NO891662L - Fremgangsmaate for rensing av slangegiftpolypeptider, samtgener og ekspresjonsvektorer for fremstilling av polypeptider. - Google Patents

Fremgangsmaate for rensing av slangegiftpolypeptider, samtgener og ekspresjonsvektorer for fremstilling av polypeptider.

Info

Publication number
NO891662L
NO891662L NO89891662A NO891662A NO891662L NO 891662 L NO891662 L NO 891662L NO 89891662 A NO89891662 A NO 89891662A NO 891662 A NO891662 A NO 891662A NO 891662 L NO891662 L NO 891662L
Authority
NO
Norway
Prior art keywords
polypeptides
amino acid
poison
hose
purification
Prior art date
Application number
NO89891662A
Other languages
English (en)
Norwegian (no)
Other versions
NO891662D0 (no
Inventor
Paul A Friedman
Zhong-Ru Gan
Robert J Gould
John W Jacobs
Mark A Polokoff
Gerard H Bencen
Victor M Garsky
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO891662D0 publication Critical patent/NO891662D0/no
Publication of NO891662L publication Critical patent/NO891662L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO89891662A 1988-04-22 1989-04-21 Fremgangsmaate for rensing av slangegiftpolypeptider, samtgener og ekspresjonsvektorer for fremstilling av polypeptider. NO891662L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18464988A 1988-04-22 1988-04-22
US18465388A 1988-04-22 1988-04-22
US30375789A 1989-02-01 1989-02-01

Publications (2)

Publication Number Publication Date
NO891662D0 NO891662D0 (no) 1989-04-21
NO891662L true NO891662L (no) 1989-10-23

Family

ID=27391870

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89891662A NO891662L (no) 1988-04-22 1989-04-21 Fremgangsmaate for rensing av slangegiftpolypeptider, samtgener og ekspresjonsvektorer for fremstilling av polypeptider.

Country Status (14)

Country Link
EP (1) EP0338634B1 (fr)
JP (1) JPH02138298A (fr)
KR (1) KR900016261A (fr)
CN (1) CN1039441A (fr)
AT (1) ATE103931T1 (fr)
AU (1) AU627724B2 (fr)
DE (1) DE68914316T2 (fr)
DK (1) DK192189A (fr)
ES (1) ES2063113T3 (fr)
FI (1) FI891916L (fr)
IL (1) IL89938A0 (fr)
NO (1) NO891662L (fr)
NZ (1) NZ228710A (fr)
PT (1) PT90321B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
EP0382451A3 (fr) * 1989-02-07 1991-05-29 Merck & Co. Inc. Polypeptides issus du venin de vipère et leurs variantes
JPH02275899A (ja) * 1989-02-09 1990-11-09 Merck & Co Inc ポリペプチド合成
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
WO1991011458A1 (fr) * 1990-02-02 1991-08-08 Genentech, Inc. PEPTIDES CYCLIQUES CONTENANT UNE SEQUENCE Arg-Gly-Asp FLANQUEE DE PROLINE
US5227469A (en) * 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
ATE155482T1 (de) * 1990-04-06 1997-08-15 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
DK0578728T3 (da) * 1991-04-05 1999-04-12 Genentech Inc Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5380646A (en) * 1992-10-19 1995-01-10 Temple University Of The Commonwealth System Of Higher Education Thrombus detection using radiolabelled disintegrins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
EP0317053B1 (fr) * 1987-11-18 1993-12-08 Temple University of the Commonwealth System of Higher Education Trigramine, un polypeptide inhibant l'aggrégation des plaquettes

Also Published As

Publication number Publication date
FI891916A7 (fi) 1989-10-23
ATE103931T1 (de) 1994-04-15
NO891662D0 (no) 1989-04-21
DE68914316D1 (de) 1994-05-11
IL89938A0 (en) 1989-12-15
NZ228710A (en) 1992-10-28
ES2063113T3 (es) 1995-01-01
AU627724B2 (en) 1992-09-03
EP0338634A2 (fr) 1989-10-25
JPH02138298A (ja) 1990-05-28
KR900016261A (ko) 1990-11-13
FI891916L (fi) 1989-10-23
PT90321A (pt) 1989-11-10
CN1039441A (zh) 1990-02-07
EP0338634A3 (fr) 1991-05-29
FI891916A0 (fi) 1989-04-21
DK192189D0 (da) 1989-04-20
PT90321B (pt) 1994-08-31
AU3329989A (en) 1990-02-15
EP0338634B1 (fr) 1994-04-06
DK192189A (da) 1989-10-23
DE68914316T2 (de) 1994-09-08

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