NO893239L - Farmasoeytisk preparat for behandling av diabetes mellitus. - Google Patents

Farmasoeytisk preparat for behandling av diabetes mellitus.

Info

Publication number: NO893239L
Authority: NO; Norway
Prior art keywords: treatment; diabetes mellitus; arg; insulin; pharmaceutical preparation
Prior art date: 1988-08-13

Application number

NO89893239A

Other languages

English (en)

Other versions

NO178914B (no

NO178914C (no

NO893239D0 (no

Inventor

Michael Doerschug

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-13

Filing date

1989-08-11

Publication date

1990-02-14

1989-08-11 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-08-11 Publication of NO893239D0 publication Critical patent/NO893239D0/no

1990-02-14 Publication of NO893239L publication Critical patent/NO893239L/no

1996-03-25 Publication of NO178914B publication Critical patent/NO178914B/no

1996-07-03 Publication of NO178914C publication Critical patent/NO178914C/no

Links

206010012601 diabetes mellitus Diseases 0.000 title abstract 3
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Obesity (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO893239A 1988-08-13 1989-08-11 Fremgangsmåte for fremstilling av et farmasöytisk preparat for behandling av Diabetes mellitus NO178914C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3827533A DE3827533A1 (de)	1988-08-13	1988-08-13	Pharmazeutische zubereitung zur behandlung des diabetes mellitus

Publications (4)

Publication Number	Publication Date
NO893239D0 NO893239D0 (no)	1989-08-11
NO893239L true NO893239L (no)	1990-02-14
NO178914B NO178914B (no)	1996-03-25
NO178914C NO178914C (no)	1996-07-03

Family

ID=6360797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO893239A NO178914C (no)	1988-08-13	1989-08-11	Fremgangsmåte for fremstilling av et farmasöytisk preparat for behandling av Diabetes mellitus

Country Status (18)

Country	Link
US (1)	US5177058A (no)
EP (1)	EP0357978B1 (no)
JP (1)	JPH02101022A (no)
KR (1)	KR900002801A (no)
AT (1)	ATE75945T1 (no)
AU (1)	AU621648B2 (no)
CA (1)	CA1332354C (no)
DE (2)	DE3827533A1 (no)
DK (1)	DK395689A (no)
ES (1)	ES2039773T3 (no)
FI (1)	FI95202C (no)
GR (1)	GR3005326T3 (no)
HU (1)	HU203670B (no)
IE (1)	IE61266B1 (no)
NO (1)	NO178914C (no)
NZ (1)	NZ230280A (no)
PT (1)	PT91420B (no)
ZA (1)	ZA896149B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6875589B1 (en) *	1988-06-23	2005-04-05	Hoechst Aktiengesellschaft	Mini-proinsulin, its preparation and use
DE4024434A1 (de) *	1990-08-01	1992-02-13	Fresenius Ag	Vorrichtung zur ultrafiltrationskontrolle bzw. ultrafiltrationsregelung bei blutreinigungsverfahren
NZ250844A (en) *	1993-04-07	1996-03-26	Pfizer	Treatment of non-insulin dependant diabetes with peptides; composition
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
DE59711533D1 (de)	1996-07-26	2004-05-27	Aventis Pharma Gmbh	Insulinderivate mit erhöhter Zinkbindung
DE69924232D1 (de) *	1998-01-09	2005-04-21	Novo Nordisk As	Stabilisierte insulin-zubereitungen
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
CZ2004710A3 (cs) *	2001-12-20	2005-02-16	Eli Lilly And Company	Inzulínová sloučenina s protrahovaným účinkem
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
US20060217290A1 (en) *	2003-04-29	2006-09-28	Kohn Wayne D	Insulin analogs having protracted time action
EP2107069B1 (en) *	2003-08-05	2013-01-16	Novo Nordisk A/S	Novel insulin derivatives
CN103223160B (zh) *	2004-07-19	2015-02-18	比奥孔有限公司	胰岛素-低聚物共轭物,制剂及其用途
US20090074882A1 (en)	2005-12-28	2009-03-19	Novo Nordisk A/S	Insulin compositions and method of making a composition
JP5552046B2 (ja) *	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
US9241908B2 (en) *	2007-10-16	2016-01-26	Biocon Limited	Orally administrable solid pharmaceutical composition and a process thereof
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR20110085985A (ko) *	2008-10-30	2011-07-27	노보 노르디스크 에이/에스	하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
BR112013010345A2 (pt)	2010-10-27	2017-07-25	Novo Nordisk As	tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2143591A (en) *	1936-09-26	1939-01-10	Univ Alberta	Therapeutic preparation and process of making and using it
US2354211A (en) *	1940-07-02	1944-07-25	Burroughs Wellcome Co	Insulin preparation
DOP1982004086A (es) *	1981-08-27	1988-03-22	Lilly Co Eli	Formula farmaceutica que comprende insulina humana y proinsulina humana
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) *	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider

1988
- 1988-08-13 DE DE3827533A patent/DE3827533A1/de not_active Withdrawn
1989
- 1989-08-08 ES ES89114617T patent/ES2039773T3/es not_active Expired - Lifetime
- 1989-08-08 AT AT89114617T patent/ATE75945T1/de not_active IP Right Cessation
- 1989-08-08 DE DE8989114617T patent/DE58901401D1/de not_active Expired - Lifetime
- 1989-08-08 EP EP89114617A patent/EP0357978B1/de not_active Expired - Lifetime
- 1989-08-10 FI FI893783A patent/FI95202C/fi not_active IP Right Cessation
- 1989-08-10 PT PT91420A patent/PT91420B/pt not_active IP Right Cessation
- 1989-08-11 NO NO893239A patent/NO178914C/no unknown
- 1989-08-11 AU AU39514/89A patent/AU621648B2/en not_active Expired
- 1989-08-11 DK DK395689A patent/DK395689A/da not_active Application Discontinuation
- 1989-08-11 CA CA000608115A patent/CA1332354C/en not_active Expired - Lifetime
- 1989-08-11 NZ NZ230280A patent/NZ230280A/xx unknown
- 1989-08-11 JP JP1207057A patent/JPH02101022A/ja active Pending
- 1989-08-11 US US07/392,559 patent/US5177058A/en not_active Expired - Lifetime
- 1989-08-11 HU HU894148A patent/HU203670B/hu unknown
- 1989-08-11 IE IE259489A patent/IE61266B1/en not_active IP Right Cessation
- 1989-08-11 ZA ZA896149A patent/ZA896149B/xx unknown
- 1989-08-11 KR KR1019890011430A patent/KR900002801A/ko not_active Withdrawn
1992
- 1992-07-31 GR GR920401367T patent/GR3005326T3/el unknown

Also Published As

Publication number	Publication date
EP0357978B1 (de)	1992-05-13
NO178914B (no)	1996-03-25
DE58901401D1 (de)	1992-06-17
JPH02101022A (ja)	1990-04-12
PT91420B (pt)	1995-05-04
US5177058A (en)	1993-01-05
EP0357978A1 (de)	1990-03-14
HU203670B (en)	1991-09-30
FI893783A0 (fi)	1989-08-10
GR3005326T3 (no)	1993-05-24
HUT50443A (en)	1990-02-28
ES2039773T3 (es)	1996-07-16
DK395689A (da)	1990-02-14
FI95202C (fi)	1996-01-10
AU3951489A (en)	1990-02-15
NO178914C (no)	1996-07-03
ZA896149B (en)	1990-04-25
DE3827533A1 (de)	1990-02-15
ATE75945T1 (de)	1992-05-15
NZ230280A (en)	1991-09-25
IE61266B1 (en)	1994-10-19
IE892594L (en)	1990-02-13
PT91420A (pt)	1990-03-08
FI95202B (fi)	1995-09-29
CA1332354C (en)	1994-10-11
KR900002801A (ko)	1990-03-23
DK395689D0 (da)	1989-08-11
FI893783L (fi)	1990-02-14
AU621648B2 (en)	1992-03-19
NO893239D0 (no)	1989-08-11

Publication	Publication Date	Title
NO893239D0 (no)	1989-08-11	Farmasoeytisk preparat for behandling av diabetes mellitus.
CA2093806A1 (en)	1992-04-11	Method of treating or preventing type 1 diabetes by oral administration of insulin
DK0725648T3 (da)	2007-08-20	Leverspecifikke farmaceutiske aktivstoffer
DK642587A (da)	1987-12-08	Insulinpraeparat
KR950002785A (ko)	1995-02-16	골량을 증가시키기 위한 부갑상선 호르몬 및 랄옥시펜
BR9709845B1 (pt)	2008-11-18	preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina.
BR9401199A (pt)	1994-10-18	Preparados de medicamentos, processo para a preparação de um preparado de medicamento, processo para a preparação de uma formulação de medicamento.
WO1996024370B1 (en)	1996-09-19	Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin
DE3875108D1 (de)	1992-11-05	Physiologisch aktives polypeptid und pharmazeutische komposition.
ATE99172T1 (de)	1994-01-15	Verwendung von acetyl-l-carnitin zur behandlung von katarakt, sowie pharmazeutische zusammensetzungen fuer eine derartige behandlung.
SE8804628D0 (sv)	1988-12-22	New compounds
AU8687391A (en)	1992-05-07	Lithium treatment
BG60101B2 (bg)	1993-10-29	Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол
IT1204400B (it)	1989-03-01	Composizioni farmaceutiche contenente una calcitonina
NO810480L (no)	1981-08-14	Anologifremgangsmaate for fremstilling av terapeutisk aktive 1,3,4-oksadiazolylfenol-derivater
ATE2746T1 (de)	1983-03-15	Piperidinderivate von 4,5-dialkyl-3-hydroxypyrrol-2-carbons[ureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
ES512748A0 (es)	1983-03-01	"procedimiento para la preparacion de comprimidos a base del antibiotico fosfomicina".
DK0560207T3 (da)	2000-02-07	Præparat til oral anvendelse baseret på ibuprofen
IT1264428B1 (it)	1996-09-23	Composizioni farmaceutiche per il trattamento della psoriasi
IT1238210B (it)	1993-07-12	Esteri del cefamandolo nafato, procedimento per la loro preparazione erelative composizioni farmaceutiche.