NO921406L - GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- NO921406L NO921406L NO92921406A NO921406A NO921406L NO 921406 L NO921406 L NO 921406L NO 92921406 A NO92921406 A NO 92921406A NO 921406 A NO921406 A NO 921406A NO 921406 L NO921406 L NO 921406L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- chain
- hydrogen
- phenyl
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- -1 p-methoxybenzyl Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 229960002449 glycine Drugs 0.000 abstract 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 108090000765 processed proteins & peptides Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Difosfonsyrer med formel (I) (A) 3 N-(C)-CK-C-N¿ (B) |l O II O U.-V .j_ ¿OR-, hvor R! og R2 er hydrogen eller C1-C4-alkyl; (A) er hydrogen, halogen, hydroksy eller C1-C12~ alkyl; (B) er en binding, en C^-Cg-alkylenkjede, en cyklo- alkylalkylenkjede, en alkylenkjede substituert med cykloheksyl eller cyklopentylgrupper, eller en aralkylkjede, en alkylkjede som inneholder et heteroatom (O, S eller N-CH3) eller en ureidorest - (CH2)ni-NHCONH-(CH2)n-, hvor n varierer fra l til 5, R3 er hydrogen, C^-Cg-alkyl, C3-C6-cykloalkyl, benzyl, fenyl eller p-metoksybenzyl; (C) er Ci-Cs-alkyl, fenyl eller en aralkylkjede; R4 er hydrogen, C1-C4-alkyl eller en aminogruppe eventuelt substituert med alkyl, fenyl, benzyl, p- metoksybenzyl, acyl, aminoeddiksyre- eller pep- tidgrupper, R5 og R6 er 2-halogenetyl eller de danner sammen en 1-aziridinylrest, er nyttige som atitumormidler.Diphosphonic acids of formula (I) (A) 3 N- (C) -CK-C-N¿ (B) | l O II O U.-V .j_ ¿OR-, where R! and R 2 is hydrogen or C 1 -C 4 alkyl; (A) is hydrogen, halogen, hydroxy or C1-C12 alkyl; (B) is a bond, a C1-C8 alkylene chain, a cycloalkylalkylene chain, an alkylene chain substituted by cyclohexyl or cyclopentyl groups, or an aralkyl chain, an alkyl chain containing a heteroatom (O, S or N-CH3) or a ureido residue - (CH2) nI-NHCONH- (CH2) n-, where n varies from 1 to 5, R3 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, benzyl, phenyl or p-methoxybenzyl; (C) is C 1 -C 6 alkyl, phenyl or an aralkyl chain; R 4 is hydrogen, C 1 -C 4 alkyl or an amino group optionally substituted with alkyl, phenyl, benzyl, p-methoxybenzyl, acyl, aminoacetic acid or peptide groups, R 5 and R 6 are 2-haloethyl or together form a 1-aziridinyl residue, are useful as atitum agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22004A IT1241674B (en) | 1989-10-12 | 1989-10-12 | GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
| PCT/EP1990/001710 WO1991005791A1 (en) | 1989-10-12 | 1990-10-11 | Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO921406L true NO921406L (en) | 1992-04-09 |
| NO921406D0 NO921406D0 (en) | 1992-04-09 |
Family
ID=26069802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921406A NO921406D0 (en) | 1989-10-12 | 1992-04-09 | GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO921406D0 (en) |
-
1992
- 1992-04-09 NO NO921406A patent/NO921406D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO921406D0 (en) | 1992-04-09 |
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