NO332175B1 - Heteroarylsubstituerte imidazolderivater, fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for anvendelse til behandling av sykdom samt anvendelse av slike forbindelser for fremstilling av medikamenter for behandling av sykdom - Google Patents

Heteroarylsubstituerte imidazolderivater, fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for anvendelse til behandling av sykdom samt anvendelse av slike forbindelser for fremstilling av medikamenter for behandling av sykdom Download PDF

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Publication number
NO332175B1
NO332175B1 NO20055758A NO20055758A NO332175B1 NO 332175 B1 NO332175 B1 NO 332175B1 NO 20055758 A NO20055758 A NO 20055758A NO 20055758 A NO20055758 A NO 20055758A NO 332175 B1 NO332175 B1 NO 332175B1
Authority
NO
Norway
Prior art keywords
methyl
formula
compound
chloro
imidazol
Prior art date
Application number
NO20055758A
Other languages
English (en)
Norwegian (no)
Other versions
NO20055758D0 (no
NO20055758L (no
Inventor
Sabine Kolczewski
Bernd Buettelmann
Georg Jaeschke
Eric Vieira
Simona Maria Ceccarelli
Richard Hugh Phillip Porter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20055758D0 publication Critical patent/NO20055758D0/no
Publication of NO20055758L publication Critical patent/NO20055758L/no
Publication of NO332175B1 publication Critical patent/NO332175B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20055758A 2003-06-12 2005-12-05 Heteroarylsubstituerte imidazolderivater, fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for anvendelse til behandling av sykdom samt anvendelse av slike forbindelser for fremstilling av medikamenter for behandling av sykdom NO332175B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03012290 2003-06-12
PCT/EP2004/006111 WO2004111040A1 (fr) 2003-06-12 2004-06-07 Derives d'imidazoles substitues par heteroaryle, utilises comme antagonistes du recepteur de glutamate

Publications (3)

Publication Number Publication Date
NO20055758D0 NO20055758D0 (no) 2005-12-05
NO20055758L NO20055758L (no) 2005-12-07
NO332175B1 true NO332175B1 (no) 2012-07-16

Family

ID=33495606

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055758A NO332175B1 (no) 2003-06-12 2005-12-05 Heteroarylsubstituerte imidazolderivater, fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for anvendelse til behandling av sykdom samt anvendelse av slike forbindelser for fremstilling av medikamenter for behandling av sykdom

Country Status (23)

Country Link
US (1) US7241760B2 (fr)
EP (1) EP1670784B1 (fr)
JP (1) JP4395512B2 (fr)
KR (1) KR100717914B1 (fr)
CN (1) CN100462363C (fr)
AR (1) AR044657A1 (fr)
AT (1) ATE495168T1 (fr)
AU (1) AU2004247368B2 (fr)
BR (1) BRPI0411350A (fr)
CA (1) CA2527587C (fr)
CL (1) CL2004001430A1 (fr)
CO (1) CO5660263A2 (fr)
DE (1) DE602004031030D1 (fr)
ES (1) ES2358512T3 (fr)
IL (1) IL172080A (fr)
MX (1) MXPA05013233A (fr)
MY (1) MY140206A (fr)
NO (1) NO332175B1 (fr)
NZ (1) NZ543638A (fr)
RU (1) RU2327697C2 (fr)
TW (1) TWI336700B (fr)
WO (1) WO2004111040A1 (fr)
ZA (1) ZA200509908B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
WO2006099972A1 (fr) 2005-03-23 2006-09-28 F. Hoffmann-La Roche Ag Derives d'acetylenyl-pyrazolo-pyrimidine comme antagonistes mglur2
JP5048675B2 (ja) 2005-09-27 2012-10-17 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類
DE102006011574A1 (de) 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
WO2009024491A1 (fr) * 2007-08-20 2009-02-26 F. Hoffmann-La Roche Ag Utilisation d'antagonistes de mglur5 pour le traitement d'un reflux gastroœsophagien pathologique
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US9447099B2 (en) 2011-10-04 2016-09-20 Hoffmann-La Roche Inc. Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
EP4069685A1 (fr) * 2019-12-02 2022-10-12 F. Hoffmann-La Roche AG Inhibiteurs d'alcynyle- (hétéroaryl)-carboxamide hcn1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US6774138B2 (en) * 1999-08-31 2004-08-10 Merck & Co., Inc. Thiazolyl(pyridyl)ethyne compounds
JP4815083B2 (ja) * 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法
JP5154728B2 (ja) * 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
DE10040683C2 (de) * 2000-08-19 2002-06-27 Hinderer & Muehlich Kg Verfahren zum Positionieren einer Patrize an einer Gegendruckwalze einer Prägestation
WO2002046166A1 (fr) * 2000-12-04 2002-06-13 F. Hoffmann-La Roche Ag Derives phenylethenyle ou phenylethinyle servant d'antagonistes de recepteur de glutamate

Also Published As

Publication number Publication date
KR20060021886A (ko) 2006-03-08
WO2004111040A1 (fr) 2004-12-23
CN1802368A (zh) 2006-07-12
ATE495168T1 (de) 2011-01-15
CO5660263A2 (es) 2006-07-31
CN100462363C (zh) 2009-02-18
JP4395512B2 (ja) 2010-01-13
MXPA05013233A (es) 2006-03-09
DE602004031030D1 (de) 2011-02-24
TW200510331A (en) 2005-03-16
CA2527587A1 (fr) 2004-12-23
RU2327697C2 (ru) 2008-06-27
KR100717914B1 (ko) 2007-05-11
IL172080A (en) 2012-03-29
ES2358512T3 (es) 2011-05-11
AR044657A1 (es) 2005-09-21
RU2006100106A (ru) 2007-07-20
HK1093071A1 (zh) 2007-02-23
BRPI0411350A (pt) 2006-07-11
CA2527587C (fr) 2010-09-28
NZ543638A (en) 2008-05-30
TWI336700B (en) 2011-02-01
CL2004001430A1 (es) 2005-05-06
MY140206A (en) 2009-11-30
NO20055758D0 (no) 2005-12-05
JP2006527203A (ja) 2006-11-30
NO20055758L (no) 2005-12-07
AU2004247368A1 (en) 2004-12-23
US20040254179A1 (en) 2004-12-16
EP1670784B1 (fr) 2011-01-12
AU2004247368B2 (en) 2007-11-22
EP1670784A1 (fr) 2006-06-21
US7241760B2 (en) 2007-07-10
ZA200509908B (en) 2006-11-29

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