NO920175L - Fremgangsmaate for reversert fasekromatografi - Google Patents

Fremgangsmaate for reversert fasekromatografi

Info

Publication number
NO920175L
NO920175L NO92920175A NO920175A NO920175L NO 920175 L NO920175 L NO 920175L NO 92920175 A NO92920175 A NO 92920175A NO 920175 A NO920175 A NO 920175A NO 920175 L NO920175 L NO 920175L
Authority
NO
Norway
Prior art keywords
nonionic
soluble
water
column
contrast media
Prior art date
Application number
NO92920175A
Other languages
English (en)
Other versions
NO310062B1 (no
NO920175D0 (no
Inventor
Narcisco O Doran
Thomas J Dunn
Mills T Kneller
Youlin Lin
David Ming-Lee Wong
David H White
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of NO920175L publication Critical patent/NO920175L/no
Publication of NO920175D0 publication Critical patent/NO920175D0/no
Publication of NO310062B1 publication Critical patent/NO310062B1/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
NO920175A 1990-02-26 1992-01-14 Fremgangsmåte for reversert fasekromatografi NO310062B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48426190A 1990-02-26 1990-02-26
US07/646,836 US5204005A (en) 1990-02-26 1991-01-28 Reversed phase chromatographic process
PCT/US1991/001201 WO1991012868A1 (en) 1990-02-26 1991-02-21 Reversed phase chromatographic process

Publications (3)

Publication Number Publication Date
NO920175L true NO920175L (no) 1992-01-14
NO920175D0 NO920175D0 (no) 1992-01-14
NO310062B1 NO310062B1 (no) 2001-05-14

Family

ID=27047932

Family Applications (1)

Application Number Title Priority Date Filing Date
NO920175A NO310062B1 (no) 1990-02-26 1992-01-14 Fremgangsmåte for reversert fasekromatografi

Country Status (12)

Country Link
US (1) US5204005A (no)
EP (1) EP0470247B1 (no)
AT (1) ATE151655T1 (no)
AU (1) AU626755B2 (no)
CA (1) CA2062962A1 (no)
DE (1) DE69125665T2 (no)
DK (1) DK0470247T3 (no)
ES (1) ES2103309T3 (no)
GR (1) GR3023716T3 (no)
IE (1) IE910617A1 (no)
NO (1) NO310062B1 (no)
WO (1) WO1991012868A1 (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811581A (en) * 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
IT1282674B1 (it) * 1996-02-23 1998-03-31 Bracco Spa Processo per la purificazione di agenti contrastografici opacizzanti
EP0873169A1 (en) * 1995-12-01 1998-10-28 Mallinckrodt Medical Imaging-Ireland Reversed phase chromatographic process
EP0863782B1 (en) * 1995-12-01 2001-08-16 Mallinckrodt Medical Imaging-Ireland Reversed phase chromatographic process
US5972225A (en) * 1996-05-07 1999-10-26 Cook Imaging Corporation Process for remediating endotoxin-contaminated bulk non-ionic contrast media
EP0907395B1 (en) * 1996-06-05 2001-11-07 Mallinckrodt Medical Imaging-Ireland Reversed phase chromatographic process
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
JP4879392B2 (ja) * 2000-11-09 2012-02-22 日本錬水株式会社 クロマト分離方法
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
US8480889B2 (en) * 2006-04-27 2013-07-09 Agilent Technologies, Inc. Chromatographic stationary phase
JP2010537931A (ja) * 2007-08-27 2010-12-09 マリンクロッド・インコーポレイテッド ナノ濾過および逆相クロマトグラフィーによる水溶性化合物からのシリカの除去
JP5504513B2 (ja) * 2008-02-19 2014-05-28 株式会社タニタ カラム充填剤、これを用いたカラムおよび分離方法
CN102215953A (zh) * 2008-11-19 2011-10-12 安万托特性材料股份有限公司 基于苯氧基烷基和烷氧基-或苯氧基-苯基烷基配体的新色谱介质
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
EP2483235A1 (en) 2009-09-30 2012-08-08 Mallinckrodt LLC Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system
EP2483236A1 (en) 2009-09-30 2012-08-08 Mallinckrodt LLC Reduction of fused bicyclic impurities in triiodinated x-ray contrast media
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
KR101418431B1 (ko) * 2012-09-28 2014-07-11 경북대학교 산학협력단 인산염을 포함하는 삼요오드화 화합물 및 이를 포함하는 ｘ-선 조영제
CN104045580A (zh) * 2014-06-25 2014-09-17 上海华震科技有限公司 一种碘普罗胺脱色纯化工艺
KR20190061526A (ko) 2017-11-28 2019-06-05 엠에프씨 주식회사 크로마토그래피에 의한 조영제의 정제 방법
FR3084668A1 (fr) 2018-08-02 2020-02-07 Guerbet Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法
CN113061099A (zh) * 2021-03-27 2021-07-02 浙江司太立制药股份有限公司 一种高纯度碘造影剂单体的分离纯化方法
CN115078600B (zh) * 2021-08-30 2023-11-03 清华苏州环境创新研究院 一种固相萃取小柱填料的前处理方法
CN116106431B (zh) * 2021-11-09 2024-10-11 北京北陆药业股份有限公司 利用高效液相色谱法分离碘普罗胺及相关杂质的分离及定量分析方法
CN115382518A (zh) * 2022-05-24 2022-11-25 青岛科技大学 一种液相色谱填料及其制备方法
CN117486750B (zh) * 2022-12-30 2026-04-21 西安蓝晓科技新材料股份有限公司 一种碘克沙醇的纯化方法
CN117756660B (zh) * 2024-01-19 2026-03-17 重庆圣华曦药业股份有限公司 一种碘佛醇杂质的去除方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110737A1 (de) * 1981-03-16 1982-10-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zum abtrennen und reinigen von wasserloeslichen, nicht-ionischen verbindungen
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent

Also Published As

Publication number Publication date
DE69125665D1 (de) 1997-05-22
EP0470247A4 (en) 1992-07-08
AU7580591A (en) 1991-09-18
AU626755B2 (en) 1992-08-06
GR3023716T3 (en) 1997-09-30
ATE151655T1 (de) 1997-05-15
NO310062B1 (no) 2001-05-14
EP0470247B1 (en) 1997-04-16
IE910617A1 (en) 1991-08-28
NO920175D0 (no) 1992-01-14
CA2062962A1 (en) 1991-08-27
EP0470247A1 (en) 1992-02-12
DE69125665T2 (de) 1997-10-30
WO1991012868A1 (en) 1991-09-05
ES2103309T3 (es) 1997-09-16
DK0470247T3 (da) 1997-10-27
US5204005A (en) 1993-04-20

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