NO833768L - Absorberbart hemostatisk materiale. - Google Patents

Absorberbart hemostatisk materiale.

Info

Publication number: NO833768L
Authority: NO; Norway
Prior art keywords: textile; approx; material according; hemostatic; days
Prior art date: 1982-10-18

Application number

NO833768A

Other languages

English (en)

Norwegian (no)

Inventor

Eli Pines

Timothy Joseph Cunningham

Original Assignee

Johnson & Johnson Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-18

Filing date

1983-10-17

Publication date

1984-04-24

1983-10-17 Application filed by Johnson & Johnson Prod Inc filed Critical Johnson & Johnson Prod Inc

1984-04-24 Publication of NO833768L publication Critical patent/NO833768L/no

Links

239000000463 material Substances 0.000 title claims description 54
230000002439 hemostatic effect Effects 0.000 title claims description 38
239000004753 textile Substances 0.000 claims description 39
238000010521 absorption reaction Methods 0.000 claims description 31
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 12
108090000190 Thrombin Proteins 0.000 claims description 12
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 12
229960004072 thrombin Drugs 0.000 claims description 12
238000001727 in vivo Methods 0.000 claims description 10
229920001577 copolymer Polymers 0.000 claims description 9
239000000701 coagulant Substances 0.000 claims description 6
229920001519 homopolymer Polymers 0.000 claims description 5
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims description 4
108010000499 Thromboplastin Proteins 0.000 claims description 4
102000002262 Thromboplastin Human genes 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
230000005855 radiation Effects 0.000 claims description 3
208000032843 Hemorrhage Diseases 0.000 description 14
230000000740 bleeding effect Effects 0.000 description 14
229920000642 polymer Polymers 0.000 description 13
GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 8
239000000835 fiber Substances 0.000 description 8
239000000203 mixture Substances 0.000 description 8
238000006460 hydrolysis reaction Methods 0.000 description 7
239000000047 product Substances 0.000 description 7
239000004744 fabric Substances 0.000 description 6
230000007062 hydrolysis Effects 0.000 description 6
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 5
206010052428 Wound Diseases 0.000 description 5
208000027418 Wounds and injury Diseases 0.000 description 5
238000002513 implantation Methods 0.000 description 5
102000008186 Collagen Human genes 0.000 description 4
108010035532 Collagen Proteins 0.000 description 4
230000015271 coagulation Effects 0.000 description 4
238000005345 coagulation Methods 0.000 description 4
229920001436 collagen Polymers 0.000 description 4
238000009940 knitting Methods 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000000243 solution Substances 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
206010041647 Splenic haemorrhage Diseases 0.000 description 3
229940030225 antihemorrhagics Drugs 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
230000000025 haemostatic effect Effects 0.000 description 3
239000000126 substance Substances 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
238000005481 NMR spectroscopy Methods 0.000 description 2
108010094028 Prothrombin Proteins 0.000 description 2
102100027378 Prothrombin Human genes 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000010586 diagram Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000010894 electron beam technology Methods 0.000 description 2
238000001125 extrusion Methods 0.000 description 2
239000011888 foil Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
239000002874 hemostatic agent Substances 0.000 description 2
229940039716 prothrombin Drugs 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
206010007191 Capillary fragility Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
108010049003 Fibrinogen Proteins 0.000 description 1
102000008946 Fibrinogen Human genes 0.000 description 1
241000233866 Fungi Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
229920002201 Oxidized cellulose Polymers 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
210000001015 abdomen Anatomy 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000010171 animal model Methods 0.000 description 1
210000000702 aorta abdominal Anatomy 0.000 description 1
230000003881 arterial anastomosis Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000001112 coagulating effect Effects 0.000 description 1
239000000515 collagen sponge Substances 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
230000008014 freezing Effects 0.000 description 1
238000007710 freezing Methods 0.000 description 1
229920006158 high molecular weight polymer Polymers 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000005470 impregnation Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
230000001788 irregular Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940107304 oxidized cellulose Drugs 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
-1 polyglactin 910 Chemical compound 0.000 description 1
229920006254 polymer film Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000009738 saturating Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
230000003393 splenic effect Effects 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000001026 thromboplastic effect Effects 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000009941 weaving Methods 0.000 description 1
238000004804 winding Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Epidemiology (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Materials For Medical Uses (AREA)

NO833768A 1982-10-18 1983-10-17 Absorberbart hemostatisk materiale. NO833768L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43514882A	1982-10-18	1982-10-18
US50500883A	1983-06-16	1983-06-16

Publications (1)

Publication Number	Publication Date
NO833768L true NO833768L (no)	1984-04-24

Family

ID=27030441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO833768A NO833768L (no)	1982-10-18	1983-10-17	Absorberbart hemostatisk materiale.

Country Status (6)

Country	Link
EP (1)	EP0109197A2 (da)
AU (1)	AU2022183A (da)
DK (1)	DK478283A (da)
ES (1)	ES8502343A1 (da)
NO (1)	NO833768L (da)
NZ (1)	NZ205863A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2124842C (en)	1992-10-02	2003-07-15	Patrick R. Gruber	A melt-stable lactide polymer fabric and process for manufacture thereof
US5393594A (en) *	1993-10-06	1995-02-28	United States Surgical Corporation	Absorbable non-woven fabric
DE19721876A1 (de) *	1997-05-16	1998-11-19	Ethicon Gmbh	Implantat und Verfahren zum Herstellen eines Implantats
US6056970A (en) *	1998-05-07	2000-05-02	Genzyme Corporation	Compositions comprising hemostatic compounds and bioabsorbable polymers
CA2504812A1 (en) *	2002-11-14	2004-05-27	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Thrombin-carrying bioabsorbable synthetic nonwoven fabric
US7749204B2 (en) *	2004-10-20	2010-07-06	Ethicon, Inc.	Reinforced absorbable multilayered fabric for use in tissue repair and regeneration
US9358318B2 (en)	2004-10-20	2016-06-07	Ethicon, Inc.	Method of making a reinforced absorbable multilayered hemostatic wound dressing
EP1809343B1 (en)	2004-10-20	2012-08-15	Ethicon, Inc.	A reinforced absorbable multilayered hemostatic wound dressing and method of making
WO2018012605A1 (ja)	2016-07-13	2018-01-18	持田製薬株式会社	癒着防止用組成物

1983
- 1983-10-04 NZ NZ205863A patent/NZ205863A/en unknown
- 1983-10-17 NO NO833768A patent/NO833768L/no unknown
- 1983-10-17 EP EP83306273A patent/EP0109197A2/en not_active Withdrawn
- 1983-10-17 ES ES526527A patent/ES8502343A1/es not_active Expired
- 1983-10-17 DK DK478283A patent/DK478283A/da not_active Application Discontinuation
- 1983-10-17 AU AU20221/83A patent/AU2022183A/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2022183A (en)	1984-05-03
ES526527A0 (es)	1985-01-01
DK478283D0 (da)	1983-10-17
ES8502343A1 (es)	1985-01-01
EP0109197A2 (en)	1984-05-23
DK478283A (da)	1984-04-19
NZ205863A (en)	1985-09-13

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US5876451A (en)	1999-03-02	Medical device and method for producing the same
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