NO901423L - Fremgangsmaate for fremstilling av selektive adenosinreseptormidler. - Google Patents

Fremgangsmaate for fremstilling av selektive adenosinreseptormidler.

Info

Publication number: NO901423L
Authority: NO; Norway
Prior art keywords: carbon atoms; adenosine; hydrogen; proviso; beta
Prior art date: 1989-03-29

Application number

NO90901423A

Other languages

English (en)

Other versions

NO173996B (no

NO173996C (no

NO901423D0 (no

Inventor

Norton Paul Peet

Shyam Sunder

Nelson Lowell Lentz

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-29

Filing date

1990-03-28

Publication date

1990-10-01

1990-03-28 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-03-28 Publication of NO901423D0 publication Critical patent/NO901423D0/no

1990-10-01 Publication of NO901423L publication Critical patent/NO901423L/no

1993-11-22 Publication of NO173996B publication Critical patent/NO173996B/no

1994-03-02 Publication of NO173996C publication Critical patent/NO173996C/no

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
102000009346 Adenosine receptors Human genes 0.000 abstract 3
108050000203 Adenosine receptors Proteins 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
230000003247 decreasing effect Effects 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
238000000338 in vitro Methods 0.000 abstract 2
230000001766 physiological effect Effects 0.000 abstract 2
150000003838 adenosines Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
HMFHBZSHGGEWLO-TXICZTDVSA-N beta-D-ribose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-TXICZTDVSA-N 0.000 abstract 1
230000027455 binding Effects 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000000296 purinergic P1 receptor antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO901423A 1989-03-29 1990-03-28 Analogifremgangsmaate for fremstilling av selektive adenosinreseptormidler NO173996C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32991989A	1989-03-29	1989-03-29

Publications (4)

Publication Number	Publication Date
NO901423D0 NO901423D0 (no)	1990-03-28
NO901423L true NO901423L (no)	1990-10-01
NO173996B NO173996B (no)	1993-11-22
NO173996C NO173996C (no)	1994-03-02

Family

ID=23287579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO901423A NO173996C (no)	1989-03-29	1990-03-28	Analogifremgangsmaate for fremstilling av selektive adenosinreseptormidler

Country Status (18)

Country	Link
EP (1)	EP0390112B1 (no)
JP (1)	JP2954971B2 (no)
KR (1)	KR0168647B1 (no)
CN (1)	CN1034575C (no)
AT (1)	ATE162791T1 (no)
AU (1)	AU630439B2 (no)
CA (1)	CA2013380C (no)
DE (1)	DE69031989T2 (no)
DK (1)	DK0390112T3 (no)
ES (1)	ES2114524T3 (no)
FI (1)	FI95910C (no)
GR (1)	GR3026173T3 (no)
HU (1)	HU206354B (no)
IL (1)	IL93892A (no)
NO (1)	NO173996C (no)
NZ (1)	NZ233078A (no)
PT (1)	PT93588B (no)
ZA (1)	ZA902280B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9022644D0 (en) *	1990-10-18	1990-11-28	Ici Plc	Heterocyclic compounds
IT1254915B (it) *	1992-04-24	1995-10-11	Gloria Cristalli	Derivati di adenosina ad attivita' a2 agonista
JPH08500967A (ja) *	1992-06-12	1996-02-06	ガーヴァンインスティチュートオブメディカルリサーチ	ヒトＡ１，Ａ２ａおよびＡ２ｂアデノシン受容体をエンコードするＤＮＡ配列
FR2741881B1 (fr) *	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
GB9613021D0 (en) *	1996-06-21	1996-08-28	Pharmacia Spa	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
AR023463A1 (es)	1999-04-16	2002-09-04	Schering Corp	Uso de compuestos de azetidinona
GB0100621D0 (en)	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds VI
KR100468352B1 (ko) *	2002-09-24	2005-01-27	한국과학기술연구원	신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
WO2004092177A1 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
JP2015172077A (ja) *	2015-06-24	2015-10-01	中国医学科学院葯物研究所	Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途
US12202832B2 (en)	2017-04-27	2025-01-21	Takeda Pharmaceutical Company Limited	Heterocyclic compounds having a calcium-sensing receptor antagonistic activity
US11806350B2 (en) *	2020-11-19	2023-11-07	Ildong Pharmaceutical Co., Ltd.	Prevention and/or treatment of CNS disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE601946A (no) *	1960-03-31
NL283192A (no) *	1961-09-14
NL128629C (no) *	1966-05-07
DE1795828A1 (de) *	1966-12-21	1975-11-27	Boehringer Mannheim Gmbh	Adenosinderivate
DE2139107A1 (de) *	1971-08-04	1973-02-15	Merck Patent Gmbh	Heterocyclisch substituierte adenosinverbindungen
US3862189A (en) *	1973-08-14	1975-01-21	Warner Lambert Co	Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
AU527013B2 (en) *	1979-01-10	1983-02-10	Imperial Chemical Industries Ltd.	Pure during derivatives and defoliation of cotton
US4388308A (en) *	1980-06-09	1983-06-14	G.D. Searle & Co.	N6 -[(2-Hydroxypropyl)aryl]adenosines
US4514405A (en) *	1981-09-17	1985-04-30	Merck Patent Gesellschaft Mit Beschrankter Haftung	Use of adenosine derivatives as anticonvulsants
EP0300144A3 (en) *	1984-04-18	1989-09-27	Whitby Research Incorporated	N-6 alkyl substituted adenosine derivatives as cardiac vasodilators
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
DE3529497A1 (de) *	1985-08-17	1987-02-26	Boehringer Mannheim Gmbh	N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3712735A1 (de) *	1987-04-15	1988-11-10	Boehringer Mannheim Gmbh	Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel
KR910700253A (ko) *	1989-01-31	1991-03-14	로버트 제이, 바란	N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질

1990
- 1990-03-23 ZA ZA902280A patent/ZA902280B/xx unknown
- 1990-03-26 IL IL9389290A patent/IL93892A/en not_active IP Right Cessation
- 1990-03-26 AU AU52215/90A patent/AU630439B2/en not_active Ceased
- 1990-03-26 NZ NZ233078A patent/NZ233078A/en unknown
- 1990-03-27 HU HU901856A patent/HU206354B/hu not_active IP Right Cessation
- 1990-03-28 DK DK90105920T patent/DK0390112T3/da active
- 1990-03-28 EP EP90105920A patent/EP0390112B1/en not_active Expired - Lifetime
- 1990-03-28 AT AT90105920T patent/ATE162791T1/de not_active IP Right Cessation
- 1990-03-28 DE DE69031989T patent/DE69031989T2/de not_active Expired - Fee Related
- 1990-03-28 FI FI901549A patent/FI95910C/fi not_active IP Right Cessation
- 1990-03-28 KR KR1019900004159A patent/KR0168647B1/ko not_active Expired - Fee Related
- 1990-03-28 ES ES90105920T patent/ES2114524T3/es not_active Expired - Lifetime
- 1990-03-28 PT PT93588A patent/PT93588B/pt not_active IP Right Cessation
- 1990-03-28 NO NO901423A patent/NO173996C/no not_active IP Right Cessation
- 1990-03-28 CN CN90101711A patent/CN1034575C/zh not_active Expired - Fee Related
- 1990-03-29 CA CA002013380A patent/CA2013380C/en not_active Expired - Fee Related
- 1990-03-29 JP JP2079072A patent/JP2954971B2/ja not_active Expired - Fee Related
1998
- 1998-02-18 GR GR980400348T patent/GR3026173T3/el unknown

Also Published As

Publication number	Publication date
CN1034575C (zh)	1997-04-16
GR3026173T3 (en)	1998-05-29
ZA902280B (en)	1990-12-28
JP2954971B2 (ja)	1999-09-27
NZ233078A (en)	1993-11-25
DE69031989D1 (de)	1998-03-05
AU5221590A (en)	1990-10-04
EP0390112A2 (en)	1990-10-03
FI95910B (fi)	1995-12-29
CA2013380A1 (en)	1990-09-29
CN1045973A (zh)	1990-10-10
DE69031989T2 (de)	1998-09-03
FI95910C (fi)	1996-04-10
CA2013380C (en)	2001-05-22
NO173996B (no)	1993-11-22
AU630439B2 (en)	1992-10-29
IL93892A (en)	1994-11-28
HUT53648A (en)	1990-11-28
ATE162791T1 (de)	1998-02-15
JPH02289570A (ja)	1990-11-29
ES2114524T3 (es)	1998-06-01
KR0168647B1 (ko)	1999-01-15
FI901549A0 (fi)	1990-03-28
NO173996C (no)	1994-03-02
KR900014389A (ko)	1990-10-23
PT93588A (pt)	1990-11-20
HU901856D0 (en)	1990-08-28
EP0390112A3 (en)	1992-02-12
HU206354B (en)	1992-10-28
EP0390112B1 (en)	1998-01-28
PT93588B (pt)	1996-08-30
DK0390112T3 (da)	1998-09-23
NO901423D0 (no)	1990-03-28

Legal Events

Date	Code	Title	Description
2003-10-27	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN SEPTEMBER 2003

Publication	Publication Date	Title
NO901423D0 (no)	1990-03-28	Fremgangsmaate for fremstilling av selektive adenosinreseptormidler.
ES2007411A6 (es)	1989-06-16	Procedimiento de preparar nuevos agentes psicoestimulantes.
CA2038747A1 (en)	1991-09-27	Selective adenosine receptor agents
KR860008973A (ko)	1986-12-19	2-피롤리돈 유도체
ATE71092T1 (de)	1992-01-15	Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
EP0390111A3 (en)	1991-05-08	Selective adenosine receptor compounds
ES2008067T3 (es)	1994-11-16	Analogos de prostaciclina (pgi2).
EP0882734A3 (en)	2004-08-25	5'-Deoxy-cytidine derivatives
GB2152508A (en)	1985-08-07	Pyrimidine derivatives
KR950703572A (ko)	1995-09-20	A-2 수용체 친화성을 갖는 2-치환된 아데노신[2-Substituted adenosines with A-2receptor affinity]
ES2032386T3 (es)	1993-02-16	Un procedimiento para la preparacion de un derivado de glucopiranosa.
ES2061544T3 (es)	1994-12-16	Nuevos derivados de glucopiranosa.
ES555671A0 (es)	1987-07-16	Un procedimiento para preparar un derivado de ergolina