MA54543A - Inhibiteurs de kif18a - Google Patents

Inhibiteurs de kif18a

Info

Publication number
MA54543A
MA54543A MA054543A MA54543A MA54543A MA 54543 A MA54543 A MA 54543A MA 054543 A MA054543 A MA 054543A MA 54543 A MA54543 A MA 54543A MA 54543 A MA54543 A MA 54543A
Authority
MA
Morocco
Prior art keywords
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054543A
Other languages
English (en)
Inventor
Abhisek Banerjee
Matthew Paul Bourbeau
James Alexander Brown
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Kexue Li
Qingyian Liu
Jonathan Dante Low
Vu Ma
Ana Elena Minatti
Liping H Pettus
Nuria A Tamayo
Mary Catherine Walton
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54543A publication Critical patent/MA54543A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA054543A 2018-12-20 2019-12-20 Inhibiteurs de kif18a MA54543A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783061P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54543A true MA54543A (fr) 2022-03-30

Family

ID=69187977

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054543A MA54543A (fr) 2018-12-20 2019-12-20 Inhibiteurs de kif18a

Country Status (25)

Country Link
US (4) US11236069B2 (fr)
EP (1) EP3897852B1 (fr)
JP (1) JP7407196B2 (fr)
KR (1) KR102875569B1 (fr)
CN (2) CN113226473B (fr)
AR (1) AR117490A1 (fr)
AU (1) AU2019403486B2 (fr)
BR (1) BR112021011989A2 (fr)
CA (1) CA3123871A1 (fr)
CL (1) CL2021001634A1 (fr)
CO (1) CO2021008224A2 (fr)
CR (1) CR20210387A (fr)
EA (1) EA202191730A1 (fr)
IL (1) IL283639B2 (fr)
JO (1) JOP20210154B1 (fr)
MA (1) MA54543A (fr)
MX (1) MX2021007156A (fr)
PE (1) PE20211475A1 (fr)
PH (1) PH12021551409A1 (fr)
SA (1) SA521422303B1 (fr)
SG (1) SG11202106520VA (fr)
TW (1) TWI844602B (fr)
UA (1) UA129950C2 (fr)
UY (1) UY38526A (fr)
WO (1) WO2020132648A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL283639B2 (en) * 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
AU2019404576B2 (en) * 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019401495B2 (en) 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
MA54550A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
JP2023521802A (ja) * 2020-04-14 2023-05-25 アムジエン・インコーポレーテツド 新生物疾患の処置のためのｋｉｆ１８ａ阻害剤
JP7654071B2 (ja) 2020-10-20 2025-03-31 アムジエン・インコーポレーテツド 複素環スピロ化合物及び使用方法
WO2022093856A1 (fr) 2020-10-27 2022-05-05 Amgen Inc. Composés spiro hétérocycliques et procédés d'utilisation
EP4329888A1 (fr) 2021-04-29 2024-03-06 Amgen Inc. Composés de 2-aminobenzothiazole et leurs procédés d'utilisation
EP4361142A4 (fr) * 2021-06-25 2025-07-09 Hangzhou Innogate Pharma Co Ltd Composé destiné à être utilisé en tant qu'inhibiteur de kif18a
TW202321213A (zh) 2021-07-21 2023-06-01 美商安進公司 Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式
KR20240109977A (ko) * 2021-08-26 2024-07-12 볼라스트라 쎄라퓨틱스, 인코포레이티드 Kif18a의 스피로 인돌린 억제제
MX2024005996A (es) 2021-11-19 2024-05-30 Wigen Biomedicine Tech Shanghai Co Ltd Inhibidor de kif18a.
AU2023211589A1 (en) * 2022-01-26 2024-07-25 Amgen Inc. Synthesis of a kif18a inhibitor
JP2025508702A (ja) 2022-02-16 2025-04-10 アムジエン・インコーポレーテツド キナゾリン化合物、及び変異ｋｒａｓタンパク質の阻害剤としてのその使用
CN118715215A (zh) 2022-02-16 2024-09-27 美国安进公司 作为突变kras蛋白抑制剂的喹唑啉化合物及其用途
CN118613478A (zh) * 2022-03-17 2024-09-06 微境生物医药科技(上海)有限公司 Kif18a抑制剂
AU2023254325B2 (en) * 2022-04-15 2026-06-04 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Kif18a inhibitor and use thereof
CN116789637B (zh) * 2022-05-13 2024-08-02 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
EP4524136A4 (fr) * 2022-05-13 2025-08-06 Shanghai Apeiron Therapeutics Company Ltd Inhibiteur de kinésine kif18a et son utilisation
US20250382298A1 (en) 2022-06-30 2025-12-18 Suzhou Genhouse Bio Co., Ltd. Nitrogen-containing compound and use thereof
CN117510463B (zh) * 2022-08-05 2026-05-29 长春金赛药业有限责任公司 Kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024032661A1 (fr) * 2022-08-11 2024-02-15 山东轩竹医药科技有限公司 Inhibiteur de kif18a et son utilisation
US20260062416A1 (en) * 2022-08-12 2026-03-05 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
CR20250087A (es) * 2022-08-18 2025-07-11 Accent Therapeutics Inc Inhibidores de kif18a y usos de estos
AU2023337160A1 (en) * 2022-09-08 2025-03-20 Changchun Genescience Pharmaceutical Co., Ltd. Kif18a inhibitor compound, and pharmaceutical composition and preparation method therefor and use thereof
WO2024051812A1 (fr) * 2022-09-09 2024-03-14 先声再明医药有限公司 Composé amide, composition et utilisation correspondante
CN119072473B (zh) * 2022-09-30 2026-05-29 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024067465A1 (fr) * 2022-09-30 2024-04-04 山东轩竹医药科技有限公司 Inhibiteur de kif18a
CN117917405A (zh) * 2022-10-21 2024-04-23 杭州邦顺制药有限公司 Kif18a蛋白抑制剂
JP2025539080A (ja) 2022-11-14 2025-12-03 アムジエン・インコーポレーテツド 大環状ｋｒａｓ阻害剤及び使用方法
JP2025538601A (ja) * 2022-11-24 2025-11-28 インベンティスバイオ カンパニー リミテッド 複素環化合物、その製造方法および用途
CN115594664B (zh) * 2022-11-25 2023-02-24 英矽智能科技(上海)有限公司 一类螺环衍生物作为kif18a抑制剂
WO2024114730A1 (fr) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 Composition pharmaceutique pour le traitement du cancer
JP2026508745A (ja) * 2022-12-02 2026-03-12 シェンチェン ジョングァー バイオロジカル テクノロジー カンパニー リミテッド アミド又はウレア系化合物
CN120265626A (zh) * 2022-12-14 2025-07-04 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
CN120641408A (zh) * 2022-12-16 2025-09-12 抟相医药(上海)有限公司 含氮化合物、药物组合物及其用途
WO2024137984A1 (fr) * 2022-12-22 2024-06-27 Accent Therapeutics, Inc. Inhibiteurs de kif18a et utilisations associées
US20260209248A1 (en) * 2022-12-28 2026-07-23 Insilico Medicine Ip Limited Inhibitors of kif18a and uses thereof
CN120569373A (zh) * 2023-01-05 2025-08-29 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和医药上的用途
TW202434237A (zh) * 2023-01-20 2024-09-01 香港商英矽智能科技知識產權有限公司 Kif18a之抑制劑及其用途
CN118598855A (zh) * 2023-03-06 2024-09-06 武汉人福创新药物研发中心有限公司 抑制kif18a的化合物及其用途
CN115947717B (zh) * 2023-03-09 2023-05-30 英矽智能科技(上海)有限公司 一类kif18a抑制剂
KR20250154490A (ko) 2023-03-10 2025-10-28 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 방향족 아미드 유도체, 이의 제조 방법, 및 그의 용도
CN121002013A (zh) * 2023-04-18 2025-11-21 南京同诺康医药科技有限公司 Kif18a抑制剂及其制备方法和用途
CN116535400B (zh) * 2023-04-26 2024-08-16 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用
EP4748837A1 (fr) 2023-07-21 2026-05-27 Zhejiang Hisun Pharmaceutical Co., Ltd. Dérivé d'amide aromatique, son procédé de préparation et son utilisation
CN121752573A (zh) * 2023-08-02 2026-03-27 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2025035759A1 (fr) * 2023-08-17 2025-02-20 深圳市祥根生物有限公司 Inhibiteur de kif18a et son utilisation
CN121712776A (zh) * 2023-09-26 2026-03-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
CN119823101A (zh) * 2023-10-13 2025-04-15 武汉人福创新药物研发中心有限公司 Kif18a抑制剂化合物的盐、晶型及其制备方法和用途
TW202527941A (zh) * 2023-10-13 2025-07-16 美商依安彼克醫療有限公司 Ｋｉｆ調節劑化合物及使用方法
WO2025163351A1 (fr) * 2024-02-02 2025-08-07 Satyarx Pharma Innovations Pvt Ltd Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de kif18a
WO2025185706A1 (fr) * 2024-03-07 2025-09-12 长春金赛药业有限责任公司 Sel pharmaceutiquement acceptable et forme cristalline d'un inhibiteur de kif18a, procédé de préparation correspondant et utilisation associée
WO2025185704A1 (fr) * 2024-03-07 2025-09-12 长春金赛药业有限责任公司 Forme cristalline d'un inhibiteur de kif18a, son procédé de préparation et son utilisation
WO2025190325A1 (fr) * 2024-03-13 2025-09-18 海南先声再明医药股份有限公司 Combinaison pharmaceutique d'inhibiteur de kif18a et d'inhibiteur de tubuline et son utilisation
TW202602882A (zh) 2024-03-14 2026-01-16 美商安進公司 作為ｋｒａｓ調節劑的大環化合物及其用途
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025195205A1 (fr) * 2024-03-21 2025-09-25 甫康（上海）健康科技有限责任公司 Composé sulfanilamide et son utilisation
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025242166A1 (fr) * 2024-05-22 2025-11-27 InventisBio Co., Ltd. Composés hétérocycliques, leurs procédés de préparation et leurs utilisations
TW202617145A (zh) * 2024-07-02 2026-05-01 大陸商長春金賽藥業有限責任公司 Ｋｉｆ１８ａ抑制劑治療卵巢癌的用途
WO2026021411A1 (fr) * 2024-07-23 2026-01-29 Insilico Medicine Ip Limited Inhibiteurs de kif18a et leurs utilisations
WO2026055477A1 (fr) 2024-09-06 2026-03-12 Amgen Inc. Composés macrocycliques constituant des modulateurs de kras et leurs utilisations

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
GB2116183B (en) 1982-03-03 1985-06-05 Genentech Inc Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
JP2762522B2 (ja) 1989-03-06 1998-06-04 藤沢薬品工業株式会社 血管新生阻害剤
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
PT98990A (pt) 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5892112A (en) 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
DE69222637T2 (de) 1991-05-10 1998-02-26 Rhone Poulenc Rorer Int Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
ZA935111B (en) 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
PT669929E (pt) 1992-11-13 2007-04-30 Immunex Corp Ligando de elk, uma citoquina
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5516658A (en) 1993-08-20 1996-05-14 Immunex Corporation DNA encoding cytokines that bind the cell surface receptor hek
AU693475B2 (en) 1993-10-01 1998-07-02 Novartis Ag Pyrimidineamine derivatives and processes for the preparation thereof
US5656643A (en) 1993-11-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
EP0729471A1 (fr) 1993-11-19 1996-09-04 Abbott Laboratories Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs
BR9408323A (pt) 1993-12-17 1997-08-19 Sandoz Ag Derivados de rapamicina
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
WO1995024190A2 (fr) 1994-03-07 1995-09-14 Sugen, Inc. Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant
EP0756627A1 (fr) 1994-04-15 1997-02-05 Amgen Inc. Nouvelles proteines tyrosine kinases receptrices analogues a l'eph, du type hek5, hek7, hek8, hek11
ES2109796T3 (es) 1994-05-03 1998-01-16 Ciba Geigy Ag Derivados de pirrolopirimidilo con efecto antiproliferante.
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
US5919905A (en) 1994-10-05 1999-07-06 Immunex Corporation Cytokine designated LERK-6
US6057124A (en) 1995-01-27 2000-05-02 Amgen Inc. Nucleic acids encoding ligands for HEK4 receptors
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
ATE446955T1 (de) 1995-03-30 2009-11-15 Pfizer Prod Inc Chinazolinone derivate
JP4249804B2 (ja) 1995-04-03 2009-04-08 ノバルティス・アクチエンゲゼルシャフト ピラゾール誘導体およびその製造法
CA2218503C (fr) 1995-04-20 2001-07-24 Pfizer Inc. Derives d'acide hydroxamique arylsufonyle en tant qu'inhibiteurs de mmp et de tnf
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5650415A (en) 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE69624921T2 (de) 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
PL188959B1 (pl) 1995-07-06 2005-05-31 Novartis Ag Pirolopirymidyny i sposoby ich wytwarzania
DE19534177A1 (de) 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
DK0780386T3 (da) 1995-12-20 2003-02-03 Hoffmann La Roche Matrixmetalloproteaseinhibitorer
US6140317A (en) 1996-01-23 2000-10-31 Novartis Ag Pyrrolopyrimidines and processes for their preparation
JP3406763B2 (ja) 1996-01-30 2003-05-12 東レ・ダウコーニング・シリコーン株式会社 シリコーンゴム組成物
GB9603097D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
DE19629652A1 (de) 1996-03-06 1998-01-29 Thomae Gmbh Dr K 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608588A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE59710417D1 (de) 1996-03-15 2003-08-14 Novartis Ag N-7 HETEROCYCLYL-PYRROLO[ 2,3-d]PYRIMIDINE UND IHRE VERWENDUNG
CN100503580C (zh) 1996-04-12 2009-06-24 沃尼尔·朗伯公司 酪氨酸激酶的不可逆抑制剂
GB9607729D0 (en) 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
BR9709959A (pt) 1996-06-24 2000-05-09 Pfizer Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
WO1998002441A2 (fr) 1996-07-12 1998-01-22 Ariad Pharmaceuticals, Inc. Elements et procedes pour traiter ou prevenir les mycoses pathogènes
EP0818442A3 (fr) 1996-07-12 1998-12-30 Pfizer Inc. Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
AR007855A1 (es) 1996-07-13 1999-11-24 Glaxo Group Ltd Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
US6391874B1 (en) 1996-07-13 2002-05-21 Smithkline Beecham Corporation Fused heterocyclic compounds as protein tyrosine kinase inhibitors
EP0923585B1 (fr) 1996-07-18 2002-05-08 Pfizer Inc. Composes a base de phosphinate inhibiteurs des metalloproteases matricielles
DK0920505T3 (da) 1996-08-16 2008-09-08 Schering Corp Pattedyrcelleoverfladeantigener og tilhörende reagenser
US6111090A (en) 1996-08-16 2000-08-29 Schering Corporation Mammalian cell surface antigens; related reagents
EP0922030A1 (fr) 1996-08-23 1999-06-16 Pfizer Inc. Derives de l'acide arylsulfonylamino hydroxamique
PT938486E (pt) 1996-08-23 2008-03-27 Novartis Ag Pirrolopirimidinas substituídas e processos para a sua preparação
WO1998014449A1 (fr) 1996-10-02 1998-04-09 Novartis Ag Derives de pyrazole condenses et procedes pour leur preparation
CA2266519C (fr) 1996-10-02 2007-01-23 Novartis Ag Derives de pyrimidine et procedes de preparation de ces derniers
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
EP0837063A1 (fr) 1996-10-17 1998-04-22 Pfizer Inc. Dérivés de 4-aminoquinazoline
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
US6077864A (en) 1997-01-06 2000-06-20 Pfizer Inc. Cyclic sulfone derivatives
HUP0000852A2 (hu) 1997-02-03 2001-05-28 Pfizer Products Inc. Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
ES2301194T3 (es) 1997-02-05 2008-06-16 Warner-Lambert Company Llc Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular.
JP2000507975A (ja) 1997-02-07 2000-06-27 ファイザー・インク Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
NZ336836A (en) 1997-02-11 2001-02-23 Pfizer Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
US6150395A (en) 1997-05-30 2000-11-21 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
WO1999007701A1 (fr) 1997-08-05 1999-02-18 Sugen, Inc. Derives de quinoxaline tricyclique utiles en tant qu'inhibiteurs de proteine tyrosine kinase
TR200000368T2 (tr) 1997-08-08 2000-07-21 Pfizer Products Inc. Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
CA2308114A1 (fr) 1997-10-21 1999-04-29 Human Genome Sciences, Inc. Proteines tr11, tr11sv1 et tr11sv2 de type recepteur du facteur de necrose tumorale humain
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
JP2002502607A (ja) 1998-02-09 2002-01-29 ジェネンテク・インコーポレイテッド 新規な腫瘍壊死因子レセプター相同体及びそれをコードする核酸
DE69940808D1 (de) 1998-03-04 2009-06-10 Bristol Myers Squibb Co Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
KR100743287B1 (ko) 1998-05-29 2007-07-26 수젠, 인크. 피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
AU747427B2 (en) 1998-07-10 2002-05-16 Merck & Co., Inc. Novel angiogenesis inhibitors
CA2341409A1 (fr) 1998-08-31 2000-03-09 Merck And Co., Inc. Nouveaux inhibiteurs d'angiogenese
EP1004578B1 (fr) 1998-11-05 2004-02-25 Pfizer Products Inc. Dérivés d'hydroxamide de l'acide 5-oxo-pyrrolidine-2-carboxylique
EP2298311B1 (fr) 1999-01-13 2012-05-09 Bayer HealthCare LLC Urées de diphényle à substitution omega-carboxyaryle en tant qu'inhibiteurs de la p38 kinase
ATE329596T1 (de) 1999-03-30 2006-07-15 Novartis Pharma Gmbh Phthalazinderivate zur behandlung von entzündlicher erkrankungen
GB9912961D0 (en) 1999-06-03 1999-08-04 Pfizer Ltd Metalloprotease inhibitors
US6521424B2 (en) 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
NZ516258A (en) 1999-06-07 2004-02-27 Immunex Corp Tek antagonists
ATE376837T1 (de) 1999-07-12 2007-11-15 Genentech Inc Stimulierung oder hemmung von angiogenese und herzvaskularisierung mit tumor nekrose faktor ligand/rezeptor homologen
IL147803A0 (en) 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
CA2387138A1 (fr) 1999-10-18 2001-04-26 University Of Connecticut Derives indoliques cannabimimetiques
PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
JP5336686B2 (ja) 1999-11-24 2013-11-06 スージェン， インク． 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
US6515004B1 (en) 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6727225B2 (en) 1999-12-20 2004-04-27 Immunex Corporation TWEAK receptor
US7074408B2 (en) 2000-02-25 2006-07-11 Immunex Corporation Use of integrin antagonists to inhibit angiogenesis
US6651123B1 (en) 2000-03-30 2003-11-18 International Business Machines Corporation File system locking
US6534309B1 (en) 2000-08-03 2003-03-18 Cytokinetics, Inc. Motor proteins and methods for their use
US6630500B2 (en) 2000-08-25 2003-10-07 Cephalon, Inc. Selected fused pyrrolocarbazoles
MXPA03005696A (es) 2000-12-21 2003-10-06 Glaxo Group Ltd Pirimidinaminas como moduladores de angiogenesis.
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20020147198A1 (en) 2001-01-12 2002-10-10 Guoqing Chen Substituted arylamine derivatives and methods of use
EP1517904A4 (fr) 2002-05-23 2007-02-21 Merck & Co Inc Inhibiteurs de kinesine mitotique
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
EP2305813A3 (fr) 2002-11-14 2012-03-28 Dharmacon, Inc. SIRNA fonctionnel et hyperfonctionnel
US7423018B2 (en) 2002-12-13 2008-09-09 University Of Massachusetts Kinesin-like proteins and methods of use
AU2004244626A1 (en) 2003-05-23 2004-12-09 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services GITR ligand and GITR ligand-related molecules and antibodies and uses thereof
CA2531454C (fr) 2003-07-08 2011-10-25 Novartis Ag Utilisation de rapamycine et de derives de rapamycine pour traiter les pertes de masse osseuse
EP1660126A1 (fr) 2003-07-11 2006-05-31 Schering Corporation Agonistes ou antagonistes du recepteur du facteur de necrose tumorale induit par les glucocorticoides (gitr) ou de son ligand utilises dans le traitement des troubles immuns, des infections et du cancer
EP1648900A4 (fr) 2003-07-11 2010-02-10 Ariad Pharma Inc Macrocycles contenant du phosphore
TW200523262A (en) 2003-07-29 2005-07-16 Smithkline Beecham Corp Inhibitors of AKT activity
US7638549B2 (en) 2003-08-15 2009-12-29 Merck & Co. Inc. Mitotic kinesin inhibitors
EP1692318A4 (fr) 2003-12-02 2008-04-02 Genzyme Corp Compositions et methodes pour le diagnostic et le traitement du cancer du poumon
BRPI0417498A (pt) 2003-12-09 2007-05-29 Us Gov Health & Human Serv método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular
GB0409799D0 (en) 2004-04-30 2004-06-09 Isis Innovation Method of generating improved immune response
US7504413B2 (en) 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
EP1765402A2 (fr) 2004-06-04 2007-03-28 Duke University Methodes et compositions ameliorant l'immunite par depletion in vivo de l'activite cellulaire immunosuppressive
MXPA06014909A (es) * 2004-06-18 2007-02-28 Chiron Corp Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer.
DE602005024572D1 (de) 2004-08-18 2010-12-16 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
JP4242911B2 (ja) 2004-08-26 2009-03-25 ファイザー・インク プロテインキナーゼ阻害薬としてのエナンチオピュアなアミノヘテロアリール化合物
TW200626610A (en) 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
JP5238936B2 (ja) 2005-03-25 2013-07-17 ジーアイティーアール，インク． Ｇｉｔｒ結合分子およびその使用
WO2006114788A1 (fr) 2005-04-25 2006-11-02 Ramot At Tel Aviv University Ltd. Polypeptides de kinesine, polynucleotides codant pour ceux-ci et compositions et leurs methodes d'utilisation
EP3530736A3 (fr) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (pd-1) et procédés de traitement du cancer à l'aide d'anticorps anti-pd-1 seuls ou combinés à d'autres formulations immunothérapeutiques
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CN101267824A (zh) 2005-09-20 2008-09-17 辉瑞产品公司 使用酪氨酸激酶抑制剂的治疗剂型和方法
EP1942888A2 (fr) 2005-11-02 2008-07-16 Cytokinetics, Inc. Entites et compositions chimiques et methodes associees
WO2007133822A1 (fr) 2006-01-19 2007-11-22 Genzyme Corporation Anticorps anti-gitr destinés au traitement du cancer
JP2009543770A (ja) 2006-07-14 2009-12-10 アステックス・セラピューティクス・リミテッド Ｃｄｋ及びｇｓｋの阻害のためのピラゾール誘導体の組合せ剤
AR062200A1 (es) 2006-08-04 2008-10-22 Aeterna Zentaris Gmbh Derivados de antraceno y su uso para el tratamiento de emfermedades tumorales bengnas y malingnas
PE20081679A1 (es) 2006-12-07 2008-12-18 Hoffmann La Roche Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
PT2175884T (pt) 2007-07-12 2016-09-21 Gitr Inc Terapias de combinação empregando moléculas de ligação a gitr
BRPI0816769A2 (pt) 2007-09-12 2016-11-29 Hoffmann La Roche combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
WO2009055730A1 (fr) 2007-10-25 2009-04-30 Genentech, Inc. Procédé de préparation de composés de thiénopyrimidine
JP2011526794A (ja) 2008-07-02 2011-10-20 エマージェント プロダクト デベロップメント シアトル， エルエルシー ＴＧＦ−βアンタゴニスト多重標的結合性分子
JPWO2010030002A1 (ja) 2008-09-12 2012-02-02 国立大学法人三重大学 外来性ｇｉｔｒリガンド発現細胞
TW201103904A (en) * 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
IN2015DN02826A (fr) 2009-09-03 2015-09-11 Merck Sharp & Dohme
EP2295543A1 (fr) 2009-09-11 2011-03-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé de préparation de virus de la grippe
GB0919054D0 (en) 2009-10-30 2009-12-16 Isis Innovation Treatment of obesity
US20130089554A1 (en) 2009-12-29 2013-04-11 Emergent Product Development Seattle, Llc RON Binding Constructs and Methods of Use Thereof
WO2011085261A1 (fr) * 2010-01-08 2011-07-14 Selexagen Therapeutics, Inc. Inhibiteurs de hedgehog
EP2694509B1 (fr) 2011-04-05 2016-05-18 Pfizer Limited Dérivés de pyrrolo-[2,3-d]pyrimidine en tant qu'inhibiteurs des kinases associées à la tropomyosine
CN102796103A (zh) * 2011-05-23 2012-11-28 南京英派药业有限公司 6-（芳基甲酰）咪唑并[1,2-a]嘧啶和6-（芳基甲酰）[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用
KR20140048968A (ko) 2011-07-13 2014-04-24 파마시클릭스, 인코포레이티드 브루톤형 티로신 키나제의 억제제
US20130108641A1 (en) 2011-09-14 2013-05-02 Sanofi Anti-gitr antibodies
US9890430B2 (en) 2012-06-12 2018-02-13 Washington University Copy number aberration driven endocrine response gene signature
CN103242332B (zh) 2013-05-13 2015-11-04 江西科技师范大学 1-n酰基取代吲哚酮衍生物
ES2672992T3 (es) 2013-08-09 2018-06-19 Takeda Pharmaceutical Company Limited Compuesto aromático
WO2015183776A1 (fr) 2014-05-29 2015-12-03 Merck Sharp & Dohme Corp. Procédés de traitement du cancer avec un inhibiteur de wee1
EP3233918A1 (fr) 2014-12-19 2017-10-25 Novartis AG Polythérapies
WO2016168660A1 (fr) 2015-04-17 2016-10-20 Forma Therapeutics, Inc. Tétralines de 3-spiro-7-acide hydroxamique en tant qu'inhibiteurs de hdac
JP6913032B2 (ja) 2015-05-20 2021-08-04 ザ・ブロード・インスティテュート・インコーポレイテッド 共通ネオ抗原
SG10202008909VA (en) 2016-03-24 2020-10-29 Bayer Pharma AG Prodrugs of cytotoxic active agents having enzymatically cleavable groups
EP3737666A4 (fr) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Agents de dégradation de protéines et utilisations associées
CN108768023B (zh) 2018-08-13 2020-01-07 珠海格力电器股份有限公司 转子组件及交替极电机
DE102018213662A1 (de) 2018-08-14 2020-02-20 Robert Bosch Gmbh Lautsprecher mit einem darin enthaltenen Leuchtelement
CN109039072B (zh) 2018-08-21 2020-09-08 南京南瑞继保电气有限公司 一种双极双向直流变换器及其控制方法和控制装置
AU2019401495B2 (en) 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
IL283639B2 (en) 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
MA54550A (fr) * 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
EP3946470A4 (fr) 2019-04-05 2023-05-31 Earli Inc. Méthodes et compositions améliorées pour biomarqueurs synthétiques
KR102449386B1 (ko) 2019-05-03 2022-10-05 주식회사 디시젠 암 예후 예측방법 및 이의 조성물
US20230093080A1 (en) 2019-07-15 2023-03-23 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US20220289724A1 (en) 2019-08-02 2022-09-15 Amgen Inc. Kif18a inhibitors
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
MX428368B (es) 2019-08-02 2025-11-13 Amgen Inc Inhibidores de kif18a
EP4103045A4 (fr) 2020-02-16 2024-08-14 Genetikaplus Ltd. Procédés de pronostic thérapeutique
US12187992B2 (en) 2020-02-19 2025-01-07 The Regents Of The University Of California Method and device for early cancer screening
JP2023521802A (ja) 2020-04-14 2023-05-25 アムジエン・インコーポレーテツド 新生物疾患の処置のためのｋｉｆ１８ａ阻害剤
WO2021231413A1 (fr) 2020-05-11 2021-11-18 University Of Vermont Approche de traitement impliquant l'inhibition de kif18a pour des tumeurs instables du point de vue chromosomique
TW202220958A (zh) 2020-08-07 2022-06-01 美商卡司馬療法公司 Ｔｒｐｍｌ調節劑
WO2022093856A1 (fr) 2020-10-27 2022-05-05 Amgen Inc. Composés spiro hétérocycliques et procédés d'utilisation
EP4319821A4 (fr) 2021-04-09 2026-05-06 Nanjing University Conjugué et son procédé de préparation et son utilisation
EP4361142A4 (fr) 2021-06-25 2025-07-09 Hangzhou Innogate Pharma Co Ltd Composé destiné à être utilisé en tant qu'inhibiteur de kif18a
TW202321213A (zh) 2021-07-21 2023-06-01 美商安進公司 Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式
KR20240109977A (ko) 2021-08-26 2024-07-12 볼라스트라 쎄라퓨틱스, 인코포레이티드 Kif18a의 스피로 인돌린 억제제
CN118076586A (zh) 2021-09-16 2024-05-24 微境生物医药科技(上海)有限公司 Kif18a抑制剂
WO2023061478A1 (fr) 2021-10-15 2023-04-20 先声再明医药有限公司 Composé tricyclique
MX2024005996A (es) 2021-11-19 2024-05-30 Wigen Biomedicine Tech Shanghai Co Ltd Inhibidor de kif18a.
AU2023211589A1 (en) 2022-01-26 2024-07-25 Amgen Inc. Synthesis of a kif18a inhibitor
WO2023146979A1 (fr) 2022-01-27 2023-08-03 The Board Of Trustees Of The Leland Stanford Junior University Plateforme de cytométrie de masse à cellule unique pour cartographier les effets d'agents candidats sur le cartilage
AU2023254325B2 (en) 2022-04-15 2026-06-04 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Kif18a inhibitor and use thereof
AU2023261964A1 (en) 2022-04-28 2024-11-07 Volastra Therapeutics, Inc. Compounds for inhibiting kif18a
WO2023212714A1 (fr) 2022-04-29 2023-11-02 Amgen Inc. Inhibition de kif18a pour le traitement du cancer
US20250382298A1 (en) 2022-06-30 2025-12-18 Suzhou Genhouse Bio Co., Ltd. Nitrogen-containing compound and use thereof
WO2024032661A1 (fr) 2022-08-11 2024-02-15 山东轩竹医药科技有限公司 Inhibiteur de kif18a et son utilisation
US20260062416A1 (en) 2022-08-12 2026-03-05 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
CR20250087A (es) 2022-08-18 2025-07-11 Accent Therapeutics Inc Inhibidores de kif18a y usos de estos
AU2023337160A1 (en) 2022-09-08 2025-03-20 Changchun Genescience Pharmaceutical Co., Ltd. Kif18a inhibitor compound, and pharmaceutical composition and preparation method therefor and use thereof
WO2024051812A1 (fr) 2022-09-09 2024-03-14 先声再明医药有限公司 Composé amide, composition et utilisation correspondante
CN119855812A (zh) 2022-09-14 2025-04-18 海南先声再明医药股份有限公司 多并环类化合物及其用途
CN119998300A (zh) 2022-09-29 2025-05-13 海南先声再明医药股份有限公司 一类稠环化合物及其用途
CN119072473B (zh) 2022-09-30 2026-05-29 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
CN119894878A (zh) 2022-10-13 2025-04-25 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和用途
CN117917405A (zh) 2022-10-21 2024-04-23 杭州邦顺制药有限公司 Kif18a蛋白抑制剂
WO2024099398A1 (fr) 2022-11-10 2024-05-16 南京明德新药研发有限公司 Classe de composés sulfonamide contenant un hétérocycle ortho-condensé et leur utilisation
AU2024226158A1 (en) 2023-02-23 2025-08-14 Volastra Therapeutics, Inc. Solid formulations and polymorphic forms of indoline inhibitors of kif18a
EP4735420A1 (fr) 2023-06-29 2026-05-06 Volastra Therapeutics, Inc. Inhibiteurs d'aryl indol-3-yl cétone et d'aryl indazol-3-yl cétone de kif18a
WO2025090640A1 (fr) 2023-10-23 2025-05-01 Volastra Therapeutics, Inc. Formulations solides et formes polymorphes d'inhibiteurs d'indoline de kif18a

Also Published As

Publication number Publication date
JP2022513972A (ja) 2022-02-09
TWI844602B (zh) 2024-06-11
TW202034924A (zh) 2020-10-01
US20220106293A1 (en) 2022-04-07
JOP20210154B1 (ar) 2023-09-17
IL283639B2 (en) 2024-06-01
IL283639A (en) 2021-07-29
CR20210387A (es) 2021-08-19
SA521422303B1 (ar) 2023-12-11
UY38526A (es) 2020-06-30
KR102875569B1 (ko) 2025-10-23
US20200239441A1 (en) 2020-07-30
CN120398830A (zh) 2025-08-01
US20240317715A1 (en) 2024-09-26
WO2020132648A1 (fr) 2020-06-25
AU2019403486A1 (en) 2021-06-24
US12054476B2 (en) 2024-08-06
JOP20210154A1 (ar) 2023-01-30
PE20211475A1 (es) 2021-08-05
AR117490A1 (es) 2021-08-11
US11236069B2 (en) 2022-02-01
CN113226473A (zh) 2021-08-06
MX2021007156A (es) 2021-08-16
SG11202106520VA (en) 2021-07-29
CL2021001634A1 (es) 2021-12-10
EP3897852A1 (fr) 2021-10-27
EP3897852B1 (fr) 2026-07-22
CA3123871A1 (fr) 2020-06-25
BR112021011989A2 (pt) 2021-09-08
PH12021551409A1 (en) 2022-05-16
CO2021008224A2 (es) 2021-07-30
IL283639B1 (en) 2024-02-01
CN113226473B (zh) 2025-05-13
EA202191730A1 (ru) 2021-08-24
AU2019403486B2 (en) 2025-04-24
UA129950C2 (uk) 2025-09-24
US12509442B2 (en) 2025-12-30
JP7407196B2 (ja) 2023-12-28
KR20210106474A (ko) 2021-08-30
US20260098029A1 (en) 2026-04-09

Similar Documents

Publication Publication Date Title
IL283639A (en) Kif18a inhibitors
MA54550A (fr) Inhibiteurs de kif18a
EP4007752C0 (fr) Inhibiteurs de kif18a
EP4007753C0 (fr) Inhibiteurs de kif18a
MA52812A (fr) Inhibiteurs de sarm1
EP4007756C0 (fr) Inhibiteurs de kif18a
IL269196A (en) Novel inhibitors
EP3843714A4 (fr) Inhibiteurs de cd73
EP3833355A4 (fr) Inhibiteurs de prmt5
MA52813A (fr) Inhibiteurs de sarm1
DK3740479T3 (da) Dna-pk-hæmmere
EP3788042A4 (fr) Inhibiteurs de bcl-2
MA52413A (fr) Inhibiteurs de cd73
MA52809A (fr) Inhibiteurs de sarm1
EP3541932A4 (fr) Inhibiteurs de crispr-cas9
DK3571192T3 (da) Jak1-selektive inhibitorer
MA52635A (fr) Inhibiteurs de magl
EP3980011A4 (fr) Inhibiteurs de sarm1
EP3787635A4 (fr) Inhibiteurs de cd73
EP3856176A4 (fr) Inhibiteurs de vap-1
EP3817736A4 (fr) Inhibiteurs de pikfyve
EP3773537A4 (fr) Inhibiteurs de stat3
DK3630744T3 (da) Pyrazol-magl-inhibitorer
IL281514A (en) O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
EP3856194A4 (fr) Inhibiteurs de vap-1