NO902720L - Fremstilling og anvendelse av plasmider for isolering av en plasminogenaktivator. - Google Patents

Fremstilling og anvendelse av plasmider for isolering av en plasminogenaktivator.

Info

Publication number: NO902720L
Authority: NO; Norway
Prior art keywords: plasmids; rscu; protein; synthetic; preparation
Prior art date: 1989-07-19

Application number

NO90902720A

Other languages

English (en)

Other versions

NO304952B1 (no

NO902720D0 (no

Inventor

Regina E Brigelius-Flohe

Leopold Flohe

Wolfgang Hillen

Gerd J Steffens

Wolfgang Strassburger

Martin R F Wilhelm

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-19

Filing date

1990-06-19

Publication date

1991-01-21

1990-06-19 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

1990-06-19 Publication of NO902720D0 publication Critical patent/NO902720D0/no

1991-01-21 Publication of NO902720L publication Critical patent/NO902720L/no

1999-03-08 Publication of NO304952B1 publication Critical patent/NO304952B1/no

Links

239000013612 plasmid Substances 0.000 title abstract 6
108010001014 Plasminogen Activators Proteins 0.000 title abstract 2
102000001938 Plasminogen Activators Human genes 0.000 title abstract 2
229940127126 plasminogen activator Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
238000002955 isolation Methods 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 5
102000004169 proteins and genes Human genes 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
241000588921 Enterobacteriaceae Species 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
108091081024 Start codon Proteins 0.000 abstract 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
108010073863 saruplase Proteins 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

NO902720A 1989-07-19 1990-06-19 Plasmider for anvendelse ved fremstilling av en plasminogenaktivator og anvendelse av plasmidet NO304952B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3923866		1989-07-19

Publications (3)

Publication Number	Publication Date
NO902720D0 NO902720D0 (no)	1990-06-19
NO902720L true NO902720L (no)	1991-01-21
NO304952B1 NO304952B1 (no)	1999-03-08

Family

ID=6385369

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO902720A NO304952B1 (no)	1989-07-19	1990-06-19	Plasmider for anvendelse ved fremstilling av en plasminogenaktivator og anvendelse av plasmidet

Country Status (29)

Country	Link
US (1)	US5637503A (no)
EP (1)	EP0408945B1 (no)
JP (1)	JP3236284B2 (no)
KR (1)	KR0167761B1 (no)
AT (1)	ATE131534T1 (no)
AU (1)	AU631662B2 (no)
CA (1)	CA2020656C (no)
DD (1)	DD298426A5 (no)
DE (2)	DE4020438A1 (no)
DK (1)	DK0408945T3 (no)
ES (1)	ES2083399T3 (no)
FI (1)	FI102386B (no)
GR (1)	GR3019294T3 (no)
HR (1)	HRP920596B1 (no)
HU (1)	HU214243B (no)
IE (1)	IE901849A1 (no)
IL (1)	IL94529A (no)
LT (1)	LT3611B (no)
LV (1)	LV10120B (no)
MT (1)	MTP1063B (no)
NO (1)	NO304952B1 (no)
NZ (1)	NZ234542A (no)
PL (1)	PL166199B1 (no)
PT (1)	PT94776B (no)
RU (1)	RU2073720C1 (no)
SI (1)	SI9011347B (no)
SK (1)	SK280028B6 (no)
YU (1)	YU48371B (no)
ZA (1)	ZA904006B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2067226A1 (no) *	1969-11-27	1971-08-20	Cefilac
DE4101736A1 (de) *	1991-01-22	1992-07-23	Gruenenthal Gmbh	Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) *	1994-11-17	1996-05-23	Gruenenthal Gmbh	Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
DE4442665A1 (de) *	1994-11-30	1996-06-05	Gruenenthal Gmbh	Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften
KR100467034B1 (ko) *	1996-12-27	2006-04-07	주식회사 엘지생활건강	압축성형타입오일케익화장료및그의제조방법
KR100372233B1 (ko) *	1997-03-12	2003-06-11	주식회사 코리아나화장품	미백 파우더, 그의 제조방법 및 그를 함유하는 메이크업 미백 화장료
RU2140453C1 (ru) *	1999-04-06	1999-10-27	Общество с ограниченной ответственностью Научно-производственное предприятие "Техноген"	Рекомбинантная плазмидная днк p ua bc22, кодирующая модифицированный активатор плазминогена урокиназного типа, нетранслируемый днк-элемент - искусственная межгенная последовательность мгп14 и штамм бактерий escherichia coli - продуцент модифицированного активатора плазминогена урокиназного типа
KR100341638B1 (ko) *	2000-03-17	2002-06-22	유상옥,송운한	기능성 표면처리 분체의 제조 방법 및 이를 함유하는메이크업 화장료 조성물
JP4124639B2 (ja)	2002-12-17	2008-07-23	株式会社日本触媒	大腸菌を用いたｓ−ヒドロキシニトリルリアーゼの製造方法
US7906276B2 (en) *	2004-06-30	2011-03-15	Kimberly-Clark Worldwide, Inc.	Enzymatic detection techniques
AU2007352618B2 (en)	2007-05-02	2013-07-18	Boehringer Ingelheim Animal Health USA Inc.	DNA plasmids having improved expression and stability
RU2553533C2 (ru) *	2013-10-23	2015-06-20	Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум")	Способ выделения и очистки рекомбинантной человеческой проурокиназы м5
CN104555732A (zh) *	2015-01-18	2015-04-29	河南省中原起重机械总厂	一种多功能门式起重机

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4558010A (en) *	1980-04-03	1985-12-10	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom
US4370417A (en) *	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
GR78180B (no) *	1982-04-15	1984-09-26	Genentech Inc
US4710464A (en) *	1984-09-27	1987-12-01	Eli Lilly And Company	Transcription terminators
EP0210279B1 (en) *	1985-01-25	1991-08-14	Sagami Chemical Research Center	Stabilized human prourokinase
FR2594845B1 (fr) *	1986-02-21	1989-12-01	Genetica	Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
FI100106B (fi) *	1986-12-05	1997-09-30	Novartis Ag	Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
EP0303028A1 (en) *	1987-08-10	1989-02-15	GRUPPO LEPETIT S.p.A.	Method for preparing single chain urokinase
JP2970811B2 (ja) *	1987-10-30	1999-11-02	オンコゲンアリミテッドパートナーシップ	原核生物細胞中にポリペプチドを調製するための発現システム

1990
- 1990-05-22 IE IE184990A patent/IE901849A1/en not_active Application Discontinuation
- 1990-05-23 ZA ZA904006A patent/ZA904006B/xx unknown
- 1990-05-28 IL IL94529A patent/IL94529A/xx not_active IP Right Cessation
- 1990-06-19 NO NO902720A patent/NO304952B1/no not_active IP Right Cessation
- 1990-06-20 SK SK3067-90A patent/SK280028B6/sk unknown
- 1990-06-25 HU HU903970A patent/HU214243B/hu not_active IP Right Cessation
- 1990-06-27 DE DE4020438A patent/DE4020438A1/de not_active Withdrawn
- 1990-06-28 MT MT1063A patent/MTP1063B/xx unknown
- 1990-06-29 DK DK90112400.8T patent/DK0408945T3/da active
- 1990-06-29 AT AT90112400T patent/ATE131534T1/de not_active IP Right Cessation
- 1990-06-29 EP EP90112400A patent/EP0408945B1/de not_active Expired - Lifetime
- 1990-06-29 DE DE59009961T patent/DE59009961D1/de not_active Expired - Fee Related
- 1990-06-29 ES ES90112400T patent/ES2083399T3/es not_active Expired - Lifetime
- 1990-07-06 CA CA002020656A patent/CA2020656C/en not_active Expired - Fee Related
- 1990-07-09 AU AU58832/90A patent/AU631662B2/en not_active Ceased
- 1990-07-11 SI SI9011347A patent/SI9011347B/sl unknown
- 1990-07-11 YU YU134790A patent/YU48371B/sh unknown
- 1990-07-12 US US07/551,907 patent/US5637503A/en not_active Expired - Fee Related
- 1990-07-17 PL PL90286087A patent/PL166199B1/pl unknown
- 1990-07-17 NZ NZ234542A patent/NZ234542A/xx unknown
- 1990-07-18 KR KR1019900010860A patent/KR0167761B1/ko not_active Expired - Fee Related
- 1990-07-18 JP JP18816990A patent/JP3236284B2/ja not_active Expired - Fee Related
- 1990-07-18 RU SU4831114/13A patent/RU2073720C1/ru not_active IP Right Cessation
- 1990-07-18 DD DD90342894A patent/DD298426A5/de not_active IP Right Cessation
- 1990-07-18 FI FI903640A patent/FI102386B/fi not_active IP Right Cessation
- 1990-07-19 PT PT94776A patent/PT94776B/pt not_active IP Right Cessation
1992
- 1992-09-29 HR HRP-1347/90A patent/HRP920596B1/xx not_active IP Right Cessation
- 1992-11-13 LV LVP-92-204A patent/LV10120B/lv unknown
1993
- 1993-07-12 LT LTIP776A patent/LT3611B/lt not_active IP Right Cessation
1996
- 1996-03-13 GR GR960400698T patent/GR3019294T3/el unknown

Also Published As

Publication number	Publication date
US5637503A (en)	1997-06-10
YU48371B (sh)	1998-07-10
HK1005193A1 (en)	1998-12-24
IL94529A (en)	1997-11-20
GR3019294T3 (en)	1996-06-30
CA2020656A1 (en)	1991-01-20
ATE131534T1 (de)	1995-12-15
IL94529A0 (en)	1991-03-10
JPH0365189A (ja)	1991-03-20
IE901849A1 (en)	1991-06-19
NZ234542A (en)	1991-09-25
KR910003105A (ko)	1991-02-26
LV10120B (en)	1994-10-20
NO304952B1 (no)	1999-03-08
NO902720D0 (no)	1990-06-19
DE59009961D1 (de)	1996-01-25
FI102386B1 (fi)	1998-11-30
HRP920596B1 (en)	1999-12-31
AU631662B2 (en)	1992-12-03
ES2083399T3 (es)	1996-04-16
LTIP776A (en)	1995-01-31
ZA904006B (en)	1991-03-27
LV10120A (lv)	1994-05-10
PT94776B (pt)	1997-09-30
SI9011347B (sl)	1999-02-28
KR0167761B1 (ko)	1999-01-15
MTP1063B (en)	1991-04-08
HU214243B (hu)	1998-03-02
SK306790A3 (en)	1999-07-12
RU2073720C1 (ru)	1997-02-20
DK0408945T3 (da)	1996-04-09
EP0408945A1 (de)	1991-01-23
PT94776A (pt)	1991-03-20
SI9011347A (sl)	1998-04-30
DE4020438A1 (de)	1991-01-31
EP0408945B1 (de)	1995-12-13
SK280028B6 (sk)	1999-07-12
HRP920596A2 (en)	1998-06-30
HU903970D0 (en)	1990-11-28
LT3611B (en)	1995-12-27
FI903640A0 (fi)	1990-07-18
CA2020656C (en)	2001-05-22
JP3236284B2 (ja)	2001-12-10
PL286087A1 (en)	1991-03-11
YU134790A (sh)	1992-12-21
HUT54211A (en)	1991-01-28
AU5883290A (en)	1991-01-24
FI102386B (fi)	1998-11-30
DD298426A5 (de)	1992-02-20
PL166199B1 (pl)	1995-04-28

Legal Events

Date	Code	Title	Description
2005-04-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO902720D0 (no)	1990-06-19	Fremstilling og anvendelse av plasmider for isolering av en plasminogenaktivator.
DK348986D0 (da)	1986-07-22	Fremgangsmaade til forstaerkning af ekspressionen af rekombinant dna-produkter
DE3686217D1 (de)	1992-09-03	Alkalische protease, verfahren zur herstellung von hybridvektoren und genetisch transformierte mikroorganismen.
US6171823B1 (en)	2001-01-09	Process for producing extracellular proteins in bacteria
WO2002040696A2 (en)	2002-05-23	Methods for large scale protein production in prokaryotes
Lin-Fa et al.	1989	Synthesis and refolding of human tissue-type plasminogen activator in Bacillus subtilis
Remaut et al.	1989	Expression of heterologous unfused protein in Escherichia coli
Petri et al.	1992	Novel plasminogen activators from the vampire bat Desmodus rotundus
PL206783B1 (pl)	2010-09-30	Sposób wytwarzania rekombinowanego tkankowego aktywatora plazminogenu tPA lub cząsteczki K2S, cząsteczka DNA, białka fuzyjne, wektor, komórka gospodarza i ich zastosowanie
Manosroi et al.	2002	Lekteplase—a Secreted Tissue Plasminogen Activator Derivative from Escherichia coli