NO880268L - Fremgangsmaate for fremstilling av antikoagulerende peptider. - Google Patents

Fremgangsmaate for fremstilling av antikoagulerende peptider.

Info

Publication number: NO880268L
Authority: NO; Norway
Prior art keywords: anticoagulating; peptides; procedure; preparation; anticoagulating peptides
Prior art date: 1987-01-23

Application number

NO88880268A

Other languages

English (en)

Other versions

NO174105B (no

NO174105C (no

NO880268D0 (no

Inventor

John L Krstenansky

Simon J T Mao

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-23

Filing date

1988-01-22

Publication date

1988-07-25

1988-01-22 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-01-22 Publication of NO880268D0 publication Critical patent/NO880268D0/no

1988-07-25 Publication of NO880268L publication Critical patent/NO880268L/no

1993-12-06 Publication of NO174105B publication Critical patent/NO174105B/no

1994-03-16 Publication of NO174105C publication Critical patent/NO174105C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

NO880268A 1987-01-23 1988-01-22 Analogifremgangsmåte for fremstilling av antikoagulerende peptider NO174105C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US641787A	1987-01-23	1987-01-23
US5316287A	1987-05-21	1987-05-21

Publications (4)

Publication Number	Publication Date
NO880268D0 NO880268D0 (no)	1988-01-22
NO880268L true NO880268L (no)	1988-07-25
NO174105B NO174105B (no)	1993-12-06
NO174105C NO174105C (no)	1994-03-16

Family

ID=26675603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO880268A NO174105C (no)	1987-01-23	1988-01-22	Analogifremgangsmåte for fremstilling av antikoagulerende peptider

Country Status (19)

Country	Link
EP (1)	EP0276014B1 (no)
JP (1)	JP2709817B2 (no)
KR (1)	KR960014105B1 (no)
CN (1)	CN88100260A (no)
AR (1)	AR245140A1 (no)
AT (1)	ATE110743T1 (no)
AU (1)	AU601801B2 (no)
CA (1)	CA1341032C (no)
DE (1)	DE3851238T2 (no)
DK (1)	DK173757B1 (no)
ES (1)	ES2063740T3 (no)
FI (1)	FI89060C (no)
HU (1)	HU199159B (no)
IE (1)	IE63547B1 (no)
IL (1)	IL85159A (no)
NO (1)	NO174105C (no)
NZ (1)	NZ223236A (no)
PH (1)	PH26263A (no)
PT (1)	PT86600B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
WO1990006128A1 (en) *	1988-12-05	1990-06-14	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
US5232912A (en) *	1988-12-07	1993-08-03	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
AU630132B2 (en) *	1988-12-07	1992-10-22	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
ZA907742B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Anticoagulant peptides
CA2026377A1 (en) *	1989-10-03	1991-04-04	John L. Krstenansky	Radiolabeled anticoagulant peptides
CA2035917C (en) *	1990-02-13	2001-10-02	John L. Krstenansky	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4005591A1 (de) *	1990-02-22	1991-09-05	Behringwerke Ag	Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
DK0540574T3 (da) *	1990-07-24	1996-09-30	Merrell Pharma Inc	Antikoagulationspeptider
US5574012A (en) *	1990-07-24	1996-11-12	Merrell Pharmaceuticals Inc.	Analogs of hirudin having anti-platelet activity
AU640502B2 (en) *	1990-07-24	1993-08-26	Merrell Dow Pharmaceuticals Inc.	Analogs of hirudin having antiplatelet activity
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) *	1991-02-07	1992-08-13	Basf Ag	Neue antikoagulatorisch wirksame peptide
CA2081305A1 (en) *	1991-03-05	1992-09-06	Japan Energy Corporation	Hirudin variants or their salts, method for their production and anticoagulants having said compounds as active ingredients
US5767235A (en) *	1991-03-05	1998-06-16	Nippon Mining Company Limited	Anticoagulant hirudin variants and methods for their production
IT1250689B (it) *	1991-07-22	1995-04-21	Marco Gerna	Analoghi dell'irudina e procedimento per la loro preparazione
WO1993003057A1 (fr) *	1991-07-31	1993-02-18	Institut Pasteur	Polypeptides aptes a induire in vivo des anticorps eux-memes capables d'inhiber l'invasion de globules rouges par des merozoites de p.falciparum, produits apparentes et leur application a la production de compositions vaccinantes
NZ268159A (en) *	1993-06-11	1997-03-24	Merrell Pharma Inc	Anticoagulant and antiplatelet peptides and their use
GB9426038D0 (en)	1994-12-22	1995-02-22	Iaf Biochem Int	Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) *	1996-06-28	1998-11-03	Bayer Corporation	Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) *	2002-04-23	2002-06-05	Evolutec Ltd	Anticoagulants
GB0711779D0 (en) *	2007-06-18	2007-07-25	Univ Singapore	Thrombin inhibitor
CN102757479B (zh) *	2012-05-09	2014-04-30	北京林业大学	高活性降血压肽及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.

1988
- 1988-01-15 CA CA000556652A patent/CA1341032C/en not_active Expired - Fee Related
- 1988-01-19 NZ NZ223236A patent/NZ223236A/xx unknown
- 1988-01-19 JP JP63007651A patent/JP2709817B2/ja not_active Expired - Fee Related
- 1988-01-21 KR KR1019880000432A patent/KR960014105B1/ko not_active Expired - Fee Related
- 1988-01-21 AR AR88309880A patent/AR245140A1/es active
- 1988-01-21 IL IL85159A patent/IL85159A/xx not_active IP Right Cessation
- 1988-01-22 ES ES88100934T patent/ES2063740T3/es not_active Expired - Lifetime
- 1988-01-22 AT AT88100934T patent/ATE110743T1/de not_active IP Right Cessation
- 1988-01-22 EP EP88100934A patent/EP0276014B1/en not_active Expired - Lifetime
- 1988-01-22 PT PT86600A patent/PT86600B/pt not_active IP Right Cessation
- 1988-01-22 IE IE16788A patent/IE63547B1/en not_active IP Right Cessation
- 1988-01-22 HU HU88258A patent/HU199159B/hu unknown
- 1988-01-22 AU AU10729/88A patent/AU601801B2/en not_active Ceased
- 1988-01-22 DE DE3851238T patent/DE3851238T2/de not_active Expired - Fee Related
- 1988-01-22 NO NO880268A patent/NO174105C/no unknown
- 1988-01-22 FI FI880286A patent/FI89060C/fi not_active IP Right Cessation
- 1988-01-22 DK DK198800310A patent/DK173757B1/da not_active IP Right Cessation
- 1988-01-22 PH PH36388A patent/PH26263A/en unknown
- 1988-01-23 CN CN198888100260A patent/CN88100260A/zh active Pending

Also Published As

Publication number	Publication date
EP0276014A2 (en)	1988-07-27
IE880167L (en)	1988-07-23
JP2709817B2 (ja)	1998-02-04
EP0276014A3 (en)	1990-05-16
FI880286A7 (fi)	1988-07-24
EP0276014B1 (en)	1994-08-31
ES2063740T3 (es)	1995-01-16
NO174105B (no)	1993-12-06
IL85159A0 (en)	1988-06-30
IL85159A (en)	1993-04-04
FI89060C (fi)	1993-08-10
DE3851238T2 (de)	1995-03-16
DK31088A (da)	1988-07-24
FI89060B (fi)	1993-04-30
AR245140A1 (es)	1993-12-30
PH26263A (en)	1992-04-01
DK173757B1 (da)	2001-09-10
AU601801B2 (en)	1990-09-20
IE63547B1 (en)	1995-05-17
KR960014105B1 (ko)	1996-10-14
FI880286A0 (fi)	1988-01-22
PT86600A (pt)	1988-02-01
KR880009045A (ko)	1988-09-13
CA1341032C (en)	2000-06-20
ATE110743T1 (de)	1994-09-15
JPS63215698A (ja)	1988-09-08
NZ223236A (en)	1989-11-28
NO174105C (no)	1994-03-16
HU199159B (en)	1990-01-29
DK31088D0 (da)	1988-01-22
DE3851238D1 (de)	1994-10-06
NO880268D0 (no)	1988-01-22
HUT46339A (en)	1988-10-28
AU1072988A (en)	1988-07-28
PT86600B (pt)	1991-12-31
CN88100260A (zh)	1988-11-09

Publication	Publication Date	Title
NO880268D0 (no)	1988-01-22	Fremgangsmaate for fremstilling av anti-koagulerende peptider.
NO882200D0 (no)	1988-05-20	Fremgangsmaate for fremstilling av kalsiumsulfat-alfa-halvhydrat.
NO880262D0 (no)	1988-01-22	Fremgangsmaate for fremstilling av b avermectiner.
NO885454L (no)	1990-06-11	Fremgangsmaate for fremstilling av triklormonosilan.
NO874467D0 (no)	1987-10-26	Fremgangsmaate for fremstilling av 3-pyrrolidinoler.
NO894210L (no)	1990-04-25	Fremgangsmaate for fremstilling av kinolyloxazol-2-oner.
NO894649D0 (no)	1989-11-22	Fremgangsmaate for fremstilling av (s)-alfa-ethyl-2-oxo-1-pyrrolidinacetamid.
NO882893L (no)	1989-01-02	Fremgangsmaate for fremstilling av ureaformaldehydharpiks.
NO895032L (no)	1990-06-18	Fremgangsmaate for fremstilling av 2-benzotiazoliner.
NO882856D0 (no)	1988-06-28	Fremgangsmaate for fremstilling av immunoundertrykkende peptider.
NO893794L (no)	1990-03-27	Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO890159L (no)	1989-07-17	Fremgangsmaate for fremstilling av 1-alkyl-5-nitroimidazoler.
NO882730L (no)	1988-12-23	Fremgangsmaate for fremstilling av aminocyklopentyletere.
NO885002D0 (no)	1988-11-09	Fremgangsmte for fremstilling av sialocylglycerolipider.
NO873400D0 (no)	1987-08-13	Fremgangsmaate for fremstilling av sulfidfri alkalivaeske.
NO895040L (no)	1990-06-18	Fremgangsmaate for fremstilling av polyhydroxybenzyloxypropanolaminer.
NO168941C (no)	1992-04-29	Fremgangsmaate for fremstilling av mercaptoacylprolin.
NO880834L (no)	1988-08-29	Fremgangsmaate for fremstilling av heterocyclyl-2-propyn-1-aminer.
NO880106L (no)	1988-08-19	Fremgangsmaate til fremstilling av kalknitrogen.
NO893796D0 (no)	1989-09-25	Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO893795D0 (no)	1989-09-25	Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO166361C (no)	1991-07-10	Fremgangsmaate for fremstilling av methyl-4-okso-5-tetradecynoat.
NO880844L (no)	1988-08-29	Fremgangsmaate for fremstilling av cytotoksiner.
NO169281C (no)	1992-06-03	Fremgangsmaate for fremstilling av heksanitrostilben.
NO890819D0 (no)	1989-02-27	Fremgangsmaate for fremstilling av hydroksybenzaldehyder.