NO890408L - 3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse. - Google Patents

3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.

Info

Publication number: NO890408L
Authority: NO; Norway
Prior art keywords: pct; acid derivatives; indolpyrodruic; pharmaceutical use; sec
Prior art date: 1987-06-03

Application number

NO89890408A

Other languages

English (en)

Norwegian (no)

Other versions

NO890408D0 (no

Inventor

Giovanna De Luca

Giovanni Di Stazio

Andrea Margonelli

Mario Materazzi

Vincenzo Politi

Original Assignee

Polifarma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-03

Filing date

1989-02-01

Publication date

1989-03-30

1989-02-01 Application filed by Polifarma Spa filed Critical Polifarma Spa

1989-02-01 Publication of NO890408D0 publication Critical patent/NO890408D0/no

1989-03-30 Publication of NO890408L publication Critical patent/NO890408L/no

Links

239000002253 acid Substances 0.000 title 1
RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical class C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO89890408A 1987-06-03 1989-02-01 3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse. NO890408L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8748014A IT1206078B (it)	1987-06-03	1987-06-03	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
PCT/IT1988/000041 WO1988009789A2 (fr)	1987-06-03	1988-06-01	Derives d'acide 3-indolepyruvique et utilisation pharmaceutique desdits derives

Publications (2)

Publication Number	Publication Date
NO890408D0 NO890408D0 (no)	1989-02-01
NO890408L true NO890408L (no)	1989-03-30

Family

ID=11263959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO89890408A NO890408L (no)	1987-06-03	1989-02-01	3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.

Country Status (13)

Country	Link
US (1)	US5002963A (fr)
EP (1)	EP0321516B1 (fr)
JP (1)	JPH02500369A (fr)
KR (1)	KR960016522B1 (fr)
AT (1)	ATE86247T1 (fr)
AU (1)	AU609500B2 (fr)
CA (1)	CA1328658C (fr)
DE (1)	DE3878866T2 (fr)
DK (1)	DK170438B1 (fr)
FI (1)	FI92055C (fr)
IT (1)	IT1206078B (fr)
NO (1)	NO890408L (fr)
WO (1)	WO1988009789A2 (fr)

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IT1224546B (it) *	1988-09-29	1990-10-04	Polifarma Spa	Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
US4960786A (en) *	1989-04-24	1990-10-02	Merrell Dow Pharmaceuticals Inc.	Excitatory amino acid antagonists
PT93943A (pt) *	1989-05-05	1991-02-08	Searle & Co	Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE3917880A1 (de) *	1989-06-01	1990-12-06	Kali Chemie Ag	Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
IT218019Z2 (it) *	1989-09-08	1992-03-05	Enea	Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) *	1989-10-04	1993-06-07	Polifarma Spa	Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5037846A (en) *	1990-01-02	1991-08-06	Pfizer Inc.	Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
DK0624569T3 (da) *	1991-02-28	1998-10-26	Merrell Pharma Inc	MMDA-antagonister
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
IT1261165B (it) *	1993-01-25	1996-05-09	Polifarma Spa	Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
FR2701948B1 (fr) *	1993-02-22	1996-07-26	Exsymol Sa	Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
US7056935B2 (en)	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6242468B1 (en)	1997-02-27	2001-06-05	Jia-He Li	Carbamate and urea compositions and neurotrophic uses
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US5945441A (en) *	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6075150A (en) *	1998-01-26	2000-06-13	Cv Therapeutics, Inc.	α-ketoamide inhibitors of 20S proteasome
EP1085853A1 (fr)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Compositions pour la croissance des cheveux a base d'amides et d'esters heterocycliques et utilisation de ces compositions
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
HUP0102935A3 (en)	1998-06-03	2002-01-28	Gpi Nil Holdings Inc Wilmingto	N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions containing them
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
US6417189B1 (en)	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
WO2001046195A1 (fr)	1999-12-21	2001-06-28	Gpi Nil Holdings, Inc.	Composes a base de derives d'hydantoïne, compositions pharmaceutiques, et modes d'utilisation
US6608196B2 (en)	2001-05-03	2003-08-19	Galileo Pharmaceuticals, Inc.	Process for solid supported synthesis of pyruvate-derived compounds
US6916850B2 (en)	2001-05-03	2005-07-12	Galileo Pharmaceuticals, Inc.	Pyruvate derivatives
DE60239072D1 (de)	2001-12-27	2011-03-10	Ajinomoto Kk	Verfahren zur herstellung von glutaminsäurederivaten
WO2009028338A1 (fr)	2007-08-24	2009-03-05	Ajinomoto Co., Inc.	Nouveau gène d'oxydase et procédé de production d'acide 3-indole-pyruvique à l'aide de ce gène
KR20120068872A (ko)	2010-10-14	2012-06-27	아지노모토 가부시키가이샤	모나틴의 제조 방법
WO2020012373A1 (fr) *	2018-07-10	2020-01-16	Polindols S.R.L.S.	Nouveaux médicaments pour des pathologies invalidantes chroniques et pour ralentir le vieillissement, sur la base d'une nouvelle route métabolique du tryptophane et leur procédé de production

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CA1096881A (fr) *	1976-10-07	1981-03-03	Roger R. Gaudette	Preparation d'acides alpha-cetocarboxyliques aliphatiques et heterocycliques
GR74635B (fr) *	1980-08-18	1984-06-29	Merck & Co Inc
DE3177130D1 (de) *	1980-08-30	1990-01-11	Hoechst Ag	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
EP0048159A3 (fr) *	1980-09-17	1982-05-12	University Of Miami	Peptides carboxyalcoyliques, thioéthers et éthers de peptides comme agents antihypertensifs
IT1148618B (it) *	1982-10-11	1986-12-03	Polifarma Spa	Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) *	1985-06-28	1987-10-22	Polifarma Spa	Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico

1987
- 1987-06-03 IT IT8748014A patent/IT1206078B/it active
1988
- 1988-05-25 CA CA000567675A patent/CA1328658C/fr not_active Expired - Fee Related
- 1988-06-01 DE DE8888904984T patent/DE3878866T2/de not_active Expired - Lifetime
- 1988-06-01 JP JP63504630A patent/JPH02500369A/ja active Pending
- 1988-06-01 WO PCT/IT1988/000041 patent/WO1988009789A2/fr not_active Ceased
- 1988-06-01 EP EP88904984A patent/EP0321516B1/fr not_active Expired - Lifetime
- 1988-06-01 AT AT88904984T patent/ATE86247T1/de not_active IP Right Cessation
- 1988-06-01 KR KR1019890700193A patent/KR960016522B1/ko not_active Expired - Fee Related
- 1988-06-01 US US07/327,804 patent/US5002963A/en not_active Expired - Lifetime
- 1988-06-01 AU AU19433/88A patent/AU609500B2/en not_active Expired
1989
- 1989-02-01 NO NO89890408A patent/NO890408L/no unknown
- 1989-02-02 FI FI890508A patent/FI92055C/fi active IP Right Grant
- 1989-02-02 DK DK046789A patent/DK170438B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI92055C (fi)	1994-09-26
WO1988009789A3 (fr)	1989-02-09
FI890508A0 (fi)	1989-02-02
EP0321516B1 (fr)	1993-03-03
DK46789A (da)	1989-03-31
US5002963A (en)	1991-03-26
AU1943388A (en)	1989-01-04
IT8748014A0 (it)	1987-06-03
DK170438B1 (da)	1995-09-04
DE3878866D1 (de)	1993-04-08
NO890408D0 (no)	1989-02-01
AU609500B2 (en)	1991-05-02
ATE86247T1 (de)	1993-03-15
JPH02500369A (ja)	1990-02-08
FI92055B (fi)	1994-06-15
DE3878866T2 (de)	1993-09-02
CA1328658C (fr)	1994-04-19
KR890701559A (ko)	1989-12-20
WO1988009789A2 (fr)	1988-12-15
FI890508L (fi)	1989-02-02
KR960016522B1 (ko)	1996-12-14
DK46789D0 (da)	1989-02-02
EP0321516A1 (fr)	1989-06-28
IT1206078B (it)	1989-04-14

Publication	Publication Date	Title
NO890408D0 (no)	1989-02-01	3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.
IL81887A0 (en)	1987-10-20	Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
DE3684190D1 (de)	1992-04-16	Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
DE69634900D1 (de)	2005-08-04	Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis
NO905608L (no)	1991-07-01	Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
DE3854741D1 (de)	1996-01-11	Behandlung von autoimmun-erkrankungen durch orale verabreichung von autoantigenen.
DE3856594D1 (de)	2008-11-27	Mittel zur behandlung der alzheimer-krankheit
DK0603301T3 (da)	1998-09-14	Farmaceutisk præparat indeholdende et urikosurikon og en excitatorisk-aminosyre-antagonist
ATE126436T1 (de)	1995-09-15	Antagonisten von exzitatorischen aminosäuren.
DE3852935D1 (de)	1995-03-16	Substituierte Alpha-Aminosäuren mit pharmazeutischer Aktivität.
MX14957A (es)	1993-11-01	Nuevos derivados de tetrazol y procedimiento para su preparacion.
DE68904462D1 (de)	1993-03-04	4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelial-gewebekrankheiten.
ATE124681T1 (de)	1995-07-15	Arzneimittelzusammensetzungen zur behandlung von psoriasis.
DK528086D0 (da)	1986-11-05	N-substituerede 3-piperidincarboxylsyrer eller n-substituerede 3-pyridincarboxylsyrer og derivater deraf
DE69010294D1 (de)	1994-08-04	Verwendung von Antiprogestomimetika zur Stimulierung des Eisprungs.
DE59902666D1 (de)	2002-10-17	Edelfosin zur behandlung von hirntumoren
DE69431199D1 (de)	2002-09-26	Melatonin-Derivate zur Verwendung in der Behandlung von Schlafstörungen
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
ATE82850T1 (de)	1992-12-15	Verwendung von 2-pyrimidinyl-1-piperazinderivaten.
DK4389A (da)	1989-01-06	Isoxazoler med nootrop virkning
SE8700136L (sv)	1988-07-16	Forfarande for behandling av amfotera aminosyror
DE3684825D1 (de)	1992-05-21	Verwendung von n-(1-allyl-2-pyrrolidinylmethyl)-2-methoxy-4-amino-5-methylsulfamoylbenzamid zur behandlung der parkinson-krankheit.