NO924899L - Fremgangsmaate for fremstilling av insulinholdige opploesninger - Google Patents

Fremgangsmaate for fremstilling av insulinholdige opploesninger

Info

Publication number: NO924899L
Authority: NO; Norway
Prior art keywords: insulinal; procedure; solutions; preparation; insulin
Prior art date: 1991-12-18

Application number

NO92924899A

Other languages

English (en)

Other versions

NO924899D0 (no

NO304743B1 (no

Inventor

Rainer Dickhardt

Bernhard Unger

Claudia Graefe

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-18

Filing date

1992-12-17

Publication date

1993-06-21

1991-12-18 Priority claimed from DE19914141794 external-priority patent/DE4141794C2/de

1992-06-20 Priority claimed from DE19924220293 external-priority patent/DE4220293C2/de

1992-12-17 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-12-17 Publication of NO924899D0 publication Critical patent/NO924899D0/no

1993-06-21 Publication of NO924899L publication Critical patent/NO924899L/no

1999-02-08 Publication of NO304743B1 publication Critical patent/NO304743B1/no

Links

238000000034 method Methods 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Inorganic Insulating Materials (AREA)
Soil Working Implements (AREA)

NO924899A 1991-12-18 1992-12-17 FremgangsmÕte for fremstilling av insulinholdige oppl÷sninger NO304743B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19914141794 DE4141794C2 (de)	1991-12-18	1991-12-18	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE19924220293 DE4220293C2 (de)	1992-06-20	1992-06-20	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Publications (3)

Publication Number	Publication Date
NO924899D0 NO924899D0 (no)	1992-12-17
NO924899L true NO924899L (no)	1993-06-21
NO304743B1 NO304743B1 (no)	1999-02-08

Family

ID=25910232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924899A NO304743B1 (no)	1991-12-18	1992-12-17	FremgangsmÕte for fremstilling av insulinholdige oppl÷sninger

Country Status (12)

Country	Link
US (1)	US5621073A (no)
EP (1)	EP0547544B1 (no)
JP (1)	JP2736214B2 (no)
AT (1)	ATE150032T1 (no)
CA (1)	CA2085719C (no)
DE (1)	DE59208181D1 (no)
DK (1)	DK0547544T3 (no)
ES (1)	ES2099193T3 (no)
FI (1)	FI108644B (no)
GR (1)	GR3023431T3 (no)
NO (1)	NO304743B1 (no)
SG (1)	SG44748A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19652713C2 (de) *	1996-12-18	2001-11-22	Aventis Pharma Gmbh	Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de)	1998-08-24	2000-03-02	Hoechst Marion Roussel De Gmbh	Verfahren zur chromatographischen Reinigung von Insulinen
US6746853B1 (en)	1999-05-19	2004-06-08	Xencor, Inc.	Proteins with insulin-like activity useful in the treatment of diabetes
RU2186581C2 (ru) *	2000-03-28	2002-08-10	Луцив Владимир Романович	Способ получения высокоочищенного монокомпонентного инсулина
CN101511387A (zh) *	2006-09-08	2009-08-19	惠氏公司	使用亲和色谱法纯化蛋白质的精氨酸洗涤液
US20120214199A1 (en) *	2011-02-23	2012-08-23	Elona Biotechnologies	Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
PL219335B1 (pl) *	2008-07-04	2015-04-30	Inst Biotechnologii I Antybiotyków	Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
US10421795B2 (en)	2012-12-17	2019-09-24	Merck Sharp & Dohme Corp.	Process for purifying insulin and analogues thereof
WO2015138548A1 (en)	2014-03-14	2015-09-17	Merck Sharp & Dohme Corp.	Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en)	2014-07-21	2018-12-18	Merck Sharp & Dohme Corp.	Chromatography process for purification of insulin and insulin analogs
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2629568C3 (de) *	1976-07-01	1981-09-10	Hoechst Ag, 6000 Frankfurt	Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
US5008241A (en) *	1985-03-12	1991-04-16	Novo Nordisk A/S	Novel insulin peptides
WO1989001485A1 (fr) *	1987-08-14	1989-02-23	Gebro Broschek Kg	Purification de peptides bruts par chromatographie liquide de preparation sous une pression moyenne
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) *	1990-09-05	1996-09-19	Hoechst Ag	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

1992
- 1992-12-14 ES ES92121255T patent/ES2099193T3/es not_active Expired - Lifetime
- 1992-12-14 DE DE59208181T patent/DE59208181D1/de not_active Expired - Lifetime
- 1992-12-14 DK DK92121255.1T patent/DK0547544T3/da active
- 1992-12-14 EP EP92121255A patent/EP0547544B1/de not_active Expired - Lifetime
- 1992-12-14 AT AT92121255T patent/ATE150032T1/de active
- 1992-12-14 SG SG1996006851A patent/SG44748A1/en unknown
- 1992-12-16 FI FI925719A patent/FI108644B/fi not_active IP Right Cessation
- 1992-12-17 CA CA002085719A patent/CA2085719C/en not_active Expired - Lifetime
- 1992-12-17 NO NO924899A patent/NO304743B1/no not_active IP Right Cessation
- 1992-12-17 JP JP4337035A patent/JP2736214B2/ja not_active Expired - Lifetime
1995
- 1995-04-28 US US08/430,273 patent/US5621073A/en not_active Expired - Lifetime
1997
- 1997-05-15 GR GR970401080T patent/GR3023431T3/el unknown

Also Published As

Publication number	Publication date
FI108644B (fi)	2002-02-28
FI925719L (fi)	1993-06-19
GR3023431T3 (en)	1997-08-29
NO924899D0 (no)	1992-12-17
US5621073A (en)	1997-04-15
FI925719A0 (fi)	1992-12-16
JP2736214B2 (ja)	1998-04-02
EP0547544A2 (de)	1993-06-23
DK0547544T3 (da)	1997-09-08
NO304743B1 (no)	1999-02-08
SG44748A1 (en)	1997-12-19
CA2085719C (en)	2005-03-01
JPH05308989A (ja)	1993-11-22
EP0547544B1 (de)	1997-03-12
EP0547544A3 (en)	1994-07-13
DE59208181D1 (de)	1997-04-17
ES2099193T3 (es)	1997-05-16
CA2085719A1 (en)	1993-06-19
ATE150032T1 (de)	1997-03-15

Legal Events

Date	Code	Title	Description
2013-01-14	MK1K	Patent expired

Publication	Publication Date	Title
NO924899L (no)	1993-06-21	Fremgangsmaate for fremstilling av insulinholdige opploesninger
LTIP713A (en)	1995-01-31	Method for the purification of insulin
ATE74003T1 (de)	1992-04-15	Waessriges pharmazeutisches praeparat.
NO307913B1 (no)	2000-06-19	Stabilt vandig preparat
ATE104690T1 (de)	1994-05-15	Photochrome substanzen (iv).
ITMI931973A0 (it)	1993-09-14	Derivati del 2-ammino-1,2,3,4-tetraudro-naftalene attivi sul sistema cardiovascolare
FR2643729B1 (fr)	1991-06-07	Branche de monture de lunettes et monture de lunettes correspondante
AU2890289A (en)	1989-08-03	Disulphide derivatives as linking agent
NO177348C (no)	1995-08-30	Fremgangsmåte til fremstilling av et cefalosporin-antibiotikum, samt 3-(fluorsulfonyl)oksy-substituerte cefemer og karbacefemer
KR960701891A (ko)	1996-03-28	폴립 펩티드 존재의 검출방법 및 폴리펩티드의 전환방법(a method of detecting the presence of and converting of a polypeptide)
DE69008019D1 (de)	1994-05-19	Benzothiazol-Derivate.
ATE155403T1 (de)	1997-08-15	Halter für eine verstellbare lagerung von scheinwerfern, insbesondere fahrzeugscheinwerfern
SE8901565D0 (sv)	1989-04-28	Teleskoperande arm, saerskilt foer sjoesaettning av livraeddningsfarkost
ES296384U (es)	1987-08-16	Mecanismo de retencion de puerta
KR890001977A (ko)	1989-04-07	피로글루타미드 유도체
ES2147150A1 (es)	2000-08-16	Interface entre instrumentos de medida analogicos y pc
FI890065A0 (fi)	1989-01-06	Foerfarande foer framstaellning av 5,8,13, 14-tetrahydrobenz/5,6/isoindolo/2,1-b/isokinolin-8,13-dionderivat.
ES1025931U (es)	1994-02-16	Juego.
ES256734U (es)	1981-10-16	Cubrecanuto de cerradura
ITMI950971A1 (it)	1996-03-21	Derivati aminotiazolici di cefalosporine aventi attivita' antibatterica
IT215228Z2 (it)	1990-09-11	Braccio telescopico con freno sul perno di brandeggio e dispositivodi pre carico fra un elemento e quello successivodel detto braccio.
LV5522A3 (lv)	1994-03-10	Tieno-(3',4',:4,5)-imidazo-(2,1-b)-tiazola atvasinajumu iegusanas panemiens