NO802859L - Fosfonsyrer og fremstilling derav - Google Patents

Fosfonsyrer og fremstilling derav

Info

Publication number: NO802859L
Authority: NO; Norway
Prior art keywords: formula; acid; process according; compound; amino
Prior art date: 1979-09-28

Application number

NO802859A

Other languages

English (en)

Norwegian (no)

Inventor

Frank Ratcliffe Atherton

Michael John Hall

Cedric Herbert Hassall

Robert Wilson Lambert

Peter Stuart Ringrose

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-09-28

Filing date

1980-09-26

Publication date

1981-03-30

1980-09-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1981-03-30 Publication of NO802859L publication Critical patent/NO802859L/no

Links

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238000000034 method Methods 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 10
125000003277 amino group Chemical group 0.000 claims description 9
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239000007858 starting material Substances 0.000 claims description 9
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RBZNWFFBUNHRQC-KHSUWTBESA-N [(3S)-3-amino-1-[[(2S)-2-aminopentanoyl]amino]-2-oxohexyl]phosphonic acid Chemical compound N[C@@H](CCC)C(=O)C(NC([C@@H](N)CCC)=O)P(O)(O)=O RBZNWFFBUNHRQC-KHSUWTBESA-N 0.000 claims description 2
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244000000010 microbial pathogen Species 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
125000002950 monocyclic group Chemical group 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
229910000510 noble metal Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
NONJJLVGHLVQQM-JHXYUMNGSA-N phenethicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C)OC1=CC=CC=C1 NONJJLVGHLVQQM-JHXYUMNGSA-N 0.000 description 1
229960004894 pheneticillin Drugs 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
229960002292 piperacillin Drugs 0.000 description 1
WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
229960004212 pivmecillinam Drugs 0.000 description 1
229910003446 platinum oxide Inorganic materials 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
229960003672 propicillin Drugs 0.000 description 1
HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229940031000 streptococcus pneumoniae Drugs 0.000 description 1
229960004932 sulbenicillin Drugs 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960004659 ticarcillin Drugs 0.000 description 1
OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
230000007306 turnover Effects 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO802859A 1979-09-28 1980-09-26 Fosfonsyrer og fremstilling derav NO802859L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7933700		1979-09-28
GB8025806		1980-08-07

Publications (1)

Publication Number	Publication Date
NO802859L true NO802859L (no)	1981-03-30

Family

ID=26273035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO802859A NO802859L (no)	1979-09-28	1980-09-26	Fosfonsyrer og fremstilling derav

Country Status (10)

Country	Link
EP (1)	EP0026867A1 (el)
AU (1)	AU6259180A (el)
DK (1)	DK409880A (el)
ES (1)	ES8200328A1 (el)
FI (1)	FI803035A7 (el)
GR (1)	GR70016B (el)
IL (1)	IL61107A0 (el)
MC (1)	MC1348A1 (el)
NO (1)	NO802859L (el)
PT (1)	PT71847B (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3381378D1 (de) *	1982-01-23	1990-05-03	Ajinomoto Kk	Derivate von aminosaeuren und antihypertensive arzneimittel diese enthaltend.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48835A (en) *	1975-01-27	1979-05-31	Sparamedica Ag	Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem
GB1585076A (en) *	1976-07-13	1981-02-25	Roche Products Ltd	Peptides of phosphonic and phosphinic acids
CA1108125A (en) *	1977-12-23	1981-09-01	Frank R. Atherton	Olgiopeptide derivatives of phosphonic acid
DE2966111D1 (en) *	1978-10-05	1983-10-06	Ciba Geigy Ag	Process for influencing plant growth
US4331591A (en) *	1978-10-05	1982-05-25	Ciba-Geigy Corporation	Chemical process for the production of α-aminophosphonic acids and peptide derivatives

1980
- 1980-09-19 EP EP80105637A patent/EP0026867A1/de not_active Withdrawn
- 1980-09-22 AU AU62591/80A patent/AU6259180A/en not_active Abandoned
- 1980-09-22 IL IL61107A patent/IL61107A0/xx unknown
- 1980-09-26 DK DK409880A patent/DK409880A/da unknown
- 1980-09-26 GR GR62972A patent/GR70016B/el unknown
- 1980-09-26 FI FI803035A patent/FI803035A7/fi not_active Application Discontinuation
- 1980-09-26 NO NO802859A patent/NO802859L/no unknown
- 1980-09-26 PT PT71847A patent/PT71847B/pt unknown
- 1980-09-27 ES ES495429A patent/ES8200328A1/es not_active Expired
- 1980-09-29 MC MC801471A patent/MC1348A1/fr unknown

Also Published As

Publication number	Publication date
ES495429A0 (es)	1981-11-01
FI803035A7 (fi)	1981-01-01
PT71847A (en)	1980-10-01
MC1348A1 (fr)	1981-06-22
AU6259180A (en)	1981-04-09
DK409880A (da)	1981-03-29
PT71847B (en)	1982-03-26
EP0026867A1 (de)	1981-04-15
IL61107A0 (en)	1980-11-30
GR70016B (el)	1982-07-23
ES8200328A1 (es)	1981-11-01

Publication	Publication Date	Title
US5599791A (en)	1997-02-04	Amides of antibiotic GE 2270 factors
DK173178B1 (da)	2000-03-06	Insulinderivater samt disse forbindelsers fysiologisk tålelige salte, fremgangsmåde til fremstilling deraf, anvendelse af d
IE60128B1 (en)	1994-06-01	Hydroxylamine derivatives,their preparation and use as medicaments
SE457954B (sv)	1989-02-13	3-amino 1-azetidinsulfonsyraderivat eller salt daerav, ett b-laktamantibiotika
IE62334B1 (en)	1995-01-25	Phosphinic acid derivatives
DE2801911A1 (de)	1978-07-20	(acyl-)-mercaptoacylaminosaeurederivate, verfahren zu deren herstellung und ihre verwendung bei der bekaempfung von durch angiotensin bedingtem hochdruck
WO1992012172A9 (en)	1996-04-04	Amides of antibiotic ge 2270 factors
NO822974L (no)	1983-03-04	Urinstoffderivater, fremgangsmaate til deres fremstilling og medikamenter inneholdende dem samt deres anvendelse
JPS60252495A (ja)	1985-12-13	スタチンまたはその誘導体を含有するレニン阻害剤
EP0344682B1 (de)	1993-11-18	Oligopeptide mit zyklischen Prolin-analogen Aminosäuren
US4128542A (en)	1978-12-05	Peptide derivatives
AU2009231118B2 (en)	2013-06-27	Highly bridged peptides from actinomadura namibiensis
NO177714B (no)	1995-07-31	Analogifremgangsmåte for fremstilling av terapeutisk aktive peptidderivater
NO802686L (no)	1978-10-24	Fremgangsmaate for fremstilling av en ester av et klavulansyreamin
US4143134A (en)	1979-03-06	Halo-phosphonopeptides
US4134972A (en)	1979-01-16	Compositions having antibiotic properties
JPS61100564A (ja)	1986-05-19	ペプチドで置換された複素環免疫促進剤
US4100275A (en)	1978-07-11	Compositions having antibiotic properties
US4127649A (en)	1978-11-28	Compositions having antibiotic properties
US5190921A (en)	1993-03-02	Amino acids and peptides having a modified tyrosine residue, their preparation and their application as medicaments
CA1212103A (en)	1986-09-30	Indolylglycyl cephalosporin derivatives
GB2061945A (en)	1981-05-20	1-oxadethiacephalosporin derivatives and process for their production
US5500414A (en)	1996-03-19	Derivatives of peptides usable as inhibitors of bacterial collagenases
HU220875B1 (en)	2002-06-29	Pentapeptide derivative, production thereof and their intermediates
US5962407A (en)	1999-10-05	Loloatin derivatives and analogs