NO903704L - Nye derivater av deoksy-2'-uridin substituert i 5-, 3' eller 5'-posisjon med alfa-aminoacyl-grupper, samt fremgangsmaate for fremstilling av slike forbindelser, og medikamenter som inneholder dem. - Google Patents

Nye derivater av deoksy-2'-uridin substituert i 5-, 3' eller 5'-posisjon med alfa-aminoacyl-grupper, samt fremgangsmaate for fremstilling av slike forbindelser, og medikamenter som inneholder dem.

Info

Publication number: NO903704L
Authority: NO; Norway
Prior art keywords: radical; pct; preparation; alfa; deoxy
Prior art date: 1988-02-24

Application number

NO90903704A

Other languages

English (en)

Other versions

NO173507C (no

NO173507B (no

NO903704D0 (no

Inventor

Jean-Luc Moriniere

Michelle Faulques

Claude Rousseau

Bernard Danree

Claude Marquer

Patrick Saur

Jean Lemoine

Jean-Yves Lacolle

Original Assignee

Inst Rech Chim Biolog

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-24

Filing date

1990-08-23

Publication date

1990-10-24

1988-02-24 Priority claimed from FR8802255A external-priority patent/FR2627492B1/fr

1988-06-28 Priority claimed from FR8808684A external-priority patent/FR2633294B1/fr

1990-08-23 Application filed by Inst Rech Chim Biolog filed Critical Inst Rech Chim Biolog

1990-08-23 Publication of NO903704D0 publication Critical patent/NO903704D0/no

1990-10-24 Publication of NO903704L publication Critical patent/NO903704L/no

1993-09-13 Publication of NO173507B publication Critical patent/NO173507B/no

1993-12-22 Publication of NO173507C publication Critical patent/NO173507C/no

Links

239000003814 drug Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
229940045145 uridine Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000005840 aryl radicals Chemical class 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
-1 alkenyl radical Chemical class 0.000 abstract 1
125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
108090000765 processed proteins & peptides Chemical group 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

NO903704A 1988-02-24 1990-08-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive derivater av deoksy-2'.uridin substituert i 5-, 3. eller 5.-posisjon med alpha-aminoacylgrupper NO173507C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR8802255A FR2627492B1 (fr)	1988-02-24	1988-02-24	Nouveaux derives de l'amino-5(prime)-dideoxy-2(prime)-5(prime)-uridine, procede pour les preparer et compositions pharmaceutiques contenant ces composes
FR8808684A FR2633294B1 (fr)	1988-06-28	1988-06-28	Nouveaux derives de l'amino-3(prime)-dideoxy-2(prime)-3(prime)-uridine, procede pour les preparer et compositions pharmaceutiques contenant ces composes
PCT/FR1989/000072 WO1989008115A1 (fr)	1988-02-24	1989-02-23	NOUVEAUX DERIVES DE LA DEOXY-2'-URIDINE SUBSTITUEE EN POSITION 5, 3' ou 5' PAR DES GROUPEMENTS alpha-AMINO ACYLES, PROCEDE POUR LEUR OBTENTION ET MEDICAMENTS LES CONTENANT

Publications (4)

Publication Number	Publication Date
NO903704D0 NO903704D0 (no)	1990-08-23
NO903704L true NO903704L (no)	1990-10-24
NO173507B NO173507B (no)	1993-09-13
NO173507C NO173507C (no)	1993-12-22

Family

ID=26226515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903704A NO173507C (no)	1988-02-24	1990-08-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive derivater av deoksy-2'.uridin substituert i 5-, 3. eller 5.-posisjon med alpha-aminoacylgrupper

Country Status (11)

Country	Link
US (1)	US5212161A (no)
EP (1)	EP0448550B1 (no)
JP (1)	JPH03504492A (no)
AT (1)	ATE109789T1 (no)
AU (1)	AU631119B2 (no)
DE (1)	DE68917479D1 (no)
DK (1)	DK200290A (no)
FI (1)	FI92324C (no)
NO (1)	NO173507C (no)
OA (1)	OA09306A (no)
WO (1)	WO1989008115A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5306722A (en) *	1992-09-02	1994-04-26	Bristol-Myers Squibb Company	Thymidine derivatives and therapeutic method of use
RU2111970C1 (ru) *	1996-06-25	1998-05-27	Иван Игоревич Федоров	3'-оксимино-2',3'-дидезоксинуклеозиды
EP1240922B1 (en) *	1997-08-08	2008-11-12	Celmed Oncology (USA), Inc.	Methods and compositions for overcoming resistance to biologic and chemotherapy
ATE413881T1 (de)	1997-08-08	2008-11-15	Celmed Oncology Usa Inc	Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
ES2172303T3 (es) *	1998-01-23	2002-09-16	Newbiotics Inc	Agentes terapeuticos obtenidos por catalisis enzimatica.
US7462605B2 (en) *	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
US6683061B1 (en) *	1999-07-22	2004-01-27	Newbiotics, Inc.	Enzyme catalyzed therapeutic activation
IL147749A0 (en) *	1999-07-22	2002-08-14	Newbiotics Inc	Methods for treating therapy-resistant tumors
US20030212037A1 (en) *	2000-12-21	2003-11-13	Christopher Boyer	Use of bvdu for inhibiting the growth of hyperproliferative cells
WO2002056832A2 (en) *	2001-01-19	2002-07-25	Newbiotics, Inc.	Methods to treat autoimmune and inflammatory conditions
MXPA03007778A (es) *	2001-03-16	2003-12-08	Holdings Ltd G	Sistema y metodo para remplazar datos de identificacion en un dispositivo portatil de transacciones.
AU2002326736B2 (en) *	2001-08-24	2007-08-02	Koronis Pharmaceuticals, Inc.	Mutagenic nucleoside analogs for the treatment of viral disease
KR100540509B1 (ko) *	2004-01-07	2006-01-11	학교법인 포항공과대학교	수화젤레이터로 사용되는 2'-데옥시우리딘 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853845A (en) *	1971-08-18	1974-12-10	Icn Pharmaceuticals	5-n-aminoacyl-5-aminouridines
US4093716A (en) *	1977-04-28	1978-06-06	Research Corporation	Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
US4128639A (en) *	1977-12-14	1978-12-05	Research Corporation	Nitrosourea analogs of thymidine
US4849513A (en) *	1983-12-20	1989-07-18	California Institute Of Technology	Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
SE8605503D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel medicinal use
SE8701605D0 (sv) *	1987-04-16	1987-04-16	Astra Ab	Novel medicinal compounds

1989
- 1989-02-23 AT AT89903177T patent/ATE109789T1/de not_active IP Right Cessation
- 1989-02-23 WO PCT/FR1989/000072 patent/WO1989008115A1/fr not_active Ceased
- 1989-02-23 DE DE68917479T patent/DE68917479D1/de not_active Expired - Lifetime
- 1989-02-23 EP EP89903177A patent/EP0448550B1/fr not_active Expired - Lifetime
- 1989-02-23 AU AU32137/89A patent/AU631119B2/en not_active Ceased
- 1989-02-23 JP JP1502971A patent/JPH03504492A/ja active Pending
- 1989-02-23 US US07/566,344 patent/US5212161A/en not_active Expired - Fee Related
1990
- 1990-08-21 DK DK200290A patent/DK200290A/da not_active Application Discontinuation
- 1990-08-23 NO NO903704A patent/NO173507C/no unknown
- 1990-08-23 FI FI904171A patent/FI92324C/fi not_active IP Right Cessation
- 1990-08-24 OA OA59844A patent/OA09306A/xx unknown

Also Published As

Publication number	Publication date
JPH03504492A (ja)	1991-10-03
OA09306A (fr)	1992-09-15
DE68917479D1 (de)	1994-09-15
AU3213789A (en)	1989-09-22
EP0448550A1 (fr)	1991-10-02
DK200290D0 (da)	1990-08-21
US5212161A (en)	1993-05-18
FI92324C (fi)	1994-10-25
EP0448550B1 (fr)	1994-08-10
ATE109789T1 (de)	1994-08-15
DK200290A (da)	1990-08-21
AU631119B2 (en)	1992-11-19
NO173507C (no)	1993-12-22
NO173507B (no)	1993-09-13
FI904171A0 (fi)	1990-08-23
NO903704D0 (no)	1990-08-23
FI92324B (fi)	1994-07-15
WO1989008115A1 (fr)	1989-09-08

Publication	Publication Date	Title
NO903704D0 (no)	1990-08-23	Nye derivater av deoksy-2'-uridin substituert i 5-,3' eller 5'-posisjon med alfa-aminoacyl-grupper, samt fremgangsmaate for fremstilling av slike forbindelser, og medikamentersom inneholder dem.
JP2590248B2 (ja)	1997-03-12	抗ウイルス・抗腫瘍・抗転移・免疫系増強ヌクレオシド類およびヌクレオチド類
CA2494340C (en)	2012-01-24	Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
JP3773153B2 (ja)	2006-05-10	シアル酸誘導体
PT98720A (pt)	1992-07-31	Processo para a preparacao de derivados de fosfolipidos de nucleosidos e de composicoes farmaceuticas que os contem
AU591310B2 (en)	1989-11-30	Process for the preparation of taxol and 10-deacetyltaxol
CN102325783A (zh)	2012-01-18	嘌呤核苷的合成
WO1990001036A1 (en)	1990-02-08	Nucleoside derivatives
UA53614C2 (uk)	2003-02-17	Спосіб очищення та виділення 2'-дезокси-2',2'-дифторнуклеозидів
WO1996013512B1 (en)	1997-03-27	L-ribofuranosyl nucleosides
DE68920965D1 (de)	1995-03-16	Zentralnervensystem wirksame Chromanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
US4754026A (en)	1988-06-28	Conversion of uracil derivatives to cytosine derivatives
IL88330A (en)	1995-03-15	2', 3'-Dideoxy-2'-Fluoronucleosides, their preparation and pharmaceutical compositions containing them.
JPH02262587A (ja)	1990-10-25	抗レトロウイルス性化合物
JPS638119B2 (no)	1988-02-19
KR940005656A (ko)	1994-03-22	항 바이러스 및 항암 활성을 갖는 2'-데옥시-2', 2'-디플루오로(2,6,8-치환된) 퓨린 뉴클레오시드 및 중간체
SE8900605D0 (sv)	1989-02-21	Carbohydrateacryl- and methacrylcopolymers and their manufacture
KR840005733A (ko)	1984-11-16	무라밀 펩타이드의 제조방법
CA1317291C (en)	1993-05-04	Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US3825541A (en)	1974-07-23	(+-)-9-(beta-(3-alpha-amino-2alpha-hydroxy)cyclopentyl)-6-substituted-purines and derivatives thereof
MA23129A1 (fr)	1994-10-01	Nouveaux derives de l'erythromycine,leur procede de preparatn et leur application
TW306924B (no)	1997-06-01
KR930701451A (ko)	1993-06-11	디알킬아미노알킬설포닐-26 프리스티나마이신 ii_b로부터 유도되는 신규한 염
DE59301421D1 (de)	1996-02-22	Amphiphile nucleosidphosphatanaloga
PT92377A (pt)	1990-05-31	Processo para a obtencao de composicoes farmaceuticas para o tratamento de estados depressivos, contendo derivados de cromano