NO850536L - Fremgangsmaate for analysering av en proeve med hensyn paa interferon epsilon. - Google Patents
Fremgangsmaate for analysering av en proeve med hensyn paa interferon epsilon.Info
- Publication number
- NO850536L NO850536L NO850536A NO850536A NO850536L NO 850536 L NO850536 L NO 850536L NO 850536 A NO850536 A NO 850536A NO 850536 A NO850536 A NO 850536A NO 850536 L NO850536 L NO 850536L
- Authority
- NO
- Norway
- Prior art keywords
- interferon
- cells
- epsilon
- stated
- sample
- Prior art date
Links
- 102100026688 Interferon epsilon Human genes 0.000 title claims description 45
- 101710147309 Interferon epsilon Proteins 0.000 title claims description 45
- 238000000034 method Methods 0.000 title claims description 16
- 238000005070 sampling Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims description 33
- 102000014150 Interferons Human genes 0.000 claims description 32
- 108010050904 Interferons Proteins 0.000 claims description 32
- 210000002919 epithelial cell Anatomy 0.000 claims description 26
- 241000700605 Viruses Species 0.000 claims description 24
- 210000002510 keratinocyte Anatomy 0.000 claims description 24
- 210000002950 fibroblast Anatomy 0.000 claims description 21
- 229940079322 interferon Drugs 0.000 claims description 18
- 239000000523 sample Substances 0.000 claims description 16
- 102000003996 Interferon-beta Human genes 0.000 claims description 11
- 108090000467 Interferon-beta Proteins 0.000 claims description 11
- 102000006992 Interferon-alpha Human genes 0.000 claims description 10
- 108010047761 Interferon-alpha Proteins 0.000 claims description 10
- 102000008070 Interferon-gamma Human genes 0.000 claims description 7
- 108010074328 Interferon-gamma Proteins 0.000 claims description 7
- 241000711975 Vesicular stomatitis virus Species 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229940044627 gamma-interferon Drugs 0.000 claims description 3
- 238000011534 incubation Methods 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 2
- 230000035899 viability Effects 0.000 claims 3
- 239000012470 diluted sample Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 19
- 229940047124 interferons Drugs 0.000 description 14
- 230000000840 anti-viral effect Effects 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 11
- 238000003556 assay Methods 0.000 description 8
- 238000004113 cell culture Methods 0.000 description 8
- 238000006386 neutralization reaction Methods 0.000 description 7
- 241000711404 Avian avulavirus 1 Species 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 229960001388 interferon-beta Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 230000000120 cytopathologic effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000009982 effect on human Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229960003130 interferon gamma Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000007758 minimum essential medium Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101000836540 Homo sapiens Aldo-keto reductase family 1 member B1 Proteins 0.000 description 1
- 101000809450 Homo sapiens Amphiregulin Proteins 0.000 description 1
- 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 1
- 101000635799 Homo sapiens Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000711408 Murine respirovirus Species 0.000 description 1
- 102100030852 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Human genes 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 102000046818 human AR Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000013365 molecular weight analysis method Methods 0.000 description 1
- 108091006934 mouse interferon-epsilon Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012521 purified sample Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/628,612 US4675282A (en) | 1984-07-06 | 1984-07-06 | Assay for interferon epsilon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO850536L true NO850536L (no) | 1986-01-07 |
Family
ID=24519613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO850536A NO850536L (no) | 1984-07-06 | 1985-02-12 | Fremgangsmaate for analysering av en proeve med hensyn paa interferon epsilon. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4675282A (de) |
| JP (1) | JPS6125060A (de) |
| AU (1) | AU3857085A (de) |
| BE (1) | BE902663A (de) |
| CA (1) | CA1244345A (de) |
| CH (1) | CH666285A5 (de) |
| DE (1) | DE3515803A1 (de) |
| DK (1) | DK99185A (de) |
| FR (1) | FR2567269A1 (de) |
| GB (1) | GB2161270A (de) |
| IT (1) | IT1183809B (de) |
| NL (1) | NL8501564A (de) |
| NO (1) | NO850536L (de) |
| SE (1) | SE8500620L (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0296158B1 (de) * | 1986-03-06 | 1992-06-17 | Commonwealth Scientific And Industrial Research Organisation | In-vitro-testverfahren zum nachweis zellulärer immunresponsen |
| ZA9811070B (en) | 1997-12-08 | 2000-07-03 | Genentech Inc | Type I interferons. |
| WO1999029863A1 (en) * | 1997-12-08 | 1999-06-17 | Genentech, Inc. | Human interferon-epsilon: a type i interferon |
| CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1443425A (en) * | 1972-10-25 | 1976-07-21 | Searle & Co | Interferon assay |
| US3910824A (en) * | 1973-10-18 | 1975-10-07 | Searle & Co | Interferon assay |
| US4241174A (en) * | 1978-11-24 | 1980-12-23 | Hoffmann-La Roche Inc. | Interferon assay |
| JPS56135420A (en) * | 1980-03-26 | 1981-10-22 | Fumiaki Taguchi | Suppressive substance of virus and its preparation |
| NO832517L (no) * | 1982-07-12 | 1984-01-13 | Damon Biotech Inc | Interferonpreparat, samt fremgangsmaate for dets fremstilling |
| IL66733A (en) * | 1982-09-07 | 1986-03-31 | Yeda Res & Dev | Assay for ifn and kit therefor |
-
1984
- 1984-07-06 US US06/628,612 patent/US4675282A/en not_active Expired - Fee Related
-
1985
- 1985-02-07 CA CA000473754A patent/CA1244345A/en not_active Expired
- 1985-02-08 AU AU38570/85A patent/AU3857085A/en not_active Abandoned
- 1985-02-12 NO NO850536A patent/NO850536L/no unknown
- 1985-02-12 SE SE8500620A patent/SE8500620L/xx not_active Application Discontinuation
- 1985-03-04 DK DK99185A patent/DK99185A/da not_active Application Discontinuation
- 1985-03-25 JP JP6051285A patent/JPS6125060A/ja active Pending
- 1985-04-30 IT IT67398/85A patent/IT1183809B/it active
- 1985-05-02 DE DE19853515803 patent/DE3515803A1/de not_active Ceased
- 1985-05-31 NL NL8501564A patent/NL8501564A/nl not_active Application Discontinuation
- 1985-06-12 FR FR8508919A patent/FR2567269A1/fr active Pending
- 1985-06-14 BE BE0/215192A patent/BE902663A/fr not_active IP Right Cessation
- 1985-07-05 CH CH2898/85A patent/CH666285A5/de not_active IP Right Cessation
- 1985-07-05 GB GB08517164A patent/GB2161270A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NL8501564A (nl) | 1986-02-03 |
| SE8500620L (sv) | 1986-01-07 |
| US4675282A (en) | 1987-06-23 |
| JPS6125060A (ja) | 1986-02-03 |
| GB8517164D0 (en) | 1985-08-14 |
| IT8567398A0 (it) | 1985-04-30 |
| DE3515803A1 (de) | 1986-01-16 |
| AU3857085A (en) | 1986-01-09 |
| DK99185A (da) | 1986-01-07 |
| IT1183809B (it) | 1987-10-22 |
| IT8567398A1 (it) | 1986-10-30 |
| DK99185D0 (da) | 1985-03-04 |
| FR2567269A1 (fr) | 1986-01-10 |
| BE902663A (fr) | 1985-09-30 |
| GB2161270A (en) | 1986-01-08 |
| CA1244345A (en) | 1988-11-08 |
| CH666285A5 (de) | 1988-07-15 |
| SE8500620D0 (sv) | 1985-02-12 |
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