NO904202L - Terapeutisk aktive bifenylmetanderivater og fremgangsmaatefor deres fremstilling. - Google Patents

Terapeutisk aktive bifenylmetanderivater og fremgangsmaatefor deres fremstilling.

Info

Publication number: NO904202L
Authority: NO; Norway
Prior art keywords: group; preparation; pharmacologically acceptable; hydrogen; bifenyl
Prior art date: 1989-09-29

Application number

NO90904202A

Other languages

English (en)

Other versions

NO176912B (no

NO904202D0 (no

NO176912C (no

Inventor

Kazutoshi Miyake

Masayuki Matsukura

Naoki Yoneda

Osamu Hiroshima

Nobuyuki Mori

Hiroki Ishihara

Takashi Musha

Toshiyuki Matsuoka

Sachiyuki Hamano

Norio Minami

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-29

Filing date

1990-09-27

Publication date

1991-04-02

1990-09-27 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1990-09-27 Publication of NO904202D0 publication Critical patent/NO904202D0/no

1991-04-02 Publication of NO904202L publication Critical patent/NO904202L/no

1995-03-13 Publication of NO176912B publication Critical patent/NO176912B/no

1995-06-21 Publication of NO176912C publication Critical patent/NO176912C/no

Links

238000000034 method Methods 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
-1 1H-tetrazol-5-yl Chemical group 0.000 abstract 2
150000001733 carboxylic acid esters Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
ZWZGXLKXKAPXMZ-UHFFFAOYSA-N 2,2'-dihydroxy-3,3'-dimethoxy-5,5'-dipropyldiphenylmethane Chemical class COC1=CC(CCC)=CC(CC=2C(=C(OC)C=C(CCC)C=2)O)=C1O ZWZGXLKXKAPXMZ-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

NO904202A 1989-09-29 1990-09-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive kondenserte imidazolforbindelser, og farmakologisk tålbare salter derav NO176912C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP25176189		1989-09-29
JP33664089		1989-12-27

Publications (4)

Publication Number	Publication Date
NO904202D0 NO904202D0 (no)	1990-09-27
NO904202L true NO904202L (no)	1991-04-02
NO176912B NO176912B (no)	1995-03-13
NO176912C NO176912C (no)	1995-06-21

Family

ID=26540341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO904202A NO176912C (no)	1989-09-29	1990-09-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive kondenserte imidazolforbindelser, og farmakologisk tålbare salter derav

Country Status (21)

Country	Link
US (1)	US5328911A (no)
EP (3)	EP0628557B1 (no)
JP (2)	JP2608341B2 (no)
KR (1)	KR930000168B1 (no)
CN (1)	CN1025331C (no)
AT (3)	ATE134998T1 (no)
AU (1)	AU641685B2 (no)
CA (1)	CA2026533A1 (no)
DD (1)	DD299301A5 (no)
DE (3)	DE69030631T2 (no)
DK (1)	DK0420237T3 (no)
ES (1)	ES2085876T3 (no)
FI (1)	FI94527C (no)
GR (1)	GR3019239T3 (no)
HU (1)	HUT55367A (no)
IE (1)	IE70593B1 (no)
MX (1)	MXPA95000470A (no)
NO (1)	NO176912C (no)
NZ (1)	NZ235469A (no)
PT (1)	PT95464B (no)
RU (1)	RU2024521C1 (no)

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EP0415886A3 (en) *	1989-08-30	1991-10-23	Ciba-Geigy Ag	Aza compounds
IL95975A (en) *	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
IL96019A0 (en) *	1989-10-31	1991-07-18	Fujisawa Pharmaceutical Co	Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0434038A1 (en) *	1989-12-22	1991-06-26	Takeda Chemical Industries, Ltd.	Fused imidazole derivatives, their production and use
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CA2041763A1 (en) *	1990-05-11	1991-11-12	Sheih-Shung T. Chen	Microbial transformation process for antihypertensive products
EP0461039B1 (fr) *	1990-06-08	1998-09-16	Hoechst Marion Roussel	Dérivés du benzimidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
AU653524B2 (en) *	1990-06-08	1994-10-06	Roussel-Uclaf	New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
CA2044806A1 (en) *	1990-07-18	1992-01-19	Roland Jaunin	Purine derivatives
RU1836357C (ru) *	1990-07-23	1993-08-23	Др.Карл Томэ ГмбХ	Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) *	1990-08-10	1992-02-12	Dr. Karl Thomae GmbH	Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung

1990
- 1990-09-06 IE IE324290A patent/IE70593B1/en not_active IP Right Cessation
- 1990-09-07 FI FI904424A patent/FI94527C/fi not_active IP Right Cessation
- 1990-09-13 US US07/583,025 patent/US5328911A/en not_active Expired - Fee Related
- 1990-09-21 AU AU63075/90A patent/AU641685B2/en not_active Ceased
- 1990-09-26 NZ NZ235469A patent/NZ235469A/xx unknown
- 1990-09-27 DE DE69030631T patent/DE69030631T2/de not_active Expired - Fee Related
- 1990-09-27 DK DK90118565.2T patent/DK0420237T3/da active
- 1990-09-27 AT AT90118565T patent/ATE134998T1/de active
- 1990-09-27 EP EP94109556A patent/EP0628557B1/en not_active Expired - Lifetime
- 1990-09-27 NO NO904202A patent/NO176912C/no unknown
- 1990-09-27 AT AT94101415T patent/ATE167186T1/de active
- 1990-09-27 EP EP94101415A patent/EP0598702B1/en not_active Expired - Lifetime
- 1990-09-27 DE DE69025687T patent/DE69025687T2/de not_active Expired - Fee Related
- 1990-09-27 AT AT94109556T patent/ATE152451T1/de not_active IP Right Cessation
- 1990-09-27 EP EP90118565A patent/EP0420237B1/en not_active Expired - Lifetime
- 1990-09-27 HU HU906243A patent/HUT55367A/hu unknown
- 1990-09-27 ES ES90118565T patent/ES2085876T3/es not_active Expired - Lifetime
- 1990-09-27 DE DE69032414T patent/DE69032414T2/de not_active Expired - Fee Related
- 1990-09-28 JP JP2257400A patent/JP2608341B2/ja not_active Expired - Lifetime
- 1990-09-28 PT PT95464A patent/PT95464B/pt not_active IP Right Cessation
- 1990-09-28 CA CA002026533A patent/CA2026533A1/en not_active Abandoned
- 1990-09-28 DD DD90344302A patent/DD299301A5/de not_active IP Right Cessation
- 1990-09-28 RU SU904831238A patent/RU2024521C1/ru active
- 1990-09-29 KR KR1019900015702A patent/KR930000168B1/ko not_active Expired - Fee Related
- 1990-09-29 CN CN90108025A patent/CN1025331C/zh not_active Expired - Fee Related
1994
- 1994-12-02 JP JP6299389A patent/JP2925962B2/ja not_active Expired - Lifetime
1995
- 1995-01-12 MX MXPA95000470A patent/MXPA95000470A/es unknown
1996
- 1996-03-07 GR GR960400236T patent/GR3019239T3/el unknown

Also Published As

Publication number	Publication date
KR910006287A (ko)	1991-04-29
JP2608341B2 (ja)	1997-05-07
EP0420237B1 (en)	1996-03-06
IE903242A1 (en)	1991-04-10
DE69025687D1 (de)	1996-04-11
DE69032414D1 (de)	1998-07-16
EP0420237A1 (en)	1991-04-03
JP2925962B2 (ja)	1999-07-28
EP0628557A1 (en)	1994-12-14
CN1050539A (zh)	1991-04-10
FI94527C (fi)	1995-09-25
EP0598702B1 (en)	1998-06-10
DE69032414T2 (de)	1998-11-19
KR930000168B1 (ko)	1993-01-11
ATE152451T1 (de)	1997-05-15
PT95464B (pt)	1997-07-31
US5328911A (en)	1994-07-12
JPH03236377A (ja)	1991-10-22
FI94527B (fi)	1995-06-15
CA2026533A1 (en)	1991-03-30
NO176912B (no)	1995-03-13
PT95464A (pt)	1991-05-22
NZ235469A (en)	1993-03-26
HUT55367A (en)	1991-05-28
FI904424A0 (fi)	1990-09-07
ATE134998T1 (de)	1996-03-15
DE69025687T2 (de)	1996-08-08
DE69030631T2 (de)	1997-09-25
HU906243D0 (en)	1991-03-28
ATE167186T1 (de)	1998-06-15
ES2085876T3 (es)	1996-06-16
DK0420237T3 (da)	1996-07-01
EP0628557B1 (en)	1997-05-02
JPH07224059A (ja)	1995-08-22
AU641685B2 (en)	1993-09-30
DE69030631D1 (de)	1997-06-05
NO904202D0 (no)	1990-09-27
CN1025331C (zh)	1994-07-06
RU2024521C1 (ru)	1994-12-15
AU6307590A (en)	1991-04-11
GR3019239T3 (en)	1996-06-30
IE70593B1 (en)	1996-12-11
MXPA95000470A (es)	2004-08-17
DD299301A5 (de)	1992-04-09
EP0598702A1 (en)	1994-05-25
NO176912C (no)	1995-06-21

Publication	Publication Date	Title
NO904202L (no)	1991-04-02	Terapeutisk aktive bifenylmetanderivater og fremgangsmaatefor deres fremstilling.
NO173139C (no)	1993-11-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-aminopyrimidinonderivater
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NO302470B1 (no)	1998-03-09	Substituerte heterocykliske karboksylsyreamider, og deres anvendelse ved fremstilling av legemiddel
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KR950704314A (ko)	1995-11-17	1,8-나프티리딘-2-온 유도체 및 그 사용 방법(1,8-naphthyridin-2-one derivative and use thereof)
CA2414787C (en)	2010-12-14	Coumarin derivatives with comt inhibiting activity
KR880007461A (ko)	1988-08-27	헤테로 사이클-치환 디포스포네이트화합물 및 이의 약제학적 조성물
DE69110828D1 (de)	1995-08-03	Heterozyklische Aminderivate, deren Herstellung und deren Verwendung.
NO900342D0 (no)	1990-01-24	Fremgangsmaate for fremstilling av terapeutisk aktive 3-fenyl-5,6-dihydrobenz(c)acridin-7-carboxylsyrer og beslektede forbindelser.
NO178025C (no)	1996-01-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
KR910000637A (ko)	1991-01-29	피롤 유도체, 이의 제조 방법 및 약제학적 활성화합물로서의 이의 용도
DK1178047T3 (da)	2004-05-24	Diazabicyclooctanderivater og terapeutiske anvendelser deraf
DE69110217D1 (de)	1995-07-13	Derivate der Kaffeinsäure und sie enthaltende pharmazeutische Zusammensetzungen.
EP0802179A4 (en)	2000-04-05	DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER
NO158676C (no)	1988-10-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-furyl-3,4-dihydroisokinolin-derivater.
DE69424295D1 (de)	2000-06-08	Bernsteinsäuremonoamidverbindung, verfahren zur deren herstellung und deren verwendung
KR950700289A (ko)	1995-01-16	퀴놀린-3-아세트산 유도체, 그의 제조법 및 용도(quinoline-3-acetic acid derivative, process for producing the same, and use thereof)
KR950032151A (ko)	1995-12-20	점착성 수용체 길항제
GB1471546A (en)	1977-04-27	1-acyl-4-substituted alkyl-piperazine or homopiperazine derivatives nad process for preparation thereof