NO930948L - Cykliske, antifungale peptider og fremgangsmaate for fremstilling av disse - Google Patents

Cykliske, antifungale peptider og fremgangsmaate for fremstilling av disse

Info

Publication number
NO930948L
NO930948L NO93930948A NO930948A NO930948L NO 930948 L NO930948 L NO 930948L NO 93930948 A NO93930948 A NO 93930948A NO 930948 A NO930948 A NO 930948A NO 930948 L NO930948 L NO 930948L
Authority
NO
Norway
Prior art keywords
hydrogen
preparing
hydroxy
procedures
cycle
Prior art date
Application number
NO93930948A
Other languages
English (en)
Other versions
NO930948D0 (no
Inventor
Frederick Joseph Burkhardt
Manuel Debono
Jeffrey Scott Nissen
Jr William Wilson Turner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO930948D0 publication Critical patent/NO930948D0/no
Publication of NO930948L publication Critical patent/NO930948L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/66—Gramicidins S, C; Tyrocidins A, B, C; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Det mr fremskaffet forbindelser med formel (1) hvor R' er hydrogen, metyl eller NK2C(OJCE?-: R" er metyl eller hydrogen; R er hydroksy eller hydrogen: R1 er hydroksy, hydrogen eller hydroksysulfonyloksy; R7 er hydroksy, hydrogen, hydroksysulfonyloksy eller f osf or.ooksy : Ro er en ny acyls idekjetie. Det blir også fremskaffet nye formuleringer, fremgangsmåter for hemming av fungal og parasittisk aktivitet og en fremgangsmåte for fremstilling av dideoksy (R=H) former av forbindelsene, karakterisert ved at den omfatter trinnet ved å utsette en forbindelse med formel (1) hvor E = OH for er. sterk syre i nærvær av et reduk- s.1 onstr.i edel i et passende opplesningsmiddel .
NO93930948A 1992-03-19 1993-03-16 Cykliske, antifungale peptider og fremgangsmaate for fremstilling av disse NO930948L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85411792A 1992-03-19 1992-03-19
US99239092A 1992-12-16 1992-12-16

Publications (2)

Publication Number Publication Date
NO930948D0 NO930948D0 (no) 1993-03-16
NO930948L true NO930948L (no) 1993-09-20

Family

ID=27127211

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93930948A NO930948L (no) 1992-03-19 1993-03-16 Cykliske, antifungale peptider og fremgangsmaate for fremstilling av disse

Country Status (25)

Country Link
EP (1) EP0561639B1 (no)
JP (3) JP3519754B2 (no)
KR (1) KR100256036B1 (no)
CN (1) CN1036715C (no)
AT (1) ATE217635T1 (no)
AU (2) AU3534193A (no)
BR (1) BR9301232A (no)
CA (1) CA2091663C (no)
CZ (1) CZ288974B6 (no)
DE (2) DE122008000006I2 (no)
DK (1) DK0561639T3 (no)
ES (1) ES2174843T3 (no)
FI (1) FI118768B (no)
HU (2) HU225783B1 (no)
IL (3) IL122315A (no)
LU (1) LU91406I2 (no)
MX (1) MX9301457A (no)
MY (1) MY136593A (no)
NL (1) NL300334I2 (no)
NO (1) NO930948L (no)
NZ (3) NZ247149A (no)
PT (1) PT561639E (no)
RU (1) RU2129562C1 (no)
TW (1) TW264477B (no)
YU (1) YU49108B (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430018A (en) * 1991-10-17 1995-07-04 Merck & Co., Inc. Cyclohexapeptide with basic nitrogen containing alkylamide groups
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2161149A1 (en) * 1993-05-04 1994-11-10 James M. Balkovec Cyclohexapeptidyl aminoalkyl ethers
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1995008341A1 (en) * 1993-09-22 1995-03-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
WO1996008266A1 (en) * 1994-09-16 1996-03-21 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
JP2897427B2 (ja) * 1994-10-07 1999-05-31 藤沢薬品工業株式会社 抗微生物活性を有する環状ヘキサペプチド化合物
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
ATE206054T1 (de) * 1995-01-26 2001-10-15 Merck & Co Inc Neue fungizide cyclohexapeptide
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5618787A (en) * 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) * 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) * 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629289A (en) * 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
AU1851797A (en) * 1996-02-01 1997-08-22 Eli Lilly And Company Cyclic peptide antifungal agents
US5693611A (en) * 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
JPH09227422A (ja) * 1996-02-12 1997-09-02 Rolic Ag シクロペンチル誘導体
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
AUPP172898A0 (en) * 1998-02-09 1998-03-05 Fujisawa Pharmaceutical Co., Ltd. New compound
US6730776B1 (en) * 1998-03-16 2004-05-04 Fujisawa Pharmaceutical Co., Ltd. WF14573 or its salt, production thereof and use thereof
EP1107981B1 (en) 1998-08-20 2005-01-26 Eli Lilly & Company Synthesis of ring-modified cyclic peptide analogs
AU766091B2 (en) 1998-12-09 2003-10-09 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
DE19907904A1 (de) 1999-02-24 2000-08-31 Clariant Gmbh Verfahren zur Herstellung von [1,1':4',1"]-Terphenylverbindungen
WO2000052037A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
KR20020002476A (ko) 1999-03-03 2002-01-09 피터 지. 스트링거 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
EP1582204B1 (en) 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
JP2002538097A (ja) 1999-03-03 2002-11-12 イーライ リリー アンド カンパニー 薬学的経口ｅｃｂ処方物および組成物の作製方法
ES2248281T3 (es) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta.
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
BRPI0409916A (pt) * 2003-04-30 2006-04-25 Inst For Pharm Discovery Inc ácidos carboxìlicos substituìdos com fenila
KR101551207B1 (ko) * 2008-09-04 2015-09-08 롬엔드하스전자재료코리아유한회사 신규한 유기 발광 화합물 및 이를 발광재료로서 채용하고 있는 유기 발광 소자
CN102464704B (zh) * 2010-11-05 2013-12-11 上海医药工业研究院 一种化合物及其制备方法和用途
HRP20231151T1 (hr) * 2012-03-19 2024-01-05 Cidara Therapeutics, Inc. Režimi za doziranje spojeva iz klase ehinokandina
ES2694561T3 (es) 2015-02-23 2018-12-21 Selectchemie Ag Composición de anidulafungina
JP6866583B2 (ja) * 2016-07-05 2021-04-28 Dic株式会社 液晶化合物
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE886576A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
BE886575A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CZ288974B6 (cs) 2001-10-17
FI118768B (fi) 2008-03-14
HUT63637A (en) 1993-09-28
HU225783B1 (en) 2007-09-28
NZ299314A (en) 2001-09-28
NL300334I1 (nl) 2008-03-03
JP3520071B2 (ja) 2004-04-19
CA2091663A1 (en) 1993-09-20
JP3519754B2 (ja) 2004-04-19
DK0561639T3 (da) 2002-06-17
ES2174843T3 (es) 2002-11-16
JPH0656892A (ja) 1994-03-01
MY136593A (en) 2008-10-31
NO930948D0 (no) 1993-03-16
AU3534193A (en) 1993-09-23
CZ41693A3 (en) 1994-07-13
AU6552996A (en) 1996-12-05
IL105048A0 (en) 1993-07-08
FI931202L (fi) 1993-09-20
JP2004115540A (ja) 2004-04-15
IL122315A0 (en) 1998-04-05
EP0561639B1 (en) 2002-05-15
IL122315A (en) 2002-03-10
DE69331922D1 (de) 2002-06-20
ATE217635T1 (de) 2002-06-15
NZ512085A (en) 2003-08-29
YU18593A (sh) 1996-10-09
DE69331922T2 (de) 2002-08-29
DE122008000006I2 (de) 2011-07-21
NL300334I2 (nl) 2008-05-01
IL105048A (en) 2001-06-14
CN1080926A (zh) 1994-01-19
NZ247149A (en) 1996-10-28
KR100256036B1 (ko) 2000-05-01
BR9301232A (pt) 1993-09-21
CN1036715C (zh) 1997-12-17
LU91406I2 (fr) 2008-03-10
JP2002226500A (ja) 2002-08-14
RU2129562C1 (ru) 1999-04-27
PT561639E (pt) 2002-10-31
TW264477B (no) 1995-12-01
KR930019694A (ko) 1993-10-18
MX9301457A (es) 1994-02-28
CA2091663C (en) 2007-10-30
DE122008000006I1 (de) 2008-04-17
EP0561639A1 (en) 1993-09-22
FI931202A0 (fi) 1993-03-18
HU9300785D0 (en) 1993-06-28
YU49108B (sh) 2004-03-12
HU211562A9 (en) 1995-12-28
AU689391B2 (en) 1998-03-26

Similar Documents

Publication Publication Date Title
MY136593A (en) Cyclic peptide antifungal agents and process for preparation thereof
KR910011891A (ko) 펩티드 화합물, 이의 제조방법 및 이를 함유하는 약학적 조성물
ATE2221T1 (de) 17-alpha-substituierte steroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung.
AU515774B2 (en) Benzopyran derivatives
DE3762860D1 (de) 2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
RU94046010A (ru) Комплексообразующие соединения и иммунореагенты направленного действия, применяемые в терапевтических целях, способ получения изображения, композиции, способ лечения
ATE38150T1 (de) Oximaether von alkylaminoalkoholen als heilmittelverbindungen und verfahren zu ihrer herstellung.
NO964551L (no) Imidazolderivater og fremgangsmåte for fremstilling av slike
ES2089258T3 (es) Derivados de 1,2,4-triazolo(1,5-a)pirimidina, procedimiento para prepararlos, asi como medicamentos que los contienen y utilizacion de los mismos.
DK163182C (da) Dialkylaminoalkoxybenzylalkoholderivater og farmaceutisk acceptable syreadditionssalte og kvaternaere ammoniumsalte deraf, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat og fremgangsmaade til fremstilling deraf
ATE35996T1 (de) 1alpha, 2alpha-methylen-6-methylen- und 6alphamethyl-pregnene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
NO881688D0 (no) 14,17beta-ethamo-14beta-oestratriener og oestrateraener, fremgangsmaater for fremstilling av disse og farmasoeytiske preparater inneholdende disse.
EP0245902A3 (en) Benzothiazinone derivatives
IE780926L (en) Chromene derivatives
JPS57131777A (en) Preparation of piperazine derivative
AU646529B2 (en) Novel preorganized hexadentate ligands useful in radiographic imaging agents
ATE15898T1 (de) Neue n-substitierte polyglycidylurazolverbindungen, verfahren zu ihrer herstellung sowie pharmazeutische zubereitungen.
DK455487D0 (da) 13alfa-alkylgonan-delta9(11)-5,10-epoxider og fremgangsmaade til fremstilling deraf
TH1556B (th) สารประกอบชนิดใหม่และสารผสมของสารนี้
TH380A (th) สารประกอบชนิดใหม่และสารผสมของสารนี้
SE7905025L (sv) Tereftalsyramonoamidderivat, forfarande for framstellning derav och antiallergiskt medel
IL67323A0 (en) New dehydrocardenolide derivatives,process for the preparation thereof and pharmaceutical preparations containing the same
NO922345L (no) Farmakologisk aktive amidkarboksylatderivater
ES8201961A1 (es) Procedimiento de obtencion de nuevos esteres carbamicos

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application