NO333744B1 - Farmasoytisk formulering omfattende et pyrimidin-A-onderivat belagt med en enterisk polymer og fremgangsmate for fremstilling derav - Google Patents

Farmasoytisk formulering omfattende et pyrimidin-A-onderivat belagt med en enterisk polymer og fremgangsmate for fremstilling derav Download PDF

Info

Publication number: NO333744B1
Authority: NO; Norway
Prior art keywords: pharmaceutical formulation; formulation according; core; active ingredient; enteric polymer
Prior art date: 2003-09-02

Application number

NO20061514A

Other languages

English (en)

Norwegian (no)

Other versions

NO20061514L (no

Inventor

Dirk Marinus Johannes Van Schie

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-02

Filing date

2006-04-03

Publication date

2013-09-09

2006-04-03 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2006-04-03 Publication of NO20061514L publication Critical patent/NO20061514L/no

2013-09-09 Publication of NO333744B1 publication Critical patent/NO333744B1/no

Links

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239000008194 pharmaceutical composition Substances 0.000 title claims description 26
238000000034 method Methods 0.000 title abstract description 12
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
201000001320 Atherosclerosis Diseases 0.000 claims abstract description 7
239000004480 active ingredient Substances 0.000 claims description 31
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239000011248 coating agent Substances 0.000 claims description 21
150000001875 compounds Chemical class 0.000 claims description 16
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
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VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 8
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 8
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 7
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
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DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 2
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DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20061514A 2003-09-02 2006-04-03 Farmasoytisk formulering omfattende et pyrimidin-A-onderivat belagt med en enterisk polymer og fremgangsmate for fremstilling derav NO333744B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0320522.6A GB0320522D0 (en)	2003-09-02	2003-09-02	Formulation
PCT/EP2004/009726 WO2005021002A1 (en)	2003-09-02	2004-08-31	Pharmaceutical formulation comprising a pyrimidine-a-one derivative coated with an enteric polymer

Publications (2)

Publication Number	Publication Date
NO20061514L NO20061514L (no)	2006-04-03
NO333744B1 true NO333744B1 (no)	2013-09-09

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ID=28686767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20061514A NO333744B1 (no)	2003-09-02	2006-04-03	Farmasoytisk formulering omfattende et pyrimidin-A-onderivat belagt med en enterisk polymer og fremgangsmate for fremstilling derav

Country Status (30)

Country	Link
US (2)	US20060287346A1 (da)
EP (1)	EP1663243B1 (da)
JP (1)	JP4892346B2 (da)
KR (1)	KR101115984B1 (da)
CN (2)	CN1874778B (da)
AR (1)	AR045547A1 (da)
AT (1)	ATE422889T1 (da)
AU (1)	AU2004268376B2 (da)
BR (1)	BRPI0414038A (da)
CA (1)	CA2537178C (da)
CY (1)	CY1108953T1 (da)
DE (1)	DE602004019547D1 (da)
DK (1)	DK1663243T3 (da)
ES (1)	ES2319124T3 (da)
GB (1)	GB0320522D0 (da)
HR (1)	HRP20090147T3 (da)
IL (1)	IL173910A (da)
IS (1)	IS2677B (da)
MA (1)	MA28033A1 (da)
MX (1)	MXPA06002436A (da)
MY (1)	MY139165A (da)
NO (1)	NO333744B1 (da)
NZ (1)	NZ545453A (da)
PL (1)	PL1663243T3 (da)
PT (1)	PT1663243E (da)
RU (1)	RU2359660C2 (da)
SI (1)	SI1663243T1 (da)
TW (1)	TWI343257B (da)
WO (1)	WO2005021002A1 (da)
ZA (1)	ZA200601599B (da)

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GB0320522D0 (en) *	2003-09-02	2003-10-01	Glaxo Group Ltd	Formulation
AU2008251467B2 (en)	2007-05-11	2014-07-31	The Trustees Of The University Of Pennsylvania	Methods of treatment of skin ulcers
CN101986785A (zh)	2007-05-11	2011-03-16	托马斯杰弗逊大学	治疗和预防神经退行性疾病和紊乱的方法
JP6222924B2 (ja)	2009-04-24	2017-11-01	イシューティカピーティーワイリミテッド	ジクロフェナクの新規製剤
EP2651403B1 (en)	2010-12-17	2020-12-02	Glaxo Group Limited	Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2013082275A1 (en)	2011-11-30	2013-06-06	Trustees Of Boston College	Inhibitors of phosphodiesterases 11 (pde11) and methods of use to elevate cortisol production
US9526734B2 (en)	2014-06-09	2016-12-27	Iceutica Pty Ltd.	Formulation of meloxicam
CN106536521B (zh)	2014-07-22	2018-08-03	葛兰素史密斯克莱知识产权发展有限公司	化合物

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IT1227899B (it) *	1988-12-23	1991-05-14	Poli Ind Chimica Spa	Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
TW209174B (da)	1991-04-19	1993-07-11	Takeda Pharm Industry Co Ltd
JPH07223970A (ja)	1994-02-10	1995-08-22	Tanabe Seiyaku Co Ltd	消化管内適所放出製剤
JP2917799B2 (ja)	1994-03-11	1999-07-12	田辺製薬株式会社	消化管内適所放出型製剤
SG80553A1 (en)	1995-07-20	2001-05-22	Tanabe Seiyaku Co	Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
JP3185206B2 (ja) *	1995-07-20	2001-07-09	田辺製薬株式会社	消化管下部放出型被覆カプセル製剤
JP2000514406A (ja) *	1996-06-06	2000-10-31	ビフォーダンアクティーゼルスカブ	アルギン酸から成る経口投与製剤用腸溶性被膜
CA2262595C (en)	1996-08-15	2005-10-18	Losan Pharma Gmbh	Easy to swallow oral medicament composition
US6296876B1 (en) *	1997-10-06	2001-10-02	Isa Odidi	Pharmaceutical formulations for acid labile substances
DK2263660T3 (da) *	1998-05-18	2018-01-02	Takeda Pharmaceuticals Co	Oralt desintegrerende tabletter.
HK1040910B (en) *	1998-11-12	2009-06-26	Smithkline Beecham Plc	Pharmaceutical composition for modified release of an insulin sensitiser and metformin
US6268385B1 (en)	1999-08-26	2001-07-31	Robert R. Whittle	Dry blend pharmaceutical formulations
EP1686119B1 (en) *	2000-02-16	2009-07-29	Smithkline Beecham Plc	Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors
AUPQ672800A0 (en) *	2000-04-06	2000-05-04	Natraherbal Pty Ltd	Garlic supplement for deodoriser
ATE273695T1 (de) *	2000-06-28	2004-09-15	Smithkline Beecham Plc	Nassvermahlung
PT1405621E (pt)	2001-06-20	2011-05-31	Takeda Pharmaceutical	Processo de prepara??o de comprimidos
JP5138856B2 (ja) *	2001-06-20	2013-02-06	武田薬品工業株式会社	錠剤の製造方法
RU2203671C1 (ru) *	2002-03-25	2003-05-10	Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан"	Противовирусный лекарственный препарат для перорального применения
GB0320522D0 (en) *	2003-09-02	2003-10-01	Glaxo Group Ltd	Formulation

2003
- 2003-09-02 GB GBGB0320522.6A patent/GB0320522D0/en not_active Ceased
2004
- 2004-08-31 JP JP2006525098A patent/JP4892346B2/ja not_active Expired - Fee Related
- 2004-08-31 WO PCT/EP2004/009726 patent/WO2005021002A1/en not_active Ceased
- 2004-08-31 BR BRPI0414038-9A patent/BRPI0414038A/pt not_active Application Discontinuation
- 2004-08-31 RU RU2006110546/15A patent/RU2359660C2/ru not_active IP Right Cessation
- 2004-08-31 PT PT04764689T patent/PT1663243E/pt unknown
- 2004-08-31 DK DK04764689T patent/DK1663243T3/da active
- 2004-08-31 KR KR1020067004235A patent/KR101115984B1/ko not_active Expired - Fee Related
- 2004-08-31 EP EP04764689A patent/EP1663243B1/en not_active Expired - Lifetime
- 2004-08-31 SI SI200431087T patent/SI1663243T1/sl unknown
- 2004-08-31 AR ARP040103126A patent/AR045547A1/es unknown
- 2004-08-31 CA CA2537178A patent/CA2537178C/en not_active Expired - Fee Related
- 2004-08-31 ES ES04764689T patent/ES2319124T3/es not_active Expired - Lifetime
- 2004-08-31 TW TW093126106A patent/TWI343257B/zh not_active IP Right Cessation
- 2004-08-31 AU AU2004268376A patent/AU2004268376B2/en not_active Ceased
- 2004-08-31 US US10/570,335 patent/US20060287346A1/en not_active Abandoned
- 2004-08-31 CN CN2004800325934A patent/CN1874778B/zh not_active Expired - Fee Related
- 2004-08-31 HR HR20090147T patent/HRP20090147T3/xx unknown
- 2004-08-31 PL PL04764689T patent/PL1663243T3/pl unknown
- 2004-08-31 AT AT04764689T patent/ATE422889T1/de active
- 2004-08-31 MX MXPA06002436A patent/MXPA06002436A/es active IP Right Grant
- 2004-08-31 NZ NZ545453A patent/NZ545453A/en not_active IP Right Cessation
- 2004-08-31 DE DE602004019547T patent/DE602004019547D1/de not_active Expired - Lifetime
- 2004-08-31 CN CN201110102640XA patent/CN102204891B/zh not_active Expired - Fee Related
- 2004-09-01 MY MYPI20043561A patent/MY139165A/en unknown
2006
- 2006-02-23 ZA ZA200601599A patent/ZA200601599B/xx unknown
- 2006-02-23 IL IL173910A patent/IL173910A/en not_active IP Right Cessation
- 2006-03-10 MA MA28866A patent/MA28033A1/fr unknown
- 2006-03-20 IS IS8366A patent/IS2677B/is unknown
- 2006-04-03 NO NO20061514A patent/NO333744B1/no not_active IP Right Cessation
2009
- 2009-04-08 CY CY20091100412T patent/CY1108953T1/el unknown
- 2009-06-05 US US12/478,934 patent/US8772303B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA06002436A (es)	2006-06-20
JP4892346B2 (ja)	2012-03-07
CA2537178C (en)	2013-03-19
ATE422889T1 (de)	2009-03-15
KR101115984B1 (ko)	2012-03-13
WO2005021002A1 (en)	2005-03-10
MA28033A1 (fr)	2006-07-03
JP2007504195A (ja)	2007-03-01
US20060287346A1 (en)	2006-12-21
CN1874778B (zh)	2011-06-22
CY1108953T1 (el)	2014-07-02
DE602004019547D1 (de)	2009-04-02
SI1663243T1 (sl)	2009-06-30
AU2004268376B2 (en)	2010-04-22
US8772303B2 (en)	2014-07-08
EP1663243B1 (en)	2009-02-18
NO20061514L (no)	2006-04-03
EP1663243A1 (en)	2006-06-07
RU2359660C2 (ru)	2009-06-27
ZA200601599B (en)	2007-05-30
HK1091734A1 (en)	2007-01-26
DK1663243T3 (da)	2009-05-04
AU2004268376A1 (en)	2005-03-10
AR045547A1 (es)	2005-11-02
CN102204891A (zh)	2011-10-05
TW200517113A (en)	2005-06-01
PT1663243E (pt)	2009-04-27
CN102204891B (zh)	2013-08-21
PL1663243T3 (pl)	2009-07-31
IL173910A0 (en)	2006-07-05
NZ545453A (en)	2009-12-24
RU2006110546A (ru)	2006-08-10
ES2319124T3 (es)	2009-05-04
HRP20090147T3 (hr)	2009-04-30
KR20060118422A (ko)	2006-11-23
US20090306113A1 (en)	2009-12-10
IS8366A (is)	2006-03-20
CN1874778A (zh)	2006-12-06
BRPI0414038A (pt)	2006-10-24
CA2537178A1 (en)	2005-03-10
IL173910A (en)	2010-11-30
MY139165A (en)	2009-08-28
GB0320522D0 (en)	2003-10-01
IS2677B (is)	2010-09-15
TWI343257B (en)	2011-06-11

Legal Events

Date	Code	Title	Description
2013-05-21	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: GLAXO GROUP LTD, GB
2019-03-25	MM1K	Lapsed by not paying the annual fees

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US8772303B2 (en)	2014-07-08	Pharmaceutical formulation
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AU2014225449B2 (en)	2018-08-16	Stabilization of moisture-sensitive drugs
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RU2593771C2 (ru)	2016-08-10	Энтеросолюбильная таблетка
WO2016012898A1 (en)	2016-01-28	Oral pharmaceutical composition of lurasidone
US20220175766A1 (en)	2022-06-09	Compositions and methods of treatment
JP5669837B2 (ja)	2015-02-18	放出制御型の有核錠剤
RU2361582C2 (ru)	2009-07-20	Таблетка, содержащая флувастатин и кармеллозу кальция
JP3944494B2 (ja)	2007-07-11	フルバスタチン含有錠剤
HK1091734B (en)	2009-09-25	Pharmaceutical formulation comprising a pyrimidine-a-one derivative coated with an enteric polymer
WO2024261701A1 (en)	2024-12-26	Edoxaban formulation.
JP2007077174A (ja)	2007-03-29	フルバスタチン含有錠剤
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