NO914979L - Tetra-aza-makrosykliske forbindelser, fremgangsmaate for deres fremstilling og anvendelse for avbilding ved magnetisk resonans - Google Patents

Tetra-aza-makrosykliske forbindelser, fremgangsmaate for deres fremstilling og anvendelse for avbilding ved magnetisk resonans

Info

Publication number
NO914979L
NO914979L NO91914979A NO914979A NO914979L NO 914979 L NO914979 L NO 914979L NO 91914979 A NO91914979 A NO 91914979A NO 914979 A NO914979 A NO 914979A NO 914979 L NO914979 L NO 914979L
Authority
NO
Norway
Prior art keywords
group
hydrogen atom
different
tetra
magnetic resonance
Prior art date
Application number
NO91914979A
Other languages
English (en)
Norwegian (no)
Other versions
NO914979D0 (no
Inventor
David Parker
Nigel Robert Arnold Beeley
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909008720A external-priority patent/GB9008720D0/en
Priority claimed from GB909008724A external-priority patent/GB9008724D0/en
Priority claimed from GB909017148A external-priority patent/GB9017148D0/en
Priority claimed from GB919104391A external-priority patent/GB9104391D0/en
Application filed by Celltech Ltd filed Critical Celltech Ltd
Publication of NO914979D0 publication Critical patent/NO914979D0/no
Publication of NO914979L publication Critical patent/NO914979L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
NO91914979A 1990-04-18 1991-12-17 Tetra-aza-makrosykliske forbindelser, fremgangsmaate for deres fremstilling og anvendelse for avbilding ved magnetisk resonans NO914979L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909008720A GB9008720D0 (en) 1990-04-18 1990-04-18 Diagnostic agents
GB909008724A GB9008724D0 (en) 1990-04-18 1990-04-18 Chemical compounds
GB909017148A GB9017148D0 (en) 1990-08-03 1990-08-03 Diagnostic agents
GB919104391A GB9104391D0 (en) 1991-03-01 1991-03-01 Diagnostic agents
PCT/GB1991/000605 WO1991016081A1 (en) 1990-04-18 1991-04-18 Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging

Publications (2)

Publication Number Publication Date
NO914979D0 NO914979D0 (no) 1991-12-17
NO914979L true NO914979L (no) 1991-12-17

Family

ID=27450496

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91914979A NO914979L (no) 1990-04-18 1991-12-17 Tetra-aza-makrosykliske forbindelser, fremgangsmaate for deres fremstilling og anvendelse for avbilding ved magnetisk resonans

Country Status (15)

Country Link
US (1) US5653960A (da)
EP (1) EP0455380B1 (da)
JP (1) JPH05500969A (da)
AT (1) ATE147635T1 (da)
AU (1) AU654951B2 (da)
CA (1) CA2057868A1 (da)
DE (1) DE69124132T2 (da)
DK (1) DK0455380T3 (da)
FI (1) FI915916A0 (da)
GB (1) GB2250198B (da)
IE (1) IE911297A1 (da)
IL (1) IL97902A (da)
NO (1) NO914979L (da)
NZ (1) NZ237868A (da)
WO (1) WO1991016081A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
NZ237868A (en) * 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
TW319763B (da) 1995-02-01 1997-11-11 Epix Medical Inc
JP3356289B2 (ja) * 1995-06-26 2002-12-16 コンキャット リミティド 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
WO2000047111A1 (en) * 1999-02-09 2000-08-17 Board Of Regents The University Of Texas System Ph sensitive mri contrast agents
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE60136476D1 (de) * 2000-09-29 2008-12-18 Anormed Inc -stickstoffhaltigen zyklischen polyaminen und deren verbindungen
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
EP1812453A1 (en) * 2004-10-20 2007-08-01 Therapharm GmbH Method of preparing or synthesizing polyazamacrocycle derivatives

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
EP0232751B1 (en) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
CA2004798A1 (en) * 1988-12-09 1990-06-09 Jacques Banville 6-aminoalkyl carbapenems
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
NZ237868A (en) * 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents

Also Published As

Publication number Publication date
GB2250198A (en) 1992-06-03
GB2250198B (en) 1994-06-22
FI915916A7 (fi) 1991-12-16
GB9126303D0 (en) 1992-02-12
US5653960A (en) 1997-08-05
ATE147635T1 (de) 1997-02-15
EP0455380A2 (en) 1991-11-06
DE69124132D1 (de) 1997-02-27
AU7673091A (en) 1991-11-11
EP0455380A3 (en) 1991-11-27
AU654951B2 (en) 1994-12-01
IL97902A0 (en) 1992-06-21
IE911297A1 (en) 1991-10-23
NZ237868A (en) 1994-04-27
EP0455380B1 (en) 1997-01-15
FI915916A0 (fi) 1991-12-16
DE69124132T2 (de) 1997-06-05
NO914979D0 (no) 1991-12-17
CA2057868A1 (en) 1991-10-19
IL97902A (en) 1996-03-31
JPH05500969A (ja) 1993-02-25
DK0455380T3 (da) 1997-02-03
WO1991016081A1 (en) 1991-10-31

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