|
ATE131827T1
(de)
*
|
1990-08-03 |
1996-01-15 |
Sterling Winthrop Inc |
Verbindungen und verfahren zur unterdrückung der genexpression
|
|
US5965722A
(en)
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
US5571903A
(en)
*
|
1993-07-09 |
1996-11-05 |
Lynx Therapeutics, Inc. |
Auto-ligating oligonucleotide compounds
|
|
AU679566B2
(en)
|
1993-09-03 |
1997-07-03 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
|
US5646155A
(en)
*
|
1994-05-12 |
1997-07-08 |
University Of Massachusetts Medical Center |
Drugs to prevent recurrent herpes virus infections
|
|
US5693791A
(en)
*
|
1995-04-11 |
1997-12-02 |
Truett; William L. |
Antibiotics and process for preparation
|
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
WO2005121368A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Chimeric gapped oligomeric compositions
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
|
US20040171028A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
|
WO2005121370A2
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that facilitate risc loading
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
SE9603171D0
(sv)
|
1996-08-30 |
1996-08-30 |
Marek Kwiatkowski |
Solid phase synthesis
|
|
US6111085A
(en)
*
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
US6127533A
(en)
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
|
US6576752B1
(en)
|
1997-02-14 |
2003-06-10 |
Isis Pharmaceuticals, Inc. |
Aminooxy functionalized oligomers
|
|
CA2294988C
(en)
|
1997-07-01 |
2015-11-24 |
Isis Pharmaceuticals Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
JP2002515514A
(ja)
*
|
1998-05-21 |
2002-05-28 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
オリゴヌクレオチドの局所送逹のための組成物及び方法
|
|
WO1999060012A1
(en)
*
|
1998-05-21 |
1999-11-25 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for non-parenteral delivery of oligonucleotides
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6673912B1
(en)
|
1998-08-07 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
2′-O-aminoethyloxyethyl-modified oligonucleotides
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
US20040009938A1
(en)
*
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
|
US6225293B1
(en)
|
1998-09-02 |
2001-05-01 |
Isis Pharmaceuticals, Inc. |
Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
|
|
IL142094A0
(en)
*
|
1998-09-29 |
2002-03-10 |
Gamida Cell Ltd |
Methods of controlling proliferation and differentiation of stem and progenitor cells
|
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
|
US6300320B1
(en)
|
1999-01-05 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Modulation of c-jun using inhibitors of protein kinase C
|
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
|
US7534605B2
(en)
*
|
1999-06-08 |
2009-05-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US7332275B2
(en)
|
1999-10-13 |
2008-02-19 |
Sequenom, Inc. |
Methods for detecting methylated nucleotides
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20030176385A1
(en)
*
|
2000-02-15 |
2003-09-18 |
Jingfang Ju |
Antisense modulation of protein expression
|
|
JP2003530841A
(ja)
*
|
2000-04-13 |
2003-10-21 |
トーマス エヌ. ワイト, |
治療的化合物および方法
|
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
|
US6656700B2
(en)
|
2000-05-26 |
2003-12-02 |
Amersham Plc |
Isoforms of human pregnancy-associated protein-E
|
|
US6686188B2
(en)
*
|
2000-05-26 |
2004-02-03 |
Amersham Plc |
Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
|
|
US20060166227A1
(en)
*
|
2000-06-20 |
2006-07-27 |
Stephen Kingsmore |
Protein expression profiling
|
|
US6323009B1
(en)
*
|
2000-06-28 |
2001-11-27 |
Molecular Staging, Inc. |
Multiply-primed amplification of nucleic acid sequences
|
|
US6958214B2
(en)
|
2000-07-10 |
2005-10-25 |
Sequenom, Inc. |
Polymorphic kinase anchor proteins and nucleic acids encoding the same
|
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
|
US20020123474A1
(en)
*
|
2000-10-04 |
2002-09-05 |
Shannon Mark E. |
Human GTP-Rho binding protein2
|
|
EP1326892A2
(de)
|
2000-10-12 |
2003-07-16 |
University of Rochester |
Zusammensetzungen die die proliferation von krebszellen hemmen
|
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
US6573051B2
(en)
*
|
2001-03-09 |
2003-06-03 |
Molecular Staging, Inc. |
Open circle probes with intramolecular stem structures
|
|
CA2441071C
(en)
|
2001-03-14 |
2010-06-22 |
Myriad Genetics, Inc. |
Tsg101-gag interaction and use thereof
|
|
ES2372321T3
(es)
|
2001-06-20 |
2012-01-18 |
Genentech, Inc. |
Composiciones y métodos para el diagnóstico y tratamiento de un tumor de pulmón.
|
|
US7803915B2
(en)
*
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
|
US20050107595A1
(en)
*
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
EP2270024B1
(de)
|
2001-06-21 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antisense-Modulation von Superoxid-Dismutase 1, Expression in Lösung
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
WO2003013437A2
(en)
*
|
2001-08-07 |
2003-02-20 |
University Of Delaware |
Compositions and methods for the prevention and treatment of huntington's disease
|
|
US20040096880A1
(en)
*
|
2001-08-07 |
2004-05-20 |
Kmiec Eric B. |
Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
US20060068405A1
(en)
*
|
2004-01-27 |
2006-03-30 |
Alex Diber |
Methods and systems for annotating biomolecular sequences
|
|
ATE486092T1
(de)
|
2001-09-18 |
2010-11-15 |
Genentech Inc |
Zusammensetzungen und verfahren für die diagnose von tumoren
|
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US20030228319A1
(en)
|
2002-04-16 |
2003-12-11 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
|
AU2002364945A1
(en)
*
|
2001-10-25 |
2003-07-09 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
AU2002367318B2
(en)
|
2002-01-02 |
2007-07-12 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
IL152904A0
(en)
|
2002-01-24 |
2003-06-24 |
Gamida Cell Ltd |
Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
|
|
EP1465982A4
(de)
*
|
2002-01-25 |
2006-06-07 |
Gamida Cell Ltd |
Verfahren zur expansion von stamm- und vorläuferzellen und damit erhaltene expandierte zellpopulationen
|
|
US7553619B2
(en)
*
|
2002-02-08 |
2009-06-30 |
Qiagen Gmbh |
Detection method using dissociated rolling circle amplification
|
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
|
US6800751B2
(en)
*
|
2002-04-11 |
2004-10-05 |
Isis Pharmaceuticals, Inc. |
Reagent and process for protecting nucleoside hydroxyl groups
|
|
WO2003093296A2
(en)
*
|
2002-05-03 |
2003-11-13 |
Sequenom, Inc. |
Kinase anchor protein muteins, peptides thereof, and related methods
|
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US20050221326A1
(en)
*
|
2002-06-12 |
2005-10-06 |
Avi Orr-Urtreger |
Oligonucleotides antibodies and kits including same for treating prostate cancer and determining predisposition thereto
|
|
WO2003105780A2
(en)
*
|
2002-06-18 |
2003-12-24 |
Epigenesis Pharmaceuticals, Inc. |
A dry powder oligonucleotide formulation, preparation and its uses
|
|
US20050287648A1
(en)
|
2002-08-05 |
2005-12-29 |
University Of Rochester |
Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
|
|
EP2330194A3
(de)
|
2002-09-13 |
2011-10-12 |
Replicor, Inc. |
Nicht-sequenzkomplementäre antivirale Oligonukleotide
|
|
US7794931B2
(en)
*
|
2002-09-20 |
2010-09-14 |
Yale University |
Riboswitches, methods for their use, and compositions for use with riboswitches
|
|
EP2272958A1
(de)
|
2002-09-26 |
2011-01-12 |
ISIS Pharmaceuticals, Inc. |
Modulierung von der Forkheadbox O1A-Expression
|
|
WO2004110345A2
(en)
*
|
2002-10-29 |
2004-12-23 |
Pharmacia Corporation |
Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
|
|
US9150605B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
AU2003287505A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
EP2336318B1
(de)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense-modulation von apolipoprotein-b-expression
|
|
PT2336318E
(pt)
|
2002-11-13 |
2013-06-12 |
Genzyme Corp |
Modulação anti-sentido da expressão de apolipoproteína b
|
|
US20060009378A1
(en)
*
|
2002-11-14 |
2006-01-12 |
Itshak Golan |
Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases
|
|
ATE444359T1
(de)
|
2002-11-15 |
2009-10-15 |
Morphotek Inc |
Verfahren zur erzeugung einer hohen antikörperproduktion von durch in-vitro- immunisierung entstandenen hybridomen
|
|
JP4915980B2
(ja)
|
2002-11-15 |
2012-04-11 |
エムユーエスシー ファウンデーション フォー リサーチ デベロップメント |
補体レセプター2標的化補体調節因子
|
|
CA2507044A1
(en)
|
2002-11-21 |
2004-06-10 |
Mary Lucero |
Purinergic modulation of smell
|
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
|
AU2003299694A1
(en)
|
2002-12-20 |
2004-07-22 |
Qiagen Gmbh |
Nucleic acid amplification
|
|
US9487823B2
(en)
|
2002-12-20 |
2016-11-08 |
Qiagen Gmbh |
Nucleic acid amplification
|
|
US6977153B2
(en)
*
|
2002-12-31 |
2005-12-20 |
Qiagen Gmbh |
Rolling circle amplification of RNA
|
|
CA2515484C
(en)
|
2003-02-11 |
2011-09-20 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
AU2004215133B2
(en)
|
2003-02-27 |
2010-10-14 |
Yeda Research And Development Co. Ltd. |
Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection
|
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
|
US20070141570A1
(en)
*
|
2003-03-07 |
2007-06-21 |
Sequenom, Inc. |
Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
|
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
|
US8043834B2
(en)
*
|
2003-03-31 |
2011-10-25 |
Qiagen Gmbh |
Universal reagents for rolling circle amplification and methods of use
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
|
CA2540692C
(en)
*
|
2003-06-02 |
2013-05-28 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
|
EP1633770B1
(de)
|
2003-06-13 |
2015-04-29 |
Alnylam Europe AG |
Doppelsträngige ribonukleinsäure mit verbesserter wirksamkeit in einem organismus
|
|
US20050016555A1
(en)
*
|
2003-07-24 |
2005-01-27 |
Lyles Mark B. |
Nucleic acid based filters
|
|
US7056332B2
(en)
*
|
2003-07-24 |
2006-06-06 |
Materials Evolution And Development Usa, Inc. |
Nucleic acid biomaterials and methods of formation and use
|
|
US7125859B2
(en)
*
|
2003-07-24 |
2006-10-24 |
Materials Evolution And Development Usa, Inc. |
Nucleic acid antioxidant compositions, methods for obtaining such compositions and formulations thereof
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
|
WO2005027962A1
(en)
*
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
US7425544B2
(en)
|
2003-09-18 |
2008-09-16 |
Eli Lilly And Company |
Modulation of eIF4E expression
|
|
US7125945B2
(en)
*
|
2003-09-19 |
2006-10-24 |
Varian, Inc. |
Functionalized polymer for oligonucleotide purification
|
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
|
AU2004291141B2
(en)
|
2003-11-17 |
2009-06-11 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
JP2007520222A
(ja)
|
2004-01-20 |
2007-07-26 |
アイシス ファーマシューティカルズ インコーポレイテッド |
グルココルチコイドレセプター発現の調節
|
|
US8778900B2
(en)
*
|
2004-01-22 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP1 expression
|
|
US7468431B2
(en)
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
|
US7842459B2
(en)
*
|
2004-01-27 |
2010-11-30 |
Compugen Ltd. |
Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
EP1730309B1
(de)
|
2004-03-15 |
2016-05-04 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur optimierung der spaltung von rna durch rnase h
|
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
JP2007531794A
(ja)
|
2004-04-05 |
2007-11-08 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
|
|
US20050260755A1
(en)
*
|
2004-04-06 |
2005-11-24 |
Isis Pharmaceuticals, Inc. |
Sequential delivery of oligomeric compounds
|
|
JP4584987B2
(ja)
|
2004-04-30 |
2010-11-24 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
C5修飾ピリミジンを含むオリゴヌクレオチド
|
|
CA2564251C
(en)
|
2004-05-21 |
2018-04-10 |
The Uab Research Foundation |
Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US7427675B2
(en)
*
|
2004-08-23 |
2008-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
EP1799812A4
(de)
*
|
2004-09-16 |
2009-09-09 |
Gamida Cell Ltd |
Verfahren zur ex-vivo-expansion von progenitor- und stammzellen durch gemeinsame kultivierung mit mesenchymzellen
|
|
CA2623471C
(en)
*
|
2004-09-23 |
2018-02-13 |
Arc Pharmaceuticals, Inc. |
Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions or inflammatory disease using low sulphate fucans
|
|
EP1843819A2
(de)
*
|
2004-11-15 |
2007-10-17 |
Obe Therapy Biotechnology S.A.S. |
Verfahren zur reduzierung von körperfett
|
|
EP1824520B1
(de)
|
2004-11-17 |
2016-04-27 |
Biosensors International Group, Ltd. |
Verfahren zum nachweis von prostatakarzinom
|
|
EP1869076A2
(de)
|
2005-03-10 |
2007-12-26 |
Genentech, Inc. |
Verfahren und zusammensetzungen zur modulation der gefässintegrität
|
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
|
US8309303B2
(en)
|
2005-04-01 |
2012-11-13 |
Qiagen Gmbh |
Reverse transcription and amplification of RNA with simultaneous degradation of DNA
|
|
WO2007008300A2
(en)
|
2005-05-31 |
2007-01-18 |
ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE |
Triblock copolymers for cytoplasmic delivery of gene-based drugs
|
|
WO2006133022A2
(en)
|
2005-06-03 |
2006-12-14 |
The Johns Hopkins University |
Compositions and methods for decreasing microrna expression for the treatment of neoplasia
|
|
US8252756B2
(en)
|
2005-06-14 |
2012-08-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
ES2435774T3
(es)
*
|
2005-07-07 |
2013-12-23 |
Yissum Research Development Company, Of The Hebrew University Of Jerusalem |
Agentes de ácido nucleico para la regulación negativa de H19, y métodos de uso del mismo
|
|
DK1929012T3
(da)
|
2005-08-11 |
2011-01-31 |
Synthetic Genomics Inc |
Fremgangsmåde til in vitro-rekombination
|
|
CA2617693A1
(en)
|
2005-08-17 |
2007-02-22 |
Medexis S.A. |
Composition and method for determination of ck19 expression
|
|
AU2006284855B2
(en)
|
2005-08-29 |
2011-10-13 |
Regulus Therapeutics Inc. |
Methods for use in modulating miR-122a
|
|
EP1762627A1
(de)
|
2005-09-09 |
2007-03-14 |
Qiagen GmbH |
Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
|
|
IL172297A
(en)
|
2005-10-03 |
2016-03-31 |
Compugen Ltd |
Soluble vegfr-1 variants for diagnosis of preeclamsia
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
EP2392647A1
(de)
|
2005-10-14 |
2011-12-07 |
MUSC Foundation For Research Development |
Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
|
|
WO2007051045A2
(en)
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
|
ATE510545T1
(de)
|
2005-11-09 |
2011-06-15 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur hemmung der expression von faktor v leiden mutationsgen
|
|
EP1966377A2
(de)
|
2005-11-21 |
2008-09-10 |
Isis Pharmaceuticals, Inc. |
Modulation der eif4e-bp2-expression
|
|
US8846393B2
(en)
|
2005-11-29 |
2014-09-30 |
Gamida-Cell Ltd. |
Methods of improving stem cell homing and engraftment
|
|
EP1974052A2
(de)
*
|
2005-12-21 |
2008-10-01 |
Yale University |
Verfahren und zusammensetzungen in verbindung mit der modulation von riboschaltern
|
|
CN101437933B
(zh)
|
2005-12-28 |
2013-11-06 |
斯克里普斯研究所 |
作为药物靶标的天然反义和非编码的rna转录物
|
|
CA2637267A1
(en)
|
2006-01-16 |
2007-07-19 |
Compugen Ltd. |
Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
|
|
CA2640058C
(en)
|
2006-01-27 |
2018-04-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
KR101304071B1
(ko)
*
|
2006-01-27 |
2013-09-06 |
아이시스 파마수티컬즈 인코포레이티드 |
6-변형된 바이시클릭 핵산 유사체
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
WO2007115168A2
(en)
|
2006-03-31 |
2007-10-11 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of eg5 gene
|
|
EP2013344B1
(de)
*
|
2006-05-03 |
2012-08-29 |
Baltic Technology Development, Ltd. |
Antisense-agentien mit kombination von mit stark gebundener base modifiziertem oligonukleotid und künstlicher nuklease
|
|
WO2007143317A2
(en)
*
|
2006-05-05 |
2007-12-13 |
Isis Pharmaceuticals, Inc |
Compounds and methods for modulating expression of crp
|
|
WO2007134181A2
(en)
*
|
2006-05-11 |
2007-11-22 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
SG171676A1
(en)
|
2006-05-11 |
2011-06-29 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of the pcsk9 gene
|
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
US7812150B2
(en)
|
2006-05-19 |
2010-10-12 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of Aha and therapeutic uses thereof
|
|
WO2007137220A2
(en)
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
|
WO2007137301A2
(en)
*
|
2006-05-23 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Modulation of chrebp expression
|
|
WO2008011473A2
(en)
|
2006-07-19 |
2008-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hbxip
|
|
EP2061799A4
(de)
*
|
2006-09-11 |
2010-12-22 |
Univ Yale |
Verfahren und zusammensetzungen zur verwendung von lysin-riboswitches
|
|
AU2007299629C1
(en)
|
2006-09-21 |
2012-05-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the HAMP gene
|
|
MX363224B
(es)
|
2006-10-03 |
2019-03-15 |
Alnylam Pharmaceuticals Inc |
Formulaciones que contienen lipidos.
|
|
EP2081596A4
(de)
|
2006-10-06 |
2010-07-21 |
Univ Utah Res Found |
Verfahren zum nachweis von augenkrankheiten und pathologischen zuständen und behandlung dafür
|
|
US8999317B2
(en)
|
2006-11-01 |
2015-04-07 |
University Of Rochester |
Methods and compositions related to the structure and function of APOBEC3G
|
|
CN101600451A
(zh)
|
2006-12-11 |
2009-12-09 |
犹他大学研究基金会 |
用于治疗病理性血管生成和血管通透性的组合物和方法
|
|
US20100129358A1
(en)
|
2006-12-22 |
2010-05-27 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
|
CA2675967A1
(en)
*
|
2007-01-16 |
2008-07-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusale M |
Nucleic acid constructs and methods for specific silencing of h19
|
|
WO2008093331A1
(en)
*
|
2007-01-29 |
2008-08-07 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Antibody conjugates for circumventing multi-drug resistance
|
|
CA2691066C
(en)
|
2007-02-09 |
2018-07-31 |
Northwestern University |
Particles for detecting intracellular targets
|
|
JP2010520749A
(ja)
*
|
2007-02-27 |
2010-06-17 |
ノースウェスタン ユニバーシティ |
ナノ粒子への分子の結合
|
|
KR20100015757A
(ko)
|
2007-03-22 |
2010-02-12 |
예일 유니버시티 |
택일적 스플라이싱을 조절하는 리보스위치와 관련된 방법 및 조성물
|
|
PE20090064A1
(es)
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
|
AP3018A
(en)
|
2007-03-29 |
2014-10-31 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expressionof a gene from the ebola
|
|
US20110091377A1
(en)
|
2007-05-11 |
2011-04-21 |
The Johns Hopkins University |
Biomarkers for melanoma
|
|
US20100286082A1
(en)
*
|
2007-05-29 |
2010-11-11 |
Yale University |
Riboswitches and methods and compositions for use of and with riboswitches
|
|
EP2164994A4
(de)
*
|
2007-05-29 |
2010-07-21 |
Univ Yale Inc |
Verfahren und zusammensetzungen in verbindung mit riboswitches zu steuerung von alternativer spleissung und rna-verarbeitung
|
|
ES2388590T3
(es)
|
2007-05-30 |
2012-10-16 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
|
|
CA2689923A1
(en)
|
2007-05-30 |
2008-12-11 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
US7807372B2
(en)
*
|
2007-06-04 |
2010-10-05 |
Northwestern University |
Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
ATE538127T1
(de)
*
|
2007-07-05 |
2012-01-15 |
Isis Pharmaceuticals Inc |
6-disubstituierte bicyclische nukleinsäureanaloga
|
|
EP2316943B1
(de)
|
2007-07-05 |
2013-06-19 |
Novartis AG |
DSRNA zur Behandlung viraler Infektionen
|
|
US8088904B2
(en)
*
|
2007-08-15 |
2012-01-03 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
JP2010538005A
(ja)
|
2007-08-28 |
2010-12-09 |
ユーエービー リサーチ ファウンデーション |
合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法
|
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
|
HRP20150512T1
(hr)
|
2007-09-04 |
2015-06-19 |
Compugen Ltd. |
Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava
|
|
US8445217B2
(en)
|
2007-09-20 |
2013-05-21 |
Vanderbilt University |
Free solution measurement of molecular interactions by backscattering interferometry
|
|
US7951785B2
(en)
*
|
2007-09-21 |
2011-05-31 |
California Institute Of Technology |
NFIA in glial fate determination, glioma therapy and astrocytoma treatment
|
|
EP2205741A2
(de)
|
2007-10-02 |
2010-07-14 |
Amgen Inc. |
ERHÖHUNG DES ERYTHROPOIETINSPIEGELS MITTELS VERWENDUNG VON MIT miRNA HYBRIDISIERBAREN NUKLEINSÄUREN UND VORLÄUFER DAVON
|
|
EP2217705A2
(de)
*
|
2007-11-05 |
2010-08-18 |
Baltic Technology Development, Ltd. |
Verwendung von oligonukleotiden mit modifizierten basen bei der hybridisierung von nukleinsäuren
|
|
US8097712B2
(en)
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
|
WO2009067243A2
(en)
*
|
2007-11-20 |
2009-05-28 |
Isis Pharmaceuticals Inc. |
Modulation of cd40 expression
|
|
US8546556B2
(en)
*
|
2007-11-21 |
2013-10-01 |
Isis Pharmaceuticals, Inc |
Carbocyclic alpha-L-bicyclic nucleic acid analogs
|
|
AU2008335202A1
(en)
|
2007-12-10 |
2009-06-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor VII gene
|
|
EP2224912B1
(de)
|
2008-01-02 |
2016-05-11 |
TEKMIRA Pharmaceuticals Corporation |
Verbesserte zusammensetzungen und verfahren zur freisetzung von nukleinsäuren
|
|
US8530640B2
(en)
*
|
2008-02-07 |
2013-09-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
SG188121A1
(en)
|
2008-03-05 |
2013-03-28 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
US8426378B2
(en)
*
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
|
US9290534B2
(en)
*
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
MX2010011508A
(es)
|
2008-04-18 |
2011-05-03 |
Baxter Int |
Composicion basada en microesferas para prevenir y/o revertir la nueva presentacion de diabetes autoinmune.
|
|
JP2011523401A
(ja)
*
|
2008-04-29 |
2011-08-11 |
ワイス・エルエルシー |
炎症を治療するための方法
|
|
US8082730B2
(en)
*
|
2008-05-20 |
2011-12-27 |
Caterpillar Inc. |
Engine system having particulate reduction device and method
|
|
BRPI0916440A2
(pt)
*
|
2008-07-15 |
2018-06-05 |
Hoffmann La Roche |
composições e métodos para inibir a expressão dos genes receptores tgf-beta
|
|
US20110237646A1
(en)
*
|
2008-08-07 |
2011-09-29 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression for the treatment of cns related disorders
|
|
EP3081648A1
(de)
|
2008-08-25 |
2016-10-19 |
Excaliard Pharmaceuticals, Inc. |
Gegen den bindegewebe-wachstumsfaktor gerichtete antisense-oligonukleotide und verwendungen davon
|
|
EP3208337A1
(de)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen zur kombinationshemmung der expression eines mutanten egfr und il-6
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
US8604192B2
(en)
*
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
|
EP3584320A1
(de)
|
2008-09-25 |
2019-12-25 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen aus lipidformulierungen und verfahren zur hemmung der serum-amyloid-a-genexpression
|
|
EP2743265B1
(de)
|
2008-10-09 |
2017-03-15 |
Arbutus Biopharma Corporation |
Verbesserte Aminolipide und Verfahren zur Freisetzung von Nukleinsäuren
|
|
JP5809058B2
(ja)
|
2008-10-15 |
2015-11-10 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
第11因子発現の調節
|
|
DK2344639T3
(en)
|
2008-10-20 |
2015-07-27 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TRANSTHYRETINE
|
|
WO2010048549A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
EP2447274B1
(de)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomerverbindungen und Verfahren
|
|
SG171737A1
(en)
*
|
2008-11-17 |
2011-07-28 |
Hoffmann La Roche |
Compositions and methods for inhibiting expression of factor vii genes
|
|
CA2744207C
(en)
|
2008-11-24 |
2019-05-28 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
|
WO2010061393A1
(en)
|
2008-11-30 |
2010-06-03 |
Compugen Ltd. |
He4 variant nucleotide and amino acid sequences, and methods of use thereof
|
|
JP6091752B2
(ja)
|
2008-12-04 |
2017-03-08 |
クルナ・インコーポレーテッド |
Epoに対する天然アンチセンス転写物の抑制によるエリスロポエチン(epo)関連疾患の治療
|
|
KR20110091796A
(ko)
|
2008-12-04 |
2011-08-12 |
오피케이오 큐알엔에이, 엘엘씨 |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
|
ES2760912T3
(es)
|
2008-12-04 |
2020-05-18 |
Curna Inc |
Tratamiento de enfermedades relacionadas con la Sirtuina 1 (SIRT1) por inhibición del transcrito antisentido natural de la Sirtuina 1
|
|
EP2633854B1
(de)
|
2008-12-05 |
2015-09-16 |
Yeda Research And Development Co. Ltd. |
miRNA-9 or miRNA-9* zur Verwendung in der Behandlung von ALS
|
|
CA2746514C
(en)
|
2008-12-10 |
2018-11-27 |
Alnylam Pharmaceuticals, Inc. |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
|
US8592386B2
(en)
*
|
2008-12-17 |
2013-11-26 |
Sarepta Therapeutics, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
JP5801205B2
(ja)
*
|
2009-01-08 |
2015-10-28 |
ノースウェスタン ユニバーシティ |
多価オリゴヌクレオチド修飾ナノ粒子コンジュゲートによる細菌タンパク質産生の阻害
|
|
EP2391343B1
(de)
|
2009-01-29 |
2017-03-01 |
Arbutus Biopharma Corporation |
Verbesserte lipidformulierung zur verabreichung von nukleinsaueren
|
|
AU2010211133A1
(en)
*
|
2009-02-03 |
2011-07-21 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of PTP1B genes
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
ES2560107T3
(es)
|
2009-02-12 |
2016-02-17 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
|
|
CN102439149B
(zh)
|
2009-02-12 |
2018-01-02 |
库尔纳公司 |
通过抑制针对胶质细胞衍生神经营养因子(gdnf)的天然反义转录物来治疗gdnf相关的疾病
|
|
WO2010099341A1
(en)
|
2009-02-26 |
2010-09-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mig-12 gene
|
|
CA2753975C
(en)
|
2009-03-02 |
2017-09-26 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
|
JP6250263B2
(ja)
|
2009-03-04 |
2017-12-20 |
クルナ・インコーポレーテッド |
サーチュイン1(sirt1)に対する天然アンチセンス転写物の抑制によるsirt1関連疾患の治療
|
|
EP2406376A1
(de)
|
2009-03-12 |
2012-01-18 |
Alnylam Pharmaceuticals, Inc. |
Lipidformulierte zusammensetzungen und verfahren zur hemmung der expression von eg5- und vegf-genen
|
|
EP2408919B1
(de)
|
2009-03-16 |
2017-10-18 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem nuklearfaktor (erythroid-derived)-like 2 (nrf2) mittels hemmung des natürlichen antisense-transkripts gegen nrf2
|
|
MX2011009752A
(es)
|
2009-03-17 |
2011-09-29 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas a homologo tipo delta 1(dlk1) por inhibicion de transcrito antisentido natural a homologo tipo delta (dlk1).
|
|
CN108451968A
(zh)
|
2009-04-15 |
2018-08-28 |
西北大学 |
寡核苷酸功能化的纳米颗粒的递送
|
|
EP3524275A1
(de)
|
2009-04-22 |
2019-08-14 |
Massachusetts Institute Of Technology |
Angeborene immununterdrückung ermöglicht die wiederholte verabreichung von langen rna-molekülen
|
|
EP2424987B1
(de)
|
2009-05-01 |
2017-11-15 |
CuRNA, Inc. |
Behandlung von hämoglobin (hbf / hbg) verwandten krankheiten durch die inhibition des natürlichen antisense transcripts zu hbf / hbg
|
|
CA3151387A1
(en)
|
2009-05-05 |
2010-11-11 |
Arbutus Biopharma Corporation |
Lipid compositions for the delivery of therapeutic agents
|
|
EP3504967A1
(de)
|
2009-05-05 |
2019-07-03 |
Arbutus Biopharma Corporation |
Verfahren zur abgabe von oligonukleotiden an immunzellen
|
|
JP6250930B2
(ja)
|
2009-05-06 |
2017-12-20 |
クルナ・インコーポレーテッド |
トリステトラプロリン(ttp)に対する天然アンチセンス転写物の抑制によるttp関連疾患の治療
|
|
WO2010129799A2
(en)
|
2009-05-06 |
2010-11-11 |
Curna, Inc. |
Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
|
|
EP2430161A1
(de)
|
2009-05-15 |
2012-03-21 |
Yale University |
Gemm-riboswitches, strukturbasierte verbindungskonstruktion mit gemm-riboswitches sowie verfahren und zusammensetzungen zur verwendung von und mit gemm-riboswitches
|
|
MX2011011395A
(es)
*
|
2009-05-15 |
2011-11-18 |
Hoffmann La Roche |
Composiciones y metodos para inhibir la expresion de genes de receptor de glucocorticoide.
|
|
US8957037B2
(en)
|
2009-05-18 |
2015-02-17 |
Curna, Inc. |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
|
KR101703695B1
(ko)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의해 tfe3 및 인슐린 수용체 기질 2(irs2)의 치료
|
|
CN103221541B
(zh)
|
2009-05-28 |
2017-03-01 |
库尔纳公司 |
通过抑制抗病毒基因的天然反义转录物来治疗抗病毒基因相关疾病
|
|
NZ712719A
(en)
|
2009-06-10 |
2017-03-31 |
Arbutus Biopharma Corp |
Improved lipid formulation
|
|
US8951981B2
(en)
|
2009-06-16 |
2015-02-10 |
Curna, Inc. |
Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
|
|
JP5944311B2
(ja)
|
2009-06-16 |
2016-07-05 |
クルナ・インコーポレーテッド |
コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
|
|
ES2618894T3
(es)
|
2009-06-24 |
2017-06-22 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
|
|
JP5907866B2
(ja)
|
2009-06-26 |
2016-04-26 |
クルナ・インコーポレーテッド |
ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療
|
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
|
WO2011005861A1
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide end caps
|
|
WO2011017516A2
(en)
|
2009-08-05 |
2011-02-10 |
Curna, Inc. |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
|
WO2011017521A2
(en)
|
2009-08-06 |
2011-02-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
AP3574A
(en)
|
2009-08-14 |
2016-02-08 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
|
US20120157324A1
(en)
|
2009-08-17 |
2012-06-21 |
Yale University |
Methylation biomarkers and methods of use
|
|
JP5964232B2
(ja)
|
2009-08-25 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
‘iqモチーフ含有gtpアーゼ活性化タンパク質’(iqgap)に対する天然アンチセンス転写産物の阻害によるiqgap関連疾患の治療
|
|
US9321823B2
(en)
|
2009-09-02 |
2016-04-26 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
MX353880B
(es)
|
2009-10-14 |
2018-01-31 |
Yissum Research Development Company Of The Hebrew Univ Of Jerusalem Ltd Star |
Composiciones para controlar ácaros varroa en abejas.
|
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
|
BR112012009409A2
(pt)
|
2009-10-22 |
2017-02-21 |
Genentech Inc |
método de identificação de uma substância inibidora, molécula antagonista, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar a molécula, composição, artigo de fabricação, método de inibição de uma atividade biológica, método de tratamento de uma condição patológica, método para detectar msp em uma amostra e método para detectar hepsina em uma amostra
|
|
AU2010315399B2
(en)
|
2009-10-27 |
2016-01-28 |
Swift Biosciences, Inc. |
Bimolecular primers
|
|
US9376690B2
(en)
|
2009-10-30 |
2016-06-28 |
Northwestern University |
Templated nanoconjugates
|
|
WO2011056215A1
(en)
|
2009-11-03 |
2011-05-12 |
Landers James P |
Versatile, visible method for detecting polymeric analytes
|
|
US20110112176A1
(en)
*
|
2009-11-09 |
2011-05-12 |
John Frederick Boylan |
Compositions and methods for inhibiting expression of kif10 genes
|
|
WO2011058555A1
(en)
|
2009-11-12 |
2011-05-19 |
Yeda Research And Development Co. Ltd. |
A method of editing dna in a cell and constructs capable of same
|
|
KR101944119B1
(ko)
|
2009-11-13 |
2019-01-30 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
안티센스 항바이러스 화합물 및 인플루엔자 바이러스 감염을 치료하는 방법
|
|
CA2781469A1
(en)
|
2009-11-23 |
2011-05-26 |
Swift Biosciences, Inc. |
Devices to extend single stranded target molecules
|
|
SG10201408598XA
(en)
|
2009-11-30 |
2015-02-27 |
Genentech Inc |
Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 )
|
|
DK2513310T3
(en)
|
2009-12-16 |
2018-02-05 |
Curna Inc |
TREATMENT OF DISEASES CONNECTED WITH MEMBRANE-BONDED TRANSCRIPTION FACTOR Peptidase, site 1 (MBTPS1), BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTION TO MBTPS1
|
|
US20110152349A1
(en)
|
2009-12-18 |
2011-06-23 |
Anke Geick |
Compositions and methods for inhibiting expression of il-18 genes
|
|
ES2661387T3
(es)
|
2009-12-23 |
2018-03-28 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor de crecimiento de hepatocitos (hgf) mediante inhibición del transcrito antisentido natural a hgf
|
|
CA2782375C
(en)
|
2009-12-23 |
2023-10-31 |
Opko Curna, Llc |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
|
JP5993744B2
(ja)
|
2009-12-29 |
2016-09-14 |
カッパーアールエヌエー,インコーポレイテッド |
核呼吸因子1(nrf1)に対する天然アンチセンス転写物の阻害による核呼吸因子1関連疾患の治療
|
|
EP2519634B1
(de)
|
2009-12-29 |
2016-06-01 |
CuRNA, Inc. |
Behandlung von durch das tumorprotein 63 (p63) vermittelten erkrankungen durch das natürliche antisense-transkript für p63
|
|
DK2521784T3
(en)
|
2010-01-04 |
2018-03-12 |
Curna Inc |
TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
|
|
KR101853509B1
(ko)
|
2010-01-06 |
2018-04-30 |
큐알엔에이, 인크. |
췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
|
|
KR101854926B1
(ko)
|
2010-01-11 |
2018-05-04 |
큐알엔에이, 인크. |
성 호르몬 결합 글로불린 (shbg)에 대한 자연 안티센스 전사체의 저해에 의한 성 호르몬 결합 글로불린 (shbg) 관련된 질환의 치료
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011088076A2
(en)
|
2010-01-12 |
2011-07-21 |
Yale University |
Structured rna motifs and compounds and methods for their use
|
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
|
CA2824843A1
(en)
|
2010-02-04 |
2011-08-11 |
Ico Therapeutics Inc. |
Dosing regimens for treating and preventing ocular disorders using c-raf antisense
|
|
TW201129365A
(en)
|
2010-02-05 |
2011-09-01 |
Hoffmann La Roche |
Compositions and methods for inhibiting expression of IKK2 genes
|
|
ES2600356T3
(es)
|
2010-02-22 |
2017-02-08 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con pirrolin-5-carboxilato reductasa 1 (PYCR1) por inhibición de transcrito antisentido natural para PYCR1
|
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
|
NZ601293A
(en)
|
2010-02-23 |
2014-10-31 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
|
MY163887A
(en)
|
2010-03-08 |
2017-11-15 |
Monsanto Technology Llc |
Polynucleotide molecules for gene regulations in plants
|
|
WO2011112516A1
(en)
|
2010-03-08 |
2011-09-15 |
Ico Therapeutics Inc. |
Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
|
|
EP3210611B1
(de)
|
2010-03-12 |
2019-08-21 |
The Brigham and Women's Hospital, Inc. |
Verfahren zur behandlung von gefässentzündungserkrankungen
|
|
WO2011113015A2
(en)
|
2010-03-12 |
2011-09-15 |
Avi Biopharma, Inc. |
Antisense modulation of nuclear hormone receptors
|
|
WO2011113054A2
(en)
|
2010-03-12 |
2011-09-15 |
Aurasense Llc |
Crosslinked polynucleotide structure
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011120046A2
(en)
|
2010-03-26 |
2011-09-29 |
Swift Biosciences, Inc. |
Methods and compositions for isolating polynucleotides
|
|
ES2893199T3
(es)
|
2010-03-29 |
2022-02-08 |
Alnylam Pharmaceuticals Inc |
Terapia de ARNbc para amiloidosis ocular relacionada con transtiretina (TTR)
|
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
|
JP2013523162A
(ja)
|
2010-04-06 |
2013-06-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Cd274/pd−l1遺伝子の発現を阻害するための組成物および方法
|
|
JP5978203B2
(ja)
|
2010-04-09 |
2016-08-24 |
カッパーアールエヌエー,インコーポレイテッド |
Fgf21に対する天然アンチセンス転写物の阻害による線維芽細胞増殖因子(fgf21)線維芽細胞増殖因子fgf21)関連疾患の治療
|
|
WO2011133695A2
(en)
|
2010-04-20 |
2011-10-27 |
Swift Biosciences, Inc. |
Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
|
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
|
US9127033B2
(en)
|
2010-04-28 |
2015-09-08 |
Isis Pharmaceuticals, Inc. |
5′ modified nucleosides and oligomeric compounds prepared therefrom
|
|
US20110294868A1
(en)
|
2010-04-29 |
2011-12-01 |
Monia Brett P |
Modulation of transthyretin expression
|
|
RU2636461C2
(ru)
|
2010-05-03 |
2017-11-23 |
Дженентек, Инк. |
Композиции и способы для диагностики и лечения опухоли
|
|
EP2957636B1
(de)
|
2010-05-03 |
2020-04-01 |
CuRNA, Inc. |
Behandlung von sirtuin 3 (sirt3)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen sirt3
|
|
CA2805086C
(en)
|
2010-05-13 |
2020-10-20 |
Sarepta Therapeutics, Inc. |
Antisense modulation of interleukins 17 and 23 signaling
|
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
|
US8895528B2
(en)
|
2010-05-26 |
2014-11-25 |
Curna, Inc. |
Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
|
|
US20130203045A1
(en)
|
2010-05-26 |
2013-08-08 |
University Of Virginia Patent Foundation |
Method for detecting nucleic acids based on aggregate formation
|
|
AU2011261434B2
(en)
|
2010-06-02 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156713A1
(en)
|
2010-06-11 |
2011-12-15 |
Vanderbilt University |
Multiplexed interferometric detection system and method
|
|
US9168297B2
(en)
|
2010-06-23 |
2015-10-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Regulation of skin pigmentation by neuregulin-1 (NRG-1)
|
|
US20130209463A1
(en)
|
2010-06-30 |
2013-08-15 |
Compugen Ltd. |
Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
|
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー,インコーポレイテッド |
Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療
|
|
WO2012021554A1
(en)
|
2010-08-09 |
2012-02-16 |
Yale University |
Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use
|
|
WO2012038956A1
(en)
|
2010-09-20 |
2012-03-29 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Method of treating neurodegenerative diseases
|
|
JP5974012B2
(ja)
|
2010-10-05 |
2016-08-23 |
ジェネンテック, インコーポレイテッド |
突然変異体スムースンド及びその使用方法
|
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
|
US20140031250A1
(en)
|
2010-10-07 |
2014-01-30 |
David Tsai Ting |
Biomarkers of Cancer
|
|
US8951983B2
(en)
|
2010-10-17 |
2015-02-10 |
Yeda Research And Development Co. Ltd. |
Methods and compositions for the treatment of insulin-associated medical conditions
|
|
WO2012052258A1
(en)
|
2010-10-18 |
2012-04-26 |
Arrowhead Research Corporation |
Compositions and methods for inhibiting expression of rrm2 genes
|
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
|
RU2611195C2
(ru)
|
2010-10-27 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных с интерферон- связанным регулятором развития 1 (ifrd1), путем ингибирования природного антисмыслового транскрипта к ifrd1
|
|
JP2012111933A
(ja)
*
|
2010-11-02 |
2012-06-14 |
Nitto Denko Corp |
熱可塑性シリコーン樹脂
|
|
WO2012064824A1
(en)
|
2010-11-09 |
2012-05-18 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
US9328346B2
(en)
|
2010-11-12 |
2016-05-03 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
AU2011329777B2
(en)
|
2010-11-17 |
2016-06-09 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
JP6071893B2
(ja)
|
2010-11-23 |
2017-02-01 |
カッパーアールエヌエー,インコーポレイテッド |
Nanogへの天然アンチセンス転写物の阻害によるnanog関連疾患の治療
|
|
US9150926B2
(en)
|
2010-12-06 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Diagnosis and treatment of adrenocortical tumors using human microRNA-483
|
|
US9127275B2
(en)
|
2010-12-10 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
|
WO2012078967A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (epo) production
|
|
EP2663323B1
(de)
|
2011-01-14 |
2017-08-16 |
The General Hospital Corporation |
Verfahren zur anzielung von mir-128 zur regelung des cholesterin-/fettstoffwechsels
|
|
DK2670404T3
(en)
|
2011-02-02 |
2018-11-19 |
Univ Princeton |
CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
|
|
SI2670411T1
(sl)
|
2011-02-02 |
2019-06-28 |
Excaliard Pharmaceuticals, Inc. |
Protismiselne spojine, ki so usmerjene na rastni faktor veznega tkiva (CTGF), za uporabo v postopku zdravljenja keloidov ali hipertrofnih brazgotin
|
|
US9562853B2
(en)
|
2011-02-22 |
2017-02-07 |
Vanderbilt University |
Nonaqueous backscattering interferometric methods
|
|
KR102365961B1
(ko)
|
2011-03-29 |
2022-02-23 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
JP2014511694A
(ja)
|
2011-04-03 |
2014-05-19 |
ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル |
修飾型rna(mod−rna)を使用する効率的なインビボタンパク質発現
|
|
NZ713461A
(en)
|
2011-04-15 |
2017-02-24 |
Compugen Ltd |
Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
|
|
US20140186844A1
(en)
|
2011-04-26 |
2014-07-03 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
|
WO2012151268A1
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system for high throughput optical and label free detection of analytes
|
|
WO2012151289A2
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system to detect aggregate formation on a substrate
|
|
ES2653247T3
(es)
|
2011-06-09 |
2018-02-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la frataxina (FXN) mediante inhibición del transcrito antisentido natural al gen FXN
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
MX360782B
(es)
|
2011-06-21 |
2018-11-16 |
Alnylam Pharmaceuticals Inc |
Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
|
|
EP3388068A1
(de)
|
2011-06-21 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzung und verfahren zur hemmung der expression von protein-c (proc)-genen
|
|
KR20230084331A
(ko)
|
2011-06-21 |
2023-06-12 |
알닐람 파마슈티칼스 인코포레이티드 |
아포리포단백질 c-iii(apoc3) 유전자의 발현 억제를 위한 조성물 및 방법
|
|
EP2723390B1
(de)
|
2011-06-23 |
2017-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1-sirnas: materialzusammensetzungen und behandlungsverfahren
|
|
AU2012277376B2
(en)
|
2011-06-30 |
2016-11-24 |
Compugen Ltd. |
Polypeptides and uses thereof for treatment of autoimmune disorders and infection
|
|
CN113430196B
(zh)
|
2011-06-30 |
2025-05-20 |
箭头药业股份有限公司 |
用于抑制乙型肝炎病毒的基因表达的组合物和方法
|
|
WO2013019857A2
(en)
|
2011-08-01 |
2013-02-07 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
|
CA2844012C
(en)
|
2011-08-04 |
2021-03-16 |
Yeda Research And Development Co. Ltd. |
Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
|
|
US9840715B1
(en)
|
2011-09-13 |
2017-12-12 |
Monsanto Technology Llc |
Methods and compositions for delaying senescence and improving disease tolerance and yield in plants
|
|
US10829828B2
(en)
|
2011-09-13 |
2020-11-10 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
CN107739737A
(zh)
|
2011-09-13 |
2018-02-27 |
孟山都技术公司 |
用于杂草控制的方法和组合物
|
|
CN110066794A
(zh)
|
2011-09-13 |
2019-07-30 |
孟山都技术公司 |
用于杂草控制的方法和组合物
|
|
US10806146B2
(en)
|
2011-09-13 |
2020-10-20 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
WO2013040116A1
(en)
|
2011-09-13 |
2013-03-21 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
US10760086B2
(en)
|
2011-09-13 |
2020-09-01 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
EP3382027A3
(de)
|
2011-09-13 |
2018-10-31 |
Monsanto Technology LLC |
Verfahren und zusammensetzungen zur unkrautbekämpfung
|
|
US9920326B1
(en)
|
2011-09-14 |
2018-03-20 |
Monsanto Technology Llc |
Methods and compositions for increasing invertase activity in plants
|
|
EP2755692B1
(de)
|
2011-09-14 |
2020-11-25 |
Northwestern University |
Nanokonjugate zur durchquerung der blut-hirn-schranke
|
|
CA2848753C
(en)
|
2011-09-14 |
2022-07-26 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
US9580713B2
(en)
|
2011-09-17 |
2017-02-28 |
Yale University |
Fluoride-responsive riboswitches, fluoride transporters, and methods of use
|
|
WO2013055865A1
(en)
|
2011-10-11 |
2013-04-18 |
The Brigham And Women's Hospital, Inc. |
Micrornas in neurodegenerative disorders
|
|
SI2766393T1
(sl)
|
2011-10-14 |
2018-10-30 |
F. Hoffmann-La Roche Ag |
Protitelesa Anti-HtrA1 in postopki uporabe
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
US9145559B2
(en)
|
2011-10-27 |
2015-09-29 |
Yeda Research And Development Co. Ltd. |
Methods of treating cancer
|
|
WO2013090457A2
(en)
|
2011-12-12 |
2013-06-20 |
Oncoimmunin Inc. |
In vivo delivery of oligonucleotides
|
|
KR20140126357A
(ko)
|
2012-02-01 |
2014-10-30 |
컴퓨젠 엘티디. |
C1orf32 항체 및 이의 암 치료를 위한 용도
|
|
EP2814950A1
(de)
|
2012-02-13 |
2014-12-24 |
Gamida-Cell Ltd. |
Durch mesenchymale stammzellen konditioniertes medium und verfahren zur herstellung und verwendung davon
|
|
JP2015509366A
(ja)
|
2012-02-22 |
2015-03-30 |
ブレインステム バイオテック リミテッド |
神経幹細胞および運動ニューロンの生成
|
|
EP3401393B1
(de)
|
2012-02-22 |
2020-02-19 |
Exostem Biotec Ltd |
Mikrornas zur erzeugung von astrocyten
|
|
CA2866625C
(en)
|
2012-03-13 |
2020-12-08 |
Swift Biosciences, Inc. |
Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
|
|
EP2639238A1
(de)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
|
|
HUE040179T2
(hu)
|
2012-03-15 |
2019-02-28 |
Curna Inc |
Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2013154798A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
HK1211316A1
(en)
|
2012-04-20 |
2016-05-20 |
艾珀特玛治疗公司 |
Mirna modulators of thermogenesis
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
EP3597741A1
(de)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetische korrektur mutierter gene
|
|
US9273949B2
(en)
|
2012-05-11 |
2016-03-01 |
Vanderbilt University |
Backscattering interferometric methods
|
|
WO2013173638A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating smn gene family expression
|
|
CA2873809A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
|
EP2855680B8
(de)
|
2012-05-24 |
2020-04-15 |
Monsanto Technology LLC |
Zusammensetzungen und verfahren zur ausschaltung einer genexpression
|
|
WO2013184209A1
(en)
|
2012-06-04 |
2013-12-12 |
Ludwig Institute For Cancer Research Ltd. |
Mif for use in methods of treating subjects with a neurodegenerative disorder
|
|
US20140038182A1
(en)
|
2012-07-17 |
2014-02-06 |
Dna Logix, Inc. |
Cooperative primers, probes, and applications thereof
|
|
US9567569B2
(en)
|
2012-07-23 |
2017-02-14 |
Gamida Cell Ltd. |
Methods of culturing and expanding mesenchymal stem cells
|
|
US9175266B2
(en)
|
2012-07-23 |
2015-11-03 |
Gamida Cell Ltd. |
Enhancement of natural killer (NK) cell proliferation and activity
|
|
WO2014022852A1
(en)
|
2012-08-03 |
2014-02-06 |
Aptamir Therapeutics, Inc. |
Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
|
|
KR102237882B1
(ko)
|
2012-08-15 |
2021-04-07 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
|
|
US9950001B2
(en)
|
2012-08-20 |
2018-04-24 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
MX364070B
(es)
|
2012-10-18 |
2019-04-10 |
Monsanto Technology Llc |
Métodos y composiciones para el control de plagas vegetales.
|
|
ES2949394T3
(es)
|
2012-11-05 |
2023-09-28 |
Found Medicine Inc |
Moléculas de fusión novedosas y usos de las mismas
|
|
WO2014071358A2
(en)
|
2012-11-05 |
2014-05-08 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
|
UY35251A
(es)
|
2013-01-01 |
2014-07-31 |
Seeds Ltd Ab |
MOLÉCULAS DE dsRNA AISLADAS Y MÉTODOS PARA USARLAS PARA SILENCIAR MOLÉCULAS DIANA DE INTERÉS
|
|
US10683505B2
(en)
|
2013-01-01 |
2020-06-16 |
Monsanto Technology Llc |
Methods of introducing dsRNA to plant seeds for modulating gene expression
|
|
CA3150658A1
(en)
|
2013-01-18 |
2014-07-24 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
US10000767B2
(en)
|
2013-01-28 |
2018-06-19 |
Monsanto Technology Llc |
Methods and compositions for plant pest control
|
|
EP2951191B1
(de)
|
2013-01-31 |
2018-10-17 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur herstellung oligomerer verbindungen unter verwendung von modifizierten kopplungsprotokollen
|
|
WO2014130922A1
(en)
|
2013-02-25 |
2014-08-28 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
|
CN105074008A
(zh)
|
2013-03-13 |
2015-11-18 |
孟山都技术有限公司 |
用于杂草控制的方法和组合物
|
|
UA121846C2
(uk)
|
2013-03-13 |
2020-08-10 |
Монсанто Текнолоджи Ллс |
Спосіб та гербіцидна композиція для контролю видів рослини роду lolium
|
|
SG10201912286TA
(en)
|
2013-03-14 |
2020-02-27 |
Alnylam Pharmaceuticals Inc |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US20140283211A1
(en)
|
2013-03-14 |
2014-09-18 |
Monsanto Technology Llc |
Methods and Compositions for Plant Pest Control
|
|
US10568328B2
(en)
|
2013-03-15 |
2020-02-25 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
EP2981617B1
(de)
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutische verwendungen einer genomänderung mit crispr-/cas-systemen
|
|
DK2991656T3
(da)
|
2013-05-01 |
2020-03-23 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
|
|
AP2015008862A0
(en)
|
2013-05-22 |
2015-11-30 |
Alnylam Pharmaceuticals Inc |
Tmprss6 irna compositions and methods of use thereof
|
|
CN113018307A
(zh)
|
2013-05-22 |
2021-06-25 |
阿尔尼拉姆医药品有限公司 |
SERPINA1 iRNA组合物及其使用方法
|
|
US20160113911A1
(en)
|
2013-06-06 |
2016-04-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
|
DK3007704T3
(da)
|
2013-06-13 |
2021-03-29 |
Antisense Therapeutics Ltd |
Kombinationsterapi til akromegali
|
|
US9850496B2
(en)
|
2013-07-19 |
2017-12-26 |
Monsanto Technology Llc |
Compositions and methods for controlling Leptinotarsa
|
|
EP3608412A3
(de)
|
2013-07-19 |
2020-04-08 |
Monsanto Technology LLC |
Zusammensetzungen und verfahren zur bekämpfung von leptinotarsa
|
|
DK3041854T3
(da)
|
2013-08-08 |
2020-03-02 |
Scripps Research Inst |
En fremgangsmåde til stedspecifik enzymatisk mærkning af nukleinsyrer in vitro gennem inkorporering af unaturlige nukleotider
|
|
EP3052626A1
(de)
|
2013-10-02 |
2016-08-10 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der lect2-genexpression
|
|
US9988627B2
(en)
|
2013-10-04 |
2018-06-05 |
Novartis Ag |
Formats for organic compounds for use in RNA interference
|
|
US10119143B2
(en)
|
2013-10-04 |
2018-11-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
CN105792832B
(zh)
|
2013-10-04 |
2021-03-23 |
诺华股份有限公司 |
用于治疗乙肝病毒的有机化合物
|
|
WO2015051045A2
(en)
|
2013-10-04 |
2015-04-09 |
Novartis Ag |
3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE
|
|
WO2015054451A1
(en)
|
2013-10-09 |
2015-04-16 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
US10053692B2
(en)
|
2013-10-21 |
2018-08-21 |
The General Hospital Corporation |
Methods relating to circulating tumor cell clusters and the treatment of cancer
|
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US9540642B2
(en)
|
2013-11-04 |
2017-01-10 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Compositions and methods for controlling arthropod parasite and pest infestations
|
|
US10301622B2
(en)
|
2013-11-04 |
2019-05-28 |
Northwestern University |
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
|
|
CA2932122C
(en)
|
2013-12-03 |
2022-04-19 |
Northwestern University |
Liposomal particles, methods of making same and uses thereof
|
|
US10385388B2
(en)
|
2013-12-06 |
2019-08-20 |
Swift Biosciences, Inc. |
Cleavable competitor polynucleotides
|
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
|
UA119253C2
(uk)
|
2013-12-10 |
2019-05-27 |
Біолоджикс, Інк. |
Спосіб боротьби із вірусом у кліща varroa та у бджіл
|
|
MX382900B
(es)
|
2013-12-12 |
2025-03-13 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE ÁCIDO RIBONUCLEICO DE INTERFERENCIA (ARNi) CONTRA EL COMPONENTE DEL COMPLEMENTO Y MÉTODOS PARA SU USO.
|
|
CN106456694B
(zh)
|
2013-12-20 |
2020-06-30 |
通用医疗公司 |
与循环肿瘤细胞相关的方法和测定法
|
|
MX368629B
(es)
|
2014-01-15 |
2019-10-08 |
Monsanto Technology Llc |
Metodos y composiciones para el control de malezas utilizando polinucleotidos de 5-enolpiruvilshikimato-3-fosfato sintasa (epsps).
|
|
JP6736467B2
(ja)
|
2014-02-04 |
2020-08-05 |
ジェネンテック, インコーポレイテッド |
平滑化変異体及びその使用方法
|
|
CN111733231A
(zh)
|
2014-02-05 |
2020-10-02 |
耶达研究及发展有限公司 |
用于治疗和诊断的微rna和包含所述微rna的组合物
|
|
AU2015217301A1
(en)
|
2014-02-11 |
2016-08-25 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (KHK) iRNA compositions and methods of use thereof
|
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
|
RU2702838C2
(ru)
|
2014-03-19 |
2019-10-11 |
Ионис Фармасьютикалз, Инк. |
Композиции для модуляции экспрессии атаксина 2
|
|
EP3757214B1
(de)
|
2014-04-01 |
2022-06-15 |
Biogen MA Inc. |
Zusammensetzungen zur modulierung der sod-1-expression
|
|
WO2015153339A2
(en)
|
2014-04-01 |
2015-10-08 |
Monsanto Technology Llc |
Compositions and methods for controlling insect pests
|
|
HUE056155T2
(hu)
|
2014-04-09 |
2022-01-28 |
Scripps Research Inst |
Nem-természetes vagy módosított nukleozid-trifoszfátok sejtekbe importálása nukleinsav-trifoszfát transzporterekkel
|
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
EP4223315A3
(de)
|
2014-05-01 |
2023-08-23 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur synthese von reaktiven konjugatclustern
|
|
CR20200228A
(es)
|
2014-05-01 |
2020-07-09 |
Ionis Pharmaceuticals Inc |
COMPOSICIONES Y MÈTODOS PARA MODULAR LA EXPRESIÒN DEL FACTOR B DEL COMPLEMENTO (Divisional 2016-0554)
|
|
TW201607559A
(zh)
|
2014-05-12 |
2016-03-01 |
阿尼拉製藥公司 |
治療serpinc1相關疾患之方法和組成物
|
|
CN106574268B
(zh)
|
2014-05-22 |
2021-02-05 |
阿尔尼拉姆医药品有限公司 |
血管紧张素原(AGT)iRNA组合物及其使用方法
|
|
JP2017518307A
(ja)
|
2014-06-02 |
2017-07-06 |
チルドレンズ メディカル センター コーポレーション |
免疫調節のための方法および組成物
|
|
EP3508198A1
(de)
|
2014-06-04 |
2019-07-10 |
Exicure, Inc. |
Multivalente ausgabe von immunmodulatoren durch liposomale sphärische nukleinsäuren für prophylaktische oder therapeutische anwendungen
|
|
WO2015190922A1
(en)
|
2014-06-10 |
2015-12-17 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
|
AU2015280252A1
(en)
|
2014-06-23 |
2017-01-12 |
Monsanto Technology Llc |
Compositions and methods for regulating gene expression via RNA interference
|
|
EP3161138A4
(de)
|
2014-06-25 |
2017-12-06 |
Monsanto Technology LLC |
Verfahren und zusammensetzungen zur zuführung von nukleinsäuren an pflanzenzellen und regulierung der genexpression
|
|
EP3760208B1
(de)
|
2014-06-25 |
2024-05-29 |
The General Hospital Corporation |
Targeting von humanem satellit ii (hsatii)
|
|
CN107001442B
(zh)
|
2014-07-15 |
2021-04-27 |
耶路撒冷希伯来大学伊森姆研究发展公司 |
Cd44的分离的多肽及其应用
|
|
US9951327B1
(en)
|
2014-07-17 |
2018-04-24 |
Integrated Dna Technologies, Inc. |
Efficient and rapid method for assembling and cloning double-stranded DNA fragments
|
|
AR101348A1
(es)
|
2014-07-29 |
2016-12-14 |
Monsanto Technology Llc |
Composiciones y métodos para el control de pestes por insectos
|
|
AU2015298263B2
(en)
|
2014-07-31 |
2020-05-14 |
Anji Pharmaceuticals, Inc. |
ApoE mimetic peptides and higher potency to clear plasma cholesterol
|
|
US12264344B2
(en)
|
2014-08-19 |
2025-04-01 |
Northwestern University |
Protein/oligonucleotide core-shell nanoparticle therapeutics
|
|
WO2016030899A1
(en)
|
2014-08-28 |
2016-03-03 |
Yeda Research And Development Co. Ltd. |
Methods of treating amyotrophic lateral scleroses
|
|
PL3185957T3
(pl)
|
2014-08-29 |
2022-11-14 |
Alnylam Pharmaceuticals, Inc. |
Patisiran do zastosowania w leczeniu amyloidozy związanej z transtyretyną
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
JP2017526367A
(ja)
|
2014-08-29 |
2017-09-14 |
チルドレンズ メディカル センター コーポレーション |
癌の処置のための方法および組成物
|
|
WO2016040589A1
(en)
|
2014-09-12 |
2016-03-17 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
WO2016040748A1
(en)
|
2014-09-12 |
2016-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for detection of smn protein in a subject and treatment of a subject
|
|
EP3198012B1
(de)
|
2014-09-26 |
2019-09-04 |
University of Massachusetts |
Rna-modulierende stoffe
|
|
TWI755351B
(zh)
|
2014-10-10 |
2022-02-21 |
美商艾爾妮蘭製藥公司 |
用於抑制hao1(羥酸氧化酶1(乙醇酸鹽氧化酶))基因表現的組合物及方法
|
|
EP3207138B1
(de)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Gegen aminolävulinsäuresynthase-1 (alas1) gerichtete polynukleotidmittel und verwendungen davon
|
|
EP3904519A1
(de)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynukleotidwirkstoffe mit abzielung auf serpinc1 (at3) und verfahren zur verwendung davon
|
|
HRP20192177T1
(hr)
|
2014-11-10 |
2020-02-21 |
Alnylam Pharmaceuticals, Inc. |
Rnai pripravci za virus hepatitisa b (hbv) i postupci njihove upotrebe
|
|
CN113846101A
(zh)
|
2014-11-17 |
2021-12-28 |
阿尔尼拉姆医药品有限公司 |
载脂蛋白C3(APOC3)iRNA组合物及其使用方法
|
|
WO2016081911A2
(en)
|
2014-11-21 |
2016-05-26 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
US12359197B2
(en)
|
2014-12-12 |
2025-07-15 |
Etagen Pharma, Inc. |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
JP6942632B2
(ja)
|
2015-01-22 |
2021-09-29 |
モンサント テクノロジー エルエルシー |
Leptinotarsa防除用組成物及びその方法
|
|
EP3247988A4
(de)
|
2015-01-23 |
2018-12-19 |
Vanderbilt University |
Robustes interferometer und verfahren zur verwendung davon
|
|
EP3256487A4
(de)
|
2015-02-09 |
2018-07-18 |
Duke University |
Zusammensetzungen und verfahren zur epigenombearbeitung
|
|
JP2018510621A
(ja)
|
2015-02-13 |
2018-04-19 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
|
EP3262181B1
(de)
|
2015-02-23 |
2024-04-10 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur flüssigphasendetritylierung von oligomeren verbindungen
|
|
WO2016135559A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
EP3268475B1
(de)
|
2015-03-11 |
2020-10-21 |
Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. |
Köderoligonukleotide zur behandlung von krankheiten
|
|
CN115537396A
(zh)
|
2015-03-27 |
2022-12-30 |
哈佛学院校长同事会 |
经过修饰的t细胞及其制备和使用方法
|
|
WO2016157175A1
(en)
|
2015-03-27 |
2016-10-06 |
Yeda Research And Development Co. Ltd. |
Methods of treating motor neuron diseases
|
|
WO2016164463A1
(en)
|
2015-04-07 |
2016-10-13 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive x chromosome
|
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
MX2017014215A
(es)
|
2015-05-04 |
2018-03-28 |
Monsanto Technology Llc |
Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos.
|
|
EP3294280A1
(de)
|
2015-05-11 |
2018-03-21 |
Yeda Research and Development Co., Ltd. |
Citrinhemmer zur behandlung von krebs
|
|
EP3302053B1
(de)
|
2015-06-02 |
2021-03-17 |
Monsanto Technology LLC |
Zusammensetzungen und verfahren zur abgabe eines polynukleotids in eine pflanze
|
|
WO2016196782A1
(en)
|
2015-06-03 |
2016-12-08 |
Monsanto Technology Llc |
Methods and compositions for introducing nucleic acids into plants
|
|
EP3307316A1
(de)
|
2015-06-12 |
2018-04-18 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon
|
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
CN108139375A
(zh)
|
2015-06-26 |
2018-06-08 |
贝斯以色列女执事医疗中心股份有限公司 |
靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法
|
|
CA2991045A1
(en)
|
2015-06-29 |
2017-01-05 |
Caris Science, Inc. |
Therapeutic oligonucleotides binding c1q
|
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
|
WO2017019918A1
(en)
|
2015-07-28 |
2017-02-02 |
Caris Science, Inc. |
Targeted oligonucleotides
|
|
WO2017021963A1
(en)
|
2015-08-03 |
2017-02-09 |
Biokine Therapeutics Ltd. |
Cxcr4 binding agents for treatment of diseases
|
|
US20180237774A1
(en)
|
2015-08-04 |
2018-08-23 |
Yeda Research And Development Co. Ltd. |
Methods of screening for riboswitches and attenuators
|
|
JP7336191B2
(ja)
|
2015-08-07 |
2023-08-31 |
アローヘッド ファーマシューティカルズ インコーポレイテッド |
B型肝炎ウイルス感染に対するRNAi療法
|
|
EP4393495A3
(de)
|
2015-09-02 |
2024-09-25 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen mit programmiertem zelltod 1-ligand 1 (pd-l1) und verfahren zur verwendung davon
|
|
EP3353297A1
(de)
|
2015-09-24 |
2018-08-01 |
Crispr Therapeutics AG |
Neuartige familie von rna-programmierbaren endonukleasen und deren verwendung in der genomeditierung und anderen anwendungen
|
|
EP3353303B1
(de)
|
2015-09-25 |
2023-08-02 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur modulation von ataxin 3-expression
|
|
EP4089175A1
(de)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genom-engineering mit typ-i-crispr-systemen in eukaryotischen zellen
|
|
EP4632068A3
(de)
|
2015-10-28 |
2026-01-21 |
Vertex Pharmaceuticals Inc. |
Materialien und verfahren zur behandlung von duchenne-muskeldystrophie
|
|
PE20181009A1
(es)
|
2015-10-30 |
2018-06-26 |
Genentech Inc |
ANTICUERPOS ANTI-HtrA1 Y METODOS DE USO DE LOS MISMOS
|
|
CA3007424A1
(en)
|
2015-11-05 |
2017-05-11 |
Children's Hospital Los Angeles |
"mobilizing leukemia cells"
|
|
MX2018005332A
(es)
|
2015-11-06 |
2018-11-09 |
Crispr Therapeutics Ag |
Materiales y metodos para tratamiento de la enfermedad de almacenamiento de glucogeno tipo 1a.
|
|
WO2017081686A1
(en)
|
2015-11-10 |
2017-05-18 |
B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University |
Means and methods for reducing tumorigenicity of cancer stem cells
|
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
JP2019500899A
(ja)
|
2015-11-23 |
2019-01-17 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
CRISPR/Cas9の核送達を通じた細胞RNAの追跡と操作
|
|
EA201891317A3
(ru)
|
2015-11-30 |
2019-04-30 |
Дьюк Юниверсити |
Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения
|
|
JP6932698B2
(ja)
|
2015-12-01 |
2021-09-08 |
クリスパー・セラピューティクス・アクチェンゲゼルシャフトCRISPR Therapeutics AG |
アルファ1アンチトリプシン欠乏症の治療のための材料および方法
|
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
EP3387127A1
(de)
|
2015-12-07 |
2018-10-17 |
Erasmus University Medical Center Rotterdam |
Enzymatische ersatztherapie und antisense-therapie für pompe-krankheit
|
|
IL259795B2
(en)
|
2015-12-07 |
2024-04-01 |
Genzyme Corp |
Methods and compositions for treating a serpinc1-associated disorder
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
CA3009308A1
(en)
|
2015-12-23 |
2017-06-29 |
Chad Albert COWAN |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
|
CA3006015A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
|
WO2017132483A1
(en)
|
2016-01-29 |
2017-08-03 |
Vanderbilt University |
Free-solution response function interferometry
|
|
WO2017134529A1
(en)
|
2016-02-02 |
2017-08-10 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
AU2017213826A1
(en)
|
2016-02-04 |
2018-08-23 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
|
EP3416689B1
(de)
|
2016-02-18 |
2023-01-18 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von schwerer kombinierter immundefizienz (scid) oder omenn syndrome
|
|
US11234996B2
(en)
|
2016-02-25 |
2022-02-01 |
The Brigham And Women's Hospital, Inc. |
Treatment methods for fibrosis targeting SMOC2
|
|
US10577607B2
(en)
|
2016-03-16 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of DYRK1B expression
|
|
WO2017158422A1
(en)
|
2016-03-16 |
2017-09-21 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
CN109715802A
(zh)
|
2016-03-18 |
2019-05-03 |
卡里斯科学公司 |
寡核苷酸探针及其用途
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US20200330609A1
(en)
|
2016-04-18 |
2020-10-22 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
CA3025486A1
(en)
|
2016-05-25 |
2017-11-30 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
|
EP3469083A1
(de)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung von paroxysmaler nächtlicher hämoglobinurie (pnh)
|
|
WO2017219017A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
EP4163293A1
(de)
|
2016-06-24 |
2023-04-12 |
The Scripps Research Institute |
Neuartiger nukleosid-triphosphat-transporter und verwendungen davon
|
|
CA3029119A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
|
WO2018002762A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders
|
|
EP3478829A1
(de)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Materialien und verfahren zur behandlung von myotoner dystrophie typ 1 (dm1) und anderen erkrankungen
|
|
AU2017292173B2
(en)
|
2016-07-06 |
2022-01-13 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of pain related disorders
|
|
DK3481856T3
(da)
|
2016-07-06 |
2025-11-10 |
Vertex Pharma |
Materialer og metoder til behandling af smerterelaterede lidelser
|
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
|
EP3481430A4
(de)
|
2016-07-11 |
2020-04-01 |
Translate Bio Ma, Inc. |
Nukleinsäurekonjugate und verwendungen davon
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
KR20230088522A
(ko)
|
2016-07-21 |
2023-06-19 |
맥스시티 인코포레이티드 |
게놈 dna를 변경하기 위한 방법 및 조성물
|
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
|
JOP20190015A1
(ar)
|
2016-08-04 |
2019-02-04 |
Arrowhead Pharmaceuticals Inc |
عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
|
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
|
US11414659B2
(en)
|
2016-09-02 |
2022-08-16 |
Dicerna Pharmaceuticals, Inc. |
4'-phosphate analogs and oligonucleotides comprising the same
|
|
EP3522898A4
(de)
|
2016-10-06 |
2020-05-27 |
Ionis Pharmaceuticals, Inc. |
Verfahren zum konjugieren von oligomeren verbindungen
|
|
EP3532638A4
(de)
|
2016-10-31 |
2020-07-29 |
University of Massachusetts |
Targeting von microrna-101-3p in der krebstherapie
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
EP3330276A1
(de)
|
2016-11-30 |
2018-06-06 |
Universität Bern |
Neuartige bicyclische nukleoside und daraus hergestellte oligomere
|
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
|
JP7206214B2
(ja)
|
2016-12-13 |
2023-01-17 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
|
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
|
JP7458785B2
(ja)
|
2017-01-23 |
2024-04-01 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒドロキシステロイド17-βデヒドロゲナーゼ13(HSD17B13)バリアント及びその使用
|
|
EP3585898A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von spinozerebellärer ataxie typ 1 (sca1) und anderen mit dem gen des proteins von spinozerebellärer ataxie typ 1 (atxn1) assoziierten erkrankungen oder störungen
|
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
EP3585899A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von primärer hyperoxalurie typ 1 (ph1) und anderen mit dem alanin-glyoxylataminotransferase (agxt)-gen assoziierten erkrankungen oder störungen
|
|
EP3585895A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Zusammensetzungen und verfahren zur geneditierung
|
|
WO2018154462A2
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
US20180284123A1
(en)
|
2017-03-30 |
2018-10-04 |
California Institute Of Technology |
Barcoded rapid assay platform useful for efficient analysis of candidate molecules and methods of making and using the platform
|
|
EP3609521A4
(de)
|
2017-04-14 |
2021-06-16 |
University of Massachusetts |
Targeting von zelltropismus-rezeptoren zur hemmung von infektionen durch das cytomegalovirus
|
|
CN118384268A
(zh)
|
2017-04-18 |
2024-07-26 |
阿尔尼拉姆医药品有限公司 |
具有乙肝病毒(hbv)感染的受试者的治疗方法
|
|
WO2018193428A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
|
CA3059321A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
|
AU2018256435B2
(en)
|
2017-04-20 |
2025-03-13 |
Atyr Pharma, Inc. |
Compositions and methods for treating lung inflammation
|
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
EP3622062A4
(de)
|
2017-05-10 |
2020-10-14 |
The Regents of the University of California |
Gerichtetes editing von zellulärer rna durch nukleare abgabe von crispr/cas9
|
|
CA3062506A1
(en)
|
2017-05-12 |
2019-05-23 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
CN111093771A
(zh)
|
2017-07-10 |
2020-05-01 |
建新公司 |
在患有血友病的受试者中治疗出血事件的方法和组合物
|
|
US12497642B2
(en)
|
2017-07-11 |
2025-12-16 |
The Scripps Research Institute |
Incorporation of unnatural nucleotides and methods of use in vivo thereof
|
|
CA3069321A1
(en)
|
2017-07-11 |
2019-01-17 |
The Scripps Research Institute |
Incorporation of unnatural nucleotides and methods thereof
|
|
EP3652186A4
(de)
|
2017-07-13 |
2021-03-31 |
Northwestern University |
Allgemeines und direktes verfahren zur herstellung von oligonukleotidfunktionalisierten metallorganischen gerüstnanopartikeln
|
|
EP3652317A1
(de)
|
2017-07-13 |
2020-05-20 |
Alnylam Pharmaceuticals, Inc. |
Lactatdehydrogenase-a (ldha)-irna-zusammensetzungen und verfahren zu ihrer verwendung
|
|
KR20250145137A
(ko)
|
2017-08-03 |
2025-10-13 |
신톡스, 인크. |
자가면역 질환의 치료를 위한 사이토카인 접합체
|
|
EP3668984A4
(de)
|
2017-08-18 |
2021-09-08 |
Ionis Pharmaceuticals, Inc. |
Modulation des notch-signalweges zur behandlung von atemwegserkrankungen
|
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
|
US11999953B2
(en)
|
2017-09-13 |
2024-06-04 |
The Children's Medical Center Corporation |
Compositions and methods for treating transposon associated diseases
|
|
US11806360B2
(en)
|
2017-09-19 |
2023-11-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
|
|
SG11202003464VA
(en)
|
2017-10-17 |
2020-05-28 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing for hemophilia a
|
|
EP3701029A1
(de)
|
2017-10-26 |
2020-09-02 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von hämoglobinopathien
|
|
SG11202002940QA
(en)
|
2017-11-01 |
2020-04-29 |
Alnylam Pharmaceuticals Inc |
Complement component c3 irna compositions and methods of use thereof
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
MA50579A
(fr)
|
2017-11-09 |
2020-09-16 |
Crispr Therapeutics Ag |
Systèmes crispr/cas ou crispr/cpf1 à auto-inactivation (sin) et leurs utilisations
|
|
EP3710587A1
(de)
|
2017-11-16 |
2020-09-23 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein-c3 kisspeptin 1 (kiss1)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
EP3714054A1
(de)
|
2017-11-20 |
2020-09-30 |
Alnylam Pharmaceuticals, Inc. |
Serum-amyloid p-komponente (apcs) irna zusammensetzungen und verfahren zu deren verwendung
|
|
US10662425B2
(en)
|
2017-11-21 |
2020-05-26 |
Crispr Therapeutics Ag |
Materials and methods for treatment of autosomal dominant retinitis pigmentosa
|
|
EP3714053B1
(de)
|
2017-11-22 |
2025-12-31 |
The University of Chicago |
Von chemischer sonde abhängige bewertung der proteinaktivität und verwendung davon
|
|
JP2021505587A
(ja)
|
2017-12-05 |
2021-02-18 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Crispr−cas9改変cd34+ヒト造血幹・前駆細胞及びその使用
|
|
WO2019118935A1
(en)
|
2017-12-14 |
2019-06-20 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
|
JP2021508491A
(ja)
|
2017-12-18 |
2021-03-11 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
高移動度グループボックス−1(HMGB1)iRNA組成物及びその使用方法
|
|
WO2019123430A1
(en)
|
2017-12-21 |
2019-06-27 |
Casebia Therapeutics Llp |
Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
|
|
US11459564B2
(en)
|
2017-12-21 |
2022-10-04 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
EP3728594A1
(de)
|
2017-12-21 |
2020-10-28 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung des usher-syndroms typ 2a
|
|
CN112105627B
(zh)
|
2017-12-29 |
2024-07-02 |
斯克利普斯研究所 |
非天然碱基对组合物及使用方法
|
|
WO2019140102A1
(en)
|
2018-01-10 |
2019-07-18 |
Translate Bio Ma, Inc. |
Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
|
|
US12215320B2
(en)
|
2018-01-12 |
2025-02-04 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing by targeting transferrin
|
|
PE20211242A1
(es)
|
2018-01-15 |
2021-07-09 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresion dnm2
|
|
JP7652567B2
(ja)
|
2018-01-19 |
2025-03-27 |
シンセナ アーゲー |
トリシクロ-dnaヌクレオシド前駆体およびそれを調製するためのプロセス
|
|
EP3740580A4
(de)
|
2018-01-19 |
2021-10-20 |
Duke University |
Genom-engineering mit crispr-cas-systemen bei eukaryonten
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
EP3749767A1
(de)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von hämoglobinopathien
|
|
US11268077B2
(en)
|
2018-02-05 |
2022-03-08 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019155465A1
(en)
|
2018-02-08 |
2019-08-15 |
Yeda Research And Development Co. Ltd. |
Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction
|
|
EP3752616A1
(de)
|
2018-02-16 |
2020-12-23 |
CRISPR Therapeutics AG |
Zusammensetzungen und verfahren zur geneditierung durch targeting von fibrinogen-alpha
|
|
EP4516358A3
(de)
|
2018-02-26 |
2025-04-23 |
Synthorx, Inc. |
Il-15-konjugate und verwendungen davon
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
|
EP3762395A1
(de)
|
2018-03-07 |
2021-01-13 |
Sanofi |
Nukleotidvorläufer, nukleotidanaloga und oligomere verbindungen damit
|
|
CA3092497A1
(en)
|
2018-03-19 |
2019-09-26 |
Crispr Therapeutics Ag |
Novel rna-programmable endonuclease systems and uses thereof
|
|
EP3768694A4
(de)
|
2018-03-22 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur modulierung der fmr1-expression
|
|
CA3095545A1
(en)
|
2018-03-30 |
2019-10-03 |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
Aptamers for targeted activaton of t cell-mediated immunity
|
|
WO2019195738A1
(en)
|
2018-04-06 |
2019-10-10 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
PE20201349A1
(es)
|
2018-04-11 |
2020-11-30 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresion de ezh2
|
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
|
WO2019210057A1
(en)
|
2018-04-27 |
2019-10-31 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Rapamycin resistant cells
|
|
CR20200605A
(es)
|
2018-05-09 |
2021-01-29 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para la reducción de la expresión de fxi
|
|
CN112189053B
(zh)
|
2018-05-09 |
2024-05-14 |
Ionis制药公司 |
用于减少atxn3表达的化合物和方法
|
|
US12582702B2
(en)
|
2018-05-11 |
2026-03-24 |
University Of Massachusetts |
Methods for improving leptin sensitivity for the treatment of obesity and diabetes
|
|
TWI851574B
(zh)
|
2018-05-14 |
2024-08-11 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
CN112585268B
(zh)
|
2018-06-28 |
2025-03-04 |
克里斯珀医疗股份公司 |
通过插入供体多核苷酸用于基因组编辑的组合物和方法
|
|
WO2020018558A1
(en)
|
2018-07-17 |
2020-01-23 |
Aronora, Inc. |
Methods for safely reducing thrombopoietin
|
|
NZ771733A
(en)
|
2018-07-25 |
2025-10-31 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn2 expression
|
|
KR102918289B1
(ko)
|
2018-08-13 |
2026-01-28 |
알닐람 파마슈티칼스 인코포레이티드 |
B형 간염 바이러스 (HBV) dsRNA 제제 조성물 및 이의 사용 방법
|
|
EP3837367A1
(de)
|
2018-08-16 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der lect2-genexpression
|
|
EP3843845B1
(de)
|
2018-08-29 |
2026-03-11 |
University Of Massachusetts |
Hemmung von proteinkinasen zur behandlung von friedreich-ataxie
|
|
SG11202102531WA
(en)
|
2018-09-14 |
2021-04-29 |
Univ Northwestern |
Programming protein polymerization with dna
|
|
CN118667811A
(zh)
|
2018-09-18 |
2024-09-20 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
|
ES2966013T3
(es)
|
2018-09-25 |
2024-04-17 |
Co Diagnostics Inc |
Diseño específico de alelo de cebadores cooperativos para genotipado de variantes de ácido nucleico mejorado
|
|
MX2021004455A
(es)
|
2018-10-17 |
2021-08-11 |
Crispr Therapeutics Ag |
Composiciones y métodos para administrar transgenes.
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
MX2021005293A
(es)
|
2018-11-08 |
2021-06-23 |
Synthorx Inc |
Conjugados de interleuquina 10 y usos de los mismos.
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
EP3880821A4
(de)
|
2018-11-15 |
2023-01-25 |
Ionis Pharmaceuticals, Inc. |
Modulatoren der irf5-expression
|
|
BR112021007476A2
(pt)
|
2018-11-21 |
2021-11-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para reduzir a expressão de príon
|
|
IL263184A
(en)
|
2018-11-21 |
2020-05-31 |
Yarden Yosef |
Method of treating cancer and compositions for same
|
|
JP7564102B2
(ja)
|
2018-11-28 |
2024-10-08 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
LNPでの使用に最適化された、CAS9をコードするmRNA
|
|
US12485136B2
(en)
|
2018-12-03 |
2025-12-02 |
Takeda Pharmaceuticals U.S.A., Inc. |
Methods for the treatment of trinucleotide repeat expansion disorders associated with MLH3 activity
|
|
US20210332495A1
(en)
|
2018-12-06 |
2021-10-28 |
Northwestern University |
Protein Crystal Engineering Through DNA Hybridization Interactions
|
|
PL4285929T3
(pl)
|
2018-12-20 |
2026-03-23 |
Humabs Biomed Sa |
Terapia skojarzona hbv
|
|
CN113631709A
(zh)
|
2018-12-20 |
2021-11-09 |
普拉克西斯精密药物股份有限公司 |
用于治疗kcnt1相关病症的组合物和方法
|
|
EP3911335A1
(de)
|
2019-01-16 |
2021-11-24 |
Genzyme Corporation |
Serpinc1-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
TW202214854A
(zh)
|
2019-01-31 |
2022-04-16 |
美商Ionis製藥公司 |
Yap1表現之調節劑
|
|
SG11202107354WA
(en)
|
2019-02-06 |
2021-08-30 |
Synthorx Inc |
Il-2 conjugates and methods of use thereof
|
|
CA3129532A1
(en)
|
2019-02-15 |
2020-08-20 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
|
WO2020171889A1
(en)
|
2019-02-19 |
2020-08-27 |
University Of Rochester |
Blocking lipid accumulation or inflammation in thyroid eye disease
|
|
JP2022521010A
(ja)
|
2019-02-21 |
2022-04-04 |
イッスム・リサーチ・デベロプメント・カムパニー・オブ・ザ・ヘブリュー・ユニバシティー・オブ・エルサレム リミテッド |
薬物誘導性腎毒性を減少させるための方法
|
|
WO2020176771A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
|
EP3937963B1
(de)
|
2019-03-12 |
2025-05-07 |
CRISPR Therapeutics AG |
Neuartige rna-programmierbare high-fidelity-endonukleasesysteme und verwendungen davon
|
|
PL3947684T3
(pl)
|
2019-03-29 |
2025-07-21 |
Ionis Pharmaceuticals, Inc. |
Związki i sposoby modulacji ube3a-ats
|
|
KR20210145213A
(ko)
|
2019-03-29 |
2021-12-01 |
다이서나 파마수이티컬, 인크. |
Kras 관련 질환 또는 장애를 치료하기 위한 조성물 및 방법
|
|
CN114174532A
(zh)
|
2019-04-05 |
2022-03-11 |
德克萨斯大学系统董事会 |
细胞条形码编码的方法和应用
|
|
MX2021013418A
(es)
|
2019-05-03 |
2021-12-10 |
Dicerna Pharmaceuticals Inc |
Moleculas inhibidoras de acido nucleico bicatenario con cadenas de sentido acortadas.
|
|
US20210047649A1
(en)
|
2019-05-08 |
2021-02-18 |
Vertex Pharmaceuticals Incorporated |
Crispr/cas all-in-two vector systems for treatment of dmd
|
|
CA3139325A1
(en)
|
2019-05-13 |
2020-11-19 |
Vir Biotechnology, Inc. |
Compositions and methods for treating hepatitis b virus (hbv) infection
|
|
TWI874408B
(zh)
|
2019-06-14 |
2025-03-01 |
美商史基普研究協會 |
於半合成生物體中複製、轉錄及轉譯之試劑及方法
|
|
US20210008161A1
(en)
|
2019-06-17 |
2021-01-14 |
Crispr Therapeutics Ag |
Methods and compositions for improved homology directed repair
|
|
EP3956450B1
(de)
|
2019-07-26 |
2025-08-13 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation von gfap
|
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP4007812A1
(de)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen der serpinfamilie f element 2 (serpinf2) und verfahren zu deren verwendung
|
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
CN114555621B
(zh)
|
2019-08-15 |
2025-10-28 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
|
TWI873169B
(zh)
|
2019-08-15 |
2025-02-21 |
美商欣爍克斯公司 |
使用il-2接合物之免疫腫瘤學組合療法
|
|
BR112022003046A8
(pt)
|
2019-08-23 |
2024-02-06 |
Synthorx Inc |
Conjugado de il-15, seu método de preparo e seus usos, bem como composição farmacêutica e método in vitro de expansão de uma ou mais das populações de células t
|
|
CN114616331B
(zh)
|
2019-09-03 |
2024-10-22 |
阿尔尼拉姆医药品有限公司 |
抑制lect2基因表达的组合物和方法
|
|
US12234271B2
(en)
|
2019-09-10 |
2025-02-25 |
Synthorx, Inc. |
Il-2 conjugates and methods of use to treat autoimmune diseases
|
|
US12319711B2
(en)
|
2019-09-20 |
2025-06-03 |
Northwestern University |
Spherical nucleic acids with tailored and active protein coronae
|
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
|
EP4045652A1
(de)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen eines elements der solute-carrier-familie und verwendungsverfahren dafür
|
|
JP7676377B2
(ja)
|
2019-10-22 |
2025-05-14 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体成分C3 iRNA組成物およびその使用方法
|
|
US12378560B2
(en)
|
2019-10-29 |
2025-08-05 |
Northwestern University |
Sequence multiplicity within spherical nucleic acids
|
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
CN119499394A
(zh)
|
2019-11-01 |
2025-02-25 |
阿尔尼拉姆医药品有限公司 |
亨廷顿(HTT)iRNA药剂组合物及其使用方法
|
|
EP4054644A1
(de)
|
2019-11-04 |
2022-09-14 |
Synthorx, Inc. |
Interleukin-10-konjugate und deren verwendungen
|
|
WO2021096763A1
(en)
|
2019-11-13 |
2021-05-20 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
|
EP4061945A1
(de)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3)-rnai-wirkstoffzusammensetzungen und verfahren zu deren verwendung
|
|
CA3159501A1
(en)
|
2019-11-27 |
2021-06-03 |
Brian Joseph CAFFERTY |
Methods of synthesizing rna molecules
|
|
CA3164599A1
(en)
|
2019-12-13 |
2021-06-17 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
|
TW202138559A
(zh)
|
2019-12-16 |
2021-10-16 |
美商阿尼拉製藥公司 |
含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法
|
|
US20230054569A1
(en)
|
2019-12-18 |
2023-02-23 |
Alia Therapeutics Srl |
Compositions and methods for treating retinitis pigmentosa
|
|
WO2021146488A1
(en)
|
2020-01-15 |
2021-07-22 |
Dicerna Pharmaceuticals, Inc. |
4'-o-methylene phosphonate nucleic acids and analogues thereof
|
|
US12503695B2
(en)
|
2020-01-27 |
2025-12-23 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
RAB13 and NET1 antisense oligonucleotides to treat metastatic cancer
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
MX2022009763A
(es)
|
2020-02-10 |
2022-09-09 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para silenciar la expresion del factor de crecimiento endotelial vascular a (vegf-a).
|
|
KR20220143106A
(ko)
|
2020-02-18 |
2022-10-24 |
알닐람 파마슈티칼스 인코포레이티드 |
아포지질단백질 C3 (APOC3) iRNA 조성물 및 이의 사용 방법
|
|
AR121446A1
(es)
|
2020-02-28 |
2022-06-08 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
BR112022017822A2
(pt)
|
2020-03-06 |
2022-11-08 |
Alnylam Pharmaceuticals Inc |
Composições de irna de cetoexocinase (khk) e métodos de uso das mesmas
|
|
EP4121534A1
(de)
|
2020-03-18 |
2023-01-25 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von patienten mit einer heterozygoten alaninglyoxylat-aminotransferase-genvariante (agxt)
|
|
CN116209759A
(zh)
|
2020-03-26 |
2023-06-02 |
阿尔尼拉姆医药品有限公司 |
冠状病毒iRNA组合物及其使用方法
|
|
US20230190785A1
(en)
|
2020-03-30 |
2023-06-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
US12534731B2
(en)
|
2020-04-01 |
2026-01-27 |
Alnylam Pharmaceuticals, Inc. |
Alpha-2A adrenergic receptor (ADRA2A) iRNA agent compositions and methods of use thereof
|
|
MX2022012493A
(es)
|
2020-04-06 |
2022-10-27 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para el silenciamiento de la expresion de miocilina (myoc).
|
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
AU2021251754A1
(en)
|
2020-04-07 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing SCN9A expression
|
|
EP4133077A1
(de)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen mit transmembran-serinprotease 2 (tmprss2) und verfahren zur verwendung davon
|
|
AU2021263554A1
(en)
|
2020-04-27 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein E (APOE) iRNA agent compositions and methods of use thereof
|
|
KR20230017789A
(ko)
|
2020-04-30 |
2023-02-06 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법
|
|
AU2021264010A1
(en)
|
2020-05-01 |
2022-12-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating ATXN1
|
|
EP4150087A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung des gap-junction-proteins beta 2 (gjb2)
|
|
EP4150076A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von methyl-cpg-bindendem protein 2 (mecp2)
|
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
EP4150077A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von transmembrankanalähnlichem protein 1 (tmc1)
|
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
EP4150086A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von leucinreicher repeat-kinase 2 (lrrk2)
|
|
EP4150089A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von retinosin 1 (rs1)
|
|
EP4150078A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten editierung von argininosuccinat-lyase (asl)
|
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
CN115885042A
(zh)
|
2020-05-22 |
2023-03-31 |
波涛生命科学有限公司 |
双链寡核苷酸组合物及其相关方法
|
|
AR122534A1
(es)
|
2020-06-03 |
2022-09-21 |
Triplet Therapeutics Inc |
Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
|
|
WO2021248052A1
(en)
|
2020-06-05 |
2021-12-09 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
|
WO2021252649A2
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Sirna compositions and methods for silencing gpam (glycerol-3-phosphate acyltransferase 1, mitochondrial) expression
|
|
BR112022024420A2
(pt)
|
2020-06-18 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de irna de xantina desidrogenase (xdh) e métodos de uso das mesmas
|
|
US20230242621A1
(en)
|
2020-06-24 |
2023-08-03 |
Vir Biotechnology, Inc. |
Engineered hepatitis b virus neutralizing antibodies and uses thereof
|
|
MX2022016254A
(es)
|
2020-06-25 |
2023-04-11 |
Synthorx Inc |
Terapia de combinación de inmunooncología con conjugados de il-2 y anticuerpos anti-egfr.
|
|
US11732263B2
(en)
|
2020-06-29 |
2023-08-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating PLP1
|
|
JP2023536472A
(ja)
|
2020-07-28 |
2023-08-25 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Appの発現を低減するための化合物及び方法
|
|
IL300283A
(en)
|
2020-08-04 |
2023-04-01 |
Dicerna Pharmaceuticals Inc |
Systemic administration of oligonucleotides
|
|
AU2021320384A1
(en)
|
2020-08-07 |
2023-02-16 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating SCN2A
|
|
WO2022066847A1
(en)
|
2020-09-24 |
2022-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
US20230392134A1
(en)
|
2020-09-30 |
2023-12-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
|
EP4225917A1
(de)
|
2020-10-05 |
2023-08-16 |
Alnylam Pharmaceuticals, Inc. |
G-protein-gekoppelter rezeptor-75 (gpr75)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
EP3978608A1
(de)
|
2020-10-05 |
2022-04-06 |
SQY Therapeutics |
Oligomere verbindung zur dystrophinrettung in dmd-patienten während des skipping exon-51
|
|
EP4225376A1
(de)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immunonkologische kombinationstherapie mit il-2-konjugaten und pembrolizumab
|
|
MX2023004032A
(es)
|
2020-10-09 |
2023-04-27 |
Synthorx Inc |
Terapias inmuno-oncologicas con conjugados de il-2.
|
|
WO2022079719A1
(en)
|
2020-10-15 |
2022-04-21 |
Yeda Research And Development Co. Ltd. |
Method of treating myeloid malignancies
|
|
JP2023546199A
(ja)
|
2020-10-20 |
2023-11-01 |
サノフイ |
アシアロ糖タンパク質受容体のための新規リガンド
|
|
WO2022087041A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
WO2022087329A1
(en)
|
2020-10-23 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
|
JP2023547615A
(ja)
|
2020-10-23 |
2023-11-13 |
ザ スクリプス リサーチ インスティテュート |
非天然ヌクレオチドを含むポリヌクレオチドの逆転写
|
|
EP4244355A1
(de)
|
2020-11-13 |
2023-09-20 |
Alnylam Pharmaceuticals, Inc. |
Gerinnungsfaktor-v (f5)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
KR20230108728A
(ko)
|
2020-11-18 |
2023-07-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
|
|
EP4256053A1
(de)
|
2020-12-01 |
2023-10-11 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur hemmung der hao1 (hydroxysäureoxidase 1 (glycolatoxidase))-genexpression
|
|
EP4259795A1
(de)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Gerinnungsfaktor x (f10)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
TW202242111A
(zh)
|
2020-12-18 |
2022-11-01 |
美商Ionis製藥公司 |
用於調節因子xii之化合物及方法
|
|
AU2021409740A1
(en)
|
2020-12-23 |
2023-07-06 |
Flagship Pioneering Innovations Vi, Llc |
Compositions of modified trems and uses thereof
|
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
TW202302148A
(zh)
|
2021-02-12 |
2023-01-16 |
美商欣爍克斯公司 |
使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
|
|
IL304880A
(en)
|
2021-02-12 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
|
WO2022174101A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Skin cancer combination therapy with il-2 conjugates and cemiplimab
|
|
JP2024509783A
(ja)
|
2021-02-25 |
2024-03-05 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
プリオンタンパク質(prnp)irna組成物およびその使用方法
|
|
WO2022182574A1
(en)
|
2021-02-26 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
JP2024508896A
(ja)
|
2021-03-04 |
2024-02-28 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アンジオポエチン様3(ANGPTL3)iRNA組成物およびその使用方法
|
|
EP4305169A1
(de)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glykogensynthasekinase-3-alpha (gsk3a)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
US20220288181A1
(en)
|
2021-03-12 |
2022-09-15 |
Northwestern University |
Antiviral vaccines using spherical nucleic acids
|
|
BR112023019981A2
(pt)
|
2021-03-29 |
2023-12-12 |
Alnylam Pharmaceuticals Inc |
Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
|
|
EP4314293A1
(de)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Prolindehydrogenase 2 (prodh2)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
TW202309280A
(zh)
|
2021-04-26 |
2023-03-01 |
美商艾拉倫製藥股份有限公司 |
跨膜絲胺酸蛋白酶6(TMPRSS6)iRNA組成物及其使用方法
|
|
WO2022232343A1
(en)
|
2021-04-29 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
|
EP4334448A1
(de)
|
2021-05-03 |
2024-03-13 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von transthyretin(ttr)-vermittelter amyloidose
|
|
EP4341401A1
(de)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Natriumglucose-cotransporter-2-(sglt2)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
WO2022246023A1
(en)
|
2021-05-20 |
2022-11-24 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
JP2024522996A
(ja)
|
2021-06-02 |
2024-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
|
EP4346904A1
(de)
|
2021-06-03 |
2024-04-10 |
Synthorx, Inc. |
Kopf-hals-krebskombinationstherapie mit einem il-2-konjugat und cetuximab
|
|
WO2022256290A2
(en)
|
2021-06-04 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP4351541A2
(de)
|
2021-06-08 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung oder prävention von erkrankungen im zusammenhang mit morbus stargardt und/oder retinal-bindendem protein 4 (rbp4)
|
|
EP4101928A1
(de)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Programmierbare typ-v-rna-endonukleasesysteme
|
|
US20240141312A1
(en)
|
2021-06-11 |
2024-05-02 |
Bayer Aktiengesellschaft |
Type v rna programmable endonuclease systems
|
|
CA3223192A1
(en)
|
2021-06-18 |
2022-12-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ifnar1 expression
|
|
WO2023278410A1
(en)
|
2021-06-29 |
2023-01-05 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
JP2024527304A
(ja)
|
2021-06-30 |
2024-07-24 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アンジオテンシノーゲン(agt)関連障害を治療するための方法および組成物
|
|
WO2023285431A1
(en)
|
2021-07-12 |
2023-01-19 |
Alia Therapeutics Srl |
Compositions and methods for allele specific treatment of retinitis pigmentosa
|
|
WO2023003805A1
(en)
|
2021-07-19 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
|
|
WO2023003995A1
(en)
|
2021-07-23 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Beta-catenin (ctnnb1) irna compositions and methods of use thereof
|
|
JP2024529437A
(ja)
|
2021-07-29 |
2024-08-06 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
3-ヒドロキシ-3-メチルグリタル-COAレダクターゼ(HMGCR)iRNA組成物およびその使用方法
|
|
IL310244A
(en)
|
2021-08-03 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Transthyretin (TTR) IRNA compositions and methods of using them
|
|
MX2024001445A
(es)
|
2021-08-04 |
2024-02-27 |
Alnylam Pharmaceuticals Inc |
Composiciones de acido ribonucleico de interferencia (arni) y metodos para silenciar el angiotensinogeno (agt).
|
|
JP2024534766A
(ja)
|
2021-08-13 |
2024-09-26 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
第XII因子(F12)iRNA組成物およびその使用方法
|
|
AU2022339821A1
(en)
|
2021-08-31 |
2024-03-07 |
Alnylam Pharmaceuticals, Inc. |
Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof
|
|
EP4144841A1
(de)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
|
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
|
AU2022345881A1
(en)
|
2021-09-20 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
|
MX2024003519A
(es)
|
2021-09-24 |
2024-04-01 |
Alnylam Pharmaceuticals Inc |
Composiciones de agentes de acido ribonucleico de interferencia (arni) de proteina tau asociada a microtubulos (mapt) y sus metodos de uso.
|
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
|
TW202334418A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
杭丁頓(HTT)iRNA劑組成物及其使用方法
|
|
JP2024541989A
(ja)
|
2021-10-29 |
2024-11-13 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体因子B(CFB)iRNA組成物およびその使用方法
|
|
EP4452327A1
(de)
|
2021-12-20 |
2024-10-30 |
Synthorx, Inc. |
Kopf-hals-krebskombinationstherapie mit einem il-2-konjugat und pembrolizumab
|
|
CA3243006A1
(en)
|
2021-12-21 |
2025-02-27 |
Alia Therapeutics Srl |
TYPE II CAS PROTEINS AND THEIR APPLICATIONS
|
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
|
CA3243301A1
(en)
|
2021-12-23 |
2023-06-29 |
Bayer Aktiengesellschaft |
NEW SMALL PROGRAMMABLE TYPE V RNA ENDONUCLEASE SYSTEMS
|
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
EP4486890A1
(de)
|
2022-03-01 |
2025-01-08 |
CRISPR Therapeutics AG |
Verfahren und zusammensetzungen zur behandlung von angiopoietin-like 3 (angptl3)-bedingten erkrankungen
|
|
CN118891266A
(zh)
|
2022-03-18 |
2024-11-01 |
迪克纳制药公司 |
使用Mn(II)或Mn(III)试剂用于合成4’-乙酰氧基-核苷的脱羧乙酰氧基化及其用于合成相应的4’-(二甲氧基磷酰基)甲氧基-核苷酸的用途
|
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
|
AU2023284048A1
(en)
|
2022-06-10 |
2024-11-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
|
JP2025527531A
(ja)
|
2022-08-18 |
2025-08-22 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ユニバーサル非標的sirna組成物およびその使用方法
|
|
EP4569113A1
(de)
|
2022-09-15 |
2025-06-18 |
Regeneron Pharmaceuticals, Inc. |
17b-hydroxysteroiddehydrogenase-typ-13 (hsd17b13)-irna-zusammensetzungen und verfahren zu ihrer verwendung
|
|
CA3267752A1
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
ENQP TYPE II CAS PROTEINS AND THEIR APPLICATIONS
|
|
CN120239607A
(zh)
|
2022-09-23 |
2025-07-01 |
Ionis制药公司 |
用于降低mecp2表达的化合物和方法
|
|
EP4619535A1
(de)
|
2022-11-16 |
2025-09-24 |
Alia Therapeutics Srl |
Typ-ii-cas-proteine und anwendungen davon
|
|
AU2023398007A1
(en)
|
2022-12-13 |
2025-06-19 |
Bayer Aktiengesellschaft |
Engineered type v rna programmable endonucleases and their uses
|
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|
|
JP2026502531A
(ja)
|
2023-01-11 |
2026-01-23 |
アリア セラピューティクス エスアールエル |
Ii型casタンパク質およびその適用
|
|
TW202449152A
(zh)
|
2023-02-09 |
2024-12-16 |
美商艾拉倫製藥股份有限公司 |
Reversir分子及其使用方法
|
|
WO2024170778A1
(en)
|
2023-02-17 |
2024-08-22 |
Anjarium Biosciences Ag |
Methods of making dna molecules and compositions and uses thereof
|
|
WO2024196937A1
(en)
|
2023-03-20 |
2024-09-26 |
Synthorx, Inc. |
Cancer therapy with il-2 peg conjugates
|
|
WO2024220746A2
(en)
|
2023-04-21 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting fatty acid synthase and related methods
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
WO2025003344A1
(en)
|
2023-06-28 |
2025-01-02 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
|
AU2024287308A1
(en)
|
2023-07-13 |
2025-12-18 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2025015338A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
AU2024299328A1
(en)
|
2023-07-21 |
2026-01-22 |
Marrow Therapeutics, Inc. |
Hematopoietic cell targeting conjugates and related methods
|
|
WO2025024493A1
(en)
|
2023-07-25 |
2025-01-30 |
Flagship Pioneering Innovations Vii, Llc |
Cas endonucleases and related methods
|
|
WO2025024486A2
(en)
|
2023-07-25 |
2025-01-30 |
Flagship Pioneering Innovations Vii, Llc |
Cas endonucleases and related methods
|
|
CN121605192A
(zh)
|
2023-08-04 |
2026-03-03 |
阿尔尼拉姆医药品有限公司 |
用于治疗ctnnb1-相关病症的方法和组合物
|
|
WO2025059113A1
(en)
|
2023-09-12 |
2025-03-20 |
The Board Of Regents Of The University Of Oklahoma |
Treatments for enhancing immune response to clostridioides difficile infections
|
|
WO2025072331A1
(en)
|
2023-09-26 |
2025-04-03 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025072699A1
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Aminoglycosides for delivery of agents to the kidney
|
|
WO2025072713A1
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Polymyxins for delivery of agents to the kidney
|
|
WO2025072672A2
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Slc6a19-targeting modulatory nucleic acid agents
|
|
WO2025076031A2
(en)
|
2023-10-03 |
2025-04-10 |
Alnylam Pharmaceuticals, Inc. |
Peritoneal macrophages comprising a nanoparticle encapsulating a nucleic acid molecule and methods of use thereof
|
|
WO2025076291A1
(en)
|
2023-10-06 |
2025-04-10 |
Bluerock Therapeutics Lp |
Engineered type v rna programmable endonucleases and their uses
|
|
AU2024369609A1
(en)
|
2023-10-31 |
2025-12-11 |
Korro Bio, Inc. |
Oligonucleotides comprising phosphoramidate internucleotide linkages
|
|
WO2025117877A2
(en)
|
2023-12-01 |
2025-06-05 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025128799A1
(en)
|
2023-12-12 |
2025-06-19 |
Korro Bio, Inc. |
Double-stranded rna-editing oligonucleotides and uses thereof
|
|
WO2025158385A1
(en)
|
2024-01-25 |
2025-07-31 |
Genzyme Corporation |
Pegylated il-2 for suppressing adaptive immune response to gene therapy
|
|
US20250263702A1
(en)
|
2024-02-19 |
2025-08-21 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting cideb and related methods
|
|
WO2025199231A2
(en)
|
2024-03-20 |
2025-09-25 |
Vertex Pharmaceuticals Incorporated |
Mucin-5b (muc5b) targeted sirna and antisense oligonucleotides and methods of use thereof
|
|
WO2025207517A2
(en)
|
2024-03-25 |
2025-10-02 |
Synthorx, Inc. |
Synthetic trna synthetases and cells comprising synthetic molecules for production of polypeptides
|
|
WO2025210147A1
(en)
|
2024-04-04 |
2025-10-09 |
Alia Therapeutics Srl |
Type v cas proteins and applications thereof
|
|
WO2025217275A2
(en)
|
2024-04-10 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Immune cell targeted compositions and related methods
|
|
WO2025259743A1
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dual conjugate compounds for extrahepatic delivery
|
|
WO2025259747A2
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
|
|
WO2026050243A1
(en)
|
2024-08-26 |
2026-03-05 |
Korro Bio, Inc. |
Galnac conjugated oligonucleotides for rna editing
|
|
WO2026055461A1
(en)
|
2024-09-05 |
2026-03-12 |
Aperture Therapeutics, Inc. |
Antibody oligonucleotide conjugates comprising an antisense polynucleotide agent conjugated to a cd33 antibody and methods of use thereof
|