NO811121L - Fremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet - Google Patents

Fremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet

Info

Publication number: NO811121L
Authority: NO; Norway
Prior art keywords: octahydro; indol; procedure; antihypertensive activity; preparing derivatives
Prior art date: 1980-04-02

Application number

NO811121A

Other languages

English (en)

Other versions

NO156609C (no

NO156609B (no

Inventor

Milton L Hoefle

George Bobowski

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-04-02

Filing date

1981-04-01

Publication date

1981-10-05

1981-02-17 Priority claimed from US06/233,940 external-priority patent/US4350704A/en

1981-04-01 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1981-10-05 Publication of NO811121L publication Critical patent/NO811121L/no

1986-02-03 Priority to NO86860366A priority Critical patent/NO156898C/no

1987-07-13 Publication of NO156609B publication Critical patent/NO156609B/no

1987-10-21 Publication of NO156609C publication Critical patent/NO156609C/no

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
230000003276 anti-hypertensive effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO811121A 1980-04-02 1981-04-01 Analogifremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet. NO156609C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO86860366A NO156898C (no)	1980-04-02	1986-02-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte acylderivater av oktahydro-1h-indol-2-karboksylsyre.

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13710680A	1980-04-02	1980-04-02
US19430780A	1980-10-06	1980-10-06
US06/233,940 US4350704A (en)	1980-10-06	1981-02-17	Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids

Publications (3)

Publication Number	Publication Date
NO811121L true NO811121L (no)	1981-10-05
NO156609B NO156609B (no)	1987-07-13
NO156609C NO156609C (no)	1987-10-21

Family

ID=27384960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO811121A NO156609C (no)	1980-04-02	1981-04-01	Analogifremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet.

Country Status (14)

Country	Link
EP (1)	EP0037231B1 (no)
KR (2)	KR850000302B1 (no)
AU (1)	AU543861B2 (no)
CA (1)	CA1205476A (no)
DE (1)	DE3175875D1 (no)
DK (2)	DK157851C (no)
ES (2)	ES500965A0 (no)
FI (1)	FI76072C (no)
HK (1)	HK30489A (no)
IE (1)	IE52663B1 (no)
IL (1)	IL62294A (no)
NO (1)	NO156609C (no)
NZ (1)	NZ196704A (no)
SG (1)	SG3889G (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4599357A (en) *	1979-12-17	1986-07-08	Ciba-Geigy Corporation	1-mercaptoalkanoylindoline-2-carboxylic acids
EP0046953B1 (de) *	1980-08-30	1989-12-06	Hoechst Aktiengesellschaft	Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
FR2492381A1 (fr) *	1980-10-21	1982-04-23	Science Union & Cie	Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
ATE20469T1 (de) *	1980-10-23	1986-07-15	Schering Corp	Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
US4374847A (en) *	1980-10-27	1983-02-22	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
GB2086390B (en) *	1980-11-03	1984-06-06	Ciba Geigy Ag	1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4479963A (en) *	1981-02-17	1984-10-30	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
EP0093805B1 (en) *	1981-02-17	1987-05-13	Warner-Lambert Company	Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
DE3134933A1 (de) *	1981-09-03	1983-03-31	Hoechst Ag, 6230 Frankfurt	"harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3226768A1 (de) *	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
CA1341296C (en) *	1981-12-29	2001-09-25	Hansjorg Urbach	2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
EP0170775B2 (de) *	1981-12-29	1994-10-12	Hoechst Aktiengesellschaft	Derivate bicyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung
DE3210496A1 (de) *	1982-03-23	1983-10-06	Hoechst Ag	Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) *	1982-03-27	1983-11-10	Hoechst Ag, 6230 Frankfurt	Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3246503A1 (de) *	1982-12-16	1984-06-20	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US5175306A (en) *	1983-01-31	1992-12-29	Hoechst Aktiengesellschaft	Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
HU191120B (en) *	1983-01-31	1987-01-28	Hoechts Ag,De	Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers
DE3303344A1 (de)	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333454A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US5684016A (en) *	1984-04-12	1997-11-04	Hoechst Aktiengesellschaft	Method of treating cardiac insufficiency
DE3413710A1 (de) *	1984-04-12	1985-10-24	Hoechst Ag, 6230 Frankfurt	Verfahren zur behandlung der herzinsuffizienz
DE3431541A1 (de) *	1984-08-28	1986-03-06	Hoechst Ag, 6230 Frankfurt	Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) *	1986-03-27	1993-07-27	Hoechst Aktiengesellschaft	Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
EP0254032A3 (en)	1986-06-20	1990-09-05	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4749688A (en) *	1986-06-20	1988-06-07	Schering Corporation	Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en)	1986-06-20	1993-10-20	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
DE3633496A1 (de) *	1986-10-02	1988-04-14	Hoechst Ag	Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
FR2605630B1 (fr) *	1986-10-22	1989-06-30	Roussel Uclaf	Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
DE3639879A1 (de) *	1986-11-21	1988-06-01	Hoechst Ag	Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3641451A1 (de) *	1986-12-04	1988-06-16	Hoechst Ag	Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DE3722007A1 (de) *	1987-07-03	1989-01-12	Hoechst Ag	Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
FR2620703B1 (fr) *	1987-09-17	1991-10-04	Adir	Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
WO2004092132A1 (en) *	2003-04-15	2004-10-28	Warner-Lambert Company Llc	[b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
EP1792896A1 (en)	2005-12-01	2007-06-06	KRKA, tovarna zdravil, d.d., Novo mesto	Process for the preparation of perindopril and salts thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE608905R (fr) *	1960-12-19	1962-04-06	Bayer Ag	Procédé de fabrication d'un composé agissant sur la tension sanguine.
DE1174781B (de) *	1960-12-24	1964-07-30	Bayer Ag	Verfahren zur Herstellung von Salzen von 1-(Guanidinoalkyl)-pyrrolidinen
US4105776A (en) *	1976-06-21	1978-08-08	E. R. Squibb & Sons, Inc.	Proline derivatives and related compounds
JPS5572169A (en) *	1978-11-27	1980-05-30	Tanabe Seiyaku Co Ltd	Isoquinoline derivative and its preparation
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4461896A (en) *	1979-02-07	1984-07-24	Norwich Eaton Pharmaceuticals, Inc.	1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
EP0018104B1 (en) *	1979-03-26	1983-05-25	Takeda Chemical Industries, Ltd.	Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US4303583A (en) *	1979-08-13	1981-12-01	American Home Products Corporation	1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
DE2937779A1 (de) *	1979-09-19	1981-04-09	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate und verfahren zu ihrer herstellung
FR2487829A2 (fr) *	1979-12-07	1982-02-05	Science Union & Cie	Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme

1981
- 1981-03-03 IE IE463/81A patent/IE52663B1/en unknown
- 1981-03-04 IL IL62294A patent/IL62294A/xx unknown
- 1981-03-05 CA CA000372381A patent/CA1205476A/en not_active Expired
- 1981-03-24 EP EP81301243A patent/EP0037231B1/en not_active Expired
- 1981-03-24 DE DE8181301243T patent/DE3175875D1/de not_active Expired
- 1981-03-30 FI FI810971A patent/FI76072C/fi not_active IP Right Cessation
- 1981-03-31 AU AU68939/81A patent/AU543861B2/en not_active Ceased
- 1981-04-01 ES ES500965A patent/ES500965A0/es active Granted
- 1981-04-01 KR KR1019810001100A patent/KR850000302B1/ko not_active Expired
- 1981-04-01 NZ NZ196704A patent/NZ196704A/en unknown
- 1981-04-01 DK DK148281A patent/DK157851C/da not_active IP Right Cessation
- 1981-04-01 NO NO811121A patent/NO156609C/no unknown
- 1981-07-22 ES ES504189A patent/ES504189A0/es active Granted
1984
- 1984-09-27 KR KR1019840005928A patent/KR850000303B1/ko not_active Expired
1988
- 1988-02-22 DK DK091088A patent/DK159419C/da not_active IP Right Cessation
1989
- 1989-01-24 SG SG38/89A patent/SG3889G/en unknown
- 1989-04-13 HK HK304/89A patent/HK30489A/xx unknown

Also Published As

Publication number	Publication date
ES8206474A1 (es)	1982-08-16
CA1205476A (en)	1986-06-03
NO156609C (no)	1987-10-21
IE52663B1 (en)	1988-01-20
DK159419B (da)	1990-10-15
NZ196704A (en)	1984-12-14
AU543861B2 (en)	1985-05-09
DK159419C (da)	1991-03-18
DK91088D0 (da)	1988-02-22
HK30489A (en)	1989-04-21
ES8205771A1 (es)	1982-06-16
KR850000303B1 (ko)	1985-03-18
FI810971L (fi)	1981-10-03
SG3889G (en)	1989-06-02
NO156609B (no)	1987-07-13
FI76072B (fi)	1988-05-31
DE3175875D1 (en)	1987-03-05
EP0037231B1 (en)	1987-01-28
IL62294A (en)	1986-07-31
DK148281A (da)	1981-10-03
FI76072C (fi)	1988-09-09
KR850000302B1 (ko)	1985-03-18
DK157851C (da)	1990-07-30
ES504189A0 (es)	1982-06-16
AU6893981A (en)	1981-10-08
EP0037231A3 (en)	1982-04-28
IL62294A0 (en)	1981-05-20
KR830005136A (ko)	1983-08-03
IE810463L (en)	1981-10-02
DK157851B (da)	1990-02-26
ES500965A0 (es)	1982-08-16
EP0037231A2 (en)	1981-10-07
DK91088A (da)	1988-02-22

Publication	Publication Date	Title
NO811121L (no)	1981-10-05	Fremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet
NO820287L (no)	1982-08-04	Fremgangsmaate for fremstilling av isocyanursyre-derivater
NO811731L (no)	1981-11-23	Fremgangsmaate for fremstilling av imidazo-rifamycin-derivater
NO813678L (no)	1982-05-03	Fremgangsmaate for fremstilling av karbostyrilderivater
NO841568L (no)	1984-10-19	Fremgangsmaate for fremstilling av terapeutisk aktive fenetanolamin-derivater
NO163227C (no)	1990-04-25	Fremgangsm te for fremstilling av 1-substituert-aryihydro-4-oksonaftyridin-derivater.
FI893100L (fi)	1989-06-26	Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
NO151895C (no)	1985-06-26	Fremgangsmaate for fremstilling av pyrido-indolderivater
NO841542L (no)	1984-10-23	Fremgangsmaate for fremstilling av terapeutisk aktive indeno-pyridazinon-derivater
NO822717L (no)	1983-02-14	Fremgangsmaate for fremstilling av pyridazinderivater
NO823637L (no)	1983-05-04	Fremgangsmaate for fremstilling av eburnamoninderivater
NO813477L (no)	1981-10-15	Fremgangsmaate for fremstilling av karbostyrilderivater
NO880294L (no)	1988-07-28	Fremgangsmaate for fremstilling av tetrahydrofuranderivater
NO851550L (no)	1985-10-21	Fremgangsmaate for fremstilling av imidazolderivater
ES497800A0 (es)	1982-05-01	Procedimiento de obtencion de derivados de acido fenilaceti-co
NO845148L (no)	1985-06-24	Fremgangsmaate for fremstilling av 16-fenoksy- og 16-substituert-fenoksy-prostatrinsyre-derivater
NO151619C (no)	1985-05-08	Fremgangsmaate for fremstilling av cyklopropan-karboksylsyreester-derivater
NO813263L (no)	1982-03-29	Fremgangsmaate for fremstilling av terapeutisk aktive kinolon-derivater
NO169441C (no)	1992-06-24	Fremgangsmaate til fremstilling av 7-oksomitosanderivater
NO844090L (no)	1985-04-15	Fremgangsmaate for fremstilling av 2-azacykloalkyltio-2-penem-3-karboksylsyre-derivater
NO850350L (no)	1985-07-31	Fremgangsmaate for fremstilling av beta-laktamase-hemmende penicillansyre-derivater
NO812842L (no)	1982-02-24	Fremgangsmaate for fremstilling av aminoacetonitil-derivater
NO831994L (no)	1983-12-05	Fremgangsmaate for fremstilling av pyrimidinon-derivater
NO842821L (no)	1985-01-14	Fremgangsmaate for fremstilling av terapeutisk aktive pyrrolidinon-derivater
NO831794L (no)	1983-11-25	Fremgangsmaate for fremstilling av 5-okso-2-pyrrolidin-propansyre-derivater