ES2089258T3 - Derivados de 1,2,4-triazolo(1,5-a)pirimidina, procedimiento para prepararlos, asi como medicamentos que los contienen y utilizacion de los mismos. - Google Patents
Derivados de 1,2,4-triazolo(1,5-a)pirimidina, procedimiento para prepararlos, asi como medicamentos que los contienen y utilizacion de los mismos.Info
- Publication number
- ES2089258T3 ES2089258T3 ES92102981T ES92102981T ES2089258T3 ES 2089258 T3 ES2089258 T3 ES 2089258T3 ES 92102981 T ES92102981 T ES 92102981T ES 92102981 T ES92102981 T ES 92102981T ES 2089258 T3 ES2089258 T3 ES 2089258T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- group
- rent
- formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPUESTOS DE FORMULA EN DONDE Q REPRESENTA H O UN GRUPO HETEROCICLICO QUE CONTIENE NITROGENO Y/O ATOMOS DE OXIGENO, S(O)P OPCIONALMENTE POR ALQUILO, ALQUENILO O FENILALQUILO, O OPCIONALMENTE SUSTITUIBLE POR FENILO, O UN GRUPO EN DONDE R SUB 4 Y R SUB 5 REPRESENTA HIDROGENO, ALQUILO, ALQUENILO, FENIALALQUILO, O AMINOALQUILO DI-(ALQUILO)-, R SUB 1 Y R SUB 2 REPRESENTA HIDROGENO O ALQUILO O R SUB 1 Y R SUB 2 JUNTOS FORMAN UN GRUPO EN DONDE Y SIMBOLIZA UN GRUPO CH SUB 2, AZUFRE, O UN GRUPO DE FORMULA EN DONDE R SUB 6 DENOTA HIDROGENO O FENILALQUILO, N Y M SON 0-5 Y Z REPRESENTA UN GRUPO EN DONDE R SUB 7 Y R SUB 8 REPRESENTA HIDROGENO, ALQUILO, LLEVANDO OPCIONALMENTE HIDROXY, CARBOXY, AMINO, MORFOLINOCARBONILO, [4-(2''-{HIDROXY}-ETILO) -PIPERAZINA-1''-YL] NALMENTE UN GRUPO HETEROCICLICO QUE CONTIENE NITROGENO Y/O ATOMOS DE OXIGENO, ALQUENILO, CICLOALQUILO, ADAMANTILO, O FENILALQUILO, ALQUILOAMINOALQUILO Y DI-(ALQUILO)-AMINOALQUILO; O R SUB 7 Y R SUB 8 FORMAN UN GRUPO EN DONDE J Y K REPRESENTA 1,2, O 3 Y W REPRESENTA OXIGENO, UN UN O UN GRUPO DE FORMULA EN DONDE R SUB 10 DENOTA HIDROGENO, ALCOXICARBONILO, SUSTITUIBLE OPCIONALMENTE POR ALQUILO, O REPRESENTANDO UN GRUPO DE FORMULA R SUB 9 EN DONDE R SUB 9 REPRESENTA ALQUILO, SUSTITUIBLE OPCIONALMENTE POR UN GRUPO ALCOXICARBONILO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU91587A HU208693B (en) | 1991-02-22 | 1991-02-22 | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2089258T3 true ES2089258T3 (es) | 1996-10-01 |
Family
ID=10950293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92102981T Expired - Lifetime ES2089258T3 (es) | 1991-02-22 | 1992-02-24 | Derivados de 1,2,4-triazolo(1,5-a)pirimidina, procedimiento para prepararlos, asi como medicamentos que los contienen y utilizacion de los mismos. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0500136B1 (es) |
| JP (1) | JPH05148267A (es) |
| KR (1) | KR920016456A (es) |
| CN (1) | CN1033585C (es) |
| AT (1) | ATE138067T1 (es) |
| AU (1) | AU642073B2 (es) |
| CA (1) | CA2061629A1 (es) |
| CS (1) | CS51592A3 (es) |
| DE (1) | DE69210647T2 (es) |
| ES (1) | ES2089258T3 (es) |
| FI (1) | FI100401B (es) |
| GB (1) | GB2254611B (es) |
| HU (1) | HU208693B (es) |
| IL (1) | IL101033A (es) |
| PL (1) | PL170050B1 (es) |
| RU (1) | RU2097382C1 (es) |
| TW (1) | TW213462B (es) |
| YU (1) | YU17592A (es) |
| ZA (1) | ZA921269B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW224044B (es) * | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
| IL108731A (en) * | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
| EP0628559B1 (en) * | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
| US5571813A (en) * | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
| US8508469B1 (en) | 1995-12-01 | 2013-08-13 | Immersion Corporation | Networked applications including haptic feedback |
| US6448253B1 (en) * | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| AU2002347055B2 (en) * | 2001-10-08 | 2006-10-12 | F. Hoffmann-La Roche Ag | Substituted Triazolopyridine Compounds |
| WO2005037837A1 (ja) * | 2003-10-17 | 2005-04-28 | Nippon Kayaku Kabushiki Kaisha | 置換２−アミノ−[１，２，４]トリアゾロ[１，５−a]ピリミジン誘導体及びその用途 |
| RU2378278C2 (ru) * | 2008-01-24 | 2010-01-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 3-СУЛЬФОНИЛ-[1,2,3]ТРИАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ |
| JP5818266B2 (ja) | 2009-09-29 | 2015-11-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | ジヒドロオロット酸デヒドロゲナーゼの阻害剤である抗マラリア剤 |
| DK3134413T3 (da) | 2014-04-23 | 2019-10-14 | Dart Neuroscience Cayman Ltd | Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1792811C2 (de) * | 1966-10-03 | 1982-12-30 | VEB Deutsches Hydrierwerk Rodleben, DDR 4530 Roßlau | "Arzneimittel mit koronargefäßerweiternder Wirkung" |
| DE2327133A1 (de) * | 1972-06-07 | 1974-01-03 | Icn Pharmaceuticals | 2-subst.-thio-s-triazolo eckige klammer auf 1,5a eckige klammer zu -pyrimidine |
| US4497814A (en) * | 1982-08-16 | 1985-02-05 | Schering Corporation | 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility |
| DD280111A1 (de) * | 1986-01-09 | 1990-06-27 | Hydrierwerk Rodleben Veb | Verfahren zur herstellung neuer triazolo-pyrimidine |
-
1991
- 1991-02-22 HU HU91587A patent/HU208693B/hu not_active IP Right Cessation
-
1992
- 1992-02-21 KR KR1019920002616A patent/KR920016456A/ko not_active Abandoned
- 1992-02-21 RU SU925011062A patent/RU2097382C1/ru active
- 1992-02-21 GB GB9203736A patent/GB2254611B/en not_active Expired - Fee Related
- 1992-02-21 JP JP4070092A patent/JPH05148267A/ja active Pending
- 1992-02-21 ZA ZA921269A patent/ZA921269B/xx unknown
- 1992-02-21 AU AU11175/92A patent/AU642073B2/en not_active Ceased
- 1992-02-21 CA CA002061629A patent/CA2061629A1/en not_active Abandoned
- 1992-02-21 YU YU17592A patent/YU17592A/sh unknown
- 1992-02-21 FI FI920776A patent/FI100401B/fi active
- 1992-02-21 CS CS92515A patent/CS51592A3/cs unknown
- 1992-02-21 IL IL10103392A patent/IL101033A/en not_active IP Right Cessation
- 1992-02-21 PL PL92293564A patent/PL170050B1/pl unknown
- 1992-02-22 CN CN92101158A patent/CN1033585C/zh not_active Expired - Fee Related
- 1992-02-24 EP EP92102981A patent/EP0500136B1/en not_active Expired - Lifetime
- 1992-02-24 ES ES92102981T patent/ES2089258T3/es not_active Expired - Lifetime
- 1992-02-24 AT AT92102981T patent/ATE138067T1/de not_active IP Right Cessation
- 1992-02-24 DE DE69210647T patent/DE69210647T2/de not_active Expired - Fee Related
- 1992-04-09 TW TW081102762A patent/TW213462B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| AU1117592A (en) | 1992-08-27 |
| CS51592A3 (en) | 1992-10-14 |
| CN1064277A (zh) | 1992-09-09 |
| HUT61308A (en) | 1992-12-28 |
| GB2254611B (en) | 1995-04-26 |
| GB2254611A (en) | 1992-10-14 |
| EP0500136A1 (en) | 1992-08-26 |
| HU208693B (en) | 1993-12-28 |
| CA2061629A1 (en) | 1992-08-23 |
| IL101033A0 (en) | 1992-11-15 |
| RU2097382C1 (ru) | 1997-11-27 |
| FI920776A0 (fi) | 1992-02-21 |
| IL101033A (en) | 1996-07-23 |
| KR920016456A (ko) | 1992-09-24 |
| DE69210647T2 (de) | 1997-01-09 |
| FI100401B (fi) | 1997-11-28 |
| PL170050B1 (pl) | 1996-10-31 |
| YU17592A (sh) | 1995-03-27 |
| PL293564A1 (en) | 1992-11-02 |
| ATE138067T1 (de) | 1996-06-15 |
| TW213462B (es) | 1993-09-21 |
| AU642073B2 (en) | 1993-10-07 |
| HU910587D0 (en) | 1991-09-30 |
| DE69210647D1 (de) | 1996-06-20 |
| EP0500136B1 (en) | 1996-05-15 |
| GB9203736D0 (en) | 1992-04-08 |
| CN1033585C (zh) | 1996-12-18 |
| JPH05148267A (ja) | 1993-06-15 |
| FI920776A7 (fi) | 1992-08-23 |
| ZA921269B (en) | 1993-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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