NO900930L - Amidering av pyridiner. - Google Patents

Amidering av pyridiner.

Info

Publication number: NO900930L
Authority: NO; Norway
Prior art keywords: reacting; vii; formula; lower alkyl; chloro
Prior art date: 1989-02-28

Application number

NO90900930A

Other languages

English (en)

Other versions

NO900930D0 (no

NO176879C (no

NO176879B (no

Inventor

Michelangelo Scalone

Peter Vogt

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-28

Filing date

1990-02-27

Publication date

1990-08-29

1990-02-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1990-02-27 Publication of NO900930D0 publication Critical patent/NO900930D0/no

1990-08-29 Publication of NO900930L publication Critical patent/NO900930L/no

1995-03-06 Publication of NO176879B publication Critical patent/NO176879B/no

1995-06-14 Publication of NO176879C publication Critical patent/NO176879C/no

Links

RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
230000009435 amidation Effects 0.000 title 1
238000007112 amidation reaction Methods 0.000 title 1
GCTFDMFLLBCLPF-UHFFFAOYSA-N 2,5-dichloropyridine Chemical compound ClC1=CC=C(Cl)N=C1 GCTFDMFLLBCLPF-UHFFFAOYSA-N 0.000 abstract 4
LVEYOSJUKRVCCF-UHFFFAOYSA-N 1,3-bis(diphenylphosphino)propane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCP(C=1C=CC=CC=1)C1=CC=CC=C1 LVEYOSJUKRVCCF-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
ZBPYOEMMLMVVQT-UHFFFAOYSA-N 5-chloropyridine-2-carboxamide Chemical compound NC(=O)C1=CC=C(Cl)C=N1 ZBPYOEMMLMVVQT-UHFFFAOYSA-N 0.000 abstract 1
GJLOKYIYZIOIPN-UHFFFAOYSA-N 5-chloropyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(Cl)C=N1 GJLOKYIYZIOIPN-UHFFFAOYSA-N 0.000 abstract 1
229910002666 PdCl2 Inorganic materials 0.000 abstract 1
150000001345 alkine derivatives Chemical class 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
125000004956 cyclohexylene group Chemical group 0.000 abstract 1
125000004979 cyclopentylene group Chemical group 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 abstract 1
YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 abstract 1
ZOUWOGOTHLRRLS-UHFFFAOYSA-N palladium;phosphane Chemical compound P.[Pd] ZOUWOGOTHLRRLS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2442—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems
- B01J31/2447—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring
- B01J31/2452—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring with more than one complexing phosphine-P atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
- B01J31/2414—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom comprising aliphatic or saturated rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
- B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
- B01J2231/4266—Sonogashira-type, i.e. RY + HC-CR' triple bonds, in which R=aryl, alkenyl, alkyl and R'=H, alkyl or aryl
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4277—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues
- B01J2231/4283—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues using N nucleophiles, e.g. Buchwald-Hartwig amination
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0202—Polynuclearity
- B01J2531/0205—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/824—Palladium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/84—Metals of the iron group
- B01J2531/842—Iron
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Transceivers (AREA)
Mobile Radio Communication Systems (AREA)

NO900930A 1989-02-28 1990-02-27 Fremgangsmåte ved fremstilling av pyridin-2-karboksamider NO176879C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH73689		1989-02-28
CH432389		1989-12-04

Publications (4)

Publication Number	Publication Date
NO900930D0 NO900930D0 (no)	1990-02-27
NO900930L true NO900930L (no)	1990-08-29
NO176879B NO176879B (no)	1995-03-06
NO176879C NO176879C (no)	1995-06-14

Family

ID=25685532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO900930A NO176879C (no)	1989-02-28	1990-02-27	Fremgangsmåte ved fremstilling av pyridin-2-karboksamider

Country Status (20)

Country	Link
US (2)	US5380861A (no)
EP (2)	EP0582825B1 (no)
JP (1)	JP2806483B2 (no)
KR (1)	KR0153523B1 (no)
AT (2)	ATE179171T1 (no)
AU (1)	AU628930B2 (no)
CA (2)	CA2008878C (no)
CY (1)	CY2196B1 (no)
DE (2)	DE59008449D1 (no)
DK (2)	DK0582825T3 (no)
ES (2)	ES2068264T3 (no)
FI (1)	FI98458C (no)
GR (1)	GR3030679T3 (no)
HR (1)	HRP930352B1 (no)
HU (1)	HU210940B (no)
IE (2)	IE66322B1 (no)
NO (1)	NO176879C (no)
NZ (1)	NZ232661A (no)
PT (1)	PT93272B (no)
YU (1)	YU47342B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0520325A1 (de) *	1991-06-28	1992-12-30	F.Hoffmann-La Roche & Co. Aktiengesellschaft	Verwendung von Monoaminoxidase-B-Hemmern zur Verhütung und Behandlung von Entzugserscheinungen nach Alkohol- und Drogenmissbrauch
PT798296E (pt) *	1996-03-21	2004-04-30	Lonza Ag	Processo para a producao de arilamidas de acidos carboxilicos heteroaromaticos
SK283920B6 (sk)	1996-03-28	2004-05-04	Lonza Ag	Spôsob výroby arylamidov heteroaromatických karboxylových kyselín
ES2143816T3 (es) *	1996-05-09	2000-05-16	Lonza Ag	Procedimiento para la preparacion de arilamidas de acidos carboxilicos heteroaromaticos.
US5900484A (en) *	1996-09-18	1999-05-04	Lonza Ag	Process for the preparation of arylamides of heteroaromatic carboxylic acids
CA2209392C (en) *	1996-07-23	2007-02-20	Yves Bessard	Process for preparing pyridinecarboxylic esters
TW575563B (en) *	1997-08-19	2004-02-11	American Cyanamid Co	Process for the preparation of pyridyl carboxylic amides and esters
US6372909B1 (en)	1998-11-20	2002-04-16	Schering Corporation	Synthesis of intermediates useful in preparing tricyclic compounds
AR028138A1 (es) *	1998-11-20	2003-04-30	Schering Corp	Sintesis de intermediarios utiles para preparar compuestos triciclicos
EP1078923B1 (en)	1999-08-02	2006-03-08	F. Hoffmann-La Roche Ag	Process for the preparation of benzothiophene derivatives
US8138209B2 (en) *	2005-07-13	2012-03-20	Jenrin Discovery, Inc.	Substituted picolinamides as MAO-B inhibitors useful for treating obesity
WO2008010796A1 (en) *	2006-07-18	2008-01-24	Renaissance Medicine, Llc	Process for preparing pyridine-2-carboxamides and intermediates therefor
WO2008010794A1 (en) *	2006-07-18	2008-01-24	Renaissance Medicine, Llc	Pharmaceutical preparations of crystalline lazabemide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2749350A (en) *	1953-03-30	1956-06-05	Phillips Petroleum Co	Selective oxidation of nitrogen-containing heterocyclic compounds
CH583198A5 (no) *	1972-02-07	1976-12-31	Microbial Chem Res Found
IL62794A0 (en) *	1980-06-02	1981-07-31	American Cyanamid Co	Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents
CA1261335A (en) *	1984-08-29	1989-09-26	Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee	Ethylenediamine monoamide derivatives
JP3000220B2 (ja) *	1987-03-14	2000-01-17	日本農薬株式会社	カルボン酸の製造法

1990
- 1990-01-30 CA CA002008878A patent/CA2008878C/en not_active Expired - Fee Related
- 1990-01-30 CA CA002245055A patent/CA2245055C/en not_active Expired - Fee Related
- 1990-02-19 DK DK93110620T patent/DK0582825T3/da active
- 1990-02-19 DK DK90103106.2T patent/DK0385210T3/da not_active Application Discontinuation
- 1990-02-19 DE DE59008449T patent/DE59008449D1/de not_active Expired - Fee Related
- 1990-02-19 DE DE59010868T patent/DE59010868D1/de not_active Expired - Fee Related
- 1990-02-19 EP EP93110620A patent/EP0582825B1/de not_active Expired - Lifetime
- 1990-02-19 ES ES90103106T patent/ES2068264T3/es not_active Expired - Lifetime
- 1990-02-19 AT AT93110620T patent/ATE179171T1/de not_active IP Right Cessation
- 1990-02-19 ES ES93110620T patent/ES2131544T3/es not_active Expired - Lifetime
- 1990-02-19 EP EP90103106A patent/EP0385210B1/de not_active Expired - Lifetime
- 1990-02-19 AT AT90103106T patent/ATE118481T1/de not_active IP Right Cessation
- 1990-02-21 HU HU90871A patent/HU210940B/hu not_active IP Right Cessation
- 1990-02-23 AU AU50153/90A patent/AU628930B2/en not_active Ceased
- 1990-02-23 NZ NZ232661A patent/NZ232661A/xx unknown
- 1990-02-26 JP JP2042718A patent/JP2806483B2/ja not_active Expired - Fee Related
- 1990-02-26 PT PT93272A patent/PT93272B/pt not_active IP Right Cessation
- 1990-02-27 KR KR1019900002481A patent/KR0153523B1/ko not_active Expired - Fee Related
- 1990-02-27 IE IE70390A patent/IE66322B1/en not_active IP Right Cessation
- 1990-02-27 NO NO900930A patent/NO176879C/no not_active IP Right Cessation
- 1990-02-27 YU YU37390A patent/YU47342B/sh unknown
- 1990-02-27 IE IE950449A patent/IE950449L/xx not_active IP Right Cessation
- 1990-02-28 FI FI901014A patent/FI98458C/fi not_active IP Right Cessation
1993
- 1993-03-12 HR HRP-373/90A patent/HRP930352B1/xx not_active IP Right Cessation
- 1993-05-25 US US08/067,329 patent/US5380861A/en not_active Expired - Lifetime
1994
- 1994-09-12 US US08/304,460 patent/US5534635A/en not_active Expired - Fee Related
1999
- 1999-07-02 GR GR990401761T patent/GR3030679T3/el unknown
2000
- 2000-09-20 CY CY0000047A patent/CY2196B1/xx unknown

Also Published As

Publication number	Publication date
IE900703L (en)	1990-08-28
JP2806483B2 (ja)	1998-09-30
CA2245055C (en)	2003-03-25
PT93272A (pt)	1990-08-31
EP0385210A3 (en)	1990-12-05
DE59010868D1 (de)	1999-05-27
FI98458B (fi)	1997-03-14
KR910015541A (ko)	1991-09-30
JPH02268161A (ja)	1990-11-01
GR3030679T3 (en)	1999-11-30
HU210940B (en)	1995-09-28
AU628930B2 (en)	1992-09-24
YU47342B (sh)	1995-01-31
AU5015390A (en)	1990-09-06
EP0385210A2 (de)	1990-09-05
DK0582825T3 (da)	1999-10-25
PT93272B (pt)	1997-01-31
CA2008878C (en)	2003-01-21
NZ232661A (en)	1993-04-28
CY2196B1 (en)	2002-11-08
DK0385210T3 (da)	1995-05-22
HU900871D0 (en)	1990-05-28
ES2068264T3 (es)	1995-04-16
HRP930352A2 (en)	1997-06-30
US5534635A (en)	1996-07-09
YU37390A (en)	1991-08-31
DE59008449D1 (de)	1995-03-23
NO900930D0 (no)	1990-02-27
EP0582825A1 (de)	1994-02-16
IE950449L (en)	1990-08-28
CA2008878A1 (en)	1990-08-31
EP0385210B1 (de)	1995-02-15
NO176879C (no)	1995-06-14
FI98458C (fi)	1997-06-25
HRP930352B1 (en)	1999-10-31
CA2245055A1 (en)	1990-08-31
HUT53875A (en)	1990-12-28
FI901014A0 (fi)	1990-02-28
US5380861A (en)	1995-01-10
ATE179171T1 (de)	1999-05-15
ATE118481T1 (de)	1995-03-15
IE66322B1 (en)	1995-12-27
KR0153523B1 (ko)	1998-11-16
EP0582825B1 (de)	1999-04-21
NO176879B (no)	1995-03-06
ES2131544T3 (es)	1999-08-01

Legal Events

Date	Code	Title	Description
2004-12-20	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO900930L (no)	1990-08-29	Amidering av pyridiner.
IS1692B (is)	1998-04-20	Nýjar aðferðir til framleiðslu á finasteríð efnum
Bessard et al.	1999	The preparation of pyridinecarboxylates from chloropyridines by the palladium-catalyzed alkoxycarbonylation
US4172203A (en)	1979-10-23	Method for preparing dichloromethyl pyridines
Lee et al.	1999	One-pot Synthesis of Ketones Using N-Methoxy-N-methyl-2-pyridyl Urethane
Takacs et al.	2007	Aminocarbonylation of 2-iodothiophene: High-yielding synthesis of thiophen-2-yl-glyoxylamides
JPS6425759A (en)	1989-01-27	2,6-dichloropyridine derivative
ES8206409A1 (es)	1982-09-01	Procedimiento para la preparacion de derivados de esteres alquilicos del acido carbonico, esencialmente libres de com-puestos nitrogenados.
KR910010079B1 (ko)	1991-12-14	벤즈이미다졸 유도체의 제조방법
ES8303281A1 (es)	1983-02-16	"procedimiento para la preparacion en continuo de esteres alquilos de acidos carboxilicos alifaticos saturados".
DK0589381T3 (da)	1996-06-17	Fremgangsmåde til fremstilling af perfluor-2-methyl-4-methoxypentan
JPS55120564A (en)	1980-09-17	Production of chloro-beta-trifluoromethylpyridines
ES251905A1 (es)	1960-03-01	Un procedimiento para preparar 4-quinazolinonas
GB1550726A (en)	1979-08-22	Process for the production of 2,3:5,6-bil-(cicloalkeno)-pyridines
ATE269308T1 (de)	2004-07-15	Herstellung von 3-chloromethylpyridinhydrochlorid
GB1523630A (en)	1978-09-06	Process for producing a product having dyed fibrous surface
KR910016704A (ko)	1991-11-05	풀루오로메틸이 치환된 피리딘 디카르복실레이트의 제조방법
GEP19950099B (en)	1995-02-27	Method for Production of Metal Arsenic