)	2008-01-17
AR033987A1 (es)	2004-01-21
EP1368318B1 (en)	2007-12-05
BR0112600A (pt)	2003-06-24
KR20030017642A (ko)	2003-03-03
WO2002007673A2 (en)	2002-01-31
MXPA03000556A (es)	2003-06-06
EP1368318A4 (en)	2006-08-23
EP1368318A2 (en)	2003-12-10
DE60131781T2 (de)	2008-12-24
HUP0300758A2 (hu)	2003-08-28
JP2004509077A (ja)	2004-03-25
CZ2003142A3 (cs)	2003-06-18
MY133881A (en)	2007-11-30
CN1582275A (zh)	2005-02-16

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JP2014037439A (ja)	2014-02-27	キナーゼカスケードを調節するための組成物および方法
WO1999051241A1 (en)	1999-10-14	Calcilytic compounds and method of use
US6335338B1 (en)	2002-01-01	Calcilytic compounds
NO325333B1 (no)	2008-03-31	Kalsilytiske forbindelser og anvendelsen av slike for fremstilling av et preparat for behandling av ulike lidelser
US6417215B1 (en)	2002-07-09	Calcilytic compounds
CN102336686A (zh)	2012-02-01	2-(7-甲氧基-1-萘基)乙氰的制备方法
US6864267B2 (en)	2005-03-08	Calcilytic compounds
AU2001276923A1 (en)	2002-05-02	Calcilytic compounds
WO1998044925A1 (en)	1998-10-15	Calcilytic compounds
EP1254106B1 (en)	2009-02-25	Calcilytic compounds
US20040009980A1 (en)	2004-01-15	Calcilytic compounds
US6291459B1 (en)	2001-09-18	Calcilytic compounds
EP1383511B1 (en)	2006-10-25	Calcilytic compounds
US20020052509A1 (en)	2002-05-02	Calcilytic compounds and method of use
WO2006042007A2 (en)	2006-04-20	Chromenone compounds as calcilytics