NO792113L - Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse - Google Patents

Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse

Info

Publication number: NO792113L
Authority: NO; Norway
Prior art keywords: group; compound; formula; hydrogen; same meaning
Prior art date: 1978-06-30

Application number

NO792113A

Other languages

English (en)

Norwegian (no)

Inventor

Gustav Benny Roger Samuelsson

Axel Karl Gunnar Aaberg

Eugene William Byrnes

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-06-30

Filing date

1979-06-22

Publication date

1980-01-03

1979-06-22 Application filed by Haessle Ab filed Critical Haessle Ab

1980-01-03 Publication of NO792113L publication Critical patent/NO792113L/no

Links

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238000000034 method Methods 0.000 title claims description 34
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102000012740 beta Adrenergic Receptors Human genes 0.000 title claims description 4
108010079452 beta Adrenergic Receptors Proteins 0.000 title claims description 4
230000000903 blocking effect Effects 0.000 title description 7
150000003839 salts Chemical class 0.000 claims description 52
125000000217 alkyl group Chemical group 0.000 claims description 42
239000001257 hydrogen Substances 0.000 claims description 35
229910052739 hydrogen Inorganic materials 0.000 claims description 35
239000000203 mixture Substances 0.000 claims description 33
-1 phenoxy-hydroxypropylamine compound Chemical class 0.000 claims description 33
239000000825 pharmaceutical preparation Substances 0.000 claims description 29
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239000002253 acid Substances 0.000 claims description 24
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 22
239000004480 active ingredient Substances 0.000 claims description 20
239000002585 base Substances 0.000 claims description 19
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
238000002360 preparation method Methods 0.000 claims description 15
125000004432 carbon atom Chemical group C* 0.000 claims description 13
150000002431 hydrogen Chemical class 0.000 claims description 12
229910052736 halogen Inorganic materials 0.000 claims description 11
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 11
125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
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150000001412 amines Chemical class 0.000 claims description 10
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
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CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
210000001715 carotid artery Anatomy 0.000 description 1
238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
231100000153 central nervous system (CNS) toxicity Toxicity 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
UZEDIBTVIIJELN-UHFFFAOYSA-N chromium(2+) Chemical class [Cr+2] UZEDIBTVIIJELN-UHFFFAOYSA-N 0.000 description 1
XBWRJSSJWDOUSJ-UHFFFAOYSA-L chromium(ii) chloride Chemical compound Cl[Cr]Cl XBWRJSSJWDOUSJ-UHFFFAOYSA-L 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
239000012459 cleaning agent Substances 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
230000002920 convulsive effect Effects 0.000 description 1
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239000013078 crystal Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
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238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000013401 experimental design Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
238000001640 fractional crystallisation Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
125000004997 halocarbonyl group Chemical group 0.000 description 1
239000004312 hexamethylene tetramine Substances 0.000 description 1
235000010299 hexamethylene tetramine Nutrition 0.000 description 1
150000004678 hydrides Chemical class 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
229940071870 hydroiodic acid Drugs 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
150000002440 hydroxy compounds Chemical class 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
239000012442 inert solvent Substances 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
239000011630 iodine Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
208000028756 lack of coordination Diseases 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
229910000103 lithium hydride Inorganic materials 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
210000003141 lower extremity Anatomy 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960002510 mandelic acid Drugs 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229910001092 metal group alloy Inorganic materials 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000002464 muscle smooth vascular Anatomy 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
UGENBJKPPGFFAT-UHFFFAOYSA-N pamatolol Chemical compound COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1 UGENBJKPPGFFAT-UHFFFAOYSA-N 0.000 description 1
229950007530 pamatolol Drugs 0.000 description 1
WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
230000036513 peripheral conductance Effects 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
CPKXFZDVSRECFF-UHFFFAOYSA-M potassium;4-(3-hydroxypropyl)phenolate Chemical compound [K+].OCCCC1=CC=C([O-])C=C1 CPKXFZDVSRECFF-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
230000011514 reflex Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000007017 scission Effects 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000020374 simple syrup Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
NESLWCLHZZISNB-UHFFFAOYSA-M sodium phenolate Chemical compound [Na+].[O-]C1=CC=CC=C1 NESLWCLHZZISNB-UHFFFAOYSA-M 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002889 sympathetic effect Effects 0.000 description 1
230000006794 tachycardia Effects 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
235000010215 titanium dioxide Nutrition 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
239000002966 varnish Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

NO792113A 1978-06-30 1979-06-22 Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse NO792113L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE7807408A SE7807408L (sv)	1978-06-30	1978-06-30	Hjertaktiva foreningar

Publications (1)

Publication Number	Publication Date
NO792113L true NO792113L (no)	1980-01-03

Family

ID=20335352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO792113A NO792113L (no)	1978-06-30	1979-06-22	Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse

Country Status (11)

Country	Link
EP (1)	EP0007294A3 (de)
JP (1)	JPS559084A (de)
AU (1)	AU4831779A (de)
DD (1)	DD144665A5 (de)
DK (1)	DK275179A (de)
FI (1)	FI792059A7 (de)
NO (1)	NO792113L (de)
NZ (1)	NZ190810A (de)
SE (1)	SE7807408L (de)
SU (3)	SU843733A3 (de)
ZA (1)	ZA792939B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55124742A (en) *	1979-03-20	1980-09-26	Kyowa Hakko Kogyo Co Ltd	Novel aminoalcohol derivative
JPS5746946A (en) *	1980-07-09	1982-03-17	Sandoz Ag	3-aminopropoxyphenyl derivative, manufacture and medicine containing same
DE3125870C2 (de) *	1980-07-09	1994-09-15	William John Louis	3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
US4410548A (en) *	1980-07-09	1983-10-18	Reckitt & Colman Products Limited	Propanolamine derivatives
FR2497194B1 (fr) *	1980-08-07	1985-06-14	Sandoz Sa	Nouveaux composes phenoliques
GB8519154D0 (en) *	1985-07-30	1985-09-04	Ici Plc	Aromatic ethers
DE3544172A1 (de) *	1985-12-13	1987-06-19	Lentia Gmbh	Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung
JPS6341451A (ja) *	1986-08-06	1988-02-22	Nippon Kayaku Co Ltd	エ−テル誘導体およびそれを有効成分とする殺ダニ、殺虫組成物
DE3706585A1 (de) *	1987-02-25	1988-09-08	Schering Ag	Aryl- und aryloxy-substituierte tert.-alkylenamine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
GB8925032D0 (en) *	1989-11-06	1989-12-28	Ici Plc	Chemical compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD80923A (de) *
US3412154A (en) *	1964-08-12	1968-11-19	Parke Davis & Co	Amino-substituted phenone compounds
FR2119843B1 (de) *	1970-12-28	1974-03-22	Laroche Navarro Labo
FR2119844B1 (de) *	1970-12-28	1974-03-22	Laroche Navarro Labo
ZA754241B (en) *	1974-11-01	1976-06-30	Haessle Ab	New amines

1978
- 1978-06-30 SE SE7807408A patent/SE7807408L/xx unknown
1979
- 1979-06-13 ZA ZA792939A patent/ZA792939B/xx unknown
- 1979-06-22 AU AU48317/79A patent/AU4831779A/en not_active Abandoned
- 1979-06-22 NO NO792113A patent/NO792113L/no unknown
- 1979-06-25 NZ NZ190810A patent/NZ190810A/xx unknown
- 1979-06-26 EP EP79850061A patent/EP0007294A3/de not_active Withdrawn
- 1979-06-28 DD DD79213965A patent/DD144665A5/de unknown
- 1979-06-29 FI FI792059A patent/FI792059A7/fi not_active Application Discontinuation
- 1979-06-29 SU SU792784303A patent/SU843733A3/ru active
- 1979-06-29 DK DK275179A patent/DK275179A/da unknown
- 1979-06-30 JP JP8206379A patent/JPS559084A/ja active Pending
1980
- 1980-05-15 SU SU802921247A patent/SU873872A3/ru active
- 1980-05-15 SU SU802921298A patent/SU860692A1/ru active

Also Published As

Publication number	Publication date
SU843733A3 (ru)	1981-06-30
FI792059A7 (fi)	1981-01-01
NZ190810A (en)	1981-10-19
JPS559084A (en)	1980-01-22
EP0007294A3 (de)	1980-03-19
SU860692A1 (ru)	1981-08-30
AU4831779A (en)	1980-01-03
SU873872A3 (ru)	1981-10-15
SE7807408L (sv)	1979-12-31
EP0007294A2 (de)	1980-01-23
DD144665A5 (de)	1980-10-29
DK275179A (da)	1979-12-31
ZA792939B (en)	1980-06-25

Publication	Publication Date	Title
US4460580A (en)	1984-07-17	N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency
US4234595A (en)	1980-11-18	3-Indolyl-tertiary butylaminopropanols
EP0284621B1 (de)	1995-01-18	Psychostimulierendes mittel
GB2096988A (en)	1982-10-27	Aromatic hydroxyamines
IL31246A (en)	1972-09-28	Phenylethananolamine compounds, their preparations and veterinary medicinal products containing them
FI63745B (fi)	1983-04-29	Foerfarande foer framstaellning av nya terapeutiskt vaerdefulla aminer
CA1052387A (en)	1979-04-10	Heart active compounds
US3996382A (en)	1976-12-07	Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
NO792113L (no)	1980-01-03	Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse
US4132709A (en)	1979-01-02	[2]Benzopyrano[4,3-c]pyridine derivatives and process therefor
US3949088A (en)	1976-04-06	Substituted phenoxy propanol amines used for treating cardiovascular diseases
JPS6033424B2 (ja)	1985-08-02	フェニルエチルアミンの誘導体、その製造方法およびフェニルエチルアミンの誘導体を有効成分とする高血圧および心臓血管病の治療薬
JPS6379876A (ja)	1988-04-09	新規なナフチル誘導体、その製造法およびそれらの化合物を含有する医薬組成物
US4198424A (en)	1980-04-15	Substituted 1-phenyl-2-pyrrolidin-2-yl-ethanols, their synthesis, their use and their compositions
JPS61501854A (ja)	1986-08-28	新規なド−パミン・アゴニスト
IE41652B1 (en)	1980-02-27	Amines
US4263325A (en)	1981-04-21	β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
JPS5859947A (ja)	1983-04-09	３−フエノキシプロパン−２−オ−ル誘導体
CA1134822A (en)	1982-11-02	Hexahydro-1,4-oxazepines, their preparation, and drugs containing these compounds
CA1065894A (en)	1979-11-06	Phenoxypropanolamines
CA1093096A (en)	1981-01-06	Heart active derivatives of 1-amino-2,3-dihydroxy propane
US4161542A (en)	1979-07-17	Heart active compounds
US4035420A (en)	1977-07-12	Substituted ureido alkylene phenoxy propanolamines
US4263323A (en)	1981-04-21	β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
EP0064487A1 (de)	1982-11-10	Substituierte 3-(parasubstituierte) Phenoxy-1-alkylamino-2-propanole sowie Verfahren zu deren Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und Methode zur Behandlung von Herzversagen