NO910982L - Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller. - Google Patents

Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller.

Info

Publication number
NO910982L
NO910982L NO91910982A NO910982A NO910982L NO 910982 L NO910982 L NO 910982L NO 91910982 A NO91910982 A NO 91910982A NO 910982 A NO910982 A NO 910982A NO 910982 L NO910982 L NO 910982L
Authority
NO
Norway
Prior art keywords
uratoxydase
microorganisms
expression vector
gene coding
active protein
Prior art date
Application number
NO91910982A
Other languages
English (en)
Other versions
NO308139B1 (no
NO910982D0 (no
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/fr
Priority claimed from FR8917466A external-priority patent/FR2656530B1/fr
Priority claimed from PCT/FR1990/000532 external-priority patent/WO1991000909A1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO910982D0 publication Critical patent/NO910982D0/no
Publication of NO910982L publication Critical patent/NO910982L/no
Publication of NO308139B1 publication Critical patent/NO308139B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
NO910982A 1989-07-13 1991-03-12 FremgangsmÕte for fremstilling av rekombinant protein som har spesifikk uratoksydaseaktivitet, rekombinant gen som koder for proteinet, ekspresjonsvektor samt vertsceller som inneholder de rekombinante gen NO308139B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.
PCT/FR1990/000532 WO1991000909A1 (fr) 1989-07-13 1990-07-13 Proteine a activite urate oxydase, gene recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformees

Publications (3)

Publication Number Publication Date
NO910982D0 NO910982D0 (no) 1991-03-12
NO910982L true NO910982L (no) 1991-05-10
NO308139B1 NO308139B1 (no) 2000-07-31

Family

ID=27446701

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910982A NO308139B1 (no) 1989-07-13 1991-03-12 FremgangsmÕte for fremstilling av rekombinant protein som har spesifikk uratoksydaseaktivitet, rekombinant gen som koder for proteinet, ekspresjonsvektor samt vertsceller som inneholder de rekombinante gen

Country Status (3)

Country Link
US (2) US5382518A (no)
KR (1) KR0159107B1 (no)
NO (1) NO308139B1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
EP1009836A1 (en) * 1997-09-05 2000-06-21 Pentapharm A.G. Expression vector for improved production of polypeptides in yeast
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US20060188971A1 (en) * 1998-08-06 2006-08-24 Duke University Urate oxidase
JP2002524053A (ja) 1998-08-06 2002-08-06 デューク・ユニバーシティー 尿酸オキシダーゼ
ES2245114T3 (es) 1998-08-06 2005-12-16 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
US6376210B1 (en) 1999-07-06 2002-04-23 General Atomics Methods and compositions for assaying analytes
US7192729B2 (en) 1999-07-06 2007-03-20 General Atomics Methods for assaying homocysteine
EP1503788B1 (en) 2002-04-25 2011-06-29 Shire Human Genetic Therapies, Inc. Treatment of alpha-galactosidase a deficiency
WO2006110761A2 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. A variant form of urate oxidase and use thereof
US8148123B2 (en) * 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
HUE052976T2 (hu) 2005-04-11 2021-06-28 Horizon Pharma Rheumatology Llc Urát-oxidáz variáns formái és azok alkalmazása
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
WO2006125452A1 (en) * 2005-05-23 2006-11-30 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
CN100406560C (zh) * 2006-03-15 2008-07-30 中国人民解放军军事医学科学院微生物流行病研究所 一种表达黄曲霉尿酸氧化酶的方法及其专用基因
CN101622270B (zh) * 2006-04-12 2014-01-01 萨文特医药公司 用阳离子表面活性剂纯化蛋白质的方法
HUP1200205A3 (en) 2009-06-25 2012-09-28 Savient Pharmaceuticals Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
CN110234340A (zh) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 泼尼松和尿酸酶分子的组合疗法及其用途
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
KR102557569B1 (ko) * 2021-03-04 2023-07-20 전남대학교산학협력단 메타노사에타 콘실리에서 유래한 티로실-tRNA 합성효소 및 이를 이용한 단백질 생산방법
WO2023277574A1 (ko) * 2021-06-29 2023-01-05 주식회사 프로앱텍 Bcn 링커를 이용한 요산산화효소-알부민 컨쥬게이트의 생산 방법 및 이의 용도
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (no) * 1967-03-29 1968-09-09
US4431739A (en) * 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein

Also Published As

Publication number Publication date
US5382518A (en) 1995-01-17
US5541098A (en) 1996-07-30
NO308139B1 (no) 2000-07-31
NO910982D0 (no) 1991-03-12
KR920701443A (ko) 1992-08-11
KR0159107B1 (ko) 1998-11-16

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Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: RASBURICASE; NAT. REG. NO/DATE: NO , EP/1/00/17 20010614; FIRST REG. NO/DATE: EP , EP/1/00/17 20010223

Spc suppl protection certif: 2001018

Filing date: 20011030

Extension date: 20150713

MK1K Patent expired
SPCX Expiry of an spc

Free format text: PRODUCT NAME: RASBURICASE; NAT. REG. NO/DATE: NO , EP/1/00/17 20010614; FIRST REG. NO/DATE: EP , EP/1/00/17 20010223;

Spc suppl protection certif: 2001018

Effective date: 20150713