NO872810L - Fremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse. - Google Patents

Fremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse.

Info

Publication number: NO872810L
Authority: NO; Norway
Prior art keywords: compound; preparing; procedure; minoxidil; formula
Prior art date: 1986-10-07

Application number

NO872810A

Other languages

English (en)

Norwegian (no)

Other versions

NO872810D0 (no

Inventor

Jyrki Laemsae

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-07

Filing date

1987-07-06

Publication date

1988-04-08

1987-07-06 Application filed by Farmos Oy filed Critical Farmos Oy

1987-07-06 Publication of NO872810D0 publication Critical patent/NO872810D0/no

1988-04-08 Publication of NO872810L publication Critical patent/NO872810L/no

Links

238000000034 method Methods 0.000 title claims description 15
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 9
ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 8
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
229960003632 minoxidil Drugs 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 4
239000007800 oxidant agent Substances 0.000 claims description 4
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
USSBDBZGEDUBHE-UHFFFAOYSA-L magnesium;2-oxidooxycarbonylbenzoate Chemical compound [Mg+2].[O-]OC(=O)C1=CC=CC=C1C([O-])=O USSBDBZGEDUBHE-UHFFFAOYSA-L 0.000 claims 2
125000000217 alkyl group Chemical group 0.000 claims 1
NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 8
238000007254 oxidation reaction Methods 0.000 description 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 6
230000003647 oxidation Effects 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 5
FODOUIXGKGNSMR-UHFFFAOYSA-L magnesium;2-oxidooxycarbonylbenzoate;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[O-]OC(=O)C1=CC=CC=C1C([O-])=O FODOUIXGKGNSMR-UHFFFAOYSA-L 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
239000000047 product Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 3
150000001298 alcohols Chemical class 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
239000002904 solvent Substances 0.000 description 3
IDCARVYLHZLEMC-UHFFFAOYSA-N (2,6-diaminopyrimidin-4-yl) 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OC1=CC(N)=NC(N)=N1 IDCARVYLHZLEMC-UHFFFAOYSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
239000006227 byproduct Substances 0.000 description 2
230000001590 oxidative effect Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
SWELIMKTDYHAOY-UHFFFAOYSA-N 2,4-diamino-6-hydroxypyrimidine Chemical compound NC1=CC(=O)N=C(N)N1 SWELIMKTDYHAOY-UHFFFAOYSA-N 0.000 description 1
SXIUYERFFIKRTI-UHFFFAOYSA-N C1=CC(C)=CC=C1S(=O)(=O)OC1=CC(N)=[N+]([O-])C(N)=N1 Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OC1=CC(N)=[N+]([O-])C(N)=N1 SXIUYERFFIKRTI-UHFFFAOYSA-N 0.000 description 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
229940030600 antihypertensive agent Drugs 0.000 description 1
239000002220 antihypertensive agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000002360 explosive Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000004687 hexahydrates Chemical class 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
150000004965 peroxy acids Chemical class 0.000 description 1
239000003444 phase transfer catalyst Substances 0.000 description 1
239000002574 poison Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
150000003461 sulfonyl halides Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
231100000167 toxic agent Toxicity 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO872810A 1986-10-07 1987-07-06 Fremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse. NO872810L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI864046A FI864046L (fi)	1986-10-07	1986-10-07	Foerfarande foer framstaellning av en terapeutiskt aktiv foerening.

Publications (2)

Publication Number	Publication Date
NO872810D0 NO872810D0 (no)	1987-07-06
NO872810L true NO872810L (no)	1988-04-08

Family

ID=8523270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO872810A NO872810L (no)	1986-10-07	1987-07-06	Fremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse.

Country Status (18)

Country	Link
US (1)	US4866174A (da)
EP (1)	EP0270201B1 (da)
JP (1)	JPS6396175A (da)
KR (1)	KR880005095A (da)
AT (1)	ATE61584T1 (da)
AU (1)	AU590431B2 (da)
CA (1)	CA1268766A (da)
DE (1)	DE3768617D1 (da)
DK (1)	DK348687A (da)
ES (1)	ES2021048B3 (da)
FI (2)	FI864046L (da)
FR (1)	FR2604707B1 (da)
HU (1)	HUT44533A (da)
IL (1)	IL83351A0 (da)
NO (1)	NO872810L (da)
NZ (1)	NZ221011A (da)
PT (1)	PT85392B (da)
ZA (1)	ZA875174B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI871773A0 (fi) *	1987-04-22	1987-04-22	Farmos Oy	Foerfarande foer framstaellning av en terapeutiskt aktiv foerening.
FR2636840B1 (fr) *	1988-09-23	1990-12-21	Norchim Sarl	Sel du 6-piperidino-2,4-diaminopyrimidine-3-oxyde et de l'acide aceturique, leur preparation et leur application dermatocosmetologiques
NZ244301A (en) *	1991-09-20	1994-08-26	Merck & Co Inc	Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
FR2697251B1 (fr) *	1992-10-22	1994-12-02	Synthelabo	N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.
CN117247357A (zh) *	2023-09-20	2023-12-19	吉林大学	一种米诺地尔的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3644364A (en) *	1970-03-31	1972-02-22	Upjohn Co	Compounds and process
US3998827A (en) *	1971-04-07	1976-12-21	The Upjohn Company	6-amino-4-(substituted piperidino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
HU177601B (en) *	1978-10-27	1981-11-28	Egyt Gyogyszervegyeszeti Gyar	New process for preparing 6-piperidino-2,4-diamino-pyrimidine-3-oxide
DE3064301D1 (en) *	1979-10-18	1983-08-25	Interox Chemicals Ltd	Magnesium salts of peroxycarboxylic acids, processes for their preparation and their use as bleaching agents in washing compositions, and processes
US4483781A (en) *	1983-09-02	1984-11-20	The Procter & Gamble Company	Magnesium salts of peroxycarboxylic acids

1986
- 1986-10-07 FI FI864046A patent/FI864046L/fi not_active Application Discontinuation
1987
- 1987-06-16 FR FR8708342A patent/FR2604707B1/fr not_active Expired
- 1987-07-06 NO NO872810A patent/NO872810L/no unknown
- 1987-07-07 DK DK348687A patent/DK348687A/da unknown
- 1987-07-09 NZ NZ221011A patent/NZ221011A/xx unknown
- 1987-07-10 AU AU75517/87A patent/AU590431B2/en not_active Ceased
- 1987-07-13 US US07/072,725 patent/US4866174A/en not_active Expired - Fee Related
- 1987-07-15 ZA ZA875174A patent/ZA875174B/xx unknown
- 1987-07-16 AT AT87306305T patent/ATE61584T1/de active
- 1987-07-16 ES ES87306305T patent/ES2021048B3/es not_active Expired - Lifetime
- 1987-07-16 EP EP87306305A patent/EP0270201B1/en not_active Expired - Lifetime
- 1987-07-16 DE DE8787306305T patent/DE3768617D1/de not_active Expired - Lifetime
- 1987-07-23 PT PT85392A patent/PT85392B/pt unknown
- 1987-07-27 IL IL83351A patent/IL83351A0/xx unknown
- 1987-07-28 KR KR1019870008195A patent/KR880005095A/ko not_active Withdrawn
- 1987-08-19 HU HU873719A patent/HUT44533A/hu unknown
- 1987-09-01 CA CA000545907A patent/CA1268766A/en not_active Expired - Fee Related
- 1987-09-11 FI FI873933A patent/FI78910C/fi not_active IP Right Cessation
- 1987-10-06 JP JP62252299A patent/JPS6396175A/ja active Pending

Also Published As

Publication number	Publication date
ES2021048B3 (es)	1991-10-16
JPS6396175A (ja)	1988-04-27
DK348687A (da)	1988-04-08
FI864046A7 (fi)	1988-04-08
FR2604707A1 (fr)	1988-04-08
FI873933A0 (fi)	1987-09-11
FI78910C (fi)	1989-10-10
DK348687D0 (da)	1987-07-07
US4866174A (en)	1989-09-12
EP0270201B1 (en)	1991-03-13
PT85392A (en)	1987-08-01
PT85392B (en)	1990-01-04
FI864046L (fi)	1988-04-08
DE3768617D1 (de)	1991-04-18
FI78910B (fi)	1989-06-30
AU7551787A (en)	1988-04-14
CA1268766A (en)	1990-05-08
KR880005095A (ko)	1988-06-28
AU590431B2 (en)	1989-11-02
FI864046A0 (fi)	1986-10-07
ATE61584T1 (de)	1991-03-15
FI873933L (fi)	1988-04-08
EP0270201A1 (en)	1988-06-08
NZ221011A (en)	1990-05-28
ZA875174B (en)	1988-01-20
FR2604707B1 (fr)	1989-06-09
IL83351A0 (en)	1987-12-31
NO872810D0 (no)	1987-07-06
HUT44533A (en)	1988-03-28

Publication	Publication Date	Title
CA1340960C (en)	2000-04-18	Chroman derivatives
AU652238B2 (en)	1994-08-18	Sulfonamides and their medical use
AU653604B2 (en)	1994-10-06	Novel sulfonamides
EP0824524B1 (en)	2004-09-08	Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase
CA2110944A1 (en)	1994-06-11	Novel sulfonamides
SU786894A3 (ru)	1980-12-07	Способ получени производных 3,4-дигидрохиназолина или их солей
WO2010077062A2 (en)	2010-07-08	Preparation method of statin compound and benzothiazolyl sulfone compound used therein
NO140069B (no)	1979-03-19	Pulverformet, lagringsbestandig vaskemiddelblanding
NO872810L (no)	1988-04-08	Fremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse.
HUT56096A (en)	1991-07-29	Process for producing chromane derivatives and pharmaceutical compositions containing them
CN104994855B (zh)	2018-06-05	制备逆转录酶抑制剂的方法
KR100654265B1 (ko)	2006-12-07	4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법
JP3156026B2 (ja)	2001-04-16	ホスホン酸ジエステル誘導体
HU196207B (en)	1988-10-28	Process for preparing 9-/2-hydroxy-ethoxy/-methyl-guanine
HU219231B (en)	2001-03-28	N-5-protected 2,5-diamino-4,6-dichloro-pyrimidine derivatives , process for producing them and intermediates
NO147838B (no)	1983-03-14	Mellomprodukt til bruk ved fremstilling av det hypotensive middel 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimetoksykinazolin
US3180866A (en)	1965-04-27	Substituted sulfapyrimidine derivatives
US3431263A (en)	1969-03-04	Certain 2-benzenesulfonamido-5-oxypyrimidines
SU1117298A1 (ru)	1984-10-07	Способ получени производного урацила
JP3013778B2 (ja)	2000-02-28	ベンゼンスルホンアミド誘導体及びその製法
IL23556A (en)	1968-12-26	2-Sulfonamido pyrimidines are converted instead of 5
HU198949B (en)	1989-12-28	Process for producing 5-substituted-3'azido-2',3'-dideoxyribonucleosides
JPS6031832B2 (ja)	1985-07-24	１−（２′−テトラヒドロフリル）−５−フルオロウラシルの製造法
JPS609036B2 (ja)	1985-03-07	ウラシル誘導体の製法
HU177579B (hu)	1981-11-28	Eljárás 3-\|(2-metil-4-amino-5-pirimidinil)-iiietil\|“5-(2-hídroxietilH-metiI- -2(3H)-tiazoltion előállítására