NO328211B1 - Intraokulaere trykksenkende preparater for topisk administrering omfattende en angiotensin II-antagonist, en borsyre og en etylendiamintetraeddiksyre. - Google Patents

Intraokulaere trykksenkende preparater for topisk administrering omfattende en angiotensin II-antagonist, en borsyre og en etylendiamintetraeddiksyre. Download PDF

Info

Publication number: NO328211B1
Authority: NO; Norway
Prior art keywords: groups; salts; intraocular pressure; methyl; acid
Prior art date: 1999-06-11

Application number

NO20016023A

Other languages

English (en)

Norwegian (no)

Other versions

NO20016023L (no

NO20016023D0 (no

Inventor

Takashi Shiokari

Tomihisa Yokoyama

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-11

Filing date

2001-12-10

Publication date

2010-01-11

2001-12-10 Application filed by Sankyo Co filed Critical Sankyo Co

2001-12-10 Publication of NO20016023D0 publication Critical patent/NO20016023D0/no

2002-01-29 Publication of NO20016023L publication Critical patent/NO20016023L/no

2010-01-11 Publication of NO328211B1 publication Critical patent/NO328211B1/no

Links

KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 title claims abstract description 20
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title claims abstract description 16
239000004327 boric acid Substances 0.000 title claims abstract description 16
229940123413 Angiotensin II antagonist Drugs 0.000 title claims abstract description 14
239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract description 14
239000000203 mixture Substances 0.000 title abstract description 10
238000011200 topical administration Methods 0.000 title abstract description 7
238000002360 preparation method Methods 0.000 claims description 49
150000001875 compounds Chemical class 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 16
230000004410 intraocular pressure Effects 0.000 claims description 15
239000003755 preservative agent Substances 0.000 claims description 6
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239000003814 drug Substances 0.000 claims description 5
230000002335 preservative effect Effects 0.000 claims description 5
208000010412 Glaucoma Diseases 0.000 claims description 4
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
206010030043 Ocular hypertension Diseases 0.000 claims description 2
229940079593 drug Drugs 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
101800000734 Angiotensin-1 Proteins 0.000 claims 1
102400000344 Angiotensin-1 Human genes 0.000 claims 1
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 claims 1
239000005557 antagonist Substances 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 11
-1 boron ions Chemical class 0.000 description 222
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LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 12
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 12
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
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238000012360 testing method Methods 0.000 description 6
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IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
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XDVOLDOITVSJGL-UHFFFAOYSA-N 3,7-dihydroxy-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B(O)OB2OB(O)OB1O2 XDVOLDOITVSJGL-UHFFFAOYSA-N 0.000 description 2
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
239000006172 buffering agent Substances 0.000 description 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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239000000969 carrier Substances 0.000 description 2
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235000019438 castor oil Nutrition 0.000 description 2
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239000003085 diluting agent Substances 0.000 description 2
CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 description 2
125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 2
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ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20016023A 1999-06-11 2001-12-10 Intraokulaere trykksenkende preparater for topisk administrering omfattende en angiotensin II-antagonist, en borsyre og en etylendiamintetraeddiksyre. NO328211B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16494599		1999-06-11
PCT/JP2000/003779 WO2000076543A1 (fr)	1999-06-11	2000-06-09	Composition permettant de reduire la tension oculaire et destinee a l'administration topique

Publications (3)

Publication Number	Publication Date
NO20016023D0 NO20016023D0 (no)	2001-12-10
NO20016023L NO20016023L (no)	2002-01-29
NO328211B1 true NO328211B1 (no)	2010-01-11

Family

ID=15802847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20016023A NO328211B1 (no)	1999-06-11	2001-12-10	Intraokulaere trykksenkende preparater for topisk administrering omfattende en angiotensin II-antagonist, en borsyre og en etylendiamintetraeddiksyre.

Country Status (23)

Country	Link
US (1)	US6777436B2 (fr)
EP (1)	EP1186302B1 (fr)
KR (1)	KR100611543B1 (fr)
CN (1)	CN1198650C (fr)
AT (1)	ATE295721T1 (fr)
AU (1)	AU759513B2 (fr)
BR (1)	BR0011477A (fr)
CA (1)	CA2376780C (fr)
CZ (1)	CZ300553B6 (fr)
DE (1)	DE60020230T2 (fr)
ES (1)	ES2242619T3 (fr)
HU (1)	HUP0201466A3 (fr)
IL (2)	IL146917A0 (fr)
MX (1)	MXPA01012752A (fr)
NO (1)	NO328211B1 (fr)
NZ (1)	NZ516033A (fr)
PL (1)	PL200009B1 (fr)
PT (1)	PT1186302E (fr)
RU (1)	RU2227740C2 (fr)
TR (1)	TR200103603T2 (fr)
TW (1)	TWI245639B (fr)
WO (1)	WO2000076543A1 (fr)
ZA (1)	ZA200109943B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
TW200304812A (en) *	2002-03-08	2003-10-16	Sankyo Co	An eye drop containing a tetrazole derivative
US20050119299A1 (en) *	2002-03-08	2005-06-02	Sankyo Company, Limited	Ophthalmic solutions containing tetrazole derivatives
RU2420280C2 (ru) *	2005-04-21	2011-06-10	Сантен Фармасьютикал Ко., Лтд	Терапевтическое средство против кератоконъюнктивального расстройства
US8349368B2 (en) *	2007-11-30	2013-01-08	Toltec Pharmaceuticals, Llc	Compositions and methods for treating vaginal infections and pathogenic vaginal biofilms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991015206A1 (fr) *	1990-04-05	1991-10-17	E.I. Du Pont De Nemours And Company	Traitement du glaucome et de l'hypertension oculaire a l'aide d'imidazoles en tant qu'antagonistes de recepteur d'angiotensine-ii
TW200402B (fr) *	1990-08-13	1993-02-21	Senju Pharma Co
RU2007152C1 (ru) *	1992-10-01	1994-02-15	Курский Государственный Медицинский Институт	Офтальмологическое средство и способ его получения
CZ154994A3 (en)	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
US5889020A (en) *	1994-02-08	1999-03-30	Ciba Vision Corporation	Treatment of normotensive glaucoma with angiotensin II antagonists
AU684916B2 (en)	1994-03-16	1998-01-08	Sankyo Company Limited	Ocular tension depressant
JPH07324034A (ja) *	1994-05-30	1995-12-12	Toa Yakuhin Kk	フマル酸ケトチフェン含有の点眼剤

2000
- 2000-06-09 ES ES00935630T patent/ES2242619T3/es not_active Expired - Lifetime
- 2000-06-09 IL IL14691700A patent/IL146917A0/xx active IP Right Grant
- 2000-06-09 TR TR2001/03603T patent/TR200103603T2/xx unknown
- 2000-06-09 RU RU2001133273/15A patent/RU2227740C2/ru not_active IP Right Cessation
- 2000-06-09 WO PCT/JP2000/003779 patent/WO2000076543A1/fr not_active Ceased
- 2000-06-09 CZ CZ20014415A patent/CZ300553B6/cs not_active IP Right Cessation
- 2000-06-09 MX MXPA01012752A patent/MXPA01012752A/es active IP Right Grant
- 2000-06-09 CN CNB008113513A patent/CN1198650C/zh not_active Expired - Fee Related
- 2000-06-09 PT PT00935630T patent/PT1186302E/pt unknown
- 2000-06-09 AT AT00935630T patent/ATE295721T1/de not_active IP Right Cessation
- 2000-06-09 NZ NZ516033A patent/NZ516033A/en not_active IP Right Cessation
- 2000-06-09 TW TW089111297A patent/TWI245639B/zh not_active IP Right Cessation
- 2000-06-09 EP EP00935630A patent/EP1186302B1/fr not_active Expired - Lifetime
- 2000-06-09 HU HU0201466A patent/HUP0201466A3/hu unknown
- 2000-06-09 DE DE60020230T patent/DE60020230T2/de not_active Expired - Lifetime
- 2000-06-09 PL PL352161A patent/PL200009B1/pl not_active IP Right Cessation
- 2000-06-09 BR BR0011477-4A patent/BR0011477A/pt not_active Application Discontinuation
- 2000-06-09 KR KR1020017015901A patent/KR100611543B1/ko not_active Expired - Fee Related
- 2000-06-09 AU AU51086/00A patent/AU759513B2/en not_active Ceased
- 2000-06-09 CA CA002376780A patent/CA2376780C/fr not_active Expired - Fee Related
2001
- 2001-12-03 ZA ZA200109943A patent/ZA200109943B/en unknown
- 2001-12-04 IL IL146917A patent/IL146917A/en not_active IP Right Cessation
- 2001-12-10 NO NO20016023A patent/NO328211B1/no not_active IP Right Cessation
- 2001-12-10 US US10/016,535 patent/US6777436B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TR200103603T2 (tr)	2002-05-21
CA2376780C (fr)	2008-05-06
NZ516033A (en)	2003-09-26
US6777436B2 (en)	2004-08-17
ATE295721T1 (de)	2005-06-15
HUP0201466A3 (en)	2003-04-28
AU759513B2 (en)	2003-04-17
KR20020015343A (ko)	2002-02-27
EP1186302A1 (fr)	2002-03-13
ZA200109943B (en)	2003-03-03
EP1186302A4 (fr)	2004-03-24
IL146917A0 (en)	2002-08-14
DE60020230D1 (de)	2005-06-23
HK1042050A1 (en)	2002-08-02
DE60020230T2 (de)	2006-03-09
NO20016023L (no)	2002-01-29
IL146917A (en)	2006-10-31
CN1198650C (zh)	2005-04-27
US20020147211A1 (en)	2002-10-10
KR100611543B1 (ko)	2006-08-10
CN1368889A (zh)	2002-09-11
MXPA01012752A (es)	2002-07-02
HUP0201466A2 (en)	2002-09-28
TWI245639B (en)	2005-12-21
CA2376780A1 (fr)	2000-12-21
CZ20014415A3 (cs)	2002-04-17
NO20016023D0 (no)	2001-12-10
BR0011477A (pt)	2002-03-19
AU5108600A (en)	2001-01-02
PT1186302E (pt)	2005-07-29
PL352161A1 (en)	2003-07-28
ES2242619T3 (es)	2005-11-16
PL200009B1 (pl)	2008-11-28
CZ300553B6 (cs)	2009-06-17
WO2000076543A1 (fr)	2000-12-21
EP1186302B1 (fr)	2005-05-18
RU2227740C2 (ru)	2004-04-27

Legal Events

Date	Code	Title	Description
2011-01-31	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US20080221184A1 (en)	2008-09-11	Combined agents for treatment of glaucoma
EP1186302B1 (fr)	2005-05-18	Composition permettant de reduire la tension oculaire et destinee a l'administration topique
JP4132798B2 (ja)	2008-08-13	局所投与のための眼圧低下組成物
JP3790093B2 (ja)	2006-06-28	局所投与用眼圧低下組成物
HK1042050B (en)	2005-08-12	Ocular tension lowering composition for topical adminstration
AU2003211863A1 (en)	2003-09-22	Ophthalmic solutions containing tetrazole derivatives
HK1055684A (en)	2004-01-21	Combined angiotensin ii antagonists and adrenaline receptor blockers for treatment of glaucoma
HK1055894A (en)	2004-01-30	Combined angiotensin ii antagonists and carbonic anhydrase inhibitors for treatment of glaucoma