NO901083L - Fremgangsmaate for fremstilling av nye 1,7-kondenserte 1h-indol-2-carboxylsyre-n-(1,4-benzodiazepin)-3-yl)amider. - Google Patents

Fremgangsmaate for fremstilling av nye 1,7-kondenserte 1h-indol-2-carboxylsyre-n-(1,4-benzodiazepin)-3-yl)amider.

Info

Publication number: NO901083L
Authority: NO; Norway
Prior art keywords: lower alkyl; represents hydrogen; halogen; preparation; benzodiazepin
Prior art date: 1989-03-08

Application number

NO90901083A

Other languages

English (en)

Other versions

NO901083D0 (no

NO173869B (no

NO173869C (no

Inventor

Harald Waldeck

Werner Benson

Horst Zeugner

Klaus-Ullrich Wolf

Peter-Colin Gregory

Derk Hamminga

Ineke Van Wijngaarden

Original Assignee

Kali Chemie Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-08

Filing date

1990-03-07

Publication date

1990-09-10

1989-03-08 Priority claimed from DE3907389A external-priority patent/DE3907389A1/de

1989-03-08 Priority claimed from DE3907390A external-priority patent/DE3907390A1/de

1990-03-07 Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh

1990-03-07 Publication of NO901083D0 publication Critical patent/NO901083D0/no

1990-09-10 Publication of NO901083L publication Critical patent/NO901083L/no

1993-11-08 Publication of NO173869B publication Critical patent/NO173869B/no

1994-02-16 Publication of NO173869C publication Critical patent/NO173869C/no

Links

GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
HCUARRIEZVDMPT-UHFFFAOYSA-N Indole-2-carboxylic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 title 1
150000001408 amides Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)

NO901083A 1989-03-08 1990-03-07 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider NO173869C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3907389A DE3907389A1 (de)	1989-03-08	1989-03-08	Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide
DE3907390A DE3907390A1 (de)	1989-03-08	1989-03-08	Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide

Publications (4)

Publication Number	Publication Date
NO901083D0 NO901083D0 (no)	1990-03-07
NO901083L true NO901083L (no)	1990-09-10
NO173869B NO173869B (no)	1993-11-08
NO173869C NO173869C (no)	1994-02-16

Family

ID=25878542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO901083A NO173869C (no)	1989-03-08	1990-03-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider

Country Status (20)

Country	Link
US (1)	US5010076A (no)
EP (1)	EP0387618B1 (no)
JP (1)	JP3010558B2 (no)
KR (1)	KR920003627B1 (no)
CN (1)	CN1032208C (no)
AT (1)	ATE109146T1 (no)
AU (1)	AU616835B2 (no)
CS (1)	CS390091A3 (no)
DE (1)	DE59006544D1 (no)
DK (1)	DK0387618T3 (no)
ES (1)	ES2057216T3 (no)
FI (1)	FI92486C (no)
HK (1)	HK1006570A1 (no)
HU (2)	HU207317B (no)
IE (1)	IE65030B1 (no)
IL (1)	IL93401A (no)
NO (1)	NO173869C (no)
NZ (1)	NZ232774A (no)
PH (1)	PH26955A (no)
PT (1)	PT93360B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07103105B2 (ja) *	1989-05-12	1995-11-08	杏林製薬株式会社	インドール誘導体及びその製造方法
US5264419A (en) *	1990-08-31	1993-11-23	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (en) *	1991-05-14	1992-11-15	Mark S. Chambers	Benzodiazephine derivatives, compositions containing them and their use in therapy
DE4128015A1 (de) *	1991-08-23	1993-02-25	Kali Chemie Pharma Gmbh	1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) *	1992-02-21	1992-04-08	Merck Sharp & Dohme	Therapeutic agents
US5360802A (en) *	1992-05-11	1994-11-01	Merck Sharpe & Dohme Ltd.	Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) *	1993-02-17	1994-08-18	Kali Chemie Pharma Gmbh	5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) *	1994-12-07	1996-09-17	Merck Sharp & Dohme Ltd.	Benzodiazepine derivatives
NZ314105A (en) *	1996-02-02	1997-12-19	Sumitomo Pharma	Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
WO2000018391A1 (en) *	1998-09-30	2000-04-06	Takeda Chemical Industries, Ltd.	Drugs for improving vesical excretory strength
CA2446696A1 (fr) *	2001-06-07	2002-12-12	Neuro3D	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
JP2006509832A (ja) *	2002-10-30	2006-03-23	ニューロ３デー	サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用
FR2846653B1 (fr) *	2002-10-30	2007-04-20	Neuro3D	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
WO2014098000A1 (en) *	2012-12-17	2014-06-26	Daiichi Sankyo Company, Limited	Process for preparation of a tricyclic heterocycle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0139584B1 (fr) *	1983-10-17	1988-05-18	Synthelabo	Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
CA1332410C (en) *	1984-06-26	1994-10-11	Roger M. Freidinger	Benzodiazepine analogs
US4820834A (en) *	1984-06-26	1989-04-11	Merck & Co., Inc.	Benzodiazepine analogs
FR2567126B1 (fr) *	1984-07-06	1986-12-12	Synthelabo	Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) *	1986-01-02	1986-12-09	Merck & Co., Inc.	Process for 3-acylamino benzodiazepines
NZ227229A (en) *	1987-12-10	1991-03-26	Duphar Int Res	Indole derivatives and pharmaceutical compositions
FR2630440B1 (fr) *	1988-04-25	1991-09-20	Jouveinal Sa	Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) *	1988-09-09	1994-10-07	Fujisawa Pharmaceutical Co	Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (fr) *	1989-09-28	1991-03-29	Jouveinal Sa	Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

1990
- 1990-02-14 IL IL9340190A patent/IL93401A/en not_active IP Right Cessation
- 1990-02-14 PH PH40052A patent/PH26955A/en unknown
- 1990-03-01 ES ES90103990T patent/ES2057216T3/es not_active Expired - Lifetime
- 1990-03-01 DE DE59006544T patent/DE59006544D1/de not_active Expired - Fee Related
- 1990-03-01 DK DK90103990.9T patent/DK0387618T3/da active
- 1990-03-01 AT AT90103990T patent/ATE109146T1/de not_active IP Right Cessation
- 1990-03-01 EP EP90103990A patent/EP0387618B1/de not_active Expired - Lifetime
- 1990-03-05 NZ NZ232774A patent/NZ232774A/en unknown
- 1990-03-05 CN CN90101141A patent/CN1032208C/zh not_active Expired - Fee Related
- 1990-03-07 HU HU901333A patent/HU207317B/hu not_active IP Right Cessation
- 1990-03-07 FI FI901154A patent/FI92486C/fi not_active IP Right Cessation
- 1990-03-07 US US07/489,502 patent/US5010076A/en not_active Expired - Lifetime
- 1990-03-07 KR KR1019900003005A patent/KR920003627B1/ko not_active Expired
- 1990-03-07 NO NO901083A patent/NO173869C/no unknown
- 1990-03-07 IE IE81390A patent/IE65030B1/en not_active IP Right Cessation
- 1990-03-07 PT PT93360A patent/PT93360B/pt not_active IP Right Cessation
- 1990-03-07 AU AU50753/90A patent/AU616835B2/en not_active Ceased
- 1990-03-08 JP JP2055191A patent/JP3010558B2/ja not_active Expired - Fee Related
1991
- 1991-12-19 CS CS913900A patent/CS390091A3/cs unknown
1994
- 1994-09-30 HU HU94P/P00034P patent/HU210354A9/hu unknown
1998
- 1998-06-17 HK HK98105568A patent/HK1006570A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE900813L (en)	1990-09-08
KR900014391A (ko)	1990-10-23
KR920003627B1 (ko)	1992-05-04
ATE109146T1 (de)	1994-08-15
HUT53641A (en)	1990-11-28
AU616835B2 (en)	1991-11-07
HU210354A9 (en)	1995-03-28
EP0387618B1 (de)	1994-07-27
US5010076A (en)	1991-04-23
DE59006544D1 (de)	1994-09-01
PT93360B (pt)	1996-02-29
HU901333D0 (en)	1990-05-28
DK0387618T3 (da)	1994-08-22
NO901083D0 (no)	1990-03-07
ES2057216T3 (es)	1994-10-16
FI92486C (fi)	1994-11-25
PH26955A (en)	1992-12-03
CN1032208C (zh)	1996-07-03
CS390091A3 (en)	1992-06-17
JP3010558B2 (ja)	2000-02-21
IL93401A (en)	1994-08-26
NO173869B (no)	1993-11-08
HU207317B (en)	1993-03-29
CN1045392A (zh)	1990-09-19
FI901154A0 (fi)	1990-03-07
EP0387618A1 (de)	1990-09-19
IE65030B1 (en)	1995-10-04
NO173869C (no)	1994-02-16
NZ232774A (en)	1991-04-26
HK1006570A1 (en)	1999-03-05
FI92486B (fi)	1994-08-15
IL93401A0 (en)	1990-11-29
PT93360A (pt)	1990-11-07
AU5075390A (en)	1990-09-13
JPH02273678A (ja)	1990-11-08

Publication	Publication Date	Title
NO901083D0 (no)	1990-03-07	Fremgangsmaate for fremstilling av nye 1,7-kondenserte 1h-indol-2-carboxylsyre-n-(1,4-benzodiazepin)-3-yl)amider.
ATE208779T1 (de)	2001-11-15	Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
ATE36152T1 (de)	1988-08-15	Azaprostacycline, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DK0544765T3 (da)	1995-12-27	Piperazinylderivater med affinitet for 5-HT-receptorer
PT83725B (pt)	1989-05-12	Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
NZ201514A (en)	1985-09-13	1-phenyl-2-substituted aminocarbonyl indole compounds and pharmaceutical compositions
FI842500A0 (fi)	1984-06-20	Foerfarande foer framstaellning av -karbolinderivat.
IT1193608B (it)	1988-07-21	Derivati di arilossipropanolamina,procedimento per la loro preparazione composizioni farmaceutiche che li contengono e loro impiego terapeutico
ZA867616B (en)	1987-05-27	Tetrahydro-beta-carbolines,process for their production and their use as drugs
DK274082A (da)	1982-12-20	Fremgangsmaade til fremstilling af 2-acylaminomethyl-1,4-benzodiazepin-forbindelser og mellemprodukter til brug herved
CA2011658A1 (en)	1990-09-08	New 1,7-annelated 1h-indole-2-carboxylic acid-n-(1,4-benzodiazepin-3-yl) amides
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
ATE6635T1 (de)	1984-03-15	Biologisch aktive trizyklische amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
PL244080A1 (en)	1985-01-16	Process for preparing novel 1,1-dioxides of 4-hydroxy-2h-1,2-benzothiazine-3-carbonamide
ES528712A0 (es)	1985-01-01	Procedimiento para preparar nuevos compuestos heterociclicos
ATE17490T1 (de)	1986-02-15	Dithiino (1,4) (2,3-c) pyrrolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.