ES2099193T3 - Procedimiento para la obtencion de soluciones con contenido en insulina. - Google Patents

Procedimiento para la obtencion de soluciones con contenido en insulina.

Info

Publication number
ES2099193T3
ES2099193T3 ES92121255T ES92121255T ES2099193T3 ES 2099193 T3 ES2099193 T3 ES 2099193T3 ES 92121255 T ES92121255 T ES 92121255T ES 92121255 T ES92121255 T ES 92121255T ES 2099193 T3 ES2099193 T3 ES 2099193T3
Authority
ES
Spain
Prior art keywords
procedure
insulin content
insulin
obtaining solutions
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92121255T
Other languages
English (en)
Inventor
Rainer Dr Dickhardt
Bernhard Dr Unger
Claudia Grafe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914141794 external-priority patent/DE4141794C2/de
Priority claimed from DE19924220293 external-priority patent/DE4220293C2/de
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2099193T3 publication Critical patent/ES2099193T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Soil Working Implements (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE INSULINA, QUE ESTA CASI LIBRE DE PROTEASAS Y/O DE INSULINA ACETILADA EN POSICION A9, POR MEDIO DE LA CROMATOGRAFIA EN DISOLVENTES ACUOSOS, CON REGULADOR TAMPON, QUE CONTIENEN DISOLVENTES ORGANICOS SOLUBLES EN AGUA, UN GEL DE SILICE MODIFICADO LIPOFILO, POR EL QUE EL REGULADOR DE TAMPON SOLUBLE CONTIENE ACETONA O ACETONITRILO.
ES92121255T 1991-12-18 1992-12-14 Procedimiento para la obtencion de soluciones con contenido en insulina. Expired - Lifetime ES2099193T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19914141794 DE4141794C2 (de) 1991-12-18 1991-12-18 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE19924220293 DE4220293C2 (de) 1992-06-20 1992-06-20 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Publications (1)

Publication Number Publication Date
ES2099193T3 true ES2099193T3 (es) 1997-05-16

Family

ID=25910232

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92121255T Expired - Lifetime ES2099193T3 (es) 1991-12-18 1992-12-14 Procedimiento para la obtencion de soluciones con contenido en insulina.

Country Status (12)

Country Link
US (1) US5621073A (es)
EP (1) EP0547544B1 (es)
JP (1) JP2736214B2 (es)
AT (1) ATE150032T1 (es)
CA (1) CA2085719C (es)
DE (1) DE59208181D1 (es)
DK (1) DK0547544T3 (es)
ES (1) ES2099193T3 (es)
FI (1) FI108644B (es)
GR (1) GR3023431T3 (es)
NO (1) NO304743B1 (es)
SG (1) SG44748A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
RU2186581C2 (ru) * 2000-03-28 2002-08-10 Луцив Владимир Романович Способ получения высокоочищенного монокомпонентного инсулина
TW200821026A (en) * 2006-09-08 2008-05-16 Wyeth Corp Arginine wash in protein purification using affinity chromatography
US20120214199A1 (en) * 2011-02-23 2012-08-23 Elona Biotechnologies Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
US10421795B2 (en) 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
WO2016014325A1 (en) 2014-07-21 2016-01-28 Merck Sharp & Dohme Corp. Chromatography process for purification of inlsulin and insulin analogs
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
WO1989001485A1 (fr) * 1987-08-14 1989-02-23 Gebro Broschek Kg Purification de peptides bruts par chromatographie liquide de preparation sous une pression moyenne
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Also Published As

Publication number Publication date
DE59208181D1 (de) 1997-04-17
US5621073A (en) 1997-04-15
CA2085719A1 (en) 1993-06-19
EP0547544A2 (de) 1993-06-23
SG44748A1 (en) 1997-12-19
NO924899D0 (no) 1992-12-17
NO304743B1 (no) 1999-02-08
FI925719A0 (fi) 1992-12-16
NO924899L (no) 1993-06-21
CA2085719C (en) 2005-03-01
JP2736214B2 (ja) 1998-04-02
FI108644B (fi) 2002-02-28
EP0547544A3 (en) 1994-07-13
GR3023431T3 (en) 1997-08-29
ATE150032T1 (de) 1997-03-15
EP0547544B1 (de) 1997-03-12
JPH05308989A (ja) 1993-11-22
FI925719L (fi) 1993-06-19
DK0547544T3 (da) 1997-09-08

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