NO924479L - Nye aminoalkanfosfinsyrer og deres salter - Google Patents

Nye aminoalkanfosfinsyrer og deres salter

Info

Publication number
NO924479L
NO924479L NO92924479A NO924479A NO924479L NO 924479 L NO924479 L NO 924479L NO 92924479 A NO92924479 A NO 92924479A NO 924479 A NO924479 A NO 924479A NO 924479 L NO924479 L NO 924479L
Authority
NO
Norway
Prior art keywords
ethyl
dichlorophenyl
dimethoxyphenyl
hydrogen
chloro
Prior art date
Application number
NO92924479A
Other languages
English (en)
Other versions
NO924479D0 (no
Inventor
Stuart John Mickel
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO924479D0 publication Critical patent/NO924479D0/no
Publication of NO924479L publication Critical patent/NO924479L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Air Bags (AREA)

Abstract

Forbindelse med formel I O R! R, HO ii r / \P ¿ CH2-CH-CH2 ¿ N (I) R R3 hvor a) R betyr butyl, S.± hydrogen, R2 3,4-dlklor- benzyl, l-(4-klorfenyl)etyl- eller l-(3,4-diklor )- fenetyl og R3 hydrogen eller b) R betyr dietoksymetyl, R! hydrogen og R2 2,6- eller 3,5-dlklorbenzyl, pyrid-3- ylmetyl, l-(4-metoksyfenyl)etyl, l-(4-klor-3-Jod- fenyl)etyl eller l-(3-klor-4-Jod-fenyl)etyl eller Rt betyr hydroksy og R2 3,4-dlklorbenzyl, l-(3-klor-4-Jod- fenyl)etyl, l-(4-klor-3-jodfenyl)etyl eller l-(3,4- diklorfenyl)etyl og R3 hydrogen eller R betyr syklo- heksylmetyl, Rx hydrogen og R2 3,5-diklorbenzyl. chinolin-4-ylmetyl, l-(3-klorfenyl)etyl, eller 1- (3,4,5-trimetoksyfenyl)etyl eller Rj betyr hydroksy og R2 3,4-dimetylbenzyl, 3,4-metylendloksybenzyl, l-(3- klorfenyl)etyl, l-(3,4-diklorfenyl)etyl, l-(3-klor-4- Jod-fenyl)etyl, l-(4-klor-3-Jod-fenyl)etyl, l-(2.4- dimetoksyfenyl)etyl, l-(2,5-dimetoksyfenyl)etyl, 1- (2,6-dimetoksyfenyl)etyl, l-(3,4-dimetoksyfenyl)etyl, l-(3,4-metylendioksyfenyl)etyl, l-(3,5-dlmetoksy- fenyl)etyl, l-(3,4,5-trimetoksy)fenyletyl,3-fenylprop- 2-yl, 2-(3,4-diklorfenyl)-propyl 2-(3,4-diklorfenyl)- propyl, 3-(3,4-diklorfenyl)prop-2-yl eller 3-fenyl-3- i hydroksy-prop-2-yl og R3 hydrogen eler R betyr "; sykloheksylmetyl, Rx hydrogen, R2 4-klorbenzyl og R3 metyl eller R betyr sykloheks-3-enylmetyl, Ki(S)- hydroksy, R2 l(S)-(3,4-diklorfenyl)etyl og R3 hydrogen eller R betyr benzyl, Rj^ hydroksy, R2 a-syklopropyl- 3,4-dlklor-benzyl, 3 ,4 ,5-trimetoksybenzyl, l-(3,4- ^ dlmetoksyfenyl)etyl, l-(3,4-diklorfenyl)etyl, 2-(3,4- i diklorfenyl)etyl, l-(3-klor-4-Jod-fenyljetyl, l-(3,4- ^ diklorfenyl)-2-hydroksy-etyl, 2-(3,4-diklorfenyl)-2- hydroksyetyl, l-(2,4-dimetoksyfenyl)etyl, l-(2,5- dimetoksyfenyl)etyl, l-(2,6-dimetoksyfenyl)etyl, i- x (3,4-dimetoksyfenyl)etyl, l-(3,4-metylendioksyfenyl)- : etyl, l-(3,4,5-trimetoksyfenyl)etyl, 3-fenylprop-2-yl, .-.: 3-fenyl-3-hydroksy-prop-2-yl, l-, 2- eller 3-(3,4- diklorfenylJpropyl, 3-(3 ,4-diklorfenyl)prop-2-yl, 3- (3,4-dlklorfenyl)-3-hydroksy-prop-2-yl eller 4-(3,4- ;; diklorfenyl )butyl og R3 hydrogen, ellerR betyr 4- ¿ klorbenzyl, 4-metylbenzyl, 4-metoksybenzyl eller sykloheks-3-enmetyl og R! , R2 og R3 står for hydrogen, og deres salter innehar GAGAB-antagonistlske egenskaper og kan bli anvendt for behandling av sykdommer som påvirkes av GABAg antagonister.
NO92924479A 1991-11-21 1992-11-20 Nye aminoalkanfosfinsyrer og deres salter NO924479L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH340491 1991-11-21

Publications (2)

Publication Number Publication Date
NO924479D0 NO924479D0 (no) 1992-11-20
NO924479L true NO924479L (no) 1993-05-24

Family

ID=4255259

Family Applications (4)

Application Number Title Priority Date Filing Date
NO92924479A NO924479L (no) 1991-11-21 1992-11-20 Nye aminoalkanfosfinsyrer og deres salter
NO974116A NO974116D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter
NO974117A NO974117D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter
NO974115A NO974115D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO974116A NO974116D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter
NO974117A NO974117D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter
NO974115A NO974115D0 (no) 1991-11-21 1997-09-08 Nye aminoalkanfosfinsyrer og deres salter

Country Status (14)

Country Link
US (2) US5376684A (no)
EP (2) EP0543780A3 (no)
JP (1) JPH05247069A (no)
KR (1) KR930010047A (no)
AU (2) AU662938B2 (no)
CA (1) CA2083307A1 (no)
FI (1) FI925243L (no)
IL (1) IL103808A0 (no)
MX (1) MX9206702A (no)
NO (4) NO924479L (no)
NZ (1) NZ245185A (no)
PH (1) PH30097A (no)
TW (1) TW213466B (no)
ZA (1) ZA928979B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
WO1997011953A1 (en) * 1995-09-28 1997-04-03 Novartis Ag Novel hydroxylated and alkoxylated n- and/or p-aralkylphosphinic acid derivatives
AU744189B2 (en) 1997-06-23 2002-02-14 Neuro Therapeutics Limited Neurologically-active compounds
DE10014127A1 (de) * 2000-03-22 2001-10-18 Hassan Jomaa Verwendung von phosphororganischen Verbindungen zur Behandlung von Infektionen
US6462084B1 (en) 2001-05-14 2002-10-08 Brookhaven Science Associates, Llc Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
AR052669A1 (es) * 2005-02-11 2007-03-28 Aventis Pharma Inc Esteres de acido de acido propano - fosfinico sustituido; composiciones farmaceuticas que los contienen y su uso para el tratamiento de trastornos psiquiatricos.
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
DE3362581D1 (en) * 1982-04-23 1986-04-24 Ciba Geigy Ag Herbicide and plant-growth regulator product
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
US5300679A (en) * 1987-12-04 1994-04-05 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
DK270488D0 (da) * 1988-05-18 1988-05-18 Novo Industri As Hidtil ukendte o-substituerede ketoximer
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
GB8911017D0 (en) * 1989-05-13 1989-06-28 Ciba Geigy Ag Substituted aminoalkylphosphinic acids
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
GB8912814D0 (en) * 1989-06-03 1989-07-19 Ciba Geigy Ag P-substituted propane-phospinic acid compounds
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids

Also Published As

Publication number Publication date
NO924479D0 (no) 1992-11-20
MX9206702A (es) 1994-06-30
TW213466B (no) 1993-09-21
EP0543780A3 (en) 1993-09-01
NO974117L (no) 1993-05-24
IL103808A0 (en) 1993-04-04
EP0767174A1 (de) 1997-04-09
NO974115L (no) 1993-05-24
US5500418A (en) 1996-03-19
NO974115D0 (no) 1997-09-08
AU662938B2 (en) 1995-09-21
NO974116L (no) 1993-05-24
EP0543780A2 (de) 1993-05-26
NO974117D0 (no) 1997-09-08
JPH05247069A (ja) 1993-09-24
NO974116D0 (no) 1997-09-08
FI925243A7 (fi) 1993-05-22
AU2850492A (en) 1993-05-27
AU4045695A (en) 1996-04-26
FI925243L (fi) 1993-05-22
US5376684A (en) 1994-12-27
PH30097A (en) 1996-12-27
ZA928979B (en) 1994-04-15
KR930010047A (ko) 1993-06-21
NZ245185A (en) 1995-04-27
CA2083307A1 (en) 1993-05-22
FI925243A0 (fi) 1992-11-18

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