NO333788B1 - 6-[2-(fosfonometoksy)alkoksy]pyrimidin forbindelser med antiviral aktivitet, anvendelse derav for fremstilling av et medikament, preparat omfattende forbindelsene og fremgangsmate for fremstilling av forbindelsene. - Google Patents

6-[2-(fosfonometoksy)alkoksy]pyrimidin forbindelser med antiviral aktivitet, anvendelse derav for fremstilling av et medikament, preparat omfattende forbindelsene og fremgangsmate for fremstilling av forbindelsene. Download PDF

Info

Publication number: NO333788B1
Authority: NO; Norway
Prior art keywords: hydroxymethyl; compound; amino; methyl; hydroxy
Prior art date: 2001-06-29

Application number

NO20035797A

Other languages

English (en)

Norwegian (no)

Other versions

NO20035797L (no

Inventor

Antonin Holy

Jan Balzarini

Erik De Clercq

Original Assignee

Acad Of Science Czech Republic

Rega Stichting

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-29

Filing date

2003-12-23

Publication date

2013-09-16

2003-12-23 Application filed by Acad Of Science Czech Republic, Rega Stichting filed Critical Acad Of Science Czech Republic

2004-02-24 Publication of NO20035797L publication Critical patent/NO20035797L/no

2013-09-16 Publication of NO333788B1 publication Critical patent/NO333788B1/no

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150000001875 compounds Chemical class 0.000 title claims abstract description 184
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VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
YFNGWGVTFYSJHE-UHFFFAOYSA-K trisodium;phosphonoformate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O YFNGWGVTFYSJHE-UHFFFAOYSA-K 0.000 description 1
HDZZVAMISRMYHH-LITAXDCLSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O HDZZVAMISRMYHH-LITAXDCLSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20035797A 2001-06-29 2003-12-23 6-[2-(fosfonometoksy)alkoksy]pyrimidin forbindelser med antiviral aktivitet, anvendelse derav for fremstilling av et medikament, preparat omfattende forbindelsene og fremgangsmate for fremstilling av forbindelsene. NO333788B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30221201P	2001-06-29	2001-06-29
PCT/CZ2002/000038 WO2003002580A1 (fr)	2001-06-29	2002-06-28	Nouveaux composes et methodes therapeutiques

Publications (2)

Publication Number	Publication Date
NO20035797L NO20035797L (no)	2004-02-24
NO333788B1 true NO333788B1 (no)	2013-09-16

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ID=23166777

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Application Number	Title	Priority Date	Filing Date
NO20035797A NO333788B1 (no)	2001-06-29	2003-12-23	6-[2-(fosfonometoksy)alkoksy]pyrimidin forbindelser med antiviral aktivitet, anvendelse derav for fremstilling av et medikament, preparat omfattende forbindelsene og fremgangsmate for fremstilling av forbindelsene.
NO20131091A NO335725B1 (no)	2001-06-29	2013-08-09	Anvendelse av 6-[2-(fosfonometoksy)alkoksy]pyrimidinderivater til fremstilling av et forløperlegemiddel med antiviral aktivitet, og et preparat derav.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20131091A NO335725B1 (no)	2001-06-29	2013-08-09	Anvendelse av 6-[2-(fosfonometoksy)alkoksy]pyrimidinderivater til fremstilling av et forløperlegemiddel med antiviral aktivitet, og et preparat derav.

Country Status (21)

Country	Link
US (2)	US6818633B2 (fr)
EP (1)	EP1406911B1 (fr)
JP (1)	JP4545434B2 (fr)
KR (1)	KR100891366B1 (fr)
CN (1)	CN1329404C (fr)
AP (1)	AP1622A (fr)
AU (1)	AU2002315625B2 (fr)
BR (1)	BRPI0210746B8 (fr)
CA (1)	CA2452036C (fr)
CZ (1)	CZ297267B6 (fr)
EA (1)	EA006020B1 (fr)
ES (1)	ES2564144T3 (fr)
HU (1)	HU230519B1 (fr)
IL (2)	IL159494A0 (fr)
MX (1)	MXPA04000138A (fr)
NO (2)	NO333788B1 (fr)
NZ (1)	NZ530685A (fr)
PL (1)	PL207187B1 (fr)
TR (1)	TR200302288T2 (fr)
WO (1)	WO2003002580A1 (fr)
ZA (1)	ZA200400236B (fr)

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NZ543864A (en) *	2003-06-16	2009-10-30	Leuven K U Res & Dev	Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060211650A1 (en) *	2004-12-16	2006-09-21	Forest Laboratories, Inc.	Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
ES2401285T3 (es)	2004-12-16	2013-04-18	The Regents Of The University Of California	Fármacos con el pulmón como diana
EP1906971A2 (fr) *	2005-07-27	2008-04-09	Gilead Sciences, Inc.	Composes antiviraux
US7473683B2 (en)	2005-09-14	2009-01-06	The Board Of Trustees Of The Leland Stanford Junior University	Nonpolar thymidine analogs
US20080318986A1 (en) *	2005-10-13	2008-12-25	Schiffman Rhett M	Ddc Compositions
FR2908133B1 (fr) *	2006-11-08	2012-12-14	Centre Nat Rech Scient	Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
NZ615939A (en) *	2011-05-10	2015-04-24	Aratana Therapeutics Nv	Compounds for use in the treatment of feline retroviral infections
SG10201800188SA (en)	2013-03-15	2018-02-27	Univ California	Acyclic nucleoside phosphonate diesters
CN104119385B (zh) *	2014-07-24	2017-04-05	廖国超	核苷类似物的磷酸酯前药及其应用
CN111808136B (zh)	2014-09-15	2024-06-11	加利福尼亚大学董事会	核苷酸类似物
EP3350191B9 (fr)	2015-09-15	2021-12-22	The Regents of the University of California	Analogues nucléotidiques
CA3097255A1 (fr)	2018-04-23	2019-10-31	Centre National De La Recherche Scientifique	Nouveaux analogues d'acyclonucleosides antiviraux
KR20250052378A (ko)	2022-07-21	2025-04-18	안티바 바이오사이언시즈, 인크.	Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
CN117430644B (zh) *	2023-10-24	2025-08-01	合肥工业大学	一种钴配合物的制备及用途

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CS263952B1 (en)	1985-04-25	1989-05-12	Holy Antonin	Remedy with antiviral effect
CS263951B1 (en)	1985-04-25	1989-05-12	Antonin Holy	9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en)	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
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2002
- 2002-06-28 EP EP02740215.5A patent/EP1406911B1/fr not_active Expired - Lifetime
- 2002-06-28 EA EA200400117A patent/EA006020B1/ru unknown
- 2002-06-28 BR BRPI0210746 patent/BRPI0210746B8/pt not_active IP Right Cessation
- 2002-06-28 NZ NZ530685A patent/NZ530685A/en not_active IP Right Cessation
- 2002-06-28 US US10/187,166 patent/US6818633B2/en not_active Expired - Lifetime
- 2002-06-28 CZ CZ20040142A patent/CZ297267B6/cs not_active IP Right Cessation
- 2002-06-28 CA CA002452036A patent/CA2452036C/fr not_active Expired - Lifetime
- 2002-06-28 TR TR2003/02288T patent/TR200302288T2/xx unknown
- 2002-06-28 JP JP2003508961A patent/JP4545434B2/ja not_active Expired - Lifetime
- 2002-06-28 KR KR1020037017181A patent/KR100891366B1/ko not_active Expired - Lifetime
- 2002-06-28 WO PCT/CZ2002/000038 patent/WO2003002580A1/fr not_active Ceased
- 2002-06-28 ES ES02740215.5T patent/ES2564144T3/es not_active Expired - Lifetime
- 2002-06-28 PL PL366852A patent/PL207187B1/pl unknown
- 2002-06-28 MX MXPA04000138A patent/MXPA04000138A/es active IP Right Grant
- 2002-06-28 HU HU0400345A patent/HU230519B1/hu unknown
- 2002-06-28 IL IL15949402A patent/IL159494A0/xx active IP Right Grant
- 2002-06-28 AP APAP/P/2004/002953A patent/AP1622A/en active
- 2002-06-28 CN CNB028145712A patent/CN1329404C/zh not_active Expired - Lifetime
- 2002-06-28 AU AU2002315625A patent/AU2002315625B2/en not_active Expired
2003
- 2003-12-22 IL IL159494A patent/IL159494A/en unknown
- 2003-12-23 NO NO20035797A patent/NO333788B1/no not_active IP Right Cessation
2004
- 2004-01-13 ZA ZA200400236A patent/ZA200400236B/en unknown
- 2004-09-21 US US10/946,421 patent/US20050038058A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
CZ297267B6 (cs)	2006-10-11
ES2564144T3 (es)	2016-03-18
CA2452036C (fr)	2009-09-29
HU230519B1 (hu)	2016-10-28
BRPI0210746B1 (pt)	2018-09-18
ZA200400236B (en)	2004-08-18
AU2002315625B2 (en)	2008-05-01
KR20040027521A (ko)	2004-04-01
AP1622A (en)	2006-06-16
NO335725B1 (no)	2015-02-02
IL159494A0 (en)	2004-06-01
JP2005511490A (ja)	2005-04-28
EA006020B1 (ru)	2005-08-25
TR200302288T2 (tr)	2004-12-21
CZ2004142A3 (cs)	2004-05-12
CA2452036A1 (fr)	2003-01-09
BR0210746A (pt)	2004-07-20
PL207187B1 (pl)	2010-11-30
HUP0400345A3 (en)	2007-05-29
US6818633B2 (en)	2004-11-16
US20050038058A1 (en)	2005-02-17
NO20035797L (no)	2004-02-24
IL159494A (en)	2008-06-05
US20030109499A1 (en)	2003-06-12
MXPA04000138A (es)	2005-06-06
BRPI0210746B8 (pt)	2021-05-25
NO20131091L (no)	2004-02-24
CN1533397A (zh)	2004-09-29
NZ530685A (en)	2006-09-29
EA200400117A1 (ru)	2004-08-26
AP2004002953A0 (en)	2004-03-31
HUP0400345A2 (hu)	2004-09-28
EP1406911A1 (fr)	2004-04-14
JP4545434B2 (ja)	2010-09-15
EP1406911B1 (fr)	2016-01-06
BRPI0210746A8 (pt)	2018-07-10
KR100891366B1 (ko)	2009-04-02
WO2003002580A8 (fr)	2003-01-30
PL366852A1 (en)	2005-02-07
CN1329404C (zh)	2007-08-01
WO2003002580A1 (fr)	2003-01-09

Legal Events

Date	Code	Title	Description
2022-07-11	MK1K	Patent expired

Publication	Publication Date	Title
NO20131091L (no)	2004-02-24	6-[2-(fosfonometoksy)alkoksy]pyrimidinderivater med antiviral aktivitet
CA2479846C (fr)	2007-07-24	Derives de phosphonomethoxymethylpurine/pyrimidine
JP2012153731A (ja)	2012-08-16	抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物
AU2002315625A1 (en)	2003-05-29	6-2'-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
Valiaeva et al.	2006	Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro
JP2006527702A5 (fr)	2007-09-06
HK1063430B (en)	2017-10-13	6-[2-(phosphonomethoxy)alkoxy]pyrimidine derivatives having antiviral activity
CA2015671C (fr)	2000-04-25	Derives de phosphonomethoxytetrahydrofuranyl-purine/pyrimidine
HK1088013B (en)	2011-08-12	Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs