NO331790B1 - Fremgangsmate for utvinning av en naturlig blanding av konjugerte ostrogener som er utarmet pa fenoliske urininnholdsstoffer, fra urinen til drektige hopper. - Google Patents

Fremgangsmate for utvinning av en naturlig blanding av konjugerte ostrogener som er utarmet pa fenoliske urininnholdsstoffer, fra urinen til drektige hopper. Download PDF

Info

Publication number: NO331790B1
Authority: NO; Norway
Prior art keywords: temperatures; mixture; adsorption resin; water; conjugated estrogens
Prior art date: 2001-12-01

Application number

NO20042761A

Other languages

English (en)

Norwegian (no)

Other versions

NO20042761L (no

Inventor

Heinz-Helmer Rasche

Olaf Rupp

Original Assignee

Abbott Products Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-01

Filing date

2004-06-30

Publication date

2012-04-02

2004-06-30 Application filed by Abbott Products Gmbh filed Critical Abbott Products Gmbh

2004-06-30 Publication of NO20042761L publication Critical patent/NO20042761L/no

2012-04-02 Publication of NO331790B1 publication Critical patent/NO331790B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 63
239000000203 mixture Substances 0.000 title claims abstract description 60
229940035811 conjugated estrogen Drugs 0.000 title claims abstract description 48
210000002700 urine Anatomy 0.000 title claims abstract description 33
230000008569 process Effects 0.000 title claims abstract description 5
230000002485 urinary effect Effects 0.000 title claims description 15
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title claims description 11
239000000470 constituent Substances 0.000 title claims description 6
238000011084 recovery Methods 0.000 title 1
229920005989 resin Polymers 0.000 claims abstract description 84
239000011347 resin Substances 0.000 claims abstract description 84
238000001179 sorption measurement Methods 0.000 claims abstract description 78
239000000262 estrogen Substances 0.000 claims abstract description 45
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
238000005406 washing Methods 0.000 claims description 39
239000012530 fluid Substances 0.000 claims description 19
-1 aliphatic ketones Chemical class 0.000 claims description 9
239000003960 organic solvent Substances 0.000 claims description 8
239000012465 retentate Substances 0.000 claims description 8
239000007787 solid Substances 0.000 claims description 8
239000003480 eluent Substances 0.000 claims description 6
238000000605 extraction Methods 0.000 claims description 5
238000005374 membrane filtration Methods 0.000 claims description 5
239000012141 concentrate Substances 0.000 claims description 4
150000002170 ethers Chemical class 0.000 claims description 4
210000003097 mucus Anatomy 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
229940011871 estrogen Drugs 0.000 abstract description 24
239000000284 extract Substances 0.000 abstract description 12
QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 abstract description 2
238000002414 normal-phase solid-phase extraction Methods 0.000 abstract description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
239000007788 liquid Substances 0.000 description 15
238000010828 elution Methods 0.000 description 14
229940088597 hormone Drugs 0.000 description 14
239000005556 hormone Substances 0.000 description 14
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000013543 active substance Substances 0.000 description 12
150000002148 esters Chemical class 0.000 description 10
QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 9
229930003836 cresol Natural products 0.000 description 9
238000004128 high performance liquid chromatography Methods 0.000 description 9
239000000126 substance Substances 0.000 description 8
238000001816 cooling Methods 0.000 description 7
229920001467 poly(styrenesulfonates) Polymers 0.000 description 7
238000000926 separation method Methods 0.000 description 7
239000002253 acid Substances 0.000 description 6
239000003463 adsorbent Substances 0.000 description 6
239000003814 drug Substances 0.000 description 6
239000000047 product Substances 0.000 description 6
230000009467 reduction Effects 0.000 description 6
238000012360 testing method Methods 0.000 description 6
229920001429 chelating resin Polymers 0.000 description 5
JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical class OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 5
125000001931 aliphatic group Chemical group 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
239000011148 porous material Substances 0.000 description 4
235000011121 sodium hydroxide Nutrition 0.000 description 4
239000002904 solvent Substances 0.000 description 4
XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
230000008901 benefit Effects 0.000 description 3
HVDGDHBAMCBBLR-UHFFFAOYSA-N enterolactone Chemical compound OC1=CC=CC(CC2C(C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-UHFFFAOYSA-N 0.000 description 3
238000001914 filtration Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
230000008929 regeneration Effects 0.000 description 3
238000011069 regeneration method Methods 0.000 description 3
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
229910000272 alkali metal oxide Inorganic materials 0.000 description 2
150000001340 alkali metals Chemical class 0.000 description 2
229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
150000001896 cresols Chemical class 0.000 description 2
238000003795 desorption Methods 0.000 description 2
SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 2
238000011049 filling Methods 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
239000005457 ice water Substances 0.000 description 2
150000007529 inorganic bases Chemical class 0.000 description 2
238000011835 investigation Methods 0.000 description 2
229920000831 ionic polymer Polymers 0.000 description 2
239000000463 material Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
239000012071 phase Substances 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
238000012545 processing Methods 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
238000005496 tempering Methods 0.000 description 2
238000000108 ultra-filtration Methods 0.000 description 2
JKKFKPJIXZFSSB-UHFFFAOYSA-N 1,3,5(10)-estratrien-17-one 3-sulfate Natural products OS(=O)(=O)OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 JKKFKPJIXZFSSB-UHFFFAOYSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
BNHGVULTSGNVIX-UHFFFAOYSA-N 1-(2-ethoxyethoxy)ethanol Chemical compound CCOCCOC(C)O BNHGVULTSGNVIX-UHFFFAOYSA-N 0.000 description 1
206010003439 Artificial menopause Diseases 0.000 description 1
HVDGDHBAMCBBLR-PBHICJAKSA-N Enterolactone Chemical compound OC1=CC=CC(C[C@H]2[C@@H](C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-PBHICJAKSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
241000700605 Viruses Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000005233 alkylalcohol group Chemical group 0.000 description 1
239000003957 anion exchange resin Substances 0.000 description 1
230000000507 anthelmentic effect Effects 0.000 description 1
229940124339 anthelmintic agent Drugs 0.000 description 1
239000000921 anthelmintic agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000008859 change Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
150000004292 cyclic ethers Chemical class 0.000 description 1
230000002542 deteriorative effect Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000001076 estrogenic effect Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000007429 general method Methods 0.000 description 1
230000002070 germicidal effect Effects 0.000 description 1
238000002657 hormone replacement therapy Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
238000002386 leaching Methods 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
238000001728 nano-filtration Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
238000005457 optimization Methods 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920000768 polyamine Polymers 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000003303 reheating Methods 0.000 description 1
239000004576 sand Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
230000002277 temperature effect Effects 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
238000011282 treatment Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

NO20042761A 2001-12-01 2004-06-30 Fremgangsmate for utvinning av en naturlig blanding av konjugerte ostrogener som er utarmet pa fenoliske urininnholdsstoffer, fra urinen til drektige hopper. NO331790B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10159161A DE10159161A1 (de)	2001-12-01	2001-12-01	Verfahren zur Gewinnung von Oestrogenen aus Stutenharn
PCT/EP2002/013343 WO2003048183A2 (fr)	2001-12-01	2002-11-27	Procede d'obtention d'estrogenes a partir d'urine de jument

Publications (2)

Publication Number	Publication Date
NO20042761L NO20042761L (no)	2004-06-30
NO331790B1 true NO331790B1 (no)	2012-04-02

Family

ID=7707777

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20042761A NO331790B1 (no)	2001-12-01	2004-06-30	Fremgangsmate for utvinning av en naturlig blanding av konjugerte ostrogener som er utarmet pa fenoliske urininnholdsstoffer, fra urinen til drektige hopper.

Country Status (21)

Country	Link
US (1)	US7439235B2 (fr)
EP (1)	EP1453527B1 (fr)
JP (1)	JP4414761B2 (fr)
CN (1)	CN1286472C (fr)
AR (1)	AR037670A1 (fr)
AT (1)	ATE339215T1 (fr)
AU (1)	AU2002352161B2 (fr)
BR (1)	BR0214607A (fr)
CA (1)	CA2468933C (fr)
DE (2)	DE10159161A1 (fr)
DK (1)	DK1453527T3 (fr)
ES (1)	ES2268125T3 (fr)
HU (1)	HU229187B1 (fr)
IL (2)	IL162229A0 (fr)
MX (1)	MXPA04005144A (fr)
NO (1)	NO331790B1 (fr)
PL (1)	PL205545B1 (fr)
PT (1)	PT1453527E (fr)
RU (1)	RU2308955C2 (fr)
TW (1)	TWI252106B (fr)
WO (1)	WO2003048183A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6266342B1 (en)	1998-04-08	2001-07-24	Nortel Networks Limited	Adaption resource module and operating method therefor
US8349819B2 (en)	2002-10-09	2013-01-08	Dr. Reddy's Laboratories New York, Inc.	Steroid extraction process from urine sources
ATE410435T1 (de)	2003-07-17	2008-10-15	Solvay Pharm Gmbh	Verfahren zur gewinnung eines natürlichen gemisches konjugierter equin esrtrogene
CN1325062C (zh) *	2005-12-06	2007-07-11	新疆特丰药业股份有限公司	从孕马尿中获取结合雌激素混合物方法及其所用大孔吸附树脂的应用
EP1800727A1 (fr) *	2005-12-20	2007-06-27	DSMIP Assets B.V.	Procédé de traitement d'un mélange aqueux comprenant un composé dipolar aprotique
ITMI20052516A1 (it)	2005-12-29	2007-06-30	Evultis Sa	PROCESSO PER L'ISOLAMENTO DI PèRINCIPI FARMACOLOGICAMENTE ATTIVI DI ORIGINE VEGETALE ED ANIMALE
US20140371180A1 (en)	2013-06-14	2014-12-18	Dr. Reddy's Laboratories Ltd.	Process for purification and isolation of estrogens
RU2738478C1 (ru) *	2020-01-22	2020-12-14	Богдан Иванович Асатуров	Способ и устройство для получения гормонального концентрата из мочи

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU23563A1 (ru) *	1920-12-28	1931-10-31	Е.Б. Дерапкова	Способ получени гормонов передней доли гипофиза
US3769401A (en) *	1970-11-19	1973-10-30	Frosst & Co	Chemical process
RU2071334C1 (ru) *	1993-01-11	1997-01-10	Научно-производственное объединение "Иммунопрепарат"	Способ получения сырца гонадотропина хорионического
HU9500323D0 (en) *	1994-02-08	1995-03-28	Solvay Deutschland	Process for separating estrogenes from urine of mares with foal
JP3504336B2 (ja) *	1994-06-15	2004-03-08	株式会社半導体エネルギー研究所	半導体装置の作製方法
TW406861U (en) *	1994-07-28	2000-09-21	Semiconductor Energy Lab	Laser processing system
US6478263B1 (en) *	1997-01-17	2002-11-12	Semiconductor Energy Laboratory Co., Ltd.	Semiconductor device and its manufacturing method
JP3729955B2 (ja) *	1996-01-19	2005-12-21	株式会社半導体エネルギー研究所	半導体装置の作製方法
US6465287B1 (en) *	1996-01-27	2002-10-15	Semiconductor Energy Laboratory Co., Ltd.	Method for fabricating a semiconductor device using a metal catalyst and high temperature crystallization
DE59610985D1 (de) *	1996-08-30	2004-05-19	Solvay Pharm Gmbh	Verfahren zur gewinnung von oestrogenen aus stutenharn
PL185920B1 (pl) *	1996-08-30	2003-08-29	Solvay Pharm Gmbh	Sposób otrzymywania estrogenów z moczu klaczySposób otrzymywania estrogenów z moczu klaczy
DE10037389A1 (de) *	2000-08-01	2002-02-14	Solvay Pharm Gmbh	Verfahren und Vorrichtung zur Anreicherung und Stabilisierung von konjugierten Oestrogenen aus Stutenharn

2001
- 2001-12-01 DE DE10159161A patent/DE10159161A1/de not_active Withdrawn
2002
- 2002-11-21 AR ARP020104482A patent/AR037670A1/es unknown
- 2002-11-27 JP JP2003549371A patent/JP4414761B2/ja not_active Expired - Fee Related
- 2002-11-27 AT AT02787839T patent/ATE339215T1/de active
- 2002-11-27 RU RU2004120299/15A patent/RU2308955C2/ru not_active IP Right Cessation
- 2002-11-27 ES ES02787839T patent/ES2268125T3/es not_active Expired - Lifetime
- 2002-11-27 HU HU0402194A patent/HU229187B1/hu not_active IP Right Cessation
- 2002-11-27 IL IL16222902A patent/IL162229A0/xx unknown
- 2002-11-27 CN CNB028229231A patent/CN1286472C/zh not_active Expired - Fee Related
- 2002-11-27 PL PL368904A patent/PL205545B1/pl unknown
- 2002-11-27 MX MXPA04005144A patent/MXPA04005144A/es active IP Right Grant
- 2002-11-27 WO PCT/EP2002/013343 patent/WO2003048183A2/fr not_active Ceased
- 2002-11-27 DK DK02787839T patent/DK1453527T3/da active
- 2002-11-27 DE DE50208167T patent/DE50208167D1/de not_active Expired - Lifetime
- 2002-11-27 AU AU2002352161A patent/AU2002352161B2/en not_active Ceased
- 2002-11-27 TW TW091134426A patent/TWI252106B/zh not_active IP Right Cessation
- 2002-11-27 EP EP02787839A patent/EP1453527B1/fr not_active Expired - Lifetime
- 2002-11-27 CA CA2468933A patent/CA2468933C/fr not_active Expired - Fee Related
- 2002-11-27 BR BR0214607-0A patent/BR0214607A/pt not_active Application Discontinuation
- 2002-11-27 PT PT02787839T patent/PT1453527E/pt unknown
2004
- 2004-05-30 IL IL162229A patent/IL162229A/en not_active IP Right Cessation
- 2004-06-01 US US10/857,355 patent/US7439235B2/en not_active Expired - Fee Related
- 2004-06-30 NO NO20042761A patent/NO331790B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
TW200300693A (en)	2003-06-16
RU2308955C2 (ru)	2007-10-27
DK1453527T3 (da)	2006-10-09
DE10159161A1 (de)	2003-06-18
HUP0402194A2 (hu)	2005-02-28
AU2002352161B2 (en)	2009-12-24
AR037670A1 (es)	2004-12-01
US20050014738A1 (en)	2005-01-20
JP4414761B2 (ja)	2010-02-10
WO2003048183A3 (fr)	2003-08-14
PL205545B1 (pl)	2010-04-30
HU229187B1 (en)	2013-09-30
HUP0402194A3 (en)	2012-10-29
ES2268125T3 (es)	2007-03-16
NO20042761L (no)	2004-06-30
MXPA04005144A (es)	2004-08-11
AU2002352161A1 (en)	2003-06-17
CN1286472C (zh)	2006-11-29
PL368904A1 (en)	2005-04-04
CA2468933A1 (fr)	2003-06-12
BR0214607A (pt)	2004-09-14
DE50208167D1 (de)	2006-10-26
HK1073241A1 (en)	2005-09-30
ATE339215T1 (de)	2006-10-15
WO2003048183A2 (fr)	2003-06-12
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PT1453527E (pt)	2006-11-30
TWI252106B (en)	2006-04-01
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CN1589150A (zh)	2005-03-02
IL162229A0 (en)	2005-11-20
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