ES2099193T3 - Procedimiento para la obtencion de soluciones con contenido en insulina. - Google Patents
Procedimiento para la obtencion de soluciones con contenido en insulina.Info
- Publication number
- ES2099193T3 ES2099193T3 ES92121255T ES92121255T ES2099193T3 ES 2099193 T3 ES2099193 T3 ES 2099193T3 ES 92121255 T ES92121255 T ES 92121255T ES 92121255 T ES92121255 T ES 92121255T ES 2099193 T3 ES2099193 T3 ES 2099193T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- insulin content
- insulin
- obtaining solutions
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Inorganic Insulating Materials (AREA)
- Soil Working Implements (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE INSULINA, QUE ESTA CASI LIBRE DE PROTEASAS Y/O DE INSULINA ACETILADA EN POSICION A9, POR MEDIO DE LA CROMATOGRAFIA EN DISOLVENTES ACUOSOS, CON REGULADOR TAMPON, QUE CONTIENEN DISOLVENTES ORGANICOS SOLUBLES EN AGUA, UN GEL DE SILICE MODIFICADO LIPOFILO, POR EL QUE EL REGULADOR DE TAMPON SOLUBLE CONTIENE ACETONA O ACETONITRILO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19914141794 DE4141794C2 (de) | 1991-12-18 | 1991-12-18 | Verfahren zur Reinigung von Insulin und/oder Insulinderivaten |
| DE19924220293 DE4220293C2 (de) | 1992-06-20 | 1992-06-20 | Verfahren zur Reinigung von Insulin und/oder Insulinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2099193T3 true ES2099193T3 (es) | 1997-05-16 |
Family
ID=25910232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92121255T Expired - Lifetime ES2099193T3 (es) | 1991-12-18 | 1992-12-14 | Procedimiento para la obtencion de soluciones con contenido en insulina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5621073A (es) |
| EP (1) | EP0547544B1 (es) |
| JP (1) | JP2736214B2 (es) |
| AT (1) | ATE150032T1 (es) |
| CA (1) | CA2085719C (es) |
| DE (1) | DE59208181D1 (es) |
| DK (1) | DK0547544T3 (es) |
| ES (1) | ES2099193T3 (es) |
| FI (1) | FI108644B (es) |
| GR (1) | GR3023431T3 (es) |
| NO (1) | NO304743B1 (es) |
| SG (1) | SG44748A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19652713C2 (de) * | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19838097A1 (de) | 1998-08-24 | 2000-03-02 | Hoechst Marion Roussel De Gmbh | Verfahren zur chromatographischen Reinigung von Insulinen |
| US6746853B1 (en) | 1999-05-19 | 2004-06-08 | Xencor, Inc. | Proteins with insulin-like activity useful in the treatment of diabetes |
| RU2186581C2 (ru) * | 2000-03-28 | 2002-08-10 | Луцив Владимир Романович | Способ получения высокоочищенного монокомпонентного инсулина |
| CN101511387A (zh) * | 2006-09-08 | 2009-08-19 | 惠氏公司 | 使用亲和色谱法纯化蛋白质的精氨酸洗涤液 |
| US20120214199A1 (en) * | 2011-02-23 | 2012-08-23 | Elona Biotechnologies | Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
| US10421795B2 (en) | 2012-12-17 | 2019-09-24 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
| WO2015138548A1 (en) | 2014-03-14 | 2015-09-17 | Merck Sharp & Dohme Corp. | Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature |
| US10155799B2 (en) | 2014-07-21 | 2018-12-18 | Merck Sharp & Dohme Corp. | Chromatography process for purification of insulin and insulin analogs |
| PE20210857A1 (es) | 2016-12-16 | 2021-05-18 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2629568C3 (de) * | 1976-07-01 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten |
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| WO1989001485A1 (fr) * | 1987-08-14 | 1989-02-23 | Gebro Broschek Kg | Purification de peptides bruts par chromatographie liquide de preparation sous une pression moyenne |
| DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DE4028120C2 (de) * | 1990-09-05 | 1996-09-19 | Hoechst Ag | Verfahren zur Reinigung von Insulin und/oder Insulinderivaten |
-
1992
- 1992-12-14 ES ES92121255T patent/ES2099193T3/es not_active Expired - Lifetime
- 1992-12-14 DE DE59208181T patent/DE59208181D1/de not_active Expired - Lifetime
- 1992-12-14 DK DK92121255.1T patent/DK0547544T3/da active
- 1992-12-14 EP EP92121255A patent/EP0547544B1/de not_active Expired - Lifetime
- 1992-12-14 AT AT92121255T patent/ATE150032T1/de active
- 1992-12-14 SG SG1996006851A patent/SG44748A1/en unknown
- 1992-12-16 FI FI925719A patent/FI108644B/fi not_active IP Right Cessation
- 1992-12-17 CA CA002085719A patent/CA2085719C/en not_active Expired - Lifetime
- 1992-12-17 NO NO924899A patent/NO304743B1/no not_active IP Right Cessation
- 1992-12-17 JP JP4337035A patent/JP2736214B2/ja not_active Expired - Lifetime
-
1995
- 1995-04-28 US US08/430,273 patent/US5621073A/en not_active Expired - Lifetime
-
1997
- 1997-05-15 GR GR970401080T patent/GR3023431T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI108644B (fi) | 2002-02-28 |
| FI925719L (fi) | 1993-06-19 |
| GR3023431T3 (en) | 1997-08-29 |
| NO924899D0 (no) | 1992-12-17 |
| US5621073A (en) | 1997-04-15 |
| FI925719A0 (fi) | 1992-12-16 |
| JP2736214B2 (ja) | 1998-04-02 |
| EP0547544A2 (de) | 1993-06-23 |
| DK0547544T3 (da) | 1997-09-08 |
| NO304743B1 (no) | 1999-02-08 |
| SG44748A1 (en) | 1997-12-19 |
| CA2085719C (en) | 2005-03-01 |
| JPH05308989A (ja) | 1993-11-22 |
| EP0547544B1 (de) | 1997-03-12 |
| EP0547544A3 (en) | 1994-07-13 |
| DE59208181D1 (de) | 1997-04-17 |
| NO924899L (no) | 1993-06-21 |
| CA2085719A1 (en) | 1993-06-19 |
| ATE150032T1 (de) | 1997-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2099193T3 (es) | Procedimiento para la obtencion de soluciones con contenido en insulina. | |
| ES2104389T3 (es) | Formulacion acuosa estable de bencisotiazolin-3-ona y goma de xantano. | |
| ES2058725T3 (es) | Aplicacion transdermica de 2-amino-6-n-propilamino-4,5,6,7-tetrahidrobenzotiazol. | |
| ES2183023T3 (es) | Composicion farmaceutica estabilizada con un agente basico. | |
| EP0504749A3 (en) | Showerholder for a wall-slidebar | |
| AR002292A1 (es) | Espuma de poliuretano flexible, proceso para su preparacion y sistema de reaccion. | |
| YU47204B (sh) | Derivati didehidro-vitamina d3 | |
| KR890017189A (ko) | 압출성형용 세멘트 조성물 | |
| ES2115071T3 (es) | Agente para la aplicacion por via transdermica, que contiene 3-ceto-desogestrel. | |
| ES2078405T3 (es) | Procedimiento para la purificacion de insulinas por cromatografia. | |
| ATE237336T1 (de) | Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol) | |
| ES2095128T3 (es) | Uso de beta-ciclodextrina y un procedimiento para mejorar espesantes para sistemas acuosos. | |
| MX9602963A (es) | Dispositivo de indicios para torniquete y metodo de uso. | |
| ES2141003B1 (es) | Dispositivo de fijacion. | |
| BR8905004A (pt) | Aparelho e processo para enrolar uma fibra otica sobre um carretel,e,aparelho e processo para detectar a parte axial de uma fibra otica que esta sendo alimentada continuamente sobre um carretel receptor | |
| ES2060248T3 (es) | Nebulizador bombeable, acuoso, hidrofilo, que contiene nitroglicerina. | |
| ES2017086B3 (es) | Dispositivo para cerrar fisuras. | |
| ES2044302T3 (es) | Utilizacion de un sistema de poliuretano de dos componentes que contiene epoxido como pegamento. | |
| ES2054274T3 (es) | Procedimiento de preparacion de derivados de (+)-(2s,3s)-3-hidroxi-2-(4-metoxifenil)-2,3-dihidro-5h-1,5-benzotia-zepina-4-ona. | |
| ES2134021T3 (es) | Aguja de inyeccion. | |
| EA200200042A1 (ru) | Стабильный раствор ксилометазолина и оксиметазолина | |
| NO993100L (no) | Kurvebane for en pens samt skinneforbindelse som benytter en slik kurvebane | |
| ES2126774T3 (es) | Sistema de acoplamiento para montura de gafas. | |
| ES2060096T3 (es) | Nuevo derivado de hidroxifenetilamina y sus sales, procedimiento de preparacion, aplicacion como medicamentos y empleo como instrumento farmacologico especifico. | |
| AR001314A1 (es) | Compuesto de ciclohexapeptidil bis-amina, composiciones que lo contienen y metodos de uso. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 547544 Country of ref document: ES |