NO763776L - - Google Patents

Info

Publication number: NO763776L
Authority: NO; Norway
Prior art keywords: floatate; coagulation; further purification; aqueous; factor
Prior art date: 1975-11-07

Application number

NO763776A

Other languages

English (en)

Norwegian (no)

Inventor

H Schwinn

N Heimburger

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-11-07

Filing date

1976-11-05

Publication date

1977-05-10

1976-11-05 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1977-05-10 Publication of NO763776L publication Critical patent/NO763776L/no

Links

108010054218 Factor VIII Proteins 0.000 claims description 32
102000001690 Factor VIII Human genes 0.000 claims description 32
229960000301 factor viii Drugs 0.000 claims description 32
230000000694 effects Effects 0.000 claims description 27
238000000034 method Methods 0.000 claims description 27
239000000243 solution Substances 0.000 claims description 27
210000002381 plasma Anatomy 0.000 claims description 22
230000000603 anti-haemophilic effect Effects 0.000 claims description 21
239000003795 chemical substances by application Substances 0.000 claims description 19
238000000746 purification Methods 0.000 claims description 17
210000002826 placenta Anatomy 0.000 claims description 15
102000004169 proteins and genes Human genes 0.000 claims description 13
108090000623 proteins and genes Proteins 0.000 claims description 13
239000012266 salt solution Substances 0.000 claims description 13
230000015271 coagulation Effects 0.000 claims description 11
238000005345 coagulation Methods 0.000 claims description 11
150000001875 compounds Chemical class 0.000 claims description 10
238000002560 therapeutic procedure Methods 0.000 claims description 9
238000005188 flotation Methods 0.000 claims description 8
238000006467 substitution reaction Methods 0.000 claims description 8
230000002950 deficient Effects 0.000 claims description 7
239000000284 extract Substances 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
238000004587 chromatography analysis Methods 0.000 claims description 6
239000002808 molecular sieve Substances 0.000 claims description 6
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 6
239000012736 aqueous medium Substances 0.000 claims description 5
239000000084 colloidal system Substances 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
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230000002378 acidificating effect Effects 0.000 claims description 4
239000008346 aqueous phase Substances 0.000 claims description 4
238000001990 intravenous administration Methods 0.000 claims description 4
239000002904 solvent Substances 0.000 claims description 4
102000015081 Blood Coagulation Factors Human genes 0.000 claims description 3
108010039209 Blood Coagulation Factors Proteins 0.000 claims description 3
239000003114 blood coagulation factor Substances 0.000 claims description 3
229940079593 drug Drugs 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
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239000006228 supernatant Substances 0.000 claims description 3
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239000000969 carrier Substances 0.000 claims description 2
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239000002609 medium Substances 0.000 claims description 2
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238000002360 preparation method Methods 0.000 description 23
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 14
235000002639 sodium chloride Nutrition 0.000 description 13
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
239000000203 mixture Substances 0.000 description 12
238000007792 addition Methods 0.000 description 10
229960004222 factor ix Drugs 0.000 description 10
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108010088751 Albumins Proteins 0.000 description 6
102100022641 Coagulation factor IX Human genes 0.000 description 6
108010094028 Prothrombin Proteins 0.000 description 6
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229920000669 heparin Polymers 0.000 description 6
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 6
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102100026735 Coagulation factor VIII Human genes 0.000 description 3
101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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108010000499 Thromboplastin Proteins 0.000 description 3
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150000003904 phospholipids Chemical class 0.000 description 3
230000003248 secreting effect Effects 0.000 description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
239000004215 Carbon black (E152) Substances 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
102100023804 Coagulation factor VII Human genes 0.000 description 2
206010010356 Congenital anomaly Diseases 0.000 description 2
108010023321 Factor VII Proteins 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
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RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
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DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
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TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
239000002585 base Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
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239000013049 sediment Substances 0.000 description 2
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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239000013543 active substance Substances 0.000 description 1
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239000012670 alkaline solution Substances 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
239000000729 antidote Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
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210000004369 blood Anatomy 0.000 description 1
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230000005966 endogenous activation Effects 0.000 description 1
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238000002523 gelfiltration Methods 0.000 description 1
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239000000825 pharmaceutical preparation Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
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NO763776A 1975-11-07 1976-11-05 NO763776L (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2550011A DE2550011C2 (de)	1975-11-07	1975-11-07	Verfahren zur Herstellung eines antihämophilen Mittels

Publications (1)

Publication Number	Publication Date
NO763776L true NO763776L (da)	1977-05-10

Family

ID=5961172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO763776A NO763776L (da)	1975-11-07	1976-11-05

Country Status (20)

Country	Link
US (1)	US4067964A (da)
JP (1)	JPS6029362B2 (da)
AT (1)	AT358737B (da)
AU (1)	AU500621B2 (da)
BE (1)	BE848111A (da)
CA (1)	CA1077393A (da)
CH (1)	CH630805A5 (da)
DE (1)	DE2550011C2 (da)
DK (1)	DK502176A (da)
ES (1)	ES452923A1 (da)
FI (1)	FI763165A7 (da)
FR (1)	FR2330408A1 (da)
GB (1)	GB1563009A (da)
IL (1)	IL50847A (da)
IT (1)	IT1063617B (da)
LU (1)	LU76145A1 (da)
NL (1)	NL7612139A (da)
NO (1)	NO763776L (da)
SE (1)	SE7612396L (da)
ZA (1)	ZA766647B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3165600D1 (en) *	1980-01-28	1984-09-27	Baxter Travenol Lab	Prothrombin-containing therapeutic compositions and methods of producing enzymatically active blood clotting factors from prothrombin-containing blood fractions
US4459288A (en) *	1981-05-11	1984-07-10	Baxter Travenol Laboratories, Inc.	Therapeutic blood clotting factor compositions and their use
DE3625090A1 (de) *	1986-07-24	1988-01-28	Behringwerke Ag	Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung
CA1339946C (en) *	1987-03-31	1998-07-07	Michael J. Griffith	Ultrapurification process for polypeptides
JP2931319B2 (ja) *	1989-03-29	1999-08-09	吉富製薬株式会社	血液凝固第▲ｖｉｉｉ▼因子の製造法
JP3180824B2 (ja) *	1991-08-30	2001-06-25	シスメックス株式会社	血液凝固試薬
CA2437015A1 (en) *	2001-02-05	2002-08-15	Novo Nordisk Health Care Ag	Combined use of factor vii polypeptides and factor ix polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862002A (en) *	1962-05-08	1975-01-21	Sanfar Lab Inc	Production of physiologically active placental substances
BE713764A (da) *	1967-05-01	1968-09-16	Baxter Travenol Lab
BE787961A (fr) *	1971-08-24	1973-02-26	Behringwerke Ag	Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere
DE2262520C3 (de) *	1972-12-20	1987-02-12	Miles Laboratories, Inc., Elkhart, Ind.	Verfahren zur Herstellung eines lyophilisierten, lagerfähigen Konzentrats aus menschlichem Plasma

1975
- 1975-11-07 DE DE2550011A patent/DE2550011C2/de not_active Expired
1976
- 1976-11-02 NL NL7612139A patent/NL7612139A/xx not_active Application Discontinuation
- 1976-11-02 ES ES452923A patent/ES452923A1/es not_active Expired
- 1976-11-04 AT AT819476A patent/AT358737B/de not_active IP Right Cessation
- 1976-11-04 IL IL50847A patent/IL50847A/xx unknown
- 1976-11-04 CH CH1392076A patent/CH630805A5/de not_active IP Right Cessation
- 1976-11-04 FI FI763165A patent/FI763165A7/fi not_active Application Discontinuation
- 1976-11-05 LU LU76145A patent/LU76145A1/xx unknown
- 1976-11-05 NO NO763776A patent/NO763776L/no unknown
- 1976-11-05 US US05/739,278 patent/US4067964A/en not_active Expired - Lifetime
- 1976-11-05 AU AU19341/76A patent/AU500621B2/en not_active Expired
- 1976-11-05 ZA ZA766647A patent/ZA766647B/xx unknown
- 1976-11-05 CA CA265,060A patent/CA1077393A/en not_active Expired
- 1976-11-05 SE SE7612396A patent/SE7612396L/xx unknown
- 1976-11-05 DK DK502176A patent/DK502176A/da unknown
- 1976-11-05 IT IT29084/76A patent/IT1063617B/it active
- 1976-11-06 JP JP51132782A patent/JPS6029362B2/ja not_active Expired
- 1976-11-08 GB GB46384/76A patent/GB1563009A/en not_active Expired
- 1976-11-08 FR FR7633603A patent/FR2330408A1/fr active Granted
- 1976-11-08 BE BE172170A patent/BE848111A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NL7612139A (nl)	1977-05-10
GB1563009A (en)	1980-03-19
FR2330408B1 (da)	1980-03-14
SE7612396L (sv)	1977-05-08
CH630805A5 (de)	1982-07-15
AU500621B2 (en)	1979-05-24
CA1077393A (en)	1980-05-13
AT358737B (de)	1980-09-25
AU1934176A (en)	1978-05-11
ES452923A1 (es)	1977-11-16
DK502176A (da)	1977-05-08
FR2330408A1 (fr)	1977-06-03
DE2550011C2 (de)	1982-11-25
LU76145A1 (da)	1977-06-03
DE2550011A1 (de)	1977-05-12
ZA766647B (en)	1977-10-26
IT1063617B (it)	1985-02-11
FI763165A7 (da)	1977-05-08
JPS5257310A (en)	1977-05-11
ATA819476A (de)	1980-02-15
BE848111A (fr)	1977-05-09
JPS6029362B2 (ja)	1985-07-10
US4067964A (en)	1978-01-10
IL50847A (en)	1980-01-31
IL50847A0 (en)	1977-01-31

Publication	Publication Date	Title
Hovig	1963	Aggregation of rabbit blood platelets produced in vitro by saline “extract” of tendons
Margolis	1957	Initiation of blood coagulation by glass and related surfaces
US3682881A (en)	1972-08-08	Fractionation of plasma using glycine and polyethylene glycol
Alkjaersig et al.	1955	Purification and quantitative determination of platelet factor 3
DK151932B (da)	1988-01-18	Fremgangsmaade til fremstilling af et blodstoerkningsfremmende praeparat af menneskeligt blodplasma
Zucker et al.	1974	Aggregation and release reaction induced in human blood platelets by zymosan
DK155568B (da)	1989-04-24	Fremgangsmaade til stabilisering af koagulationsfaktorerne ii, viii, xiii og antithrombin iii samt plasminogen, og saaledes at disse er fibrinogen-fri og fri for risiko for en hepatitis-overfoering
NO142381B (no)	1980-05-05	Fremgangsmaate for fremstilling av den antihemofile faktor
Rapaport et al.	1967	The blood clotting properties of rabbit peritoneal leukocytes in vitro
US4870166A (en)	1989-09-26	Process for preparing high-purity dematan sulphate, and pharmaceutical compositions which contain it
NO138145B (no)	1978-04-03	Fremgangsmaate for fremstilling av et enzympreparat
JPS6160614A (ja)	1986-03-28	第８因子製剤およびその製造方法
JPH0348888B2 (da)	1991-07-25
JPH03503534A (ja)	1991-08-08	トロンボプラスチン試薬を製造するための改良された抽出方法
CA1293941C (en)	1992-01-07	Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
EP0303236B1 (en)	1992-11-11	Lignosulfonate based pharmacologic agent with anti-thrombotic activity
US4067964A (en)	1978-01-10	Antihemophilic agent and process for its manufacture
van Iwaarden et al.	1995	A novel procedure for the rapid isolation of surfactant protein A with retention of its alveolar-macrophage-stimulating properties
Bloom et al.	1972	Factor VIII (antihaemophilic factor) in tissues detected by antibody neutralization
Munro	1946	Properties of an anticoagulant found in the blood of a hemophiliac
Seegers et al.	1954	Activation of purified prothrombin with platelets combined with various crude biochemical preparations
Casillas et al.	1969	Chromatographic behaviour of clotting factors
FI87044B (fi)	1992-08-14	Foerfarande foer framstaellning av ett medel med vilket man kan behandla hemofili a, som aer resistent mot faktor viii.
Glazko et al.	1938	The mechanism of the action of saliva in blood coagulation
Fujimoto	1918	Studies on the antitrypsin of serum