ATE167186T1 - Diphenylmethane derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents

Diphenylmethane derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Info

Publication number: ATE167186T1
Authority: AT; Austria
Prior art keywords: group; pharmaceutical compositions; pharmacologically acceptable; compositions containing; hydrogen
Prior art date: 1989-09-29

Application number

AT94101415T

Other languages

English (en)

Inventor

Kazutoshi Miyake

Masayuki Matsukura

Naoki Yoneda

Osamu Hiroshima

Nobuyuki Mori

Hiroki Ishihara

Takashi Musha

Toshiyuki Matsuoka

Sachiyuki Hamano

Norio Minami

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-29

Filing date

1990-09-27

Publication date

1998-06-15

1990-09-27 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE167186T1 publication Critical patent/ATE167186T1/de

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229940054021 anxiolytics diphenylmethane derivative Drugs 0.000 title 1
CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical class C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 title 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
-1 1H-tetrazol-5-yl Chemical group 0.000 abstract 2
150000001733 carboxylic acid esters Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
ZWZGXLKXKAPXMZ-UHFFFAOYSA-N 2,2'-dihydroxy-3,3'-dimethoxy-5,5'-dipropyldiphenylmethane Chemical class COC1=CC(CCC)=CC(CC=2C(=C(OC)C=C(CCC)C=2)O)=C1O ZWZGXLKXKAPXMZ-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

AT94101415T 1989-09-29 1990-09-27 Diphenylmethane derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen ATE167186T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP25176189		1989-09-29
JP33664089		1989-12-27

Publications (1)

Publication Number	Publication Date
ATE167186T1 true ATE167186T1 (de)	1998-06-15

Family

ID=26540341

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT94101415T ATE167186T1 (de)	1989-09-29	1990-09-27	Diphenylmethane derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
AT90118565T ATE134998T1 (de)	1989-09-29	1990-09-27	Diphenylmethanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
AT94109556T ATE152451T1 (de)	1989-09-29	1990-09-27	Biphenylmethanderivate, ihre anwendung und sie enthaltende pharmacologische zusammensetzungen

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT90118565T ATE134998T1 (de)	1989-09-29	1990-09-27	Diphenylmethanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
AT94109556T ATE152451T1 (de)	1989-09-29	1990-09-27	Biphenylmethanderivate, ihre anwendung und sie enthaltende pharmacologische zusammensetzungen

Country Status (21)

Country	Link
US (1)	US5328911A (de)
EP (3)	EP0628557B1 (de)
JP (2)	JP2608341B2 (de)
KR (1)	KR930000168B1 (de)
CN (1)	CN1025331C (de)
AT (3)	ATE167186T1 (de)
AU (1)	AU641685B2 (de)
CA (1)	CA2026533A1 (de)
DD (1)	DD299301A5 (de)
DE (3)	DE69025687T2 (de)
DK (1)	DK0420237T3 (de)
ES (1)	ES2085876T3 (de)
FI (1)	FI94527C (de)
GR (1)	GR3019239T3 (de)
HU (1)	HUT55367A (de)
IE (1)	IE70593B1 (de)
MX (1)	MXPA95000470A (de)
NO (1)	NO176912C (de)
NZ (1)	NZ235469A (de)
PT (1)	PT95464B (de)
RU (1)	RU2024521C1 (de)

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1990
- 1990-09-06 IE IE324290A patent/IE70593B1/en not_active IP Right Cessation
- 1990-09-07 FI FI904424A patent/FI94527C/fi not_active IP Right Cessation
- 1990-09-13 US US07/583,025 patent/US5328911A/en not_active Expired - Fee Related
- 1990-09-21 AU AU63075/90A patent/AU641685B2/en not_active Ceased
- 1990-09-26 NZ NZ235469A patent/NZ235469A/xx unknown
- 1990-09-27 EP EP94109556A patent/EP0628557B1/de not_active Expired - Lifetime
- 1990-09-27 DE DE69025687T patent/DE69025687T2/de not_active Expired - Fee Related
- 1990-09-27 EP EP90118565A patent/EP0420237B1/de not_active Expired - Lifetime
- 1990-09-27 AT AT94101415T patent/ATE167186T1/de active
- 1990-09-27 EP EP94101415A patent/EP0598702B1/de not_active Expired - Lifetime
- 1990-09-27 HU HU906243A patent/HUT55367A/hu unknown
- 1990-09-27 DK DK90118565.2T patent/DK0420237T3/da active
- 1990-09-27 AT AT90118565T patent/ATE134998T1/de active
- 1990-09-27 AT AT94109556T patent/ATE152451T1/de not_active IP Right Cessation
- 1990-09-27 DE DE69030631T patent/DE69030631T2/de not_active Expired - Fee Related
- 1990-09-27 ES ES90118565T patent/ES2085876T3/es not_active Expired - Lifetime
- 1990-09-27 NO NO904202A patent/NO176912C/no unknown
- 1990-09-27 DE DE69032414T patent/DE69032414T2/de not_active Expired - Fee Related
- 1990-09-28 DD DD90344302A patent/DD299301A5/de not_active IP Right Cessation
- 1990-09-28 RU SU904831238A patent/RU2024521C1/ru active
- 1990-09-28 CA CA002026533A patent/CA2026533A1/en not_active Abandoned
- 1990-09-28 JP JP2257400A patent/JP2608341B2/ja not_active Expired - Lifetime
- 1990-09-28 PT PT95464A patent/PT95464B/pt not_active IP Right Cessation
- 1990-09-29 KR KR1019900015702A patent/KR930000168B1/ko not_active Expired - Fee Related
- 1990-09-29 CN CN90108025A patent/CN1025331C/zh not_active Expired - Fee Related
1994
- 1994-12-02 JP JP6299389A patent/JP2925962B2/ja not_active Expired - Lifetime
1995
- 1995-01-12 MX MXPA95000470A patent/MXPA95000470A/es unknown
1996
- 1996-03-07 GR GR960400236T patent/GR3019239T3/el unknown

Also Published As

Publication number	Publication date
EP0598702B1 (de)	1998-06-10
DE69030631T2 (de)	1997-09-25
US5328911A (en)	1994-07-12
DE69025687T2 (de)	1996-08-08
NO904202D0 (no)	1990-09-27
IE903242A1 (en)	1991-04-10
NZ235469A (en)	1993-03-26
CN1050539A (zh)	1991-04-10
FI94527C (fi)	1995-09-25
IE70593B1 (en)	1996-12-11
JP2608341B2 (ja)	1997-05-07
HUT55367A (en)	1991-05-28
JP2925962B2 (ja)	1999-07-28
EP0420237B1 (de)	1996-03-06
NO176912B (no)	1995-03-13
PT95464A (pt)	1991-05-22
ATE152451T1 (de)	1997-05-15
AU641685B2 (en)	1993-09-30
CA2026533A1 (en)	1991-03-30
PT95464B (pt)	1997-07-31
NO176912C (no)	1995-06-21
EP0598702A1 (de)	1994-05-25
EP0628557B1 (de)	1997-05-02
EP0628557A1 (de)	1994-12-14
KR930000168B1 (ko)	1993-01-11
JPH07224059A (ja)	1995-08-22
DD299301A5 (de)	1992-04-09
ES2085876T3 (es)	1996-06-16
FI94527B (fi)	1995-06-15
DK0420237T3 (da)	1996-07-01
MXPA95000470A (es)	2004-08-17
DE69032414T2 (de)	1998-11-19
NO904202L (no)	1991-04-02
DE69025687D1 (de)	1996-04-11
GR3019239T3 (en)	1996-06-30
FI904424A0 (fi)	1990-09-07
HU906243D0 (en)	1991-03-28
ATE134998T1 (de)	1996-03-15
KR910006287A (ko)	1991-04-29
CN1025331C (zh)	1994-07-06
JPH03236377A (ja)	1991-10-22
DE69032414D1 (de)	1998-07-16
RU2024521C1 (ru)	1994-12-15
AU6307590A (en)	1991-04-11
DE69030631D1 (de)	1997-06-05
EP0420237A1 (de)	1991-04-03

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DE69222570D1 (de)	1997-11-13	Phosphonsäurederivate, Verfahren zur Herstellung und ihre Verwendung
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ATE165822T1 (de)	1998-05-15	Chinolin-4-carbonylguanidin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
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KR910000637A (ko)	1991-01-29	피롤 유도체, 이의 제조 방법 및 약제학적 활성화합물로서의 이의 용도
KR900003139A (ko)	1990-03-23	테트라졸일기를 함유하는 술폰아미드류, 이들의 제조방법 및 이들을 함유하는 제약 조성물
HUT62195A (en)	1993-04-28	Process for producing weight increasing agents and fodder comprising thiobenzoyl morpholide derivatives
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ATE78816T1 (de)	1992-08-15	N-substituierte 3,4-dihydropyrimidinderivate, verfahren zu deren herstellung und diese enthaltende zusammenstellung fuer die behandlung von anordnungen eines kardiovascularen systems.
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