NO960115L - Monomere og multimere forbindelser med forsterket relaksivitet - Google Patents
Monomere og multimere forbindelser med forsterket relaksivitetInfo
- Publication number
- NO960115L NO960115L NO960115A NO960115A NO960115L NO 960115 L NO960115 L NO 960115L NO 960115 A NO960115 A NO 960115A NO 960115 A NO960115 A NO 960115A NO 960115 L NO960115 L NO 960115L
- Authority
- NO
- Norway
- Prior art keywords
- metal
- monomeric
- och2ch
- useful
- multimeric compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002184 metal Substances 0.000 abstract 3
- 125000003627 8 membered carbocyclic group Chemical group 0.000 abstract 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Farming Of Fish And Shellfish (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/241,253 US6693190B1 (en) | 1994-05-11 | 1994-05-11 | Enhanced relaxivity monomeric and multimeric compounds |
| PCT/IB1995/000337 WO1995031444A1 (en) | 1994-05-11 | 1995-05-09 | Enhanced relaxivity monomeric and multimeric compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO960115D0 NO960115D0 (no) | 1996-01-10 |
| NO960115L true NO960115L (no) | 1996-03-05 |
| NO306722B1 NO306722B1 (no) | 1999-12-13 |
Family
ID=22909910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960115A NO306722B1 (no) | 1994-05-11 | 1996-01-10 | Karbocykliske ringforbindelser samt metallchelater omfattende disse |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6693190B1 (no) |
| EP (1) | EP0708761B1 (no) |
| JP (1) | JPH09500660A (no) |
| KR (1) | KR960703874A (no) |
| CN (1) | CN1128534A (no) |
| AT (1) | ATE222244T1 (no) |
| CA (1) | CA2164944A1 (no) |
| CZ (1) | CZ8596A3 (no) |
| DE (1) | DE69527759T2 (no) |
| NO (1) | NO306722B1 (no) |
| WO (1) | WO1995031444A1 (no) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US5744616A (en) * | 1996-02-26 | 1998-04-28 | Schering Aktiengesellschaft | Process for the production of 1,4,7,10-tetraazacyclododecane and its derivatives |
| DE19608307C1 (de) * | 1996-02-26 | 1997-08-28 | Schering Ag | Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
| US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| EP1032430A2 (en) | 1997-11-17 | 2000-09-06 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| AU2001276956A1 (en) | 2000-07-17 | 2002-01-30 | California Institute Of Technology | Macrocyclic mri contrast agents |
| AU2002211517A1 (en) | 2000-10-04 | 2002-04-15 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| WO2002098897A2 (en) | 2001-06-01 | 2002-12-12 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| EP1406879A1 (en) * | 2001-07-17 | 2004-04-14 | Therpharm GmbH | Novel chelating agents and conjugates thereof, their synthesis and use as diagnostic and therapeutic agents |
| DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| DE10135355C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
| EP1427377A4 (en) | 2001-09-20 | 2006-04-12 | Cornell Res Foundation Inc | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING SKIN DISORDERS USING SPECIFIC BINDING AGENTS FOR A PROSTATE-SPECIFIC MEMBRANE ANTIGEN |
| CA2495442C (en) | 2002-09-06 | 2013-12-10 | Martin W. Brechbiel | Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same |
| ATE408712T1 (de) | 2003-01-10 | 2008-10-15 | Millennium Pharm Inc | Verfahren zur bestimmung des wiederauftretens von prostata krebs |
| WO2005003105A1 (en) * | 2003-07-08 | 2005-01-13 | The University Of Hong Kong | Synthesis of tris n-alkylated 1,4,7,10-tetraazacyclododecanes |
| US7012140B1 (en) * | 2003-07-14 | 2006-03-14 | Board Of Regents, The University Of Texas System | Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents |
| JP2007516288A (ja) * | 2003-12-23 | 2007-06-21 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 金属キレート剤として有用な新規化合物 |
| DE602005021969D1 (de) * | 2004-07-29 | 2010-08-05 | Otsuka Pharma Co Ltd | Festproben-kern-magnetresonanzmessverfahren |
| JP2008508333A (ja) * | 2004-08-05 | 2008-03-21 | ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン | 標的分子の改変および組織化のための多価キレーター |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| EP1812453A1 (en) * | 2004-10-20 | 2007-08-01 | Therapharm GmbH | Method of preparing or synthesizing polyazamacrocycle derivatives |
| EP1881852B1 (en) * | 2005-04-26 | 2009-08-19 | Koninklijke Philips Electronics N.V. | Mri contrast agents comprising cest active paramagnetic complex |
| CN101845112B (zh) * | 2010-06-02 | 2011-09-14 | 华东理工大学 | 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| EP3515896B1 (en) * | 2016-09-19 | 2024-08-21 | The Hong Kong Polytechnic University | Chiral cyclen compounds and their uses |
| ES2814555T3 (es) * | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| KR102934987B1 (ko) | 2018-11-23 | 2026-03-09 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
| CN118955761B (zh) * | 2024-09-12 | 2025-08-05 | 广东安道科技有限公司 | 一种抗菌水溶性甜菜碱改性壳聚糖及其膜的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3129906C3 (de) | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| SE465907B (sv) | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4678667A (en) | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5271927A (en) | 1986-02-13 | 1993-12-21 | Celltech Limited | Antibody conjugates with macrocyclic ligands |
| DE3625417C2 (de) | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| IT1224416B (it) | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
| FR2637895B1 (fr) | 1988-10-14 | 1992-11-06 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands |
| US5049667A (en) | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
| JP2833766B2 (ja) | 1987-07-16 | 1998-12-09 | ニユコメド・アクシエセルカペト | アミノポリカルボン酸およびその誘導体 |
| GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| JPH0720989B2 (ja) | 1988-05-25 | 1995-03-08 | アメリカ合衆国 | 大環状キレート化合物の抱合体と診断的テスト方法 |
| CA1341373C (en) | 1988-06-24 | 2002-07-02 | Roberta C. Cheng | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
| WO1990007342A1 (en) | 1988-12-23 | 1990-07-12 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
| DE69024826T2 (de) | 1989-02-10 | 1996-06-27 | Celltech Therapeutics Ltd | Aza-Macrozyklen und Verfahren zu deren Herstellung |
| US5053503A (en) | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| DE3911816A1 (de) | 1989-04-11 | 1990-10-25 | Hoechst Ag | Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden |
| IT1243801B (it) | 1990-08-29 | 1994-06-28 | Bracco Ind Chimica Spa | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
| US5162109A (en) | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
| JPH04154729A (ja) | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
| DE4035760A1 (de) | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| CA2096543A1 (en) | 1990-11-21 | 1992-05-22 | Raghavan Rajagopalan | Alkoxyamide derivatized chelates for mri |
| FR2672051B1 (fr) | 1991-01-24 | 1993-05-21 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
| GB9115375D0 (en) | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
| AU663572B2 (en) | 1992-03-27 | 1995-10-12 | Nihon Medi-Physics Co., Ltd. | Tetraazacyclododecane derivative and its use |
| US6120768A (en) * | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
-
1994
- 1994-05-11 US US08/241,253 patent/US6693190B1/en not_active Expired - Fee Related
-
1995
- 1995-05-09 JP JP7529486A patent/JPH09500660A/ja active Pending
- 1995-05-09 CZ CZ9685A patent/CZ8596A3/cs unknown
- 1995-05-09 WO PCT/IB1995/000337 patent/WO1995031444A1/en not_active Ceased
- 1995-05-09 CN CN95190415A patent/CN1128534A/zh active Pending
- 1995-05-09 CA CA002164944A patent/CA2164944A1/en not_active Abandoned
- 1995-05-09 AT AT95915988T patent/ATE222244T1/de not_active IP Right Cessation
- 1995-05-09 KR KR1019960700111A patent/KR960703874A/ko not_active Withdrawn
- 1995-05-09 DE DE69527759T patent/DE69527759T2/de not_active Expired - Fee Related
- 1995-05-09 EP EP95915988A patent/EP0708761B1/en not_active Expired - Lifetime
-
1996
- 1996-01-10 NO NO960115A patent/NO306722B1/no not_active IP Right Cessation
-
2003
- 2003-12-19 US US10/741,872 patent/US20040131551A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09500660A (ja) | 1997-01-21 |
| CN1128534A (zh) | 1996-08-07 |
| DE69527759D1 (de) | 2002-09-19 |
| US20040131551A1 (en) | 2004-07-08 |
| WO1995031444A1 (en) | 1995-11-23 |
| CZ8596A3 (en) | 1996-06-12 |
| US6693190B1 (en) | 2004-02-17 |
| KR960703874A (ko) | 1996-08-31 |
| DE69527759T2 (de) | 2003-04-10 |
| NO306722B1 (no) | 1999-12-13 |
| ATE222244T1 (de) | 2002-08-15 |
| EP0708761A1 (en) | 1996-05-01 |
| EP0708761B1 (en) | 2002-08-14 |
| CA2164944A1 (en) | 1995-11-23 |
| NO960115D0 (no) | 1996-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |