MA54543A - Inhibiteurs de kif18a - Google Patents

Inhibiteurs de kif18a

Info

Publication number
MA54543A
MA54543A MA054543A MA54543A MA54543A MA 54543 A MA54543 A MA 54543A MA 054543 A MA054543 A MA 054543A MA 54543 A MA54543 A MA 54543A MA 54543 A MA54543 A MA 54543A
Authority
MA
Morocco
Prior art keywords
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054543A
Other languages
English (en)
Inventor
Abhisek Banerjee
Matthew Paul Bourbeau
James Alexander Brown
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Kexue Li
Qingyian Liu
Jonathan Dante Low
Vu Ma
Ana Elena Minatti
Liping H Pettus
Nuria A Tamayo
Mary Catherine Walton
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54543A publication Critical patent/MA54543A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA054543A 2018-12-20 2019-12-20 Inhibiteurs de kif18a MA54543A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783061P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54543A true MA54543A (fr) 2022-03-30

Family

ID=69187977

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054543A MA54543A (fr) 2018-12-20 2019-12-20 Inhibiteurs de kif18a

Country Status (25)

Country Link
US (4) US11236069B2 (fr)
EP (1) EP3897852A1 (fr)
JP (1) JP7407196B2 (fr)
KR (1) KR102875569B1 (fr)
CN (2) CN120398830A (fr)
AR (1) AR117490A1 (fr)
AU (1) AU2019403486B2 (fr)
BR (1) BR112021011989A2 (fr)
CA (1) CA3123871A1 (fr)
CL (1) CL2021001634A1 (fr)
CO (1) CO2021008224A2 (fr)
CR (1) CR20210387A (fr)
EA (1) EA202191730A1 (fr)
IL (1) IL283639B2 (fr)
JO (1) JOP20210154B1 (fr)
MA (1) MA54543A (fr)
MX (1) MX2021007156A (fr)
PE (1) PE20211475A1 (fr)
PH (1) PH12021551409A1 (fr)
SA (1) SA521422303B1 (fr)
SG (1) SG11202106520VA (fr)
TW (1) TWI844602B (fr)
UA (1) UA129950C2 (fr)
UY (1) UY38526A (fr)
WO (1) WO2020132648A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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MX2021007157A (es) 2018-12-20 2021-08-16 Amgen Inc Heteroarilamidas utiles como inhibidores de kif18a.
CA3123227A1 (fr) * 2018-12-20 2020-06-25 Amgen Inc. Amides d'heteroaryle utiles en tant qu'inhibiteurs de kif18a
PE20211475A1 (es) 2018-12-20 2021-08-05 Amgen Inc Inhibidores de kif18a
WO2020132651A1 (fr) 2018-12-20 2020-06-25 Amgen Inc. Inhibiteurs de kif18a
CA3147272A1 (fr) 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
US12540129B2 (en) 2019-08-02 2026-02-03 Amgen Inc. KIF18A inhibitors
TW202203919A (zh) * 2020-04-14 2022-02-01 美商安進公司 用於治療贅生性疾病之ｋｉｆ１８ａ抑制劑
MX2023004518A (es) 2020-10-20 2023-06-19 Amgen Inc Compuestos espiro heterocíclicos y métodos de uso.
US20230406860A1 (en) 2020-10-27 2023-12-21 Amgen Inc. Heterocyclic spiro compounds and methods of use
JP2024517693A (ja) 2021-04-29 2024-04-23 アムジエン・インコーポレーテツド ２－アミノベンゾチアゾール化合物及びその使用方法
CA3224249A1 (fr) 2021-06-25 2022-12-29 Hangzhou Innogate Pharma Co., Ltd. Compose destine a etre utilise en tant qu'inhibiteur de kif18a
TW202321213A (zh) 2021-07-21 2023-06-01 美商安進公司 Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式
WO2023028564A1 (fr) 2021-08-26 2023-03-02 Volastra Therapeutics, Inc. Inhibiteurs spiro-indoliniques de la kif18a
WO2023088441A1 (fr) 2021-11-19 2023-05-25 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
CA3248925A1 (fr) * 2022-01-26 2023-08-03 Amgen Inc. Synthèse d'un inhibiteur de kif18a
MX2024010045A (es) 2022-02-16 2024-08-26 Amgen Inc Compuestos de quinazolina y uso de los mismos como inhibidores de proteinas mutantes kras.
MX2024010043A (es) 2022-02-16 2024-08-26 Amgen Inc Compuestos de quinazolina y uso de los mismos como inhibidores de proteinas kras mutantes.
EP4495113A4 (fr) * 2022-03-17 2026-02-18 Wigen Biomedicine Tech Shanghai Co Ltd Inhibiteur de kif18a
AU2023254325A1 (en) * 2022-04-15 2024-10-17 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Kif18a inhibitor and use thereof
WO2023217232A1 (fr) * 2022-05-13 2023-11-16 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
CN116554151B (zh) * 2022-05-13 2024-09-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
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CN117510463A (zh) * 2022-08-05 2024-02-06 长春金赛药业有限责任公司 Kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024032661A1 (fr) * 2022-08-11 2024-02-15 山东轩竹医药科技有限公司 Inhibiteur de kif18a et son utilisation
US20260062416A1 (en) * 2022-08-12 2026-03-05 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
WO2024039829A1 (fr) 2022-08-18 2024-02-22 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
JP2025533411A (ja) * 2022-09-08 2025-10-07 長春金賽薬業有限責任公司 Ｋｉｆ１８ａ阻害剤化合物、医薬組成物並びにその製造方法及び応用
CN119907796A (zh) * 2022-09-09 2025-04-29 海南先声再明医药股份有限公司 酰胺类化合物、其组合物及用途
CN119562952A (zh) * 2022-09-30 2025-03-04 山东轩竹医药科技有限公司 Kif18a抑制剂
WO2024067675A1 (fr) * 2022-09-30 2024-04-04 长春金赛药业有限责任公司 Composé inhibiteur de kif18a à cycle condensé, composition pharmaceutique, procédé de préparation correspondant et utilisation associée
CN117917405A (zh) * 2022-10-21 2024-04-23 杭州邦顺制药有限公司 Kif18a蛋白抑制剂
PE20252237A1 (es) 2022-11-14 2025-09-15 Amgen Inc Inhibidores macrociclicos de kras y metodos de uso
WO2024109923A1 (fr) * 2022-11-24 2024-05-30 InventisBio Co., Ltd. Composés hétérocycliques, leurs procédés de préparation et leurs utilisations
CN115594664B (zh) * 2022-11-25 2023-02-24 英矽智能科技(上海)有限公司 一类螺环衍生物作为kif18a抑制剂
WO2024114730A1 (fr) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 Composition pharmaceutique pour le traitement du cancer
WO2024114787A1 (fr) * 2022-12-02 2024-06-06 深圳众格生物科技有限公司 Composé amide ou urée
CN120265626A (zh) * 2022-12-14 2025-07-04 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
CN120641408A (zh) * 2022-12-16 2025-09-12 抟相医药(上海)有限公司 含氮化合物、药物组合物及其用途
WO2024137984A1 (fr) * 2022-12-22 2024-06-27 Accent Therapeutics, Inc. Inhibiteurs de kif18a et utilisations associées
CN120752230A (zh) * 2022-12-28 2025-10-03 英矽智能科技知识产权有限公司 Kif18a的抑制剂及其用途
CN120569373A (zh) * 2023-01-05 2025-08-29 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和医药上的用途
AU2024208850A1 (en) * 2023-01-20 2025-06-12 Insilico Medicine Ip Limited Inhibitors of kif18a and uses thereof
WO2024183710A1 (fr) * 2023-03-06 2024-09-12 武汉人福创新药物研发中心有限公司 Composé inhibiteur de kif18a et son utilisation
CN115947717B (zh) * 2023-03-09 2023-05-30 英矽智能科技(上海)有限公司 一类kif18a抑制剂
KR20250154490A (ko) 2023-03-10 2025-10-28 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 방향족 아미드 유도체, 이의 제조 방법, 및 그의 용도
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CN116535400B (zh) * 2023-04-26 2024-08-16 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用
WO2025021003A1 (fr) 2023-07-21 2025-01-30 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation
WO2025026392A1 (fr) * 2023-08-02 2025-02-06 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
WO2025035759A1 (fr) * 2023-08-17 2025-02-20 深圳市祥根生物有限公司 Inhibiteur de kif18a et son utilisation
CN121712776A (zh) * 2023-09-26 2026-03-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2025077882A1 (fr) * 2023-10-13 2025-04-17 武汉人福创新药物研发中心有限公司 Forme saline et forme cristalline d'un composé inhibiteur de kif18a, leur procédé de préparation et leur utilisation
WO2025081019A1 (fr) * 2023-10-13 2025-04-17 Iambic Therapeutics, Inc. Composés modulateurs de kif et méthodes d'utilisation
WO2025163351A1 (fr) * 2024-02-02 2025-08-07 Satyarx Pharma Innovations Pvt Ltd Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de kif18a
TW202600556A (zh) * 2024-03-07 2026-01-01 大陸商長春金賽藥業有限責任公司 Ｋｉｆ１８ａ抑制劑的可藥用鹽、晶型及其製備方法和用途
WO2025185704A1 (fr) * 2024-03-07 2025-09-12 长春金赛药业有限责任公司 Forme cristalline d'un inhibiteur de kif18a, son procédé de préparation et son utilisation
WO2025190325A1 (fr) * 2024-03-13 2025-09-18 海南先声再明医药股份有限公司 Combinaison pharmaceutique d'inhibiteur de kif18a et d'inhibiteur de tubuline et son utilisation
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
TW202602882A (zh) 2024-03-14 2026-01-16 美商安進公司 作為ｋｒａｓ調節劑的大環化合物及其用途
WO2025195205A1 (fr) * 2024-03-21 2025-09-25 甫康（上海）健康科技有限责任公司 Composé sulfanilamide et son utilisation
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025242166A1 (fr) * 2024-05-22 2025-11-27 InventisBio Co., Ltd. Composés hétérocycliques, leurs procédés de préparation et leurs utilisations
WO2026007956A1 (fr) * 2024-07-02 2026-01-08 长春金赛药业有限责任公司 Utilisation d'un inhibiteur de kif18a pour le traitement du cancer de l'ovaire
WO2026021411A1 (fr) * 2024-07-23 2026-01-29 Insilico Medicine Ip Limited Inhibiteurs de kif18a et leurs utilisations
WO2026055477A1 (fr) 2024-09-06 2026-03-12 Amgen Inc. Composés macrocycliques constituant des modulateurs de kras et leurs utilisations

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AR117490A1 (es) 2021-08-11
CA3123871A1 (fr) 2020-06-25
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