|
US5378696A
(en)
*
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
|
NO921449L
(no)
*
|
1991-04-17 |
1992-10-19 |
American Home Prod |
Karbamater av rapamycin
|
|
US5565560A
(en)
*
|
1991-05-13 |
1996-10-15 |
Merck & Co., Inc. |
O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
|
|
US5252732A
(en)
*
|
1991-09-09 |
1993-10-12 |
Merck & Co., Inc. |
D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
|
|
US5247076A
(en)
*
|
1991-09-09 |
1993-09-21 |
Merck & Co., Inc. |
Imidazolidyl macrolides having immunosuppressive activity
|
|
US5177203A
(en)
*
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
|
ZA935112B
(en)
*
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
ZA935111B
(en)
*
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
US5256790A
(en)
*
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
|
US5434260A
(en)
*
|
1992-10-13 |
1995-07-18 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5302584A
(en)
*
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5489680A
(en)
*
|
1992-10-13 |
1996-02-06 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5480989A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5480988A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
EP0593227B1
(en)
*
|
1992-10-13 |
2006-03-22 |
Wyeth |
Carbamates of rapamycin
|
|
US5262423A
(en)
*
|
1992-10-29 |
1993-11-16 |
American Home Products Corporation |
Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
|
|
US5258389A
(en)
*
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
|
US5349060A
(en)
*
|
1993-01-07 |
1994-09-20 |
American Home Products Corporation |
Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
|
|
US5252579A
(en)
*
|
1993-02-16 |
1993-10-12 |
American Home Products Corporation |
Macrocyclic immunomodulators
|
|
US5310903A
(en)
*
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
Imidazolidyl rapamycin derivatives
|
|
US5310901A
(en)
*
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
|
|
GB9307491D0
(en)
|
1993-04-08 |
1993-06-02 |
Sandoz Ltd |
Organic compounds
|
|
USRE40596E1
(en)
*
|
1993-04-08 |
2008-12-02 |
Novartis Ag |
Rapamycin assay
|
|
AU686629B2
(en)
|
1993-04-23 |
1998-02-12 |
Wyeth |
Rapamycin Conjugates and Antibodies
|
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
|
US5504091A
(en)
*
|
1993-04-23 |
1996-04-02 |
American Home Products Corporation |
Biotin esters of rapamycin
|
|
USRE37421E1
(en)
|
1993-07-16 |
2001-10-23 |
Smithkline Beecham Corporation |
Rapamycin derivatives
|
|
US5387680A
(en)
*
|
1993-08-10 |
1995-02-07 |
American Home Products Corporation |
C-22 ring stabilized rapamycin derivatives
|
|
US5378836A
(en)
*
|
1993-10-08 |
1995-01-03 |
American Home Products Corporation |
Rapamycin oximes and hydrazones
|
|
US5373014A
(en)
*
|
1993-10-08 |
1994-12-13 |
American Home Products Corporation |
Rapamycin oximes
|
|
US5391730A
(en)
*
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
|
WO1995014023A1
(en)
*
|
1993-11-19 |
1995-05-26 |
Abbott Laboratories |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
|
US5527907A
(en)
*
|
1993-11-19 |
1996-06-18 |
Abbott Laboratories |
Macrolide immunomodulators
|
|
US5385910A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
|
US5385908A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
|
US5385909A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
|
PT734389E
(pt)
*
|
1993-12-17 |
2000-09-29 |
Novartis Ag |
Derivados de rapamicina uteis como imunossupressores
|
|
US5389639A
(en)
*
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
|
US5525610A
(en)
*
|
1994-03-31 |
1996-06-11 |
American Home Products Corporation |
42-Epi-rapamycin and pharmaceutical compositions thereof
|
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
|
US5463048A
(en)
*
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
|
US5693648A
(en)
*
|
1994-09-30 |
1997-12-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
|
|
PE52896A1
(es)
|
1994-10-26 |
1996-12-12 |
Novartis Ag |
Composicion farmaceutica
|
|
US5491231A
(en)
*
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
|
US5563145A
(en)
*
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
|
IL122212A
(en)
*
|
1995-06-09 |
2001-08-26 |
Novartis Ag |
Rapamycin derivatives, pharmaceutical compositions comprising them and their preparation
|
|
US5780462A
(en)
*
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
|
US5922730A
(en)
*
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
|
US20030216303A1
(en)
*
|
1998-03-06 |
2003-11-20 |
Michael Ambuhl |
Emulsion preconcentrates containing cyclosporin or a macrolide
|
|
US6015809A
(en)
*
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
|
WO2000041698A1
(en)
|
1999-01-13 |
2000-07-20 |
Bayer Corporation |
φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
|
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
|
US7807211B2
(en)
|
1999-09-03 |
2010-10-05 |
Advanced Cardiovascular Systems, Inc. |
Thermal treatment of an implantable medical device
|
|
US6790228B2
(en)
|
1999-12-23 |
2004-09-14 |
Advanced Cardiovascular Systems, Inc. |
Coating for implantable devices and a method of forming the same
|
|
US20070032853A1
(en)
*
|
2002-03-27 |
2007-02-08 |
Hossainy Syed F |
40-O-(2-hydroxy)ethyl-rapamycin coated stent
|
|
US6277983B1
(en)
|
2000-09-27 |
2001-08-21 |
American Home Products Corporation |
Regioselective synthesis of rapamycin derivatives
|
|
GB0008785D0
(en)
|
2000-04-10 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
|
US6511986B2
(en)
|
2000-08-11 |
2003-01-28 |
Wyeth |
Method of treating estrogen receptor positive carcinoma
|
|
ATE411321T1
(de)
|
2000-09-19 |
2008-10-15 |
Wyeth Corp |
Wasserlösliche rapamycin-ester
|
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
ES2485841T3
(es)
|
2002-02-01 |
2014-08-14 |
Ariad Pharmaceuticals, Inc |
Compuestos que contienen fósforo y usos de los mismos
|
|
EP2324825A1
(en)
|
2002-02-11 |
2011-05-25 |
Bayer Healthcare LLC |
Aryl ureas with angiogenesis inhibiting activity
|
|
RU2344821C2
(ru)
|
2002-07-30 |
2009-01-27 |
Уайт |
Парентеральные композиции, содержащие гидроксиэфиры рапамицина
|
|
EP2517729A3
(en)
|
2003-01-27 |
2013-01-02 |
Endocyte, Inc. |
Vitamin receptor binding drug delivery conjugates
|
|
UY28213A1
(es)
|
2003-02-28 |
2004-09-30 |
Bayer Pharmaceuticals Corp |
Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
|
|
DK1626714T3
(da)
|
2003-05-20 |
2007-10-15 |
Bayer Pharmaceuticals Corp |
Dirarylurinstoffer mod sygdomme medieret af PDGFR
|
|
US20050118344A1
(en)
|
2003-12-01 |
2005-06-02 |
Pacetti Stephen D. |
Temperature controlled crimping
|
|
CN1856469B
(zh)
*
|
2003-07-23 |
2013-03-06 |
拜耳医药保健有限责任公司 |
用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲
|
|
AU2005238431A1
(en)
|
2004-04-14 |
2005-11-10 |
Wyeth |
Regiospecific synthesis of rapamycin 42-ester derivatives
|
|
MXPA06012404A
(es)
*
|
2004-04-27 |
2007-01-17 |
Wyeth Corp |
Marcado de rapamicina usando metilasas especificas de rapamicina.
|
|
EP1768662A2
(en)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
JP5149620B2
(ja)
|
2004-07-23 |
2013-02-20 |
エンドサイト,インコーポレイテッド |
2価リンカーおよびその結合体
|
|
MX2007003790A
(es)
*
|
2004-09-30 |
2007-05-24 |
Ariad Gene Therapeutics Inc |
Metodo de tratamiento.
|
|
US8313763B2
(en)
*
|
2004-10-04 |
2012-11-20 |
Tolmar Therapeutics, Inc. |
Sustained delivery formulations of rapamycin compounds
|
|
CA2582374A1
(en)
*
|
2004-10-04 |
2006-04-20 |
Qlt Usa, Inc. |
Ocular delivery of polymeric delivery formulations
|
|
BRPI0518079A
(pt)
*
|
2004-10-28 |
2008-11-04 |
Wyeth Corp |
usos de um inibidor de mtor, de uma rapamicina, e de 42-éster de rapamicina com ácido 3-hidróxi-2- (hidroximetil) -2-metilpropiÈnico, composição farmacêutica, e, embalagem farmacêutica
|
|
US8021849B2
(en)
*
|
2004-11-05 |
2011-09-20 |
Siemens Healthcare Diagnostics Inc. |
Methods and kits for the determination of sirolimus in a sample
|
|
GB0503936D0
(en)
|
2005-02-25 |
2005-04-06 |
San Raffaele Centro Fond |
Method
|
|
US20100047338A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
|
CN101175757B
(zh)
*
|
2005-03-16 |
2012-11-14 |
恩多塞特公司 |
蝶酸及其缀合物的合成和纯化
|
|
US7189582B2
(en)
*
|
2005-04-27 |
2007-03-13 |
Dade Behring Inc. |
Compositions and methods for detection of sirolimus
|
|
US20090305236A1
(en)
*
|
2005-05-11 |
2009-12-10 |
Genetic Technologies Limited |
Methods of enriching fetal cells
|
|
CN101222925A
(zh)
|
2005-07-20 |
2008-07-16 |
诺瓦提斯公司 |
嘧啶基氨基苯甲酰胺和mTOR激酶抑制剂的组合产品
|
|
SG155912A1
(en)
|
2005-07-25 |
2009-10-29 |
Trubion Pharmaceuticals Inc |
B-cell reduction using cd37-specific and cd20-specific binding molecules
|
|
KR20130113543A
(ko)
*
|
2005-08-19 |
2013-10-15 |
엔도사이트, 인코포레이티드 |
복수-약제 리간드 공액체
|
|
US20070104721A1
(en)
|
2005-11-04 |
2007-05-10 |
Wyeth |
Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
|
|
AR058561A1
(es)
*
|
2005-12-20 |
2008-02-13 |
Wyeth Corp |
Control de la estabilidad de la forma de dosificacion de cci -779 a traves del control de impurezas de sustancias de farmaco
|
|
US20070196850A1
(en)
*
|
2006-01-27 |
2007-08-23 |
University Of Washington |
Identification of aging genes through large-scale analysis
|
|
US20080051691A1
(en)
*
|
2006-08-28 |
2008-02-28 |
Wyeth |
Implantable shunt or catheter enabling gradual delivery of therapeutic agents
|
|
US20080175887A1
(en)
|
2006-11-20 |
2008-07-24 |
Lixiao Wang |
Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
|
|
US8425459B2
(en)
|
2006-11-20 |
2013-04-23 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
|
|
US9737640B2
(en)
|
2006-11-20 |
2017-08-22 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
|
US8414910B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
|
US9700704B2
(en)
|
2006-11-20 |
2017-07-11 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
|
US8414526B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
|
|
US8414525B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
|
US8998846B2
(en)
|
2006-11-20 |
2015-04-07 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
|
US20080276935A1
(en)
|
2006-11-20 |
2008-11-13 |
Lixiao Wang |
Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
|
|
WO2008101231A2
(en)
|
2007-02-16 |
2008-08-21 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
|
CN101678124A
(zh)
|
2007-03-14 |
2010-03-24 |
恩多塞特公司 |
结合配体连接的微管溶素递药缀合物
|
|
TW200901989A
(en)
|
2007-04-10 |
2009-01-16 |
Wyeth Corp |
Anti-tumor activity of CCI-779 in papillary renal cell cancer
|
|
JP2008305262A
(ja)
*
|
2007-06-08 |
2008-12-18 |
Konica Minolta Business Technologies Inc |
サーバ及びシンクライアント環境でのプリンタ紹介方法
|
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
CN101784565B
(zh)
|
2007-06-25 |
2014-12-10 |
恩多塞特公司 |
含有亲水性间隔区接头的共轭物
|
|
US20090148447A1
(en)
*
|
2007-07-06 |
2009-06-11 |
Trubion Pharmaceuticals, Inc. |
Binding Peptides Having a C-terminally Disposed Specific Binding Domain
|
|
US8685995B2
(en)
*
|
2008-03-21 |
2014-04-01 |
The University Of Chicago |
Treatment with opioid antagonists and mTOR inhibitors
|
|
US20090253733A1
(en)
*
|
2008-04-02 |
2009-10-08 |
Biointeractions, Ltd. |
Rapamycin carbonate esters
|
|
PT2132228E
(pt)
|
2008-04-11 |
2011-10-11 |
Emergent Product Dev Seattle |
Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
|
|
WO2010024898A2
(en)
|
2008-08-29 |
2010-03-04 |
Lutonix, Inc. |
Methods and apparatuses for coating balloon catheters
|
|
PT2365802T
(pt)
|
2008-11-11 |
2017-11-14 |
Univ Texas |
Microcápsulas de rapamicina e utilização para o tratamento de cancro
|
|
US20110312916A1
(en)
|
2009-02-05 |
2011-12-22 |
Tokai Pharmaceuticals, Inc. |
Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
|
|
JP2013509444A
(ja)
|
2009-10-30 |
2013-03-14 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
がんの治療方法及び治療用組成物
|
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
|
CA2792258A1
(en)
|
2010-03-05 |
2011-09-09 |
President And Fellows Of Harvard College |
Induced dendritic cell compositions and uses thereof
|
|
JP5918214B2
(ja)
|
2010-04-13 |
2016-05-18 |
ノバルティス アーゲー |
がんを治療するためのサイクリン依存性キナーゼ4またはサイクリン依存性キナーゼ(cdk4/6)阻害剤およびmtor阻害剤を含む組合せ
|
|
RU2012148706A
(ru)
|
2010-04-16 |
2014-05-27 |
Новартис Аг |
Комбинация органичемких соединений
|
|
CN102844049B
(zh)
|
2010-04-27 |
2016-06-01 |
罗切格利卡特公司 |
无岩藻糖基化CD20抗体与mTOR抑制剂的联合疗法
|
|
WO2012125569A2
(en)
|
2011-03-11 |
2012-09-20 |
Beth Israel Deaconess Medical Center, Inc. |
Anti-cd40 antibodies and uses thereof
|
|
SG193919A1
(en)
|
2011-04-25 |
2013-11-29 |
Novartis Ag |
Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
|
|
JP2014519813A
(ja)
|
2011-04-25 |
2014-08-21 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用
|
|
EP2532740A1
(en)
|
2011-06-11 |
2012-12-12 |
Michael Schmück |
Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
|
|
WO2013013708A1
(en)
|
2011-07-26 |
2013-01-31 |
Fundació Institut D'investigació Biomèdica De Bellvitge |
Treatment of acute rejection in renal transplant
|
|
WO2013126797A1
(en)
|
2012-02-24 |
2013-08-29 |
Purdue Research Foundation |
Cholecystokinin b receptor targeting for imaging and therapy
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
CN104203959B
(zh)
|
2012-06-08 |
2017-09-15 |
百多力股份公司 |
雷帕霉素40‑o‑环状烃酯、组合物和方法
|
|
WO2013192367A1
(en)
|
2012-06-22 |
2013-12-27 |
Novartis Ag |
Neuroendocrine tumor treatment
|
|
US20150290176A1
(en)
|
2012-10-12 |
2015-10-15 |
The Board Of Regents Of The University Of Texas System |
Use of mtor inhibitors to treat vascular cognitive impairment
|
|
CN104869998A
(zh)
|
2012-10-16 |
2015-08-26 |
恩多塞特公司 |
含有非天然氨基酸的药物递送缀合物以及其使用方法
|
|
EP2914260A1
(en)
|
2012-10-31 |
2015-09-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for preventing antiphospholipid syndrome (aps)
|
|
US9757432B2
(en)
|
2012-11-14 |
2017-09-12 |
Ohio State Innovation Foundation |
Materials and methods useful for treating glioblastorna
|
|
EP2968281B1
(en)
|
2013-03-13 |
2020-08-05 |
The Board of Regents of The University of Texas System |
Mtor inhibitors for prevention of intestinal polyp growth
|
|
CN105682662A
(zh)
|
2013-03-14 |
2016-06-15 |
马里兰大学巴尔的摩校区 |
雄激素受体减量调节剂及其用途
|
|
BR112016002970A2
(pt)
|
2013-08-12 |
2017-09-12 |
Tokai Pharmaceuticals Inc |
biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
|
|
DK3089737T3
(da)
|
2013-12-31 |
2021-12-13 |
Rapamycin Holdings Llc |
Orale rapamycin-nanopartikelpræparater og anvendelse.
|
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
|
BR112016014903A8
(pt)
|
2014-02-11 |
2018-05-02 |
Novartis Ag |
combinações farmacêuticas que compreendem um inibidor de pi3k, seu uso, sua preparação combinada, e embalagem comercial
|
|
EP3122376A4
(en)
|
2014-03-27 |
2017-12-20 |
The Brigham and Women's Hospital, Inc. |
Metabolically-activated drug conjugates to overcome resistance in cancer therapy
|
|
CA2968049A1
(en)
|
2014-04-16 |
2015-10-22 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
|
WO2015171723A1
(en)
|
2014-05-06 |
2015-11-12 |
Research Development Foundation |
Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy
|
|
JP2017518307A
(ja)
|
2014-06-02 |
2017-07-06 |
チルドレンズ メディカル センター コーポレーション |
免疫調節のための方法および組成物
|
|
CN105461738B
(zh)
*
|
2014-06-03 |
2019-03-08 |
中国人民解放军军事医学科学院毒物药物研究所 |
一种雷帕霉素衍生物、其制备方法、其药物组合物及用途
|
|
MX2017001981A
(es)
|
2014-09-11 |
2017-12-12 |
Univ California |
Inhibidores de diana de rapamicina en celulas de mamifero de complejo 1 (mtorc1).
|
|
WO2017029391A1
(en)
|
2015-08-20 |
2017-02-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method for treating cancer
|
|
HUE056769T2
(hu)
|
2015-09-04 |
2022-03-28 |
Primatope Therapeutics Inc |
Humanizált anti-CD40 antitestek és felhasználásuk
|
|
CN114949250A
(zh)
|
2016-04-14 |
2022-08-30 |
斯宾纳克生物科学公司 |
用于递送治疗剂的组合物、药物组合物、制备方法以及用途
|
|
JP6855470B2
(ja)
|
2016-05-27 |
2021-04-07 |
日本化薬株式会社 |
ラパマイシン又はその誘導体を含有する医薬組成物
|
|
US10532042B2
(en)
|
2016-12-22 |
2020-01-14 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
EP3624863B1
(en)
|
2017-05-15 |
2021-04-14 |
C.R. Bard, Inc. |
Medical device with drug-eluting coating and intermediate layer
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
WO2019002168A1
(en)
|
2017-06-26 |
2019-01-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING OLMSTED SYNDROME
|
|
EP3652306A1
(en)
|
2017-07-13 |
2020-05-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for increasing expansion and immunosuppressive capacity of a population of cd8+cd45rclow/-tregs
|
|
EP4403175A3
(en)
|
2017-09-08 |
2024-10-02 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
|
AU2019262978B2
(en)
|
2018-05-01 |
2023-07-13 |
Revolution Medicines, Inc. |
C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
|
|
WO2019212991A1
(en)
|
2018-05-01 |
2019-11-07 |
Revolution Medicines, Inc. |
C26-linked rapamycin analogs as mtor inhibitors
|
|
MA52501A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
JP7361722B2
(ja)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
|
EP3790886B1
(en)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7357644B2
(ja)
|
2018-06-11 |
2023-10-06 |
アムジエン・インコーポレーテツド |
がんを処置するためのkras g12c阻害剤
|
|
EP3807276B1
(en)
|
2018-06-12 |
2025-12-10 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
CA3107349A1
(en)
|
2018-07-23 |
2020-01-30 |
Enclear Therapies, Inc. |
Methods of treating neurological disorders
|
|
AU2019310040A1
(en)
|
2018-07-23 |
2021-02-11 |
Enclear Therapies, Inc. |
Methods of treating neurological disorders
|
|
EP3849545A1
(en)
|
2018-09-10 |
2021-07-21 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods for the treatment of neurofibromatosis
|
|
JP7262581B2
(ja)
|
2018-11-14 |
2023-04-21 |
ルトニックス,インコーポレーテッド |
改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
EP3883565A1
(en)
|
2018-11-19 |
2021-09-29 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
US12459932B2
(en)
|
2018-12-20 |
2025-11-04 |
Amgen Inc. |
KIF18A inhibitors
|
|
IL283639B2
(en)
|
2018-12-20 |
2024-06-01 |
Amgen Inc |
Kif18a inhibitors
|
|
MA54547A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
|
|
ES2996960T3
(en)
|
2018-12-20 |
2025-02-13 |
Amgen Inc |
Heteroaryl amides useful as kif18a inhibitors
|
|
WO2020163594A1
(en)
|
2019-02-07 |
2020-08-13 |
The Regents Of The University Of California |
Immunophilin binding agents and uses thereof
|
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
MX2021010323A
(es)
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Compuestos bicíclicos de heterociclilo y usos de este.
|
|
JP7487228B2
(ja)
|
2019-04-08 |
2024-05-20 |
バード・ペリフェラル・バスキュラー・インコーポレーテッド |
改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス
|
|
KR20220011123A
(ko)
|
2019-04-11 |
2022-01-27 |
엔클리어 테라피스, 인크. |
뇌척수액 개선 방법 및 이를 위한 디바이스 및 시스템
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
WO2020236947A1
(en)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Solid state forms
|
|
MX2022001296A
(es)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Inhibidores de kif18a.
|
|
US20220289724A1
(en)
|
2019-08-02 |
2022-09-15 |
Amgen Inc. |
Kif18a inhibitors
|
|
WO2021026101A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
CA3147276A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
US20220402916A1
(en)
|
2019-09-18 |
2022-12-22 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
|
AU2020369569A1
(en)
|
2019-10-24 |
2022-04-14 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer
|
|
PE20221253A1
(es)
|
2019-10-28 |
2022-08-16 |
Merck Sharp & Dohme |
Inhibidores de pequenas moleculas de mutante g12c de kras
|
|
CN115551500A
(zh)
|
2019-10-31 |
2022-12-30 |
大鹏药品工业株式会社 |
4-氨基丁-2-烯酰胺衍生物及其盐
|
|
CN115873020B
(zh)
|
2019-11-04 |
2025-06-13 |
锐新医药公司 |
Ras抑制剂
|
|
WO2021091982A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
CA3160142A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
PE20230249A1
(es)
|
2019-11-08 |
2023-02-07 |
Revolution Medicines Inc |
Compuestos de heteroarilo biciclicos y usos de estos
|
|
IL292315A
(en)
|
2019-11-14 |
2022-06-01 |
Amgen Inc |
Improved synthesis of kras g12c inhibitor compound
|
|
WO2021097207A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
|
EP4065231A1
(en)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
WO2021106231A1
(en)
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
US20230181536A1
(en)
|
2020-04-24 |
2023-06-15 |
Taiho Pharmaceutical Co., Ltd. |
Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
|
|
WO2021215544A1
(en)
|
2020-04-24 |
2021-10-28 |
Taiho Pharmaceutical Co., Ltd. |
Kras g12d protein inhibitors
|
|
US20230255972A1
(en)
|
2020-07-15 |
2023-08-17 |
Taiho Pharmaceutical Co., Ltd. |
Pyrimidine compound-containing combination to be used in tumor treatment
|
|
CN116209438A
(zh)
|
2020-09-03 |
2023-06-02 |
锐新医药公司 |
使用sos1抑制剂治疗具有shp2突变的恶性疾病
|
|
JP7832184B2
(ja)
|
2020-09-15 |
2026-03-17 |
レヴォリューション・メディスンズ,インコーポレイテッド |
がんの治療における、ras阻害剤としてのインドール誘導体
|
|
KR20230107804A
(ko)
|
2020-09-29 |
2023-07-18 |
엔클리어 테라피스, 인크. |
지주막하액 관리 방법 및 시스템
|
|
AR124449A1
(es)
|
2020-12-22 |
2023-03-29 |
Qilu Regor Therapeutics Inc |
Inhibidores de sos1 y usos de los mismos
|
|
PE20240088A1
(es)
|
2021-05-05 |
2024-01-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CN117500811A
(zh)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
共价ras抑制剂及其用途
|
|
AR125787A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
WO2022250170A1
(en)
|
2021-05-28 |
2022-12-01 |
Taiho Pharmaceutical Co., Ltd. |
Small molecule inhibitors of kras mutated proteins
|
|
EP4370160A1
(en)
|
2021-07-15 |
2024-05-22 |
President And Fellows Of Harvard College |
Compositions and methods relating to cells with adhered particles
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023064058A1
(en)
|
2021-10-12 |
2023-04-20 |
Peloton Therapeutics Inc. |
Tricyclic sultams and sulfamides as antitumor agents
|
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
US20250188036A1
(en)
|
2022-03-07 |
2025-06-12 |
Amgen Inc. |
A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
|
|
EP4489755A1
(en)
|
2022-03-08 |
2025-01-15 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
|
WO2023230577A1
(en)
|
2022-05-25 |
2023-11-30 |
Revolution Medicines, Inc. |
Methods of treating cancer with an mtor inhibitor
|
|
IL317476A
(en)
|
2022-06-10 |
2025-02-01 |
Revolution Medicines Inc |
Macrocyclic RAS inhibitors
|
|
JP2025521677A
(ja)
|
2022-07-06 |
2025-07-10 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
増殖性糸球体腎炎を処置するための方法
|
|
WO2024028433A1
(en)
|
2022-08-04 |
2024-02-08 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of lymphoproliferative disorders
|
|
CR20250141A
(es)
|
2022-10-14 |
2025-05-26 |
Black Diamond Therapeutics Inc |
Métodos de tratamiento del cáncer usando derivados de isoquinolina o 6-aza-quinolina
|
|
WO2024206858A1
(en)
|
2023-03-30 |
2024-10-03 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
PE20260039A1
(es)
|
2023-04-07 |
2026-01-09 |
Revolution Medicines Inc |
Inhibidores macrociclicos de ras
|
|
PE20252777A1
(es)
|
2023-04-07 |
2025-12-22 |
Revolution Medicines Inc |
Inhibidores macrociclicos de ras
|
|
KR20250169290A
(ko)
|
2023-04-14 |
2025-12-02 |
레볼루션 메디슨즈, 인크. |
Ras 억제제의 결정형, 이를 함유하는 조성물 및 이의 사용 방법
|
|
WO2024216016A1
(en)
|
2023-04-14 |
2024-10-17 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
EP4704850A1
(en)
|
2023-05-04 |
2026-03-11 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
AU2024327098A1
(en)
|
2023-08-24 |
2026-03-12 |
Taiho Pharmaceutical Co., Ltd. |
Fixed dose combinations of cedazuridine and azacitidine
|
|
US20250154171A1
(en)
|
2023-10-12 |
2025-05-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
AU2024361909A1
(en)
|
2023-10-20 |
2026-03-26 |
Merck Sharp & Dohme Llc |
Small molecule inhibitors of kras proteins
|
|
CN118027062B
(zh)
*
|
2023-11-03 |
2025-02-14 |
沈阳药科大学 |
一种雷帕霉素前药及其纳米制剂的制备和应用
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
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