NO902862L - Heteroarylamino- og heteroaryloksypyridinaminer og beslektede forbindelser og fremgangsmaate for fremstilling derav. - Google Patents
Heteroarylamino- og heteroaryloksypyridinaminer og beslektede forbindelser og fremgangsmaate for fremstilling derav.Info
- Publication number
- NO902862L NO902862L NO90902862A NO902862A NO902862L NO 902862 L NO902862 L NO 902862L NO 90902862 A NO90902862 A NO 90902862A NO 902862 A NO902862 A NO 902862A NO 902862 L NO902862 L NO 902862L
- Authority
- NO
- Norway
- Prior art keywords
- loweralkyl
- hydrogen
- heteroaryloxypyridinamines
- heteroarylamino
- procedures
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Tires In General (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/372,509 US4970219A (en) | 1989-06-28 | 1989-06-28 | Heteroarylamino- and heteroaryloxypyridinamine compounds which have useful utility in treating skin disorders |
| US07/496,723 US4983615A (en) | 1989-06-28 | 1990-03-21 | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO902862D0 NO902862D0 (no) | 1990-06-27 |
| NO902862L true NO902862L (no) | 1991-01-02 |
Family
ID=27005797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO90902862A NO902862L (no) | 1989-06-28 | 1990-06-27 | Heteroarylamino- og heteroaryloksypyridinaminer og beslektede forbindelser og fremgangsmaate for fremstilling derav. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4983615A (de) |
| EP (1) | EP0405425B1 (de) |
| JP (1) | JPH0776212B2 (de) |
| KR (1) | KR0162644B1 (de) |
| AT (1) | ATE169622T1 (de) |
| AU (1) | AU634553B2 (de) |
| CA (1) | CA2019957C (de) |
| DE (1) | DE69032550T2 (de) |
| DK (1) | DK0405425T3 (de) |
| ES (1) | ES2120404T3 (de) |
| FI (1) | FI903215A7 (de) |
| IE (1) | IE902329A1 (de) |
| IL (1) | IL94877A (de) |
| NO (1) | NO902862L (de) |
| NZ (1) | NZ234249A (de) |
| PT (1) | PT94503B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| DK0415103T3 (da) * | 1989-08-02 | 1995-06-19 | Hoechst Roussel Pharma | 2,3-Dihydro-1-(pyridinylamino)-indoler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler |
| US5037835A (en) * | 1989-10-24 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals Inc. | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| CA2124206C (en) * | 1991-11-25 | 2001-02-27 | John Eugene Macor | Indole derivatives |
| US6756367B2 (en) | 1998-02-03 | 2004-06-29 | Novartis Ag | Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them |
| US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
| DE10006139A1 (de) * | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
| WO2002016348A1 (en) * | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| KR100600550B1 (ko) | 2000-10-20 | 2006-07-13 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
| JP2003233264A (ja) * | 2002-02-12 | 2003-08-22 | Canon Inc | 定着装置 |
| EP1604665B1 (de) | 2003-03-10 | 2011-05-11 | Eisai R&D Management Co., Ltd. | C-kit kinase-hemmer |
| JP4303726B2 (ja) | 2003-11-11 | 2009-07-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア誘導体およびその製造方法 |
| JP2005242333A (ja) * | 2004-01-30 | 2005-09-08 | Canon Inc | 可撓性スリーブを有する像加熱装置 |
| JP4594125B2 (ja) | 2004-02-20 | 2010-12-08 | キヤノン株式会社 | 画像定着装置 |
| JP2005316443A (ja) * | 2004-03-30 | 2005-11-10 | Canon Inc | 像加熱装置及びこの装置に用いられる搬送ローラ |
| JP4280664B2 (ja) * | 2004-03-31 | 2009-06-17 | キヤノン株式会社 | 像加熱装置 |
| US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| CN104706637A (zh) | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
| JP5368096B2 (ja) | 2006-08-28 | 2013-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 未分化型胃癌に対する抗腫瘍剤 |
| WO2008093855A1 (ja) | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
| CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| CA2771403C (en) | 2009-08-19 | 2015-02-24 | Eisai R&D Management Co. Ltd. | Quinoline derivative-containing pharmaceutical composition |
| CN102958523B (zh) | 2010-06-25 | 2014-11-19 | 卫材R&D管理有限公司 | 使用具有激酶抑制作用的组合的抗肿瘤剂 |
| AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| JP6038128B2 (ja) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー |
| JPWO2014098176A1 (ja) | 2012-12-21 | 2017-01-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体のアモルファス及びその製造方法 |
| CA2912219C (en) | 2013-05-14 | 2021-11-16 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| EP3187491A4 (de) | 2014-08-28 | 2018-08-01 | Eisai R&D Management Co., Ltd. | Hochreines chinolinderivat und verfahren zur herstellung davon |
| US20180028662A1 (en) | 2015-02-25 | 2018-02-01 | Eisai R&D Management Co., Ltd. | Method for Suppressing Bitterness of Quinoline Derivative |
| KR20240064733A (ko) | 2015-03-04 | 2024-05-13 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| CA2988707C (en) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer |
| CN108135894B (zh) | 2015-08-20 | 2021-02-19 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
| CN110072528B (zh) | 2017-02-08 | 2022-04-26 | 卫材R&D管理有限公司 | 治疗肿瘤的药物组合物 |
| WO2018212202A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3118884A (en) * | 1959-10-19 | 1964-01-21 | Schering Corp | Derivatives of 3-azaphenothiazine and 3-azaphenoxazine |
| US3495969A (en) * | 1967-09-25 | 1970-02-17 | Mobil Oil Corp | Substituted nitropyridines as herbicides |
| AT294090B (de) * | 1969-04-22 | 1971-11-10 | Degussa | Verfahren zur Herstellung von neuen Aminopyridinen, von deren optisch aktiven bzw. diastereomeren Formen, deren Salzen und deren quartären Verbindungen |
| US3576616A (en) * | 1969-05-15 | 1971-04-27 | Monsanto Co | Herbicidal compositions and methods |
| US3721676A (en) * | 1969-11-12 | 1973-03-20 | Merck & Co Inc | Certain 3-amino-2(1h)pyridones |
| SE422799B (sv) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner |
| GB2073736B (en) * | 1979-10-03 | 1984-02-01 | Ici Ltd | Process for preparing pyridinyloxyphenoxy compounds and derivatives thereof |
| IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
| DE3608089A1 (de) * | 1986-03-08 | 1987-09-10 | Schering Ag | Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE3852335T2 (de) * | 1987-04-24 | 1995-05-11 | Hoechst Roussel Pharma | N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel. |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
-
1990
- 1990-03-21 US US07/496,723 patent/US4983615A/en not_active Expired - Fee Related
- 1990-06-26 FI FI903215A patent/FI903215A7/fi not_active Application Discontinuation
- 1990-06-26 DE DE69032550T patent/DE69032550T2/de not_active Expired - Fee Related
- 1990-06-26 AT AT90112086T patent/ATE169622T1/de not_active IP Right Cessation
- 1990-06-26 DK DK90112086T patent/DK0405425T3/da active
- 1990-06-26 EP EP90112086A patent/EP0405425B1/de not_active Expired - Lifetime
- 1990-06-26 IL IL9487790A patent/IL94877A/en not_active IP Right Cessation
- 1990-06-26 ES ES90112086T patent/ES2120404T3/es not_active Expired - Lifetime
- 1990-06-26 KR KR1019900009442A patent/KR0162644B1/ko not_active Expired - Fee Related
- 1990-06-26 NZ NZ234249A patent/NZ234249A/xx unknown
- 1990-06-27 CA CA002019957A patent/CA2019957C/en not_active Expired - Fee Related
- 1990-06-27 JP JP2166945A patent/JPH0776212B2/ja not_active Expired - Lifetime
- 1990-06-27 NO NO90902862A patent/NO902862L/no unknown
- 1990-06-27 PT PT94503A patent/PT94503B/pt not_active IP Right Cessation
- 1990-06-27 IE IE232990A patent/IE902329A1/en not_active IP Right Cessation
- 1990-06-27 AU AU57846/90A patent/AU634553B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2120404T3 (es) | 1998-11-01 |
| EP0405425A2 (de) | 1991-01-02 |
| EP0405425A3 (en) | 1992-09-09 |
| FI903215A7 (fi) | 1990-12-29 |
| KR0162644B1 (ko) | 1998-12-01 |
| FI903215A0 (fi) | 1990-06-26 |
| DE69032550T2 (de) | 1999-02-18 |
| NO902862D0 (no) | 1990-06-27 |
| JPH0776212B2 (ja) | 1995-08-16 |
| DE69032550D1 (de) | 1998-09-17 |
| AU5784690A (en) | 1991-01-03 |
| IE902329L (en) | 1990-12-28 |
| IL94877A (en) | 1995-05-26 |
| DK0405425T3 (da) | 1999-05-17 |
| PT94503A (pt) | 1991-02-08 |
| ATE169622T1 (de) | 1998-08-15 |
| JPH03115263A (ja) | 1991-05-16 |
| PT94503B (pt) | 1997-02-28 |
| IE902329A1 (en) | 1991-01-16 |
| US4983615A (en) | 1991-01-08 |
| EP0405425B1 (de) | 1998-08-12 |
| AU634553B2 (en) | 1993-02-25 |
| CA2019957C (en) | 2001-06-12 |
| KR910000707A (ko) | 1991-01-30 |
| NZ234249A (en) | 1993-08-26 |
| CA2019957A1 (en) | 1990-12-28 |
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