NO901985L - Salter av azelastin med forbedret opploeselighet. - Google Patents

Salter av azelastin med forbedret opploeselighet.

Info

Publication number: NO901985L
Authority: NO; Norway
Prior art keywords: salts; improved solubility; azelastin; azelastine; acid
Prior art date: 1989-05-05

Application number

NO90901985A

Other languages

English (en)

Norwegian (no)

Other versions

NO901985D0 (no

Inventor

Helmut Hettche

Reinhard Muckenschnabel

Gerhard Scheffler

Ilona Fleischhauer

Wolfgang Morick

Original Assignee

Asta Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-05

Filing date

1990-05-04

Publication date

1990-11-06

1990-05-04 Application filed by Asta Pharma Ag filed Critical Asta Pharma Ag

1990-05-04 Publication of NO901985D0 publication Critical patent/NO901985D0/no

1990-11-06 Publication of NO901985L publication Critical patent/NO901985L/no

Links

QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical class C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 abstract 3
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 2
229960004574 azelastine Drugs 0.000 abstract 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
235000011054 acetic acid Nutrition 0.000 abstract 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
239000000174 gluconic acid Substances 0.000 abstract 1
235000012208 gluconic acid Nutrition 0.000 abstract 1
239000004310 lactic acid Substances 0.000 abstract 1
235000014655 lactic acid Nutrition 0.000 abstract 1
239000001630 malic acid Substances 0.000 abstract 1
235000011090 malic acid Nutrition 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO90901985A 1989-05-05 1990-05-04 Salter av azelastin med forbedret opploeselighet. NO901985L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3914859		1989-05-05

Publications (2)

Publication Number	Publication Date
NO901985D0 NO901985D0 (no)	1990-05-04
NO901985L true NO901985L (no)	1990-11-06

Family

ID=6380164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO90901985A NO901985L (no)	1989-05-05	1990-05-04	Salter av azelastin med forbedret opploeselighet.

Country Status (17)

Country	Link
US (4)	US5086050A (fr)
EP (1)	EP0396069B1 (fr)
JP (1)	JPH02295987A (fr)
AT (1)	ATE107643T1 (fr)
AU (1)	AU622022B2 (fr)
CA (1)	CA2016089C (fr)
DD (1)	DD294254A5 (fr)
DE (2)	DE59006184D1 (fr)
DK (1)	DK0396069T3 (fr)
ES (1)	ES2055216T3 (fr)
FI (1)	FI902244A7 (fr)
HU (1)	HU206110B (fr)
IE (1)	IE63662B1 (fr)
NO (1)	NO901985L (fr)
NZ (1)	NZ233546A (fr)
PT (1)	PT93946B (fr)
YU (1)	YU86390A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5271946A (en) *	1988-04-20	1993-12-21	Asta Pharma Aktiengesellschaft	Controlled release azelastine-containing pharmaceutical compositions
JPH04198180A (ja) *	1990-11-28	1992-07-17	Eezai Kagaku Kk	ベンジルフタラゾン誘導体の製造方法
US5296472A (en) *	1991-12-05	1994-03-22	Vyrex Corporation	Methods for delipidation of skin and cerumen removal
JP4138910B2 (ja)	1997-07-02	2008-08-27	帝國製薬株式会社	経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤
EP1032403B1 (fr) *	1997-10-24	2012-05-02	John P. Blass	Supplement nutritionnel pour personnes atteintes d'insuffisances du metabolisme cerebral
FI109332B (fi)	1998-12-17	2002-07-15	Orion Yhtymae Oyj	Toremifeenin liukoisia koostumuksia
FI982733L (fi)	1998-12-17	2000-06-18	Orion Yhtymae Oyj	Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
GB2389530B (en) *	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
US7694694B2 (en) *	2004-05-10	2010-04-13	The Aerospace Corporation	Phase-change valve apparatuses
US20070020330A1 (en) *	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
JP5607291B2 (ja) *	2004-11-24	2014-10-15	メダファーマシューティカルズインコーポレイテッド	アゼラスチンを含む組成物およびその使用方法
US8758816B2 (en) *	2004-11-24	2014-06-24	Meda Pharmaceuticals Inc.	Compositions comprising azelastine and methods of use thereof
HUE038800T2 (hu)	2011-04-13	2018-11-28	Codexis Inc	Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
US10966989B2 (en)	2019-04-12	2021-04-06	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders
US11938139B2 (en)	2019-04-12	2024-03-26	LA PharmaTech Inc.	Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders
US11389458B2 (en)	2019-04-12	2022-07-19	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treating parkinson's and huntington's disease
US11318144B2 (en)	2019-04-12	2022-05-03	LA PharmaTech Inc.	Compositions and methods for treating Alzheimer's disease and Parkinson's disease
US11690849B2 (en)	2019-04-12	2023-07-04	LA PharmaTech Inc.	Method of treating dementia
US10639314B1 (en)	2019-04-30	2020-05-05	LA PharmaTech Inc.	Method of treating Alzheimer's disease
US11744833B2 (en)	2019-04-12	2023-09-05	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treatment of insomnia
US10898493B2 (en)	2019-04-12	2021-01-26	LA PharmaTech Inc.	Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease
US11351179B1 (en)	2021-08-05	2022-06-07	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treatment of psychiatric disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH572914A5 (fr) *	1971-01-22	1976-02-27	Asta Werke Ag Chem Fab
US3813384A (en) *	1972-01-17	1974-05-28	Asta Werke Ag Chem Fab	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
EP0174464B1 (fr) *	1984-09-14	1990-01-03	ASTA Pharma AG	Benzyl-phtalazinones substitués
ES2031813T3 (es) *	1985-11-11	1993-01-01	Asta Pharma Ag	Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona.
JPH0667844B2 (ja) *	1987-03-06	1994-08-31	エーザイ株式会社	虚血性心疾患の治療・予防剤
EP0289939A1 (fr) *	1987-05-08	1988-11-09	ASTA Pharma AG	Dérivés du 4-benzyl-1-(2H)-phtalazinone avec un radical acide aminé
ATE106883T1 (de) *	1987-11-13	1994-06-15	Asta Medica Ag	Azelastin-embonat, verfahren zu seiner herstellung und pharmazeutische zubereitungen, die als wirkstoff azelastin-embonat enthalten.
US5232919A (en) *	1987-11-13	1993-08-03	Asta Pharma Aktiengesellschaft	Azelastine embonate and compositions which contain it
AU609210B2 (en) *	1987-11-13	1991-04-26	Viatris Gmbh & Co. Kg	Azelastine embonate, processes for its preparation and pharmaceutical formulations which contain azelastine embonate as active substance
JP2794021B2 (ja) *	1988-11-02	1998-09-03	エーザイ株式会社	アゼラスチン或いはその塩類含有経皮適用製剤

1990
- 1990-04-28 DK DK90108172.9T patent/DK0396069T3/da active
- 1990-04-28 DE DE59006184T patent/DE59006184D1/de not_active Expired - Lifetime
- 1990-04-28 DE DE4013696A patent/DE4013696A1/de not_active Withdrawn
- 1990-04-28 AT AT90108172T patent/ATE107643T1/de not_active IP Right Cessation
- 1990-04-28 ES ES90108172T patent/ES2055216T3/es not_active Expired - Lifetime
- 1990-04-28 EP EP90108172A patent/EP0396069B1/fr not_active Expired - Lifetime
- 1990-05-03 NZ NZ233546A patent/NZ233546A/xx unknown
- 1990-05-03 PT PT93946A patent/PT93946B/pt not_active IP Right Cessation
- 1990-05-04 NO NO90901985A patent/NO901985L/no unknown
- 1990-05-04 HU HU902678A patent/HU206110B/hu unknown
- 1990-05-04 AU AU54736/90A patent/AU622022B2/en not_active Ceased
- 1990-05-04 YU YU00863/90A patent/YU86390A/xx unknown
- 1990-05-04 IE IE163990A patent/IE63662B1/en not_active IP Right Cessation
- 1990-05-04 DD DD90340395A patent/DD294254A5/de not_active IP Right Cessation
- 1990-05-04 CA CA002016089A patent/CA2016089C/fr not_active Expired - Lifetime
- 1990-05-04 FI FI902244A patent/FI902244A7/fi not_active IP Right Cessation
- 1990-05-07 JP JP2115947A patent/JPH02295987A/ja active Pending
1991
- 1991-02-08 US US07/652,986 patent/US5086050A/en not_active Expired - Lifetime
1996
- 1996-08-02 US US08/691,415 patent/US5859003A/en not_active Expired - Lifetime
1998
- 1998-07-28 US US09/123,431 patent/US5998403A/en not_active Expired - Fee Related
- 1998-08-20 US US09/136,971 patent/US6017909A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DD294254A5 (de)	1991-09-26
IE63662B1 (en)	1995-05-31
CA2016089C (fr)	1998-12-01
YU86390A (en)	1992-05-28
EP0396069A1 (fr)	1990-11-07
US5998403A (en)	1999-12-07
US6017909A (en)	2000-01-25
JPH02295987A (ja)	1990-12-06
ATE107643T1 (de)	1994-07-15
HUT53901A (en)	1990-12-28
DE59006184D1 (de)	1994-07-28
DE4013696A1 (de)	1990-11-08
ES2055216T3 (es)	1994-08-16
CA2016089A1 (fr)	1990-11-05
AU622022B2 (en)	1992-03-26
PT93946A (pt)	1991-01-08
AU5473690A (en)	1990-11-08
US5086050A (en)	1992-02-04
FI902244A0 (fi)	1990-05-04
NO901985D0 (no)	1990-05-04
HU902678D0 (en)	1990-09-28
HU206110B (en)	1992-08-28
PT93946B (pt)	1996-11-29
EP0396069B1 (fr)	1994-06-22
US5859003A (en)	1999-01-12
IE901639L (en)	1990-11-05
NZ233546A (en)	1991-09-25
DK0396069T3 (da)	1994-07-25
FI902244A7 (fi)	1990-11-06

Publication	Publication Date	Title
NO901985L (no)	1990-11-06	Salter av azelastin med forbedret opploeselighet.
ES8603455A1 (es)	1985-12-16	Un metodo para preparar derivados de piperazina
TW357146B (en)	1999-05-01	Tetrahydrofuran antifungals
DE69120500D1 (de)	1996-08-01	Azasteroide zur Behandlung prostatischer Hypertrophie, ihre Herstellung und Verwendung
BR0014651A (pt)	2002-06-18	Inibidores de adesão de célula mediada por "alfa" l beta2
MXPA04007068A (es)	2004-11-01	Derivados de almidon, conjugados de almidon con sustancia activa, metodo para su produccion y su uso como medicamentos.
NO20014240L (no)	2001-11-02	C16-umettede FP-selektive prostaglandinanaloger
BR9302029A (pt)	1993-11-30	Metodo para produzir uma composicao,metodo para produzir uma solucao aquosa,composicao,e,processo para retardar o crescimento microbial
ES2152097T3 (es)	2001-01-16	Empleo de esteres de acidos hidroxicarboxilicos como espesantes.
NO20010552L (no)	2001-02-01	FremgangsmÕte for fremstilling av zofenopril kalsiumsalt
KR100214903B1 (en)	1999-08-02	Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids
PT1054869E (pt)	2005-02-28	Derivados de 3,4-di-hidroquinolina como inibidores de sintases dommonoxido de azoto (nos)
DE60104103D1 (de)	2004-08-05	Verfahren zur herstellung von hochkristallinem natrium cefoperazon
SE9903345D0 (sv)	1999-09-17	Novel process
NO953992L (no)	1995-10-06	Fremgangsmåte for fremstilling av aminometanfosforsyre
NZ514573A (en)	2003-02-28	Beta-hydroxyalkylamides, process for their production and their use
FI920351A0 (fi)	1992-01-27	Foerfarande foer minskning av slembildning i anlaeggningar med vattencirkulationssystem.
DK0564770T3 (da)	1997-03-17	Diacetylproduktion
WO2003044038A3 (fr)	2004-03-18	Complexe bioactif
PT1711479E (pt)	2008-05-07	Processo para a produção de bis-anidrido de dtpa
PE20020895A1 (es)	2002-11-25	DERIVADOS DE CALOPOROSIDOS COMO INHIBIDORES DE LAS CINASAS DEPENDIENTES DE CICLINA CDK´s
FI923009A0 (fi)	1992-06-29	Koncentrerade vattenloesliga organiska lantanidsalter.
ES8504171A1 (es)	1985-04-16	Procedimiento para la preparacion de los -cetoglutaratos del 14,15-dihidro-17,18-dehidro-14 nb-hidroxi-(3 ,16 )-eburnamenina-14-carboxilato de metilo y del 14,15-dihidro-14 nb-hidroxi-(3 ,16 )-eburnamenina-14-carboxilato de metilo