NO330781B1 - Polymorfe former av {6,7-Bis(2-metoksy-etoksy) kinazolin-4-yl(3-etynyl-fenyl)aminhydroklorid, fremgangsmate for fremstilling av slike, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse som medikament samt slike forbindelser for behandling av sykdommer - Google Patents

Polymorfe former av {6,7-Bis(2-metoksy-etoksy) kinazolin-4-yl(3-etynyl-fenyl)aminhydroklorid, fremgangsmate for fremstilling av slike, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse som medikament samt slike forbindelser for behandling av sykdommer Download PDF

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Publication number
NO330781B1
NO330781B1 NO20053953A NO20053953A NO330781B1 NO 330781 B1 NO330781 B1 NO 330781B1 NO 20053953 A NO20053953 A NO 20053953A NO 20053953 A NO20053953 A NO 20053953A NO 330781 B1 NO330781 B1 NO 330781B1
Authority
NO
Norway
Prior art keywords
bis
crystalline polymorph
quinazolin
amine hydrochloride
ethynyl
Prior art date
Application number
NO20053953A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053953L (no
Inventor
Andre Gerard Bubendorf
Michael Hennig
Pirmin Hidber
Goesta Rimmler
Franziska Rohrer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32842701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO330781(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20053953L publication Critical patent/NO20053953L/no
Publication of NO330781B1 publication Critical patent/NO330781B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20053953A 2003-02-17 2005-08-25 Polymorfe former av {6,7-Bis(2-metoksy-etoksy) kinazolin-4-yl(3-etynyl-fenyl)aminhydroklorid, fremgangsmate for fremstilling av slike, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse som medikament samt slike forbindelser for behandling av sykdommer NO330781B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03003587 2003-02-17
PCT/EP2004/001244 WO2004072049A1 (fr) 2003-02-17 2004-02-11 Polymorphe de {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e)

Publications (2)

Publication Number Publication Date
NO20053953L NO20053953L (no) 2005-08-31
NO330781B1 true NO330781B1 (no) 2011-07-18

Family

ID=32842701

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053953A NO330781B1 (no) 2003-02-17 2005-08-25 Polymorfe former av {6,7-Bis(2-metoksy-etoksy) kinazolin-4-yl(3-etynyl-fenyl)aminhydroklorid, fremgangsmate for fremstilling av slike, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse som medikament samt slike forbindelser for behandling av sykdommer

Country Status (24)

Country Link
US (1) US7148231B2 (fr)
EP (1) EP1597239B2 (fr)
JP (1) JP4456079B2 (fr)
KR (1) KR100797430B1 (fr)
CN (1) CN100506803C (fr)
AT (1) ATE408605T1 (fr)
AU (1) AU2004212067C1 (fr)
BR (1) BRPI0407520A (fr)
CA (1) CA2514977C (fr)
CO (1) CO5601019A2 (fr)
DE (1) DE602004016628D1 (fr)
DK (1) DK1597239T4 (fr)
ES (1) ES2314373T5 (fr)
HR (1) HRP20050707B1 (fr)
IL (1) IL169975A (fr)
MX (1) MXPA05008598A (fr)
NO (1) NO330781B1 (fr)
NZ (1) NZ541500A (fr)
PL (1) PL225428B1 (fr)
PT (1) PT1597239E (fr)
RU (1) RU2376294C2 (fr)
SI (1) SI1597239T2 (fr)
WO (1) WO2004072049A1 (fr)
ZA (1) ZA200506339B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
WO2008000418A2 (fr) 2006-06-27 2008-01-03 Sandoz Ag Nouveau procédé de préparation de sel
CA2659307A1 (fr) 2006-07-28 2008-01-31 Synthon B.V. Forme cristalline d'erlobtinib
US8372856B2 (en) 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
US8349855B2 (en) 2007-02-21 2013-01-08 Natco Pharma Limited Polymorphs of erlotinib hydrochloride and method of preparation
NZ579997A (en) * 2007-04-04 2012-08-31 Cipla Ltd PROCESS FOR PREPARATION OF N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
WO2009024989A2 (fr) * 2007-08-17 2009-02-26 Hetero Drugs Limited Nouvelle forme hydratée de base libre d'erlotinib et procédé de préparation de la forme polymorphe a de chlorhydrate d'erlotinib sensiblement exempte de la forme polymorphe b
US20090124642A1 (en) * 2007-08-23 2009-05-14 Augusto Canavesi Crystalline forms of Erlotinib HCI and formulations thereof
US20090131665A1 (en) * 2007-08-23 2009-05-21 Ales Gavenda Process for the preparation of crystalline forms A, B and pure crystalline form a of erlotinib HCI
US20100004449A1 (en) * 2008-07-07 2010-01-07 Plus Chemicals Sa Crystalline forms of erlotinib base and erlotinib hcl
WO2010040212A1 (fr) * 2008-10-08 2010-04-15 Apotex Pharmachem Inc. Procédés de préparation du chlorhydrate d'erlotinib
EP2213281A1 (fr) 2009-02-02 2010-08-04 Ratiopharm GmbH Composition pharmaceutique comportant du N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
WO2010109443A1 (fr) 2009-03-26 2010-09-30 Ranbaxy Laboratories Limited Procede de preparation d'erlotinib ou de ses sels pharmaceutiquement acceptables
EP2499118A2 (fr) 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Procédé de synthèse de la forme a du chlorhydrate d'erlotinib et de la forme b du chlorhydrate d'erlotinib
CN101987834B (zh) * 2010-06-13 2012-07-18 信泰制药（苏州）有限公司 一种结晶形态的盐酸埃罗替尼及其制备方法
NZ628796A (en) 2010-07-23 2016-02-26 Generics Uk Ltd Pure erlotinib
US20140121373A1 (en) 2011-05-03 2014-05-01 Cadila Healthcare Limited Process for preparing stable polymorphic form of erlotinib hydrochloride
US9593083B2 (en) 2012-09-04 2017-03-14 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process
WO2014118737A1 (fr) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Sels d'erlotinib
CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
WO2016082879A1 (fr) * 2014-11-27 2016-06-02 Synthon B.V. Composition pharmaceutique comportant du chlorhydrate d'erlotinib
RU2610337C1 (ru) * 2015-12-10 2017-02-09 Индивидуальный предприниматель Михайлов Олег Ростиславович Кристаллическая β-модификация N-(3-этинилфенил)-6,7-бис(2 метоксиэтокси)хиназолин-4-амин гидрохлорида, способ её получения и фармацевтическая композиция на её основе
JP2019059685A (ja) * 2017-09-26 2019-04-18 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤
JP2020090456A (ja) * 2018-12-05 2020-06-11 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434574A (en) * 1987-07-30 1989-02-06 Mazda Motor Full mold casting device
MX9707453A (es) * 1995-03-30 1997-12-31 Pfizer Derivados de quinazolina.
US5747498A (en) † 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
TR200003166T2 (tr) 1998-04-29 2001-02-21 Osi Pharmaceuticals, Inc. N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat.
RS49836B (sr) * 1999-03-31 2008-08-07 Pfizer Products Inc., Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування

Also Published As

Publication number Publication date
ES2314373T5 (es) 2022-10-11
DE602004016628D1 (de) 2008-10-30
ES2314373T3 (es) 2009-03-16
HRP20050707A2 (en) 2006-07-31
AU2004212067A1 (en) 2004-08-26
RU2005128774A (ru) 2006-05-10
JP2006521288A (ja) 2006-09-21
HRP20050707B1 (hr) 2013-10-25
RU2376294C2 (ru) 2009-12-20
JP4456079B2 (ja) 2010-04-28
PL378561A1 (pl) 2006-05-02
CO5601019A2 (es) 2006-01-31
US7148231B2 (en) 2006-12-12
DK1597239T4 (da) 2022-09-26
SI1597239T2 (sl) 2022-10-28
CN1751032A (zh) 2006-03-22
NO20053953L (no) 2005-08-31
CN100506803C (zh) 2009-07-01
ATE408605T1 (de) 2008-10-15
AU2004212067C1 (en) 2009-09-24
SI1597239T1 (sl) 2009-02-28
PT1597239E (pt) 2008-10-10
KR100797430B1 (ko) 2008-01-23
IL169975A (en) 2011-06-30
CA2514977C (fr) 2010-06-22
EP1597239B1 (fr) 2008-09-17
MXPA05008598A (es) 2005-11-04
CA2514977A1 (fr) 2004-08-26
WO2004072049A1 (fr) 2004-08-26
PL225428B1 (pl) 2017-04-28
US20040162300A1 (en) 2004-08-19
ZA200506339B (en) 2006-05-31
KR20050095898A (ko) 2005-10-04
NZ541500A (en) 2008-03-28
DK1597239T3 (da) 2008-12-08
EP1597239B2 (fr) 2022-07-20
AU2004212067B2 (en) 2009-03-19
BRPI0407520A (pt) 2006-02-14
EP1597239A1 (fr) 2005-11-23

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