NO932117L - Hydroksaminsyrederivater - Google Patents

Hydroksaminsyrederivater

Info

Publication number: NO932117L
Authority: NO; Norway
Prior art keywords: lower alkyl; carbamoyl; atom; aryl; oxo
Prior art date: 1992-06-11

Application number

NO932117A

Other languages

English (en)

Norwegian (no)

Other versions

NO932117D0 (no

Inventor

Michael John Broadhurst

Paul Anthony Brown

William Henry Johnson

Geoffrey Lawton

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-11

Filing date

1993-06-10

Publication date

1993-12-13

1992-06-11 Priority claimed from GB929212421A external-priority patent/GB9212421D0/en

1993-06-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1993-06-10 Publication of NO932117D0 publication Critical patent/NO932117D0/no

1993-12-13 Publication of NO932117L publication Critical patent/NO932117L/no

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
-1 amino, carboxy Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
208000012659 Joint disease Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
239000002442 collagenase inhibitor Substances 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)

NO932117A 1992-06-11 1993-06-10 Hydroksaminsyrederivater NO932117L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929212421A GB9212421D0 (en)	1992-06-11	1992-06-11	Hydroxamic acid derivatives
GB939305720A GB9305720D0 (en)	1992-06-11	1993-03-19	Hydroxamic acid derivatives

Publications (2)

Publication Number	Publication Date
NO932117D0 NO932117D0 (no)	1993-06-10
NO932117L true NO932117L (no)	1993-12-13

Family

ID=26301054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO932117A NO932117L (no)	1992-06-11	1993-06-10	Hydroksaminsyrederivater

Country Status (21)

Country	Link
US (2)	US5318964A (de)
EP (1)	EP0574758B1 (de)
JP (1)	JPH0776210B2 (de)
CN (1)	CN1035616C (de)
AT (1)	ATE170840T1 (de)
AU (1)	AU659555B2 (de)
BG (1)	BG61724B1 (de)
CA (1)	CA2098168A1 (de)
CZ (1)	CZ283373B6 (de)
DE (1)	DE69320869T2 (de)
DK (1)	DK0574758T3 (de)
ES (1)	ES2121896T3 (de)
FI (1)	FI109535B (de)
HU (1)	HU9301645D0 (de)
IL (1)	IL105921A (de)
IS (1)	IS4031A (de)
MY (1)	MY108798A (de)
NO (1)	NO932117L (de)
NZ (1)	NZ247765A (de)
PH (1)	PH30245A (de)
SK (1)	SK57393A3 (de)

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EP1066273A1 (de) *	1998-03-25	2001-01-10	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitore
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
FR2780402B1 (fr) *	1998-06-30	2001-04-27	Adir	Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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US6114361A (en) *	1998-11-05	2000-09-05	Pfizer Inc.	5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
GB9903598D0 (en) *	1999-02-18	1999-04-07	Univ Manchester	Connective tissue healing
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WO2000059285A2 (en)	1999-04-02	2000-10-12	Du Pont Pharmaceuticals Company	NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE
US6696456B1 (en)	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
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EP1265865A2 (de) *	2000-03-21	2002-12-18	The Procter & Gamble Company	Difluorbuttersäure-derivate und ihre verwendung als metalloprotease-hemmer
KR20030005229A (ko) *	2000-03-21	2003-01-17	더 프록터 앤드 갬블 캄파니	메탈로프로테아제 저해제를 함유하는 탄소환식 측쇄
US6620823B2 (en)	2000-07-11	2003-09-16	Bristol-Myers Squibb Pharme Company	Lactam metalloprotease inhibitors
EP1306367B1 (de)	2000-07-19	2007-07-18	Mitsubishi Pharma Corporation	Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten
AR036053A1 (es)	2001-06-15	2004-08-04	Versicor Inc	Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
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US4743587A (en) *	1985-09-10	1988-05-10	G. D. Searle & Co.	Hydroxamic acid based collagenase inhibitors
GB8827308D0 (en) *	1988-11-23	1988-12-29	British Bio Technology	Compounds

1993
- 1993-05-24 US US08/066,832 patent/US5318964A/en not_active Expired - Fee Related
- 1993-05-26 AU AU39816/93A patent/AU659555B2/en not_active Ceased
- 1993-05-28 EP EP93108628A patent/EP0574758B1/de not_active Expired - Lifetime
- 1993-05-28 DK DK93108628T patent/DK0574758T3/da active
- 1993-05-28 ES ES93108628T patent/ES2121896T3/es not_active Expired - Lifetime
- 1993-05-28 DE DE69320869T patent/DE69320869T2/de not_active Expired - Fee Related
- 1993-05-28 AT AT93108628T patent/ATE170840T1/de not_active IP Right Cessation
- 1993-06-02 NZ NZ247765A patent/NZ247765A/en unknown
- 1993-06-04 CZ CZ931081A patent/CZ283373B6/cs unknown
- 1993-06-04 HU HU9301645A patent/HU9301645D0/hu unknown
- 1993-06-07 IL IL105921A patent/IL105921A/en not_active IP Right Cessation
- 1993-06-08 SK SK573-93A patent/SK57393A3/sk unknown
- 1993-06-09 BG BG97857A patent/BG61724B1/bg unknown
- 1993-06-09 MY MYPI93001124A patent/MY108798A/en unknown
- 1993-06-10 NO NO932117A patent/NO932117L/no unknown
- 1993-06-10 IS IS4031A patent/IS4031A/is unknown
- 1993-06-10 JP JP5165228A patent/JPH0776210B2/ja not_active Expired - Fee Related
- 1993-06-10 CN CN93107239A patent/CN1035616C/zh not_active Expired - Fee Related
- 1993-06-10 CA CA002098168A patent/CA2098168A1/en not_active Abandoned
- 1993-06-10 PH PH46328A patent/PH30245A/en unknown
- 1993-06-11 FI FI932692A patent/FI109535B/fi active
1994
- 1994-03-17 US US08/214,895 patent/US5447929A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BG97857A (bg)	1994-12-02
CN1083062A (zh)	1994-03-02
DE69320869D1 (de)	1998-10-15
MY108798A (en)	1996-11-30
EP0574758B1 (de)	1998-09-09
HU9301645D0 (en)	1993-09-28
JPH0665196A (ja)	1994-03-08
AU3981693A (en)	1993-12-16
FI932692L (fi)	1993-12-12
NZ247765A (en)	1995-11-27
NO932117D0 (no)	1993-06-10
SK57393A3 (en)	1994-05-11
DK0574758T3 (da)	1999-06-07
JPH0776210B2 (ja)	1995-08-16
FI932692A0 (fi)	1993-06-11
US5318964A (en)	1994-06-07
BG61724B1 (bg)	1998-04-30
US5447929A (en)	1995-09-05
CZ283373B6 (cs)	1998-04-15
ATE170840T1 (de)	1998-09-15
EP0574758A1 (de)	1993-12-22
FI109535B (fi)	2002-08-30
CZ108193A3 (en)	1994-02-16
CA2098168A1 (en)	1993-12-12
IL105921A0 (en)	1993-10-20
IS4031A (is)	1993-12-12
AU659555B2 (en)	1995-05-18
IL105921A (en)	1998-01-04
DE69320869T2 (de)	1999-04-29
ES2121896T3 (es)	1998-12-16
CN1035616C (zh)	1997-08-13
PH30245A (en)	1997-02-05

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NO932117L (no)	1993-12-13	Hydroksaminsyrederivater
NO932326L (no)	1993-12-27	Hydroksaminsyrederivater
HU9801923D0 (en)	1998-10-28	Pharmaceutical intermediates
AR004495A1 (es)	1998-12-16	Compuestos derivados de acido amino sustituido arilo y heteroarilo carboxilico; composicion farmaceutica que los contiene; uso de los compuestos; proceso para preparar dichos compuestos y compuestos utiles como material de partida.
ATE94534T1 (de)	1993-10-15	Antiarrhythmische verbindungen.
ATE142494T1 (de)	1996-09-15	2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
DK584886D0 (da)	1986-12-05	Vanduoplaeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
AU1214383A (en)	1983-09-15	Pyridine derivatives
ES2147836T3 (es)	2000-10-01	Derivados de 4,5-diariloxazol.
EP0943613A4 (de)	2002-07-10	Sauerstoff enthaltende heterocyclische verbindungen
DK213179A (da)	1979-11-27	Triazinderivater
AU591165B2 (en)	1989-11-30	Angiotensin converting enzyme inhibitors
MX9204877A (es)	1993-04-01	Inhibidores de acat de tetrazol de amida
KR850001761A (ko)	1985-04-01	세팔로스포린 유도체의 제조방법
GB1428626A (en)	1976-03-17	Trisubstituted 1,2,4-triazoles
HUT61967A (en)	1993-03-29	Process for producing new alkyl aminoalkyl amine- and -ether derivatives and pharmaceutical compositions comprising such compounds
YU24795A (sh)	1997-12-05	Derivati hidroksamove kiseline sa tricikličnom supstitucijom
YU39593A (sh)	1997-08-22	Derivati hidroksamne kiseline
AU569714B2 (en)	1988-02-18	Substituted 9h-8-oxo-pyrimido(2,1-f)purine-2,4-diones
BR0007729A (pt)	2001-10-30	Composto, composição farmacêutica, e, métodos decontrole de infecções bacterianas em umhospedeiro em necessidade de tal terapia, e depreparo de um composto
MY134743A (en)	2007-12-31	Derivatives of hydroxyamino-succinic acid
RU93048339A (ru)	1996-04-27	Производные гидроксамовых кислот
MY155266A (en)	2015-09-30	Selective thrombin inhibitors