ATE109789T1 - Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus. - Google Patents

Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus.

Info

Publication number
ATE109789T1
ATE109789T1 AT89903177T AT89903177T ATE109789T1 AT E109789 T1 ATE109789 T1 AT E109789T1 AT 89903177 T AT89903177 T AT 89903177T AT 89903177 T AT89903177 T AT 89903177T AT E109789 T1 ATE109789 T1 AT E109789T1
Authority
AT
Austria
Prior art keywords
radical
pct
derivatives
preparation
deoxy
Prior art date
Application number
AT89903177T
Other languages
English (en)
Inventor
Jean-Luc Moriniere
Michelle Faulques
Claude Rousseau
Bernard Danree
Claude Marquer
Patrick Saur
Jean Lemoine
Jean-Yves Lacolle
Original Assignee
Inst Rech Chim Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8802255A external-priority patent/FR2627492B1/fr
Priority claimed from FR8808684A external-priority patent/FR2633294B1/fr
Application filed by Inst Rech Chim Biolog filed Critical Inst Rech Chim Biolog
Application granted granted Critical
Publication of ATE109789T1 publication Critical patent/ATE109789T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT89903177T 1988-02-24 1989-02-23 Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus. ATE109789T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8802255A FR2627492B1 (fr) 1988-02-24 1988-02-24 Nouveaux derives de l'amino-5(prime)-dideoxy-2(prime)-5(prime)-uridine, procede pour les preparer et compositions pharmaceutiques contenant ces composes
FR8808684A FR2633294B1 (fr) 1988-06-28 1988-06-28 Nouveaux derives de l'amino-3(prime)-dideoxy-2(prime)-3(prime)-uridine, procede pour les preparer et compositions pharmaceutiques contenant ces composes

Publications (1)

Publication Number Publication Date
ATE109789T1 true ATE109789T1 (de) 1994-08-15

Family

ID=26226515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89903177T ATE109789T1 (de) 1988-02-24 1989-02-23 Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus.

Country Status (11)

Country Link
US (1) US5212161A (de)
EP (1) EP0448550B1 (de)
JP (1) JPH03504492A (de)
AT (1) ATE109789T1 (de)
AU (1) AU631119B2 (de)
DE (1) DE68917479D1 (de)
DK (1) DK200290A (de)
FI (1) FI92324C (de)
NO (1) NO173507C (de)
OA (1) OA09306A (de)
WO (1) WO1989008115A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use
RU2111970C1 (ru) * 1996-06-25 1998-05-27 Иван Игоревич Федоров 3'-оксимино-2',3'-дидезоксинуклеозиды
EP1240922B1 (de) * 1997-08-08 2008-11-12 Celmed Oncology (USA), Inc. Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
WO1999008110A1 (en) * 1997-08-08 1999-02-18 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
WO1999037753A1 (en) * 1998-01-23 1999-07-29 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
MXPA02000762A (es) * 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
US20030212037A1 (en) * 2000-12-21 2003-11-13 Christopher Boyer Use of bvdu for inhibiting the growth of hyperproliferative cells
EP1359921A4 (de) * 2001-01-19 2006-09-06 Newbiotics Inc Verfahren zur behandlung von autoimmunkrankheiten und entzündlichen erkrankungen
EP1371036A2 (de) * 2001-03-16 2003-12-17 G. Holdings Ltd Verfahren und system für erneuerung von identifikationsdaten in einer tragbaren transaktionseinrichtung
US7244717B2 (en) * 2001-08-24 2007-07-17 Koronis Pharmaceuticals, Incorporated Mutagenic nucleoside analogs for the treatment of viral disease
KR100540509B1 (ko) * 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853845A (en) * 1971-08-18 1974-12-10 Icn Pharmaceuticals 5-n-aminoacyl-5-aminouridines
US4093716A (en) * 1977-04-28 1978-06-06 Research Corporation Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
US4128639A (en) * 1977-12-14 1978-12-05 Research Corporation Nitrosourea analogs of thymidine
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Also Published As

Publication number Publication date
DE68917479D1 (de) 1994-09-15
AU631119B2 (en) 1992-11-19
NO173507C (no) 1993-12-22
JPH03504492A (ja) 1991-10-03
DK200290D0 (da) 1990-08-21
DK200290A (da) 1990-08-21
OA09306A (fr) 1992-09-15
FI92324C (fi) 1994-10-25
WO1989008115A1 (fr) 1989-09-08
AU3213789A (en) 1989-09-22
EP0448550B1 (de) 1994-08-10
NO173507B (no) 1993-09-13
FI92324B (fi) 1994-07-15
EP0448550A1 (de) 1991-10-02
NO903704D0 (no) 1990-08-23
US5212161A (en) 1993-05-18
FI904171A0 (fi) 1990-08-23
NO903704L (no) 1990-10-24

Similar Documents

Publication Publication Date Title
ATE109789T1 (de) Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus.
US3755295A (en) 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof
DE3485094D1 (de) Neue peptidderivate.
ATE47137T1 (de) Verfahren zur herstellung von taxol und von desazetyl-10-taxol.
DK326785A (da) Terapeutisk middel til paavisning og/eller behandling af tumorer og fremgangsmaade til fremstilling af et saadant middel
WO1996013512B1 (en) L-ribofuranosyl nucleosides
DK0777679T3 (da) Indføring af nukleinsyrer
ES8606394A1 (es) Procedimiento para la obtencion de tetrapeptidos sustituidos
KR930010052A (ko) 폴리사이클릭 접합체
JPS5942356A (ja) スパガリン関連化合物およびその製造法
PT80851A (de) Verfahren zur herstellung phosphatidylverbindungen
JPH02138290A (ja) 新規な免疫アジュバント化合物およびその製造方法
KR840005733A (ko) 무라밀 펩타이드의 제조방법
KR940005656A (ko) 항 바이러스 및 항암 활성을 갖는 2'-데옥시-2', 2'-디플루오로(2,6,8-치환된) 퓨린 뉴클레오시드 및 중간체
SE8900605D0 (sv) Carbohydrateacryl- and methacrylcopolymers and their manufacture
KR890016059A (ko) 포스포노알킬퓨린 유도체
ATE14126T1 (de) Verfahren zur herstellung von 2-acyl1,3,4,6,7,11b-2h-hexahydro-4-pyrazino(2,1a)isochinolinonen und zwischenprodukte.
MA23129A1 (fr) Nouveaux derives de l'erythromycine,leur procede de preparatn et leur application
DE69029708D1 (de) Verfahren zur Herstellung von AZT(3'-azido-3'-desoxythymidin) und diebezüglichen Verbindungen
DE68902627D1 (de) Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden.
KR930701451A (ko) 디알킬아미노알킬설포닐-26 프리스티나마이신 ii_b로부터 유도되는 신규한 염
ES2058723T3 (es) Bencilseleniobenzamidas de anilinas y benzilaminas.
ATE132873T1 (de) Amphiphile nucleosidphosphatanaloga
SE8105995L (sv) Nya 3-amino-substituerade steroider och deras salter, sett for framstellning och anvendning derav som lekemedel och kompositioner innehallande dem
KR960014151A (ko) 새로운 뉴클레오시드 유도체 및 그의 제조 방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties