NO922185L - 1-metylkarbapenemderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som antibiotika - Google Patents
1-metylkarbapenemderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som antibiotikaInfo
- Publication number
- NO922185L NO922185L NO92922185A NO922185A NO922185L NO 922185 L NO922185 L NO 922185L NO 92922185 A NO92922185 A NO 92922185A NO 922185 A NO922185 A NO 922185A NO 922185 L NO922185 L NO 922185L
- Authority
- NO
- Norway
- Prior art keywords
- derivatives
- preparing
- antibiotics
- procedures
- methyl
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- YKMONJZIUAOVEM-GDVGLLTNSA-N (5S)-4-methyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class CC1C=CN2[C@H]1CC2=O YKMONJZIUAOVEM-GDVGLLTNSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000003850 Dipeptidase 1 Human genes 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13154591 | 1991-06-04 | ||
| JP34573791 | 1991-12-27 | ||
| JP3052192 | 1992-02-18 | ||
| JP9128392 | 1992-04-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO922185D0 NO922185D0 (no) | 1992-06-03 |
| NO922185L true NO922185L (no) | 1992-12-07 |
| NO302475B1 NO302475B1 (no) | 1998-03-09 |
Family
ID=27459269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO922185A NO302475B1 (no) | 1991-06-04 | 1992-06-03 | 1-metylkarbapenemderivater og farmasöytisk preparat inneholdende disse |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0518558B1 (no) |
| JP (1) | JP2559949B2 (no) |
| KR (1) | KR100247855B1 (no) |
| CN (1) | CN1030767C (no) |
| AT (1) | ATE170521T1 (no) |
| AU (1) | AU651887B2 (no) |
| CA (1) | CA2070305A1 (no) |
| CZ (1) | CZ167792A3 (no) |
| DE (1) | DE69226815T2 (no) |
| DK (1) | DK0518558T3 (no) |
| ES (1) | ES2120992T3 (no) |
| FI (1) | FI101226B1 (no) |
| HU (2) | HU218289B (no) |
| IE (1) | IE921796A1 (no) |
| IL (1) | IL102093A (no) |
| MX (1) | MX9202670A (no) |
| NO (1) | NO302475B1 (no) |
| NZ (1) | NZ243022A (no) |
| RU (1) | RU2093514C1 (no) |
| TW (1) | TW203612B (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712267A (en) * | 1991-06-04 | 1998-01-27 | Sankyo Company,. Limited | Carbapenem derivatives, their preparation and their use as antibiotics |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| HU218676B (hu) * | 1992-03-11 | 2000-10-28 | Sankyo Co. Ltd. | Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
| GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| CA2099818A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
| EP0581502B1 (en) * | 1992-07-21 | 1998-10-21 | Zeneca Limited | Antibiotic carbapenem compounds |
| AU4912393A (en) * | 1993-06-15 | 1994-12-22 | Dong Kook Pharmaceutical Co., Ltd. | 1-beta-methyl-2-thiolic carbapenem derivatives |
| JP3848693B2 (ja) * | 1994-07-06 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規カルバペネム誘導体 |
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| CN1095843C (zh) * | 1995-12-21 | 2002-12-11 | 三共株式会社 | 1－甲基碳代青霉烯衍生物 |
| RU2162088C2 (ru) * | 1996-04-26 | 2001-01-20 | Санкио Компани Лимитед | 1-метилкарбапенем или его фармакологически приемлемые соли, композиция, способ предупреждения или лечения бактериальных инфекций |
| AU4020897A (en) | 1996-08-17 | 1998-03-06 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| AU1415500A (en) * | 1998-12-07 | 2000-06-26 | Sankyo Company Limited | 1-methylcarbapenem derivatives |
| GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| US6673829B2 (en) | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| EP1430027B1 (en) | 2001-09-14 | 2010-09-01 | High Point Pharmaceuticals, LLC | Novel aminoazetidine, -pyrrolidine and -piperidine derivatives |
| CN101367814B (zh) * | 2007-06-28 | 2010-12-15 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰哌啶取代的培南衍生物 |
| US8236792B2 (en) * | 2008-05-23 | 2012-08-07 | Janssen Pharmaceutica Nv | Substituted pyrrolidine amides as modulators of the histamine H3 receptor |
| KR102435777B1 (ko) | 2016-03-16 | 2022-08-23 | 오키드 파마 리미티드 | 카르바페넴 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS60233076A (ja) * | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| EP0243686B1 (en) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production |
| CA2036163C (en) * | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
| CA2036941A1 (en) * | 1990-02-23 | 1991-08-24 | Isao Kawamoto | Carbapenem derivatives having antibiotic activity, their preparation and their use |
| TW198034B (no) * | 1990-03-27 | 1993-01-11 | Manyu Seiyaku Kk | |
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| HU218676B (hu) * | 1992-03-11 | 2000-10-28 | Sankyo Co. Ltd. | Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
-
1992
- 1992-06-03 CA CA002070305A patent/CA2070305A1/en not_active Abandoned
- 1992-06-03 RU SU5052110/04A patent/RU2093514C1/ru not_active IP Right Cessation
- 1992-06-03 NO NO922185A patent/NO302475B1/no unknown
- 1992-06-03 IL IL10209392A patent/IL102093A/en not_active IP Right Cessation
- 1992-06-03 AU AU17390/92A patent/AU651887B2/en not_active Ceased
- 1992-06-03 FI FI922561A patent/FI101226B1/fi active
- 1992-06-03 JP JP4142286A patent/JP2559949B2/ja not_active Expired - Fee Related
- 1992-06-03 CZ CS921677A patent/CZ167792A3/cs unknown
- 1992-06-04 NZ NZ243022A patent/NZ243022A/xx unknown
- 1992-06-04 DE DE69226815T patent/DE69226815T2/de not_active Expired - Fee Related
- 1992-06-04 AT AT92305130T patent/ATE170521T1/de not_active IP Right Cessation
- 1992-06-04 TW TW081104407A patent/TW203612B/zh active
- 1992-06-04 HU HU9201871A patent/HU218289B/hu not_active IP Right Cessation
- 1992-06-04 DK DK92305130T patent/DK0518558T3/da active
- 1992-06-04 EP EP92305130A patent/EP0518558B1/en not_active Expired - Lifetime
- 1992-06-04 ES ES92305130T patent/ES2120992T3/es not_active Expired - Lifetime
- 1992-06-04 KR KR1019920009702A patent/KR100247855B1/ko not_active Expired - Fee Related
- 1992-06-04 CN CN92108826A patent/CN1030767C/zh not_active Expired - Fee Related
- 1992-06-04 MX MX9202670A patent/MX9202670A/es unknown
- 1992-07-01 IE IE179692A patent/IE921796A1/en not_active IP Right Cessation
-
1995
- 1995-06-29 HU HU95P/P00604P patent/HU211822A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1011980A1 (en) | 1999-07-23 |
| DE69226815T2 (de) | 1999-05-20 |
| DE69226815D1 (de) | 1998-10-08 |
| RU2093514C1 (ru) | 1997-10-20 |
| NO922185D0 (no) | 1992-06-03 |
| HUT61551A (en) | 1993-01-28 |
| FI922561A0 (fi) | 1992-06-03 |
| IL102093A (en) | 1996-12-05 |
| HU211822A9 (en) | 1995-12-28 |
| IL102093A0 (en) | 1993-01-14 |
| EP0518558B1 (en) | 1998-09-02 |
| CN1030767C (zh) | 1996-01-24 |
| AU651887B2 (en) | 1994-08-04 |
| ES2120992T3 (es) | 1998-11-16 |
| CN1069494A (zh) | 1993-03-03 |
| HU218289B (en) | 2000-07-28 |
| IE921796A1 (en) | 1992-12-16 |
| CZ167792A3 (en) | 1995-12-13 |
| NZ243022A (en) | 1993-07-27 |
| CA2070305A1 (en) | 1992-12-05 |
| KR100247855B1 (ko) | 2000-05-01 |
| MX9202670A (es) | 1993-01-01 |
| JP2559949B2 (ja) | 1996-12-04 |
| HU9201871D0 (en) | 1992-08-28 |
| TW203612B (no) | 1993-04-11 |
| DK0518558T3 (da) | 1999-05-31 |
| FI101226B (fi) | 1998-05-15 |
| JPH05339269A (ja) | 1993-12-21 |
| FI101226B1 (fi) | 1998-05-15 |
| FI922561L (fi) | 1992-12-05 |
| KR930000515A (ko) | 1993-01-15 |
| NO302475B1 (no) | 1998-03-09 |
| AU1739092A (en) | 1993-03-11 |
| ATE170521T1 (de) | 1998-09-15 |
| EP0518558A1 (en) | 1992-12-16 |
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